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Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Optimizing Molecular Diagnosis of Systemic Mastocytosis in the Era of KIT Tyrosine Kinase Inhibitors: Results of a Survey and of a Nationwide Proficiency Control Round of KIT D816V Mutation Testing Promoted By the RIMA (Rete Italiana MAstocitosi) Association

Simona Soverini, Cecilia Monaldi, Sara De Santis, Manuela Mancini, Francesco Albano, Luisa Anelli, Loredana Bruno, Ignazio Brusca, Grazia Fazio, Lilia Maria Corral Abascal, Francesca Guerrini, Clara Bono, Giovanni Iaquinta, Paola Grammatico, Elisabetta Novella, Omar Perbellini, Orietta Spinelli, Silvia Salmoiraghi, Stefano Baldoni, Alessia Persico, Giuseppa De Luca, Calogero Lauricella, Giovanna Piras, Angelo D. Palmas, Samantha Bruno, Cristina Mosca, Chiara Sartor, Cristina Papayannidis, Paola Guglielmelli, Alessandro M. Vannucchi, Patrizia Bonadonna, Francesco Mannelli, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Chiara Elena
Journal: Blood
Blood (2024) 144 (Supplement 1): 7640.
https://doi.org/10.1182/blood-2024-202485
Published: 2024
Journal Articles

T/NK Cell-Associated Transcriptomic Profile Informs Response to FLT3 Inhibitors in Acute Myeloid Leukemia

Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Marilena Ciciarello, Karyna Volkava, Samantha Bruno, Valentina Robustelli, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Federico Zingarelli, Andrea Davide Romagnoli, Caterina Azzimondi, Federica Ardizzoia, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Ajsi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Sarah Parisi, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2916.
https://doi.org/10.1182/blood-2024-205994
Published: 2024
Journal Articles

Single-Cell Metabolic Profiling Integrated with Extracellular Vesicle Analysis Reveals Novel Metabolic Vulnerabilities and Prognostic Biomarkers in Acute Myeloid Leukemia

Dorian Forte, Filippo Maltoni, Samantha Bruno, Paulina Garcia-Gonzalez, Gianluca Cristiano, Chiara Sartor, Simona Soverini, Lucia Catani, Rafael José Argüello, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 1598.
https://doi.org/10.1182/blood-2023-185909
Published: 2023
Journal Articles

Loss of Function of SETD2 Tumor Suppressor in Chronic Myeloid Leukemia (CML) Progenitors Fosters Genomic Instability and Enhances Clonogenic Potential

Sara De Santis, Manuela Mancini, Cecilia Monaldi, Gabriele Gugliotta, Samantha Bruno, Fausto Castagnetti, Miriam Iezza, Marco Cerrano, Alessandra Iurlo, Sara Galimberti, Serena Balducci, Fabio Stagno, Michele Cavo, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1785.
https://doi.org/10.1182/blood-2023-185677
Published: 2023
Journal Articles

T Cell/Natural Killer (NK) Cell Transcriptional Profiles Are Associated with Response to Gilteritinib in FLT3 -Mutated Acute Myeloid Leukemia

Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Samantha Bruno, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Sarah Parisi, Federico Zingarelli, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Marilena Ciciarello, Aisi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 2947.
https://doi.org/10.1182/blood-2023-184741
Published: 2023
Journal Articles

Mesenchymal Stromal Cells Protect Acute Myeloid Leukemia Cells from Venetoclax-Induced Apoptosis through Contact-Dependent Mechanisms

Giulia Corradi, Samantha Bruno, Gaia Mazzocchetti, Jacopo Nanni, Andrea Polimeno, Michele Cavo, Marilena Ciciarello, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 11424–11425.
https://doi.org/10.1182/blood-2022-166792
Published: 2022
Journal Articles

Extracellular Vesicle-Based Liquid Biopsy Shows Clinical Relevance and Reveals Links with Single-Cell Metabolic Signature in Acute Myeloid Leukemia

Dorian Forte, Rafael J. Argüello, Roberto Maria Pellegrino, Husam B.R. Alabed, Martina Barone, Samantha Bruno, Francesco Fabbri, Ivan Vannini, Gianluca Cristiano, Sandra Buratta, Lorena Urbanelli, Carla Emiliani, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 3389–3390.
https://doi.org/10.1182/blood-2022-165850
Published: 2022
Journal Articles

Parallel Detection of Single-Cells and Extracellular Vesicles from Bone Marrow and Peripheral Blood Reveals Asymmetric Immunometabolic Profile in Acute Myeloid Leukemia

Dorian Forte, Rafael J. Argüello, Martina Barone, Samantha Bruno, Gianluca Cristiano, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 9158–9159.
https://doi.org/10.1182/blood-2022-166761
Published: 2022
Journal Articles

Circulating Extracellular Vesicles from Acute Myeloid Leukemia Patients Drive Distinct Metabolic Profile of Leukemic Cells and Reveal Crucial Lipidomic Biomarkers

Dorian Forte, Roberto Maria Pellegrino, Francesco Fabbri, Ivan Vannini, Samantha Bruno, Giulia Corradi, Rafael J. Argüello, Gianluca Cristiano, Sandra Buratta, Lorena Urbanelli, Carla Emiliani, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2021) 138 (Supplement 1): 3471.
https://doi.org/10.1182/blood-2021-150339
Published: 2021
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Maria Chiara Fontana, MSc, Matteo Olivi, Giovanni Marconi, Mariachiara Abbenante, MD, Eugenio Fonzi, PhD, Stefania Paolini, MD PhD, Chiara Sartor, Sarah Parisi, Samantha Bruno, Martina Pazzaglia, Stefano De Polo, Jacopo Nanni, MD, Luca Bertamini, MD, Simone Ragaini, Annalisa Talami, Maria Teresa Bochicchio, Emanuela Ottaviani, Anna Ferrari, PhD, Carmen Baldazzi, Nicoletta Testoni, BSc, Torsten Haferlach, MD, Robert Kralovics, PhD, Jelena D. Milosevic Feenstra, PhD, Simona Soverini, PhD, Giovanni Martinelli, Antonio Curti, Michele Cavo, MD, Cristina Papayannidis, Giorgia Simonetti, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2748.
https://doi.org/10.1182/blood-2018-99-118183
Published: 2018
Journal Articles

The Malignant Hemopoietic Clone of Triple Negative Patients with Myelofibrosis Shows in Vitro Functional Defects but Is Highly Responsive to the Pro-Survival Signals of Circulating Autologous Microvesicles

Lucia Catani, PhD, Daria Sollazzo, Dorian Forte, Martina Barone, Cristina Morsiani, Francesco Fabbri, Giorgia Simonetti, PhD, Francesca Ricci, Samantha Bruno, Natalia Calonghi, Emanuela Ottaviani, Marco Romano, Pierluigi Tazzari, Claudio Franceschi, Massimiliano Bonafè, Nicola Vianelli, MD, Giovanni Martinelli, Michele Cavo, MD, Miriam Capri, Giuseppe Auteri, MD, Francesca Palandri, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4334.
https://doi.org/10.1182/blood-2018-99-114507
Published: 2018
Journal Articles

Alternative Overexpression of NRF2 or MYC Defines a Subgroup of Poor Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation

Giorgia Simonetti, PhD, Samantha Bruno, Carmine Onofrillo, PhD, Cristina Papayannidis, Giovanni Marconi, Michele Cavo, MD, Lorenzo Montanaro, MD PhD, Giovanni Martinelli
Journal: Blood
Blood (2018) 132 (Supplement 1): 2639.
https://doi.org/10.1182/blood-2018-99-117429
Published: 2018
Journal Articles

Bromodomain Inhibition Is Effective Against Acute Myeloid Leukemia Cells Under Hypoxia and Induces Genome-Dependent Metabolic Perturbations

Giorgia Simonetti, PhD, Samantha Bruno, MSc, Carmine Onofrillo, PhD, Marco Malferrari, PhD, Cristina Papayannidis, MD PhD, Giovanni Marconi, MD, Michele Cavo, MD, Stefania Rapino, PhD, Lorenzo Montanaro, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3936.
https://doi.org/10.1182/blood.V130.Suppl_1.3936.3936
Published: 2017
Journal Articles

A Three-Genes Signature of Anti-Apoptotic Genes Showed Different Mechanisms in Preventing Apoptosis in Acute Myeloid Leukemia Cells and Could Provide an Useful Model to Establish the Proper BH3-Mimetich Drug or Combination

Jacopo Nanni, MD, Giorgia Simonetti, PhD, Giovanni Marconi, MD, Maria Chiara Fontana, MSc, Samantha Bruno, MSc, Cristina Papayannidis, MD, Antonella Padella, Mariachiara Abbenante, MD, Silvia lo Monaco, Elena Tenti, PhD, Chiara Sartor, Sarah Parisi, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4969.
https://doi.org/10.1182/blood.V130.Suppl_1.4969.4969
Published: 2017
Journal Articles

Alterations of BRCA1 and PALB2 Define a Novel Class of Complex-Karyotype AML with a Very Bad Prognosis

Antonella Padella, Giorgia Simonetti, PhD, Marco Manfrini, PhD, Maria Chiara Fontana, Giovanni Marconi, MD, Anna Ferrari, PhD, Italo Faria do Valle, Marianna Garonzi, Cristina Papayannidis, MD PhD, Eugenia Franchini, Elisa Zuffa, PhD, Viviana Guadagnuolo, PhD, Samantha Bruno, Elena Tenti, Carmen Baldazzi, PhD, Emanuela Ottaviani, Nicoletta Testoni, Daniel Remondini, PhD, Massimo Delledonne, PhD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1677.
https://doi.org/10.1182/blood.V128.22.1677.1677
Published: 2016
Journal Articles

Chromothripsis in Acute Myeloid Leukemia Is Strongly Associated with Poor Prognosis and TP53 Alterations

Maria Chiara Fontana, Giovanni Marconi, MD, Jelena D. Milosevic Feenstra, PhD, Cristina Papayannidis, MD PhD, Marco Manfrini, PhD, Viviana Guadagnuolo, PhD, Giorgia Simonetti, PhD, Antonella Padella, Anna Ferrari, PhD, Eugenia Franchini, Andrea Ghelli Luserna di Rorà, Emanuela Ottaviani, Rossella De Tommaso, Samantha Bruno, Simona Soverini, Nicoletta Testoni, Stefania Paolini, Chiara Sartor, Sarah Parisi, MD, Elena Tenti, Robert Kralovics, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1678.
https://doi.org/10.1182/blood.V128.22.1678.1678
Published: 2016
Journal Articles

Aggressive Aneuploid Acute Myeloid Leukemia Is Dependent on Alterations of P53, Gain of APC and PLK1 and Loss of RAD50

Giorgia Simonetti, PhD, Antonella Padella, Marco Manfrini, PhD, Italo Faria do Valle, Cristina Papayannidis, MD PhD, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Carmen Baldazzi, PhD, Anna Ferrari, PhD, Samantha Bruno, Alberto Ferrarini, PhD, Simona Bernardi, PhD, Marianna Garonzi, Annalisa Astolfi, PhD, Giovanni Marconi, MD, Elisa Zuffa, PhD, Eugenia Franchini, Emanuela Ottaviani, Antonella Laginestra, Maddalena Raffini, Sara Bacilieri, Nicoletta Testoni, Massimo Delledonne, PhD, Torsten Haferlach, MD, Daniel Remondini, PhD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1702.
https://doi.org/10.1182/blood.V128.22.1702.1702
Published: 2016