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Journal Articles

Impact of Molecular Aberrations on Discordance Among Modalities of Blast Enumeration for Risk Stratification in Myelodysplastic Neoplasms

Laurenz Steiner, Navkirandeep Kaur, Johann-Christoph Jann, Alice Fabarius, Georgia Metzgeroth, Manja Meggendorfer, Wolf-Karsten Hofmann, Mohamad Jawhar, Daniel Nowak, Alexander Streuer

Blood (2024) 144 (Supplement 1): 6724.

https://doi.org/10.1182/blood-2024-211446

Published: 2024

Journal Articles

STAG2 Mutations Drive Development of Myelodysplastic Syndromes by Promoting R-Loop-Mediated Genomic Instability and Activation of cGAS-STING

Lin Han, Benjamin Braun, Caroline A. Conway, Amy Wang, Johann-Christoph Jann, Yihua Wang, Kate I. Drachman, Qingqing Yan, Elodie Hatchi, Phillip Wulfridge, William Doyle, Caroline N. Pitton, Kavitha Sarma, Zuzana Tothova

Blood (2024) 144 (Supplement 1): 4105.

https://doi.org/10.1182/blood-2024-210909

Published: 2024

Journal Articles

Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes

Blood (2023) 142 (Supplement 1): 999.

https://doi.org/10.1182/blood-2023-187519

Published: 2023

Journal Articles

Instructive Interaction between Myelodysplastic Hematopoiesis and the Bone Marrow Microenvironment at Single Cell Level

Blood (2023) 142 (Supplement 1): 3217.

https://doi.org/10.1182/blood-2023-186130

Published: 2023

Journal Articles

STAG2 loss Induces HSC Programs By Modulating Accessibility of AP-1 Bound Enhancers

Amy Wang, Lin Han, Benjamin Braun, Caroline Pitton, Johann-Christoph Jann, Zuzana Tothova

Blood (2023) 142 (Supplement 1): 1385.

https://doi.org/10.1182/blood-2023-190327

Published: 2023

Journal Articles

Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML

Emily C Wheeler, Benjamin Martin, William Doyle, Rebecca Gorelov, Melanie Donahue, Johann-Christoph Jann, Omar Abdel-Wahab, Justin Taylor, Michael Seiler, Silvia Buonamici, Roger Belizaire, Karen Adelman, Zuzana Tothova

Blood (2022) 140 (Supplement 1): 6888–6889.

https://doi.org/10.1182/blood-2022-170996

Published: 2022

Journal Articles

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Blood (2022) 140 (Supplement 1): 9749–9750.

https://doi.org/10.1182/blood-2022-165298

Published: 2022

Journal Articles

Inter-Modality Variance of Blast Quantification in Patients with Myelodysplastic Syndrome (MDS) and Its Impact on Risk Stratification and Overall Survival

Laurenz Steiner, Navkirandeep Kaur, Alexander Streuer, Johann-Christoph Jann, Alice Fabarius, Georgia Metzgeroth, Wolf-Karsten Hofmann, Daniel Nowak, Mohamad Jawhar

Blood (2022) 140 (Supplement 1): 9831–9832.

https://doi.org/10.1182/blood-2022-168850

Published: 2022

Journal Articles

Inhibition of Lysyl Oxidases Synergizes with 5-Azacytidine to Restore Erythropoiesis in Myeloid Neoplasms

Blood (2022) 140 (Supplement 1): 3054–3055.

https://doi.org/10.1182/blood-2022-159507

Published: 2022

Journal Articles

Mesenchymal Stromal Cells (MSCs) from Myelodysplastic Syndromes (MDS) Are Not Clonally Mutated I n Vivo

Johann-Christoph Jann, Maximilian Mossner, Vladimir Riabov, Eva Altrock, Nanni Schmitt, Johanna Flach, Qingyu Xu, Verena Nowak, Julia Obländer, Iris Palme, Nadine Weimer, Alexander Streuer, Ahmed Jawhar, Ali Darwich, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

Blood (2021) 138 (Supplement 1): 1514.

https://doi.org/10.1182/blood-2021-150244

Published: 2021

Journal Articles

Preclinical Assessment of Alvocidib in Combination with 5-Azacytidine in High-Risk Myelodysplastic Syndromes

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Johann-Christoph Jann, Alina Wein, Eva Altrock, Arwin Mehralivand, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mohamad Jawhar, Christel Weiss, Georgia Metzgeroth, Jason M Foulks, Wolf-Karsten Hofmann, Daniel Nowak

Blood (2021) 138 (Supplement 1): 4649.

https://doi.org/10.1182/blood-2021-150778

Published: 2021

Journal Articles

Cohesin mutations in myeloid malignancies

Johann-Christoph Jann, Zuzana Tothova

Blood (2021) 138 (8): 649–661.

https://doi.org/10.1182/blood.2019004259

Published: 2021

Journal Articles

Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)

Blood (2019) 134 (Supplement_1): 4227.

https://doi.org/10.1182/blood-2019-128075

Published: 2019

Journal Articles

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Johann-Christoph Jann, Johanna Flach, PhD, Antje Knaflic, Eva Altrock, PhD, Nanni Schmitt, MSc, Alexander Streuer, Justine Danner, Franziska Hofmann, Verena Nowak, Nina Draeger, Julia Obländer, Iris Palme, Patrick Wuchter, MD, Ahmed Jawhar, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD

Blood (2019) 134 (Supplement_1): 4218.

https://doi.org/10.1182/blood-2019-126431

Published: 2019

Journal Articles

Placebo Controlled Functional Analysis of Eltrombopag in a Preclinical Xenograft Model of Myelodysplastic Syndromes (MDS)

Nanni Schmitt, MSc, Eva Altrock, PhD, Johann-Christoph Jann, MD, Johanna Flach, PhD, Carla Sens-Albert, PhD, Justine Danner, Stefanie Uhlig, Jovita Pressler, Iris Palme, Verena Nowak, Julia Obländer, Lena Drangmeister, MD, Franziska La Meir, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, Daniel Nowak, MD

Blood (2018) 132 (Supplement 1): 942.

https://doi.org/10.1182/blood-2018-99-116341

Published: 2018

Journal Articles

RNA Sequencing of Bone Marrow Derived Mesenchymal Stromal Cells (MSCs) of Healthy Young, Healthy Old and Patients with Myelodysplastic Syndrome (MDS) Reveals Transcriptomic Changes upon Aging of the Niche and Onset of MDS

Johann-Christoph Jann, Maximilian Mossner, Florian Nolte, MD, Tobias Boch, MD, Verena Nowak, Iris Palme, Julia Obländer, Jovita Pressler, Christina Xanthopoulos, Henning Röhl, MD, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD

Blood (2016) 128 (22): 4300.

https://doi.org/10.1182/blood.V128.22.4300.4300

Published: 2016

Journal Articles

Safety and Efficacy of the CD95-Ligand Inhibitor APG101 in Transfusion-Dependent Patients with Low Risk MDS: Results from a Phase I Study

Tobias Boch, MD, Thomas Luft, MD PhD, Maximilian Mossner, Johann-Christoph Jann, Daniel Nowak, MD, Christine Folz, Jennifer Klemmer, Susanne Brendel, Harald Fricke, MD, Claudia Kunz, PhD, Wolf-Karsten Hofmann, MD, Florian Nolte, MD

Blood (2016) 128 (22): 228.

https://doi.org/10.1182/blood.V128.22.228.228

Published: 2016

Journal Articles

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

Blood (2016) 128 (9): 1246–1259.

https://doi.org/10.1182/blood-2015-11-679167

Published: 2016

Includes: Supplemental data

Journal Articles

Whole Genome Sequencing of Azole-Resistant Aspergillus Fumigatus Strains from Hematopoietic Stem Cell Recipients Identifies Candidate Molecular Targets Potentially Implicated in Novel Resistance Mediating Mechanisms - First Results

Maximilian Mossner, Birgit Spiess, PhD, Johann-Christoph Jann, Verena Nowak, Julia Obländer, Oliver Bader, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD, Dieter Buchheidt, MD, Tobias Boch, MD

Blood (2015) 126 (23): 4325.

https://doi.org/10.1182/blood.V126.23.4325.4325

Published: 2015

Journal Articles

Erythroferrone (ERFE) Is Selectively Expressed in Human CD71+ Erythroprogenitor Cells and Deregulated Overexpression Is Associated with a Favorable Outcome in Low Risk Myelodysplastic Syndrome (MDS)

Maximilian Mossner, Alexandra Stoehr, Johann-Christoph Jann, Florian Nolte, MD, Verena Nowak, Julia Oblaender, Jovita Pressler, Christina Xanthopoulos, Iris Palme, Claudia D Baldus, MD, Torsten Schulze, MD, Tobias Boch, MD, Georgia Metzgeroth, MD, Martin Neumann, MD, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD

Blood (2015) 126 (23): 2859.

https://doi.org/10.1182/blood.V126.23.2859.2859

Published: 2015

NARROW

Impact of Molecular Aberrations on Discordance Among Modalities of Blast Enumeration for Risk Stratification in Myelodysplastic Neoplasms

STAG2 Mutations Drive Development of Myelodysplastic Syndromes by Promoting R-Loop-Mediated Genomic Instability and Activation of cGAS-STING

Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes

Instructive Interaction between Myelodysplastic Hematopoiesis and the Bone Marrow Microenvironment at Single Cell Level

STAG2 loss Induces HSC Programs By Modulating Accessibility of AP-1 Bound Enhancers

Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Inter-Modality Variance of Blast Quantification in Patients with Myelodysplastic Syndrome (MDS) and Its Impact on Risk Stratification and Overall Survival

Inhibition of Lysyl Oxidases Synergizes with 5-Azacytidine to Restore Erythropoiesis in Myeloid Neoplasms

Mesenchymal Stromal Cells (MSCs) from Myelodysplastic Syndromes (MDS) Are Not Clonally Mutated I n Vivo

Preclinical Assessment of Alvocidib in Combination with 5-Azacytidine in High-Risk Myelodysplastic Syndromes

Cohesin mutations in myeloid malignancies

Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Placebo Controlled Functional Analysis of Eltrombopag in a Preclinical Xenograft Model of Myelodysplastic Syndromes (MDS)

RNA Sequencing of Bone Marrow Derived Mesenchymal Stromal Cells (MSCs) of Healthy Young, Healthy Old and Patients with Myelodysplastic Syndrome (MDS) Reveals Transcriptomic Changes upon Aging of the Niche and Onset of MDS

Safety and Efficacy of the CD95-Ligand Inhibitor APG101 in Transfusion-Dependent Patients with Low Risk MDS: Results from a Phase I Study

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

Whole Genome Sequencing of Azole-Resistant Aspergillus Fumigatus Strains from Hematopoietic Stem Cell Recipients Identifies Candidate Molecular Targets Potentially Implicated in Novel Resistance Mediating Mechanisms - First Results

Erythroferrone (ERFE) Is Selectively Expressed in Human CD71+ Erythroprogenitor Cells and Deregulated Overexpression Is Associated with a Favorable Outcome in Low Risk Myelodysplastic Syndrome (MDS)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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