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Shuichi Shirane
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Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Lindsay A.M Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, James McCloskey, Akiyoshi Takami, Tamanna Haque, Michiko Ichii, Shuichi Shirane, Masafumi Fukaya, Joseph M. Scandura, Terrence Bradley, Pankit Vachhani, Takayuki Tabayashi, Steven Green, Stanley Cheung, Prithviraj Bose, Sharad Khurana, Casey L. O'Connell, Idoroenyi Amanam, David M. Ross, Sujan Kabir, Masataka Seki, Mark Wade, Vishnu Peddagali, Zhonggai Li, Jatin Shah, Raajit K. Rampal
Journal: Blood
Blood (2023) 142 (Supplement 1): 626.
https://doi.org/10.1182/blood-2023-180164
Published: 2023
Journal Articles

Preliminary Data from the Phase I/II Study of TP-3654, a Selective Oral PIM1 Kinase Inhibitor, in Patients with Myelofibrosis Previously Treated with or Ineligible for JAK Inhibitor Therapy

Firas El Chaer, James McCloskey, Lindsay A.M. Rein, Randy A. Brown, Steven D. Green, Jeffrey J. Pu, Shuichi Shirane, Kazuya Shimoda, Michiko Ichii, Junichiro Yuda, Joseph Scandura, Sujan Kabir, Jason M Foulks, Jian Mei, Huyuan Yang, Mark Wade, Carl Stapinski, Claudia Lebedinsky, Raajit K Rampal
Journal: Blood
Blood (2022) 140 (Supplement 1): 594–595.
https://doi.org/10.1182/blood-2022-159086
Published: 2022
Journal Articles

Post-Transplant Maintenance Therapy with Azacitidine and Gemtuzumab Ozogamicin for High-Risk Hematologic Malignancies

Satoshi Kaito, MD, Yuho Najima, MD PhD, Yuya Kishida, MD, Akihito Nagata, MD, Tatsuya Konishi, MD, Yuta Yamada, MD, Shuhei Kurosawa, MD, Kota Yoshifuji, MD, Naoki Matsuyama, MD, Shuichi Shirane, MD PhD, Kyoko Inamoto, MD, Tomoyuki Uchida, MD PhD, Takashi Toya, Aiko Igarashi, MD, Hideharu Muto, MD PhD, Noriko Doki, MD PhD, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Hisashi Sakamaki, MD PhD, Kazuteru Ohashi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4517.
https://doi.org/10.1182/blood.V130.Suppl_1.4517.4517
Published: 2017
Journal Articles

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Marito Araki, Yinjie Yang, Nami Masubuchi, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihisa Mizukami, Shin Kan, Shuichi Shirane, Yoko Edahiro, Yoshitaka Sunami, Akimichi Ohsaka, Norio Komatsu
Journal: Blood
Blood (2016) 127 (10): 1307–1316.
https://doi.org/10.1182/blood-2015-09-671172
Published: 2016
Includes: Supplemental data
Journal Articles

Dynamic Increase in JAK2V617F Allele Burden Is a Predictive Parameter for the Transformation into Myelofibrosis from Polycythemia Vera and Essential Thrombocytosis

Shuichi Shirane, Marito Araki, PhD, Soji Morishita, PhD, Yumi Hironaka, Masaaki Noguchi, MD PhD, Michiaki Koike, MD PhD, Takao Hirano, MD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1832.
https://doi.org/10.1182/blood.V124.21.1832.1832
Published: 2014