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Maria Chiara Fontana
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Journal Articles

Impact of Comorbidities on Prognosis of Elderly Patients with Acute Myeloid Leukemia Who Receive Hypomethylating Agents

Giovanni Marconi, Anna Candoni, Roberta di Nicola, Chiara Sartor, Sarah Parisi, Mariachiara Abbenante, Jacopo Nanni, Gianluca Cristiano, Davide Lazzarotto, Maria Benedetta Giannini, Carmen Baldazzi, Maria Chiara Fontana, Lorenza Bandini, Emanuela Ottaviani, Nicoletta Testoni, Chiara Di Giovanni Bezzi, Rania Abd-alatif, Renato Fanin, Giovanni Martinelli, Stefania Paolini, Michele Cavo, Cristina Papayannidis, Antonio Curti
Journal: Blood
Blood (2021) 138 (Supplement 1): 3373.
https://doi.org/10.1182/blood-2021-149459
Published: 2021
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Andrea Ghelli Luserna Di Rorà, PhD, Antonella Padella, PhD, Maria Chiara Fontana, PhD, Eugenio Fonzi, PhD, Anna Ferrari, PhD, Enrica Imbrogno, PhD, Martina Ghetti, PhD, Roberta Napolitano, PhD, Maria Teresa Bochicchio, Giovanni Martinelli, MD, Giorgia Simonetti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5047.
https://doi.org/10.1182/blood-2019-129964
Published: 2019
Journal Articles

AML-CM Score Predicts Prognosis in Hemato-Geriatric Patients with New-Onset Acute Myeloid Leukemia (AML) Who Receive Hypomethylating Agents (HMA)

Giovanni Marconi, Roberta di Nicola, Chiara Sartor, MD, Mariachiara Abbenante, MD, Jacopo Nanni, MD, Gianluca Cristiano, MD, Sarah Parisi, MD PhD, Carmen Baldazzi, PhD, Maria Chiara Fontana, PhD, Lorenza Bandini, Emanuela Ottaviani, Nicoletta Testoni, Giovanni Martinelli, MD, Michele Baccarani, MD, Cristina Papayannidis, Stefania Paolini, MD PhD, Michele Cavo, Antonio Curti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2617.
https://doi.org/10.1182/blood-2019-130630
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Maria Chiara Fontana, MSc, Matteo Olivi, Giovanni Marconi, Mariachiara Abbenante, MD, Eugenio Fonzi, PhD, Stefania Paolini, MD PhD, Chiara Sartor, Sarah Parisi, Samantha Bruno, Martina Pazzaglia, Stefano De Polo, Jacopo Nanni, MD, Luca Bertamini, MD, Simone Ragaini, Annalisa Talami, Maria Teresa Bochicchio, Emanuela Ottaviani, Anna Ferrari, PhD, Carmen Baldazzi, Nicoletta Testoni, BSc, Torsten Haferlach, MD, Robert Kralovics, PhD, Jelena D. Milosevic Feenstra, PhD, Simona Soverini, PhD, Giovanni Martinelli, Antonio Curti, Michele Cavo, MD, Cristina Papayannidis, Giorgia Simonetti, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2748.
https://doi.org/10.1182/blood-2018-99-118183
Published: 2018
Journal Articles

Mitoxantrone, Etoposide and Cytarabine (MEC) Can Induce Deep Complete Remission and Is an Effective Bridge Therapy to Allotransplantation (SCT) in Refractory/Relapsed Acute Myeloid Leukemia (AML) Patients

Giovanni Marconi, Annalisa Talami, Maria Chiara Abbenante, Stefania Paolini, MD PhD, Chiara Sartor, Sarah Parisi, Stefano de Polo, Jacopo Nanni, MD, Luca Bertamini, MD, Simone Ragaini, Matteo Olivi, Maria Chiara Fontana, MSc, Maria Teresa Bochicchio, Emanuela Ottaviani, Carmen Baldazzi, Nicoletta Testoni, BSc, Giovanni Martinelli, Michele Cavo, MD, Cristina Papayannidis, Antonio Curti
Journal: Blood
Blood (2018) 132 (Supplement 1): 4036.
https://doi.org/10.1182/blood-2018-99-113036
Published: 2018
Journal Articles

A New Gene Expression Profile Signature CRLF2 Overexpression Based Identifies Novel Adult "Triple Negative" Acute Lymphoblastic Leukemia Subgroups

Anna Ferrari, PhD, Silvia Vitali, PhD, Valentina Robustelli, PhD, Andrea Ghelli Luserna Di Rora, Simona Righi, Giovanni Pasquini, Cristina Papayannidis, Giovanni Marconi, Giulia Ferrari, Maria Chiara Fontana, MSc, Enrica Imbrogno, Eugenio Fonzi, PhD, Antonella Padella, Giorgia Simonetti, PhD, Alessandra Santoro, PhD, Jesús-María Hernández-Rivas, MD PhD, Michela Tebaldi, Samanta Salvi, Carmen Baldazzi, Maria Chiara Abbenante, Nicoletta Testoni, BSc, Massimiliano Bonafè, Castellani Gastone, Elena Sabattini, Michele Cavo, MD, Daniel Remondini, Giovanni Martinelli
Journal: Blood
Blood (2018) 132 (Supplement 1): 5284.
https://doi.org/10.1182/blood-2018-99-118062
Published: 2018
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, Maria Chiara Fontana, MSc, Elisa Dan, Barbara Sinigaglia, Alessandra Iurlo, Nicola Orofino, Elisabetta Abruzzese, Marzia Salvucci, Patrizia Pregno, Antonella Gozzini, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1726.
https://doi.org/10.1182/blood-2018-99-112908
Published: 2018
Journal Articles

Higher Expression of PALB2 Predict Poor Prognosis in AML Patients and Identifies Potential Targets of Synthetic Lethal Therapies

Antonella Padella, Giovanni Marconi, Giorgia Simonetti, PhD, Andrea Ghelli Luserna Di Rora, Maria Chiara Fontana, MSc, Cristina Papayannidis, Emanuela Ottaviani, Michele Cavo, MD, Simona Soverini, PhD, Giovanni Martinelli
Journal: Blood
Blood (2018) 132 (Supplement 1): 1507.
https://doi.org/10.1182/blood-2018-99-118210
Published: 2018
Journal Articles

MDM2 and Aurora Kinase a Contribute to SETD2 Loss of Function in Advanced Systemic Mastocytosis: Implications for Pathogenesis and Treatment

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Margherita Martelli, Abbenante Maria Chiara, Antonio Curti, Elisa Ficarra, Giulia Paciello, Maria Chiara Fontana, MSc, Roberta Zanotti, MD, Massimiliano Bonifacio, Luigi Scaffidi, MD, Livio Pagano, Marianna Criscuolo, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, MD, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, Giovanni Martinelli, MD, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1779.
https://doi.org/10.1182/blood-2018-99-113278
Published: 2018
Journal Articles

SETD2 Non-Genomic Loss of Function and p53 Functional Inactivation in Advanced Systemic Mastocytosis (SM): Pathogenetic and Therapeutic Implications

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Elisa Ficarra, Giulia Paciello, Viviana Guadagnuolo, Maria Chiara Fontana, MSc, Marco Manfrini, Roberta Zanotti, MD, Livio Pagano, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, Patrizia Tosi, MD, Massimo Delledonne, Peter Valent, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2944.
https://doi.org/10.1182/blood.V130.Suppl_1.2944.2944
Published: 2017
Journal Articles

A Three-Genes Signature of Anti-Apoptotic Genes Showed Different Mechanisms in Preventing Apoptosis in Acute Myeloid Leukemia Cells and Could Provide an Useful Model to Establish the Proper BH3-Mimetich Drug or Combination

Jacopo Nanni, MD, Giorgia Simonetti, PhD, Giovanni Marconi, MD, Maria Chiara Fontana, MSc, Samantha Bruno, MSc, Cristina Papayannidis, MD, Antonella Padella, Mariachiara Abbenante, MD, Silvia lo Monaco, Elena Tenti, PhD, Chiara Sartor, Sarah Parisi, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4969.
https://doi.org/10.1182/blood.V130.Suppl_1.4969.4969
Published: 2017
Journal Articles

MHC-I Antigen Presentation Role in Immune Escape of Acute Myeloid Leukemia with High Burden of Genomic Aberration

Giovanni Marconi, MD, Maria Chiara Fontana, MSc, Eugenio Fonzi, PhD, Cristina Papayannidis, MD, Mariachiara Abbenante, MD, Emanuela Ottaviani, Nicoletta Testoni, BSc, Giorgia Simonetti, PhD, Antonella Padella, Chiara Sartor, Carmen Baldazzi, Jacopo Nanni, MD, Luca Bertamini, MD, Andrea Ghelli Luserna Di Rora, Valentina Robustelli, Martina Pazzaglia, Elena Tenti, PhD, Sarah Parisi, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3958.
https://doi.org/10.1182/blood.V130.Suppl_1.3958.3958
Published: 2017
Journal Articles

Alterations of BRCA1 and PALB2 Define a Novel Class of Complex-Karyotype AML with a Very Bad Prognosis

Antonella Padella, Giorgia Simonetti, PhD, Marco Manfrini, PhD, Maria Chiara Fontana, Giovanni Marconi, MD, Anna Ferrari, PhD, Italo Faria do Valle, Marianna Garonzi, Cristina Papayannidis, MD PhD, Eugenia Franchini, Elisa Zuffa, PhD, Viviana Guadagnuolo, PhD, Samantha Bruno, Elena Tenti, Carmen Baldazzi, PhD, Emanuela Ottaviani, Nicoletta Testoni, Daniel Remondini, PhD, Massimo Delledonne, PhD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1677.
https://doi.org/10.1182/blood.V128.22.1677.1677
Published: 2016
Journal Articles

Chromothripsis in Acute Myeloid Leukemia Is Strongly Associated with Poor Prognosis and TP53 Alterations

Maria Chiara Fontana, Giovanni Marconi, MD, Jelena D. Milosevic Feenstra, PhD, Cristina Papayannidis, MD PhD, Marco Manfrini, PhD, Viviana Guadagnuolo, PhD, Giorgia Simonetti, PhD, Antonella Padella, Anna Ferrari, PhD, Eugenia Franchini, Andrea Ghelli Luserna di Rorà, Emanuela Ottaviani, Rossella De Tommaso, Samantha Bruno, Simona Soverini, Nicoletta Testoni, Stefania Paolini, Chiara Sartor, Sarah Parisi, MD, Elena Tenti, Robert Kralovics, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1678.
https://doi.org/10.1182/blood.V128.22.1678.1678
Published: 2016
Journal Articles

Alterations in Pathways Regulating Phosphatidil Inositol 3 Phosphate (PI3P) Produce Both Cell Proliferation and Therapy Resistance, and Define a Group of Patients with Poor Prognosis in Acute Myeloid Leukemia (AML)

Giovanni Marconi, MD, Cristina Papayannidis, MD PhD, Maria Chiara Fontana, Antonella Padella, Giorgia Simonetti, PhD, Marco Manfrini, PhD, Anna Ferrari, PhD, Eugenia Franchini, Stefania Paolini, MD, Sarah Parisi, MD, Chiara Sartor, Maria Chiara Abbenante, MD, Silvia Lo Monaco, Francesca Volpato, MD, Elena Tenti, Viviana Guadagnuolo, PhD, Margherita Perricone, PhD, Maria Teresa Bochicchio, Dr., Andrea Ghelli Luserna Di Rora, Carmen Baldazzi, PhD, Valentina Robustelli, Nicoletta Testoni, Simona Soverini, Emanuela Ottaviani, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1679.
https://doi.org/10.1182/blood.V128.22.1679.1679
Published: 2016
Journal Articles

Aggressive Aneuploid Acute Myeloid Leukemia Is Dependent on Alterations of P53, Gain of APC and PLK1 and Loss of RAD50

Giorgia Simonetti, PhD, Antonella Padella, Marco Manfrini, PhD, Italo Faria do Valle, Cristina Papayannidis, MD PhD, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Carmen Baldazzi, PhD, Anna Ferrari, PhD, Samantha Bruno, Alberto Ferrarini, PhD, Simona Bernardi, PhD, Marianna Garonzi, Annalisa Astolfi, PhD, Giovanni Marconi, MD, Elisa Zuffa, PhD, Eugenia Franchini, Emanuela Ottaviani, Antonella Laginestra, Maddalena Raffini, Sara Bacilieri, Nicoletta Testoni, Massimo Delledonne, PhD, Torsten Haferlach, MD, Daniel Remondini, PhD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1702.
https://doi.org/10.1182/blood.V128.22.1702.1702
Published: 2016
Journal Articles

The Genomic and Transcriptomic Landscape of Systemic Mastocytosis

Simona Soverini, Caterina De Benedittis, Michela Rondoni, Cristina Papayannidis, MD PhD, Elisa Ficarra, PhD, Giulia Paciello, Marco Manfrini, PhD, Manuela Mancini, Roberta Zanotti, MD, Luigi Scaffidi, Giorgina Specchia, MD, Francesco Albano, Serena Merante, MD, Chiara Elena, MD, Livio Pagano, Domenica Gangemi, Patrizia Tosi, Luana Bavaro, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Alberto Ferrarini, PhD, Elisa Zago, PhD, Michele Cavo, Massimo Delledonne, PhD, Peter Valent, MD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 3136.
https://doi.org/10.1182/blood.V128.22.3136.3136
Published: 2016
Journal Articles

Blinatumomab Is Safe and Effective in Relapsed and MRD Positive B-ALL CD19+ Patients: The Bologna Compassionate Program Experience

Cristina Papayannidis, MD PhD, Stefania Paolini, MD, Alessandra Santoro, Valentina Robustelli, Simona Soverini, Caterina De Benedittis, Enrica Imbrogno, Carolina Terragna, Andrea Ghelli Luserna Di Rora, Sarah Parisi, MD, Chiara Sartor, Giovanni Marconi, MD, Silvia Lo Monaco, Maria Chiara Abbenante, MD, Maria Chiara Fontana, Antonella Padella, Anna Ferrari, PhD, Giorgia Simonetti, PhD, Elena Tenti, Federica Frabetti, Francesca Volpato, MD, Carmen Baldazzi, PhD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 5191.
https://doi.org/10.1182/blood.V128.22.5191.5191
Published: 2016