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Alessandra Iurlo
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Journal Articles

Tyrosine Kinase Inhibitors Discontinuation in Chronic Myeloid Leukemia: Observational Study of 673 Patients in Italy

Valentina Bonuomo, Emanuele Koumantakis, Selene Grano, Paola Berchialla, Fausto Castagnetti, Bruno Martino, Chiara Elena, Monica Bocchia, Isabella Capodanno, Tamara Intermesoli, Maria Cristina Miggiano, Carlo Gambacorti-Passerini, Alessandra Iurlo, Francesca Lunghi, Luigiana Luciano, Elisabetta Abruzzese, Angelo Michele Carella, Massimo Breccia, Felicetto Ferrara, Sabrina Leonetti Crescenzi, Barbara Scappini, Marco De Gobbi, Federica Sorà, Davide Rapezzi, Debora Luzi, Sara Galimberti, Monica Crugnola, Anna Rita Scortechini, Alessandro Maggi, Massimiliano Bonifacio, Mario Annunziata, Giovanni Caocci, Germana Beltrami, Francesco Cavazzini, Giuseppe Pietrantuono, Leonardo Campiotti, Fabio Stagno, Caterina Musolino, Daniela Cilloni, Giuseppe Saglio, Carmen Fava
Journal: Blood
Blood (2024) 144 (Supplement 1): 3162.
https://doi.org/10.1182/blood-2024-201493
Published: 2024
Journal Articles

Association of Hypometilating Agents + Venetoclax in the Treatment of Secondary Acute Myeloid Leukemias Evolved from Chronic Myelomonocytic Leukemia

Francesco Onida, Antonella Bruzzese, Fabrizio Cavalca, Benedetta Cambò, Anna Lina Piccioni, Lorenzo Rizzo, Pasquale Niscola, Alda Strazimiri, Antonella Poloni, Gianni Binotto, Marzia Defina, Monica Piedimonte, Giulia De Luca, Cristina Bucelli, Susanna Fenu, Prassede Salutari, Massimiliano Bonifacio, Marta Riva, Monica Crugnola, Alessandra Iurlo, Ernesto Vigna, Elena Maria Elli, Roberto Latagliata
Journal: Blood
Blood (2024) 144 (Supplement 1): 6711.
https://doi.org/10.1182/blood-2024-207060
Published: 2024
Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Personalized Transplant Decision Making for Myelofibrosis in the Era of Molecular Genetics and JAK Inhibition

Nico Gagelmann, Barbara Mora, Filippo Branzanti, Alessandro Maria Vannucchi, Massimo Breccia, Giuseppe Alberto Maria Palumbo, Massimiliano Bonifacio, Erika Morsia, Elena Maria Elli, Mario Tiribelli, Giulia Benevolo, Mirko Farina, Fabrizio Pane, Roberto Massimo Lemoli, Giovanni Caocci, Alessia Tieghi, Gianni Binotto, Francesco Cavazzini, Bruno Martino, Alessandro Isidori, Margherita Maffioli, Elisa Rumi, Tiziano Barbui, Francisco Cervantes, Matteo Giovanni Della Porta, Andrew T. Kuykendall, Marianna Caramella, Alessandra Iurlo, Valerio De Stefano, Jean-Jacques Kiladjian, David Ross, Jason Gotlib, Timothy Devos, Marco Ruggeri, Richard T. Silver, Rachel B. Salit, Thomas Schroeder, Carmelo Gurnari, Simona Pagliuca, Christina Rautenberg, Marie Robin, Marie-Thérèse Rubio, Jaroslaw Maciejewski, Alessandro Rambaldi, Maria Chiara Finazzi, Andrea Bacigalupo, Patrizia Chiusolo, Hans Christian Reinhardt, Bart L. Scott, Nicolaus Kröger, Francesco Passamonti, Francesca Palandri
Journal: Blood
Blood (2024) 144 (Supplement 1): 245.
https://doi.org/10.1182/blood-2024-210804
Published: 2024
Journal Articles

Anticoagulation Management of Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms: A Global Abdominal/Splanchnic Thrombosis Retrospective Observational Study in 486 MPN Patients (GASTRO-MPN)

Chi-Joan How, Pavlina Chrysafi, Amica Ko, Rebecca Zon, Atefeh Ghorbanzadeh, Dahniel L Sastow, Maria Georgen, Abi Prabhu, Vrushali Pachpande, Sai Sudha Valisekka, Mukul Agarwal, Amiya Ranjan Nayak, May Anne Cheong, Alessandra Iurlo, Daniele Cattaneo, Thita Chiasakul, Rishi Dhawan, Kristen M. Sanfilippo, Gabriela S. Hobbs, Damon E. Houghton, Joan Beckman, Lisa Baumann Kreuziger, Douglas Tremblay, Rushad Patell, Mandy N. Lauw
Journal: Blood
Blood (2024) 144 (Supplement 1): 16.
https://doi.org/10.1182/blood-2024-199107
Published: 2024
Journal Articles

Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitor INCB057643 in Patients with Relapsed or Refractory Myelofibrosis and Other Advanced Myeloid Neoplasms: A Phase 1 Study

Justin M. Watts, Anthony M. Hunter, Alessandro Vannuchhi, Vikas Gupta, Srinivas K Tantravahi, Alessandra Iurlo, Brandon McMahon, Francesca Palandri, María Teresa Gómez Casares, Junichiro Yuda, Emma Searle, Anna B. Halpern, Rosa Ayala, Akihiro Tomita, Blanca Xicoy, Prithviraj Bose, Brandi N. Reeves, Xuejun Chen, Lea M Burke, Feng Zhou, Fred Zheng, Pankit Vachhani
Journal: Blood
Blood (2024) 144 (Supplement 1): 658.
https://doi.org/10.1182/blood-2024-200925
Published: 2024
Journal Articles

FATE and Role of Peripheral Blood CD26+ Leukemia STEM CELLS at Diagnosis in Chronic Myeloid Leukemia Patients: FINAL Results of Prospective Flowers Study

Anna Sicuranza, Adele Santoni, Paola Pacelli, Sara Freducci, Emanuele Pacini, Elisabetta Abruzzese, Daniele Cattaneo, Alessandra Iurlo, Luigiana Luciano, Sara Galimberti, Valentina Giai, Olga Mulas, Giovanni Caocci, Federica Sorà, Isabella Capodanno, Monica Crugnola, Antonella Gozzini, Sabina Russo, Mario Annunziata, Claudio Fozza, Anna Marina Liberati, Alessandra Cartocci, Elisabetta Zappone, Emanuele Cencini, Vincenzo Sammartano, Elena Bestoso, Cristina Marzano, Dania Tocci, Teresa Miracapillo, Camilla Turriziani, Donatella Raspadori, Monica Bocchia
Journal: Blood
Blood (2024) 144 (Supplement 1): 995.
https://doi.org/10.1182/blood-2024-204689
Published: 2024
Journal Articles

Baseline Features, Treatment Choice and Early Frontline TKI Permanent Discontinuation in Patients with Newly Diagnosed Chronic Myeloid Leukemia Aged 50 - 60 Years: A “Campus CML” Study

Roberto Latagliata, Isabella Capodanno, Maria Cristina Miggiano, Cristina Bucelli, Sabrina Leonetti Crescenzi, Sabina Russo, Ida Carmosino, Atelda Romano, Federica Sorà, Massimiliano Bonifacio, Luigiana Luciano, Giovanni Caocci, Giuseppina Loglisci, Chiara Elena, Francesca Lunghi, Rikard Mullai, Immacolata Attolico, Gianni Binotto, Elena Crisà, Paolo Sportoletti, Francesco Cavazzini, Ambra Di Veroli, Anna Rita Scortechini, Anna Paola Leporace, Alessandro Maggi, Monica Crugnola, Fabio Stagno, Marco Santoro, Pamela Murgano, Davide Rapezzi, Debora Luzi, Jolanda Donatella Vincelli, Sara Galimberti, Monica Bocchia, Carmen Fava, Alessandra Malato, Elisabetta Abruzzese, Michele Pizzuti, Alessandra Iurlo, Giuseppe Saglio, Giorgina Specchia, Massimo Breccia, Mario Tiribelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1772.
https://doi.org/10.1182/blood-2024-207175
Published: 2024
Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Treatment-Free Remission in CML Patients Discontinuing Post-First Line Therapy

Selene Grano, Valentina Bonuomo, Emanuele Koumantakis, Paola Berchialla, Fausto Castagnetti, Massimo Martino, Chiara Elena, Monica Bocchia, Isabella Capodanno, Tamara Intermesoli, Maria Cristina Miggiano, Carlo Gambacorti-Passerini, Alessandra Iurlo, Francesca Lunghi, Luigiana Luciano, Elisabetta Abruzzese, Angelo Michele Carella, Massimo Breccia, Felicetto Ferrara, Sabrina Leonetti Crescenzi, Barbara Scappini, Marco De Gobbi, Federica Sorà, Davide Rapezzi, Debora Luzi, Sara Galimberti, Monica Crugnola, Anna Rita Scortechini, Alessandro Maggi, Massimiliano Bonifacio, Mario Annunziata, Giovanni Caocci, Germana Beltrami, Francesco Cavazzini, Giuseppe Pietrantuono, Leonardo Campiotti, Fabio Stagno, Caterina Musolino, Carmen Fava
Journal: Blood
Blood (2024) 144 (Supplement 1): 1778.
https://doi.org/10.1182/blood-2024-200208
Published: 2024
Journal Articles

Molecular Outcome of Chronic Myeloid Leukemia Affected Patients Not in Deep Molecular Response: The “Others” from the Gimema Labnet Network

Fabio Stagno, Rosalba Cucci, Giovanni Marsili, Fausto Castagnetti, Sara Galimberti, Barbara Izzo, Federica Sorà, Simona Soverini, Monica Messina, Alfonso Piciocchi, Massimiliano Bonifacio, Daniela Cilloni, Alessandra Iurlo, Giovanni Martinelli, Gianantonio Rosti, Paola Fazi, Marco Vignetti, Massimo Breccia, Alessandro Allegra, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 992.
https://doi.org/10.1182/blood-2024-210201
Published: 2024
Journal Articles

Hematological Improvement and Other Clinical Benefits of Elritercept As Monotherapy and in Combination with Ruxolitinib in Participants with Myelofibrosis from the Ongoing Phase 2 Restore Trial

Claire Harrison, Lynette C.Y. Chee, Timothy Devos, Maria Laura Fox, Alessandra Iurlo, Francesca Palandri, David M Ross, Shuhying Tan, Alessandro Maria Vannucchi, Marielle Wondergem, Michael Pace, Hongying Wang, Ming Yang, Ying Jiang, Suresh Bobba, Montagu Hankin, Chris Materna, Christine Graham, Sanjay Thamake, Christopher Rovaldi, Dena Grayson, Jen L. Salstrom
Journal: Blood
Blood (2024) 144 (Supplement 1): 997.
https://doi.org/10.1182/blood-2024-201729
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Long-Term Safety and Effectiveness of Ponatinib Treatment in Patients with TKI Intolerance: Subgroup Analysis of the Observational Study of Ponatinib Treatment in Patients with CML in Italy (OITI)

Massimo Breccia, Alessandra Iurlo, Fabrizio Pane, Anna Rita Scortechini, Immacolata Attolico, Marco Santoro, Marco Cerrano, Francesca Lunghi, Alessandro Maggi, Nicola Di Renzo, Valeria Sargentini, Alfonso Piciocchi, Claudia Tringali, Alessandra Malato
Journal: Blood
Blood (2024) 144 (Supplement 1): 2427.
https://doi.org/10.1182/blood-2024-200389
Published: 2024
Journal Articles

Silk Bone Marrow Niches to Model Fibrosis and Altered Megakaryopoiesis in Myeloproliferative Neoplasms

Christian Andrea Di Buduo, Carolina Paula Miguel, Giulia Della Rosa, Vittorio Abbonante, Alessandro Malara, Daniele Cattaneo, Delfina Tosi, Umberto Gianelli, Alessandra Iurlo, Alessandra Balduini
Journal: Blood
Blood (2024) 144 (Supplement 1): 1165.
https://doi.org/10.1182/blood-2024-209781
Published: 2024
Journal Articles

Prognostic Insights on PRE-Fibrotic Primary Myelofibrosis: A Clinical-Pathological Perspective in 762 Patients

Daniele Cattaneo, Barbara Mora, Cristina Bucelli, Margherita Maffioli, Elena Maria Elli, Giulia Benevolo, Valentina Bellani, Emilia Scalzulli, Filippo Branzanti, Paola Bianchi, Marta Lionetti, Bruno Martino, Umberto Gianelli, Niccolò Bolli, Francesca Palandri, Massimo Breccia, Dario Consonni, Alessandra Iurlo
Journal: Blood
Blood (2024) 144 (Supplement 1): 4550.
https://doi.org/10.1182/blood-2024-211145
Published: 2024
Journal Articles

Proteomic Screening Identifies Megakaryocyte Derived PF4/Cxcl4 As a Critical Driver of Myelofibrosis

Alessandro Malara, Daniele Capitanio, Francesca Rossella Calledda, Vittorio Abbonante, Daniele Cattaneo, Alessandra Iurlo, Cecilia Gelfi, Alessandra Balduini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1793.
https://doi.org/10.1182/blood-2023-188967
Published: 2023
Journal Articles

Association of Hypomethylating Agents + Venetoclax in the Real-Life Treatment of Myeloproliferative Neoplasms in Blastic Phase

Roberto Latagliata, Gianluca Cristiano, Dorela Lame, Alda Strazimiri, Fabrizio Cavalca, Lorenzo Rizzo, Giulia De Luca, Simone Zoletto, Vincenzo Federico, Daniele Cattaneo, Annalisa Biagi, Monica Crugnola, Pasquale Niscola, Raffaele Palmieri, Anna Lina Piccioni, Olga Mulas, Beatrice Esposito Vangone, Michelina Santopietro, Ida Carmosino, Alessandra Iurlo, Nicola Di Rienzo, Gianni Binotto, Prassede Salutari, Marta Riva, Massimiliano Bonifacio, Elena Maria Elli, Antonio Curti, Antonella Poloni
Journal: Blood
Blood (2023) 142 (Supplement 1): 1842.
https://doi.org/10.1182/blood-2023-190091
Published: 2023
Journal Articles

Efficacy and Safety of Fedratinib in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Results from the Phase 3 Randomized FREEDOM2 Study

Claire N Harrison, Ruben Mesa, Moshe Talpaz, Haifa Kathrin Al-Ali, Blanca Xicoy, Francesco Passamonti, Francesca Palandri, Giulia Benevolo, Alessandro M. Vannucchi, Clemence Mediavilla, Alessandra Iurlo, InHo Kim, Patrick Brown, Christopher Hernandez, Shelonitda Rose, Jia Wang, Jean-Jacques Kiladjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 3204.
https://doi.org/10.1182/blood-2023-173391
Published: 2023
Journal Articles

3-YEARS and Beyond Study Completion Results of the Otpkima Randomized Clinical Trial in Elderly CML Patients

Michele Malagola, Alessandra Iurlo, Cristina Bucelli, Elisabetta Abruzzese, Massimiliano Bonifacio, Fabio Stagno, Gianni Binotto, Mariella D'Adda, Monia Lunghi, Monica Crugnola, Maria Luisa Ferrari, Francesca Lunghi, Fausto Castagnetti, Gianantonio Rosti, Roberto Massimo Lemoli, Rosaria Sancetta, Maria Rosaria Coppi, Maria Teresa Corsetti, Matteo Dalmazzo, Atelda Romano, Mario Tiribelli, Antonella Russo Rossi, Sabina Russo, Anna Sicuranza, Aldo Roccaro, Giulia Butturini, Mirko Farina, Simona Bernardi, Simone Pellizzeri, Nicola Polverelli, Domenico Russo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2023-177619
Published: 2023