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Jason M Foulks
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Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

A Phase 1/2 Study of Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, in Combination with JAK Inhibitors Ruxolitinib or Momelotinib in Patients with Myelofibrosis

John O. Mascarenhas, Raajit Rampal, Firas El Chaer, Vikas Gupta, Kazuya Shimoda, Jean-Jacques Kiladjian, Francesco Passamonti, Prithviraj Bose, Joseph M. Scandura, Ruben Mesa, Lindsay A.M. Rein, Junichiro Yuda, David M Ross, Timothy Devos, Moshe Talpaz, Ronald Hoffman, Sujan Kabir, Zhonggai Li, Jason M. Foulks, Karen Ansaldo, Masataka Seki, Vishnu Peddagali, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2024) 144 (Supplement 1): 6629.
https://doi.org/10.1182/blood-2024-200268
Published: 2024
Journal Articles

Preliminary Data from the Phase I/II Study of TP-3654, a Selective Oral PIM1 Kinase Inhibitor, in Patients with Myelofibrosis Previously Treated with or Ineligible for JAK Inhibitor Therapy

Firas El Chaer, James McCloskey, Lindsay A.M. Rein, Randy A. Brown, Steven D. Green, Jeffrey J. Pu, Shuichi Shirane, Kazuya Shimoda, Michiko Ichii, Junichiro Yuda, Joseph Scandura, Sujan Kabir, Jason M Foulks, Jian Mei, Huyuan Yang, Mark Wade, Carl Stapinski, Claudia Lebedinsky, Raajit K Rampal
Journal: Blood
Blood (2022) 140 (Supplement 1): 594–595.
https://doi.org/10.1182/blood-2022-159086
Published: 2022
Journal Articles

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Johann-Christoph Jann, Alina Wein, Eva Altrock, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Mark Wunderlich, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Jason M Foulks, Daniel T. Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Wolf-Karsten Hofmann, Daniel Nowak, Mohamad Jawhar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9749–9750.
https://doi.org/10.1182/blood-2022-165298
Published: 2022
Journal Articles

Activin-like Kinase 2 (ALK2/ACVR1) Is a Resistance Factor and Therapeutic Vulnerability to FLT3 Inhibition in Acute Myeloid Leukemia

Anudishi Tyagi, Stanley Ly, Bin Yuan, Fouad El-Dana, Vivek Anand, Appalaraju Jaggupilli, Gautam Borthakur, Jason M Foulks, Steven L. Warner, Venkata Lokesh Battula
Journal: Blood
Blood (2022) 140 (Supplement 1): 3052–3053.
https://doi.org/10.1182/blood-2022-167580
Published: 2022
Journal Articles

Preclinical Assessment of Alvocidib in Combination with 5-Azacytidine in High-Risk Myelodysplastic Syndromes

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Johann-Christoph Jann, Alina Wein, Eva Altrock, Arwin Mehralivand, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mohamad Jawhar, Christel Weiss, Georgia Metzgeroth, Jason M Foulks, Wolf-Karsten Hofmann, Daniel Nowak
Journal: Blood
Blood (2021) 138 (Supplement 1): 4649.
https://doi.org/10.1182/blood-2021-150778
Published: 2021
Journal Articles

TP-0184, a Novel FLT3-ALK2 Dual Inhibitor, Targets Amino Acid Transport and Biosynthesis in AML Cells and Sensitizes AML Cells to Chemotherapy and BCL2 Inhibition

Anudishi Tyagi, Stanley Ly, Bin Yuan, Fouad El-Dana, Appalaraju Jaggupilli, Jason M Foulks, Steven L. Warner, Venkata Lokesh Battula
Journal: Blood
Blood (2021) 138 (Supplement 1): 376.
https://doi.org/10.1182/blood-2021-151251
Published: 2021
Journal Articles

Axl-RTK Inhibition Modulates Monocyte Immune Response to Enhance the Anti-Tumor Effects of CD19 Redirected Chimeric Antigen Receptor T Cells in Preclinical Models

Reona Sakemura, MDPhD, Michelle J. Cox, Elizabeth L. Siegler, PhD, Erin E. Tapper, Wendy K. Nevala, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Evandro D. Bezerra, MD, Lionel Kankeu Fonkoua, MD, Paulina Horvei, MD, Michael W. Ruff, MD, Lars Mouritsen, Jason M. Foulks, PhD, Steven L. Warner, PhD, Wei Ding, MD PhD, Susan L. Slager, PhD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MB, ChB
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-142159
Published: 2020
Journal Articles

The Oral CDK9 Inhibitor, TP-1287, Is Active in Non-Clinical Models of Multiple Myeloma

Ethika Tyagi, PhD, Clifford Whatcott, PhD, Jason M Foulks, PhD, Adam Siddiqui-Jain, PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3269.
https://doi.org/10.1182/blood-2018-99-120047
Published: 2018
Journal Articles

Axl-RTK Inhibition Modulates T Cell Functions and Synergizes with Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

Reona Sakemura, MD PhD, Nan Yang, MD, Michelle J. Cox, Sutapa Sinha, PhD, Mehrdad Hefazi, MD, Michael J. Hansen, Kendall J. Schick, Cynthia L. Forsman, PhD, Justin C. Boysen, Renee C Tschumper, Elizabeth Juarez Diaz, BS, Lars Mouritsen, Jason M Foulks, PhD, Steven L. Warner, PhD, Sameer A. Parikh, MD, Wei Ding, MD PhD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 728.
https://doi.org/10.1182/blood-2018-99-112209
Published: 2018
Journal Articles

PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids

Jason M. Foulks, Gopal K. Marathe, Noemi Michetti, Diana M. Stafforini, Guy A. Zimmerman, Thomas M. McIntyre, Andrew S. Weyrich
Journal: Blood
Blood (2009) 113 (26): 6699–6706.
https://doi.org/10.1182/blood-2008-11-186312
Published: 2009
Includes: Supplemental data