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Journal Articles

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

Karina Hamamoto, Ganqian Zhu, Julia Lesperance, Huacheng Luo, Ying D Li, Nupur Nigam, Arati Sharma, Feng-Chun Yang, David F. Claxton, Yi Qiu, Peter D. Aplan, Mingjiang Xu, Suming Huang

Blood (2024) 144 (Supplement 1): 4108.

https://doi.org/10.1182/blood-2024-199171

Published: 2024

Journal Articles

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Blood (2022) 140 (Supplement 1): 9749–9750.

https://doi.org/10.1182/blood-2022-165298

Published: 2022

Journal Articles

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Na Man, Gloria Mas Martin, PhD, Daniel Karl, PhD, Jun Sun, PhD, Fan Liu, PhD, Miguel Torres-Martin, PhD, Hidehiro Itonaga, MD PhD, Concepcion Martinez, B.S., Shi Chen, Stephanie Duffort, Pierre-Jacques Hamard, PhD, Ye Xu, PhD, Luisa Cimmino, PhDBSc, Feng-Chun Yang, MD PhD, Philip A. Cole, MD PhD, Mingjiang Xu, MD PhD, Maria E. Figueroa, MD, Stephen Nimer, MD

Blood (2019) 134 (Supplement_1): 561.

https://doi.org/10.1182/blood-2019-130507

Published: 2019

Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD

Blood (2019) 134 (Supplement_1): 210.

https://doi.org/10.1182/blood-2019-129479

Published: 2019

Journal Articles

Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

Peng Zhang, PhD, Fuhong He, PhD, Jie Bai, MD, Shi Chen, Stephen D. Nimer, MD, Yuan Zhou, PhD, Mingjiang Xu, MD PhD, Qianfei Wang, PhD, Feng-Chun Yang, MD PhD

Blood (2018) 132 (Supplement 1): 652.

https://doi.org/10.1182/blood-2018-99-110964

Published: 2018

Journal Articles

Hoxblinc Is Aberrantly Expressed in Acute Myeloid Leukemia and Functions As a Potent Oncogenic Long Non-Coding RNA in Leukemogenesis

Ganqian Zhu, PhD, Huacheng Luo, Shi Chen, Qian Lai, Ying Guo, Olga A Guryanova, MDPhD, Yi Qiu, Feng-Chun Yang, MD PhD, Wei Li, Stephen D. Nimer, MD, Suming Huang, Mingjiang Xu, MD PhD

Blood (2018) 132 (Supplement 1): 886.

https://doi.org/10.1182/blood-2018-99-112232

Published: 2018

Journal Articles

Activation of Hottip lncrna Perturbs HSC Function Leading to AML like Disease in Mice

Huacheng Luo, Ganqian Zhu, PhD, Jie Zha, MD, Bowen Yan, Ph. D, Ying Guo, Jianfeng Xu, PhD, Qian Lai, Bing Xu, MD PhD, Feng-Chun Yang, MD PhD, Wei Li, Yi Qiu, Mingjiang Xu, MD PhD, Suming Huang

Blood (2018) 132 (Supplement 1): 3877.

https://doi.org/10.1182/blood-2018-99-110218

Published: 2018

Journal Articles

Suv39h1 Represses the Progression of MLL -Rearranged Myeloid Leukemia Via Hoxb13

Yajing Chu, PhD, Yangpeng Chen, Huidong Guo, PhD, Mengke Li, Jun Shi, MD, Tao Cheng, MD, Feng-Chun Yang, MD PhD, Mingjiang Xu, MD PhD, Weiping Yuan, PhDMD

Blood (2018) 132 (Supplement 1): 3878.

https://doi.org/10.1182/blood-2018-99-113732

Published: 2018

Journal Articles

Spectrum of Gene Mutations and Clinical Significance in Myeloid Malignancies Patients with ASXL1 Mutations

Jie Bai, MD, Guangshuai Teng, Yingshao Wang, Jing Xu, Chenxiao Du, Yan Wang, Yafang Chen, Mengyao Sheng, PhD, Jiaojiao Bai, Lei Zhang, MD, Yuan Zhou, PhD, Feng-Chun Yang, MD PhD

Blood (2018) 132 (Supplement 1): 3906.

https://doi.org/10.1182/blood-2018-99-114471

Published: 2018

Journal Articles

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Blood (2018) 131 (3): 328–341.

https://doi.org/10.1182/blood-2017-06-789669

Published: 2018

Includes: Supplemental data

Journal Articles

Gain-of-Function of ASXL1 Truncating Protein in the Pathogenesis of Myeloid Malignancies

Hui Yang, PhD, Stefan Kurtenbach, PhD, Ying Guo, MD PhD, Ines Lohse, PhD, Michael Durante, PhD candidate, Peng Zhang, PhD, Yuan Zhou, PhD, William Harbour, MDPhD, Claes Wahlestedt, Mingjiang Xu, MDPhD, Feng-Chun Yang, MD PhD

Blood (2017) 130 (Supplement 1): 564.

https://doi.org/10.1182/blood.V130.Suppl_1.564.564

Published: 2017

Journal Articles

Calr Vs. JAK2 Vs. MPL Mutations in the Progression of Philadelphia-Negative Myeloproliferative Neoplasms

Jie Bai, MD, Mengyao Sheng, PhD, Wen Xing, Jiaojiao Bai, Rong Li, PhD, Jun Shi, MD, Lei Zhang, MD, Weiping Yuan, PhDMD, Feng-Chun Yang, MD PhD, Yuan Zhou, PhD

Blood (2017) 130 (Supplement 1): 5283.

https://doi.org/10.1182/blood.V130.Suppl_1.5283.5283

Published: 2017

Journal Articles

Loss of ASXL1 in the Bone Marrow Niche Dysregulates Hematopoietic Stem Cell Fates through RNA Polymerase II Complex

Peng Zhang, PhD, Zizhen Chen, PhD, Rong Li, PhD, Ying Guo, MD PhD, Mingjiang Xu, MDPhD, Yuan Zhou, PhD, Feng-Chun Yang, MD PhD

Blood (2017) 130 (Supplement 1): 133.

https://doi.org/10.1182/blood.V130.Suppl_1.133.133

Published: 2017

Journal Articles

Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Na Man, Yurong Tan, Xiao-Jian Sun, Fan Liu, Guoyan Cheng, Sarah M. Greenblatt, Camilo Martinez, Daniel L. Karl, Koji Ando, Ming Sun, Dan Hou, Bingyi Chen, Mingjiang Xu, Feng-Chun Yang, Zhu Chen, Saijuan Chen, Stephen D. Nimer, Lan Wang

Blood (2017) 129 (20): 2782–2792.

https://doi.org/10.1182/blood-2016-10-745034

Published: 2017

Includes: Supplemental data

Journal Articles

ASXL2 Is Required for Normal Hematopoiesis and Loss of a sxl2 Leads to Myeloid Malignancies in Mice

Jianping Li, Fuhong He, PhD, Peng Zhang, PhD, Shi Chen, MD PhD, Hui Shi, Yanling Sun, Guo Ying, Hui Yang, Stephen D. Nimer, MD, Qian-Fei Wang, Mingjiang Xu, MD PhD, Feng-Chun Yang, MD PhD

Blood (2016) 128 (22): 1509.

https://doi.org/10.1182/blood.V128.22.1509.1509

Published: 2016

Journal Articles

Tet2 Loss Dysregulates the Behavior of Mesenchymal Stem Cells and Increases Their Ability to Promote Tet2 -/- -Driven Myeloid Malignancy Progression

Zhigang Zhao, MD PhD, Rong Li, Lin Liu, Jinhuan Wang, Zizhen Chen, Wen Xing, MD, Weiping Yuan, PhDMD, Feng-Chun Yang, MD PhD, Yuan Zhou, PhD, Mingjiang Xu, MD PhD

Blood (2016) 128 (22): 1510.

https://doi.org/10.1182/blood.V128.22.1510.1510

Published: 2016

Journal Articles

Upregulation of Mir-99a Is Associated with Poor Prognosis of Acute Myeloid Leukemia and Promotes Myeloid Leukemia Cell Expansion

Xiaohui Si, Xiaoyun Zhang, Xing Hao, Yunan Li, Zizhen Chen, Hui Shi, Feng-Chun Yang, MD PhD, Yuan Zhou, PhD

Blood (2016) 128 (22): 5086.

https://doi.org/10.1182/blood.V128.22.5086.5086

Published: 2016

Journal Articles

Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin

Na Man, Xiao-Jian Sun, Yurong Tan, Marta García-Cao, Fan Liu, Guoyan Cheng, Megan Hatlen, Haiming Xu, Ronit Shah, Nolan Chastain, Na Liu, Gang Huang, Yuan Zhou, Mengyao Sheng, Junhong Song, Feng-Chun Yang, Robert Benezra, Stephen D. Nimer, Lan Wang

Blood (2016) 127 (19): 2322–2326.

https://doi.org/10.1182/blood-2015-11-677708

Published: 2016

Includes: Supplemental data

Journal Articles

Cooperative Effect of Haploinsufficient ASXL1 and NF1 in Acute Myeloid Leukemia Transformation

Peng Zhang, PhD, Shohei Yamamoto, MD PhD, Shi Chen, MD PhD, Yuan Zhou, PhD, Mingjiang Xu, MD PhD, Feng-Chun Yang, MD PhD

Blood (2015) 126 (23): 1224.

https://doi.org/10.1182/blood.V126.23.1224.1224

Published: 2015

Journal Articles

Combined Loss of Tet1 and Tet2 Promotes B-Cell, but Not Myeloid Malignancies in Mice

Zhigang Zhao, MDPhD, Lin Li, PhD, Meelad Dawlaty, PhD, Feng Pan, PhD, Zhe Li, PhD, Yuan Zhou, PhD, Hui Shi, MD PhD, Shi Chen, MD PhD, Ophelia Weeks, PhD, Weiping Yuan, PhD, Hongyu Ni, PhD, Feng-Chun Yang, MD PhD, Rudolph Jaenisch, PhD, Peng Jin, MDPhD, Mingjiang Xu, MDPhD

Blood (2015) 126 (23): 3650.

https://doi.org/10.1182/blood.V126.23.3650.3650

Published: 2015

NARROW

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

Hoxblinc Is Aberrantly Expressed in Acute Myeloid Leukemia and Functions As a Potent Oncogenic Long Non-Coding RNA in Leukemogenesis

Activation of Hottip lncrna Perturbs HSC Function Leading to AML like Disease in Mice

Suv39h1 Represses the Progression of MLL -Rearranged Myeloid Leukemia Via Hoxb13

Spectrum of Gene Mutations and Clinical Significance in Myeloid Malignancies Patients with ASXL1 Mutations

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Gain-of-Function of ASXL1 Truncating Protein in the Pathogenesis of Myeloid Malignancies

Calr Vs. JAK2 Vs. MPL Mutations in the Progression of Philadelphia-Negative Myeloproliferative Neoplasms

Loss of ASXL1 in the Bone Marrow Niche Dysregulates Hematopoietic Stem Cell Fates through RNA Polymerase II Complex

Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

ASXL2 Is Required for Normal Hematopoiesis and Loss of a sxl2 Leads to Myeloid Malignancies in Mice

Tet2 Loss Dysregulates the Behavior of Mesenchymal Stem Cells and Increases Their Ability to Promote Tet2 -/- -Driven Myeloid Malignancy Progression

Upregulation of Mir-99a Is Associated with Poor Prognosis of Acute Myeloid Leukemia and Promotes Myeloid Leukemia Cell Expansion

Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin

Cooperative Effect of Haploinsufficient ASXL1 and NF1 in Acute Myeloid Leukemia Transformation

Combined Loss of Tet1 and Tet2 Promotes B-Cell, but Not Myeloid Malignancies in Mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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