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Journal Articles

TET2 Deficiency Cooperates with MSH6 Mutation to Promote the Progression of MDS/MPN through Increasing Tumor Stem Cell Frequency

Yangpeng Chen, Haoyuan Li, Mingjiang Xu, Qifa Liu
Journal: Blood
Blood (2024) 144 (Supplement 1): 6579.
https://doi.org/10.1182/blood-2024-209187
Published: 2024
Journal Articles

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

Karina Hamamoto, Ganqian Zhu, Julia Lesperance, Huacheng Luo, Ying D Li, Nupur Nigam, Arati Sharma, Feng-Chun Yang, David F. Claxton, Yi Qiu, Peter D. Aplan, Mingjiang Xu, Suming Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4108.
https://doi.org/10.1182/blood-2024-199171
Published: 2024
Journal Articles

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Dongxu Jiang, Feng Pan, Yihong Guan, Xiaorong Gu, Naomi Kawashima, Divya Jyoti Singh, Danai Dima, Guangbo Qu, Edward F Greenberg, Valeria Visconte, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2022) 140 (Supplement 1): 1989–1990.
https://doi.org/10.1182/blood-2022-169467
Published: 2022
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

Long noncoding RNAs: emerging regulators of normal and malignant hematopoiesis

Yi Qiu, Mingjiang Xu, Suming Huang
Journal: Blood
Blood (2021) 138 (23): 2327–2336.
https://doi.org/10.1182/blood.2021011992
Published: 2021
Journal Articles

Therapeutic Targeting of TET-Dioxygenase Deficiency in Myeloid Malignancies

Yihong Guan, Anand D. Tiwari, Metis Hasipek, Dale Grabowski, Daniel Lindner, James G Phillips, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3985.
https://doi.org/10.1182/blood-2021-152744
Published: 2021
Journal Articles

Hottip -Mediated R-Loops Regulate CTCF TAD Boundary to Control WNT/b-Catenin Pathway in AML Genome

Huacheng Luo, PhD, Ganqian Zhu, PhD, Xiaoyan Ma, MD PhD, David F. Claxton, MD, Yi Qiu, PhD, Mingjiang Xu, MDPhD, Suming Huang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-137816
Published: 2020
Journal Articles

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Na Man, Gloria Mas Martin, PhD, Daniel Karl, PhD, Jun Sun, PhD, Fan Liu, PhD, Miguel Torres-Martin, PhD, Hidehiro Itonaga, MD PhD, Concepcion Martinez, B.S., Shi Chen, Stephanie Duffort, Pierre-Jacques Hamard, PhD, Ye Xu, PhD, Luisa Cimmino, PhDBSc, Feng-Chun Yang, MD PhD, Philip A. Cole, MD PhD, Mingjiang Xu, MD PhD, Maria E. Figueroa, MD, Stephen Nimer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 561.
https://doi.org/10.1182/blood-2019-130507
Published: 2019
Journal Articles

Hottip Lncrna Reinforces CTCF Defined Chromatin Boundaries and Drives Wnt Target Gene Expression in AML Leukemogenesis

Huacheng Luo, Ganqian Zhu, PhD, Tsz Kan Fung, Yi Qiu, PhD, Mingjiang Xu, MD PhD, Chi Wai Eric So, Suming Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 277.
https://doi.org/10.1182/blood-2019-127323
Published: 2019
Journal Articles

TET2 Loss Accelerates Leukemogenesis By Disrupting Mismatch Repair Proteins

Ashwin Kishtagari, MBBS, Yihong Guan, PhD, Cassandra M Kerr, MS, Hassan Awada, MD, Jibran Durrani, Edward F Greenberg, MD, Xiaorong Gu, PhD, Feng Pan, PhD, Valeria Visconte, PhD, Dewen You, PhD, Guangbo Qu, PhD, Amy C Graham, BS, MS, Bartlomiej P. Przychodzen, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Daniel Gackowski, PhD, Ryszard Ólinski, Professor, Yu-Wei Cheng, PhD, Mikkael A. Sekeres, MD MS, Mingjiang Xu, MD PhD, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1200.
https://doi.org/10.1182/blood-2019-132005
Published: 2019
Journal Articles

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Yihong Guan, Edward F Greenberg, MD, Metis Hasipek, PhD, Cassandra M. Hirsch, Amy C Graham, BS, MS, Tomas Radivoyevitch, PhD, Shi Chen, Xiaochen Liu, Valeria Visconte, PhD, Dewen You, PhD, Eiju Negoro, MD PhD, Bartlomiej P. Przychodzen, Hideki Makishima, MD PhD, Aziz Nazha, Daniel Gackowski, PhD, Ewelina Zarakowska, Mridul Mukherji, D.Phil., Mikkael A. Sekeres, MD MS, Mingjiang Xu, MD PhD, Ryszard Ólinski, Professor, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 4346.
https://doi.org/10.1182/blood-2018-99-119712
Published: 2018
Journal Articles

Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

Peng Zhang, PhD, Fuhong He, PhD, Jie Bai, MD, Shi Chen, Stephen D. Nimer, MD, Yuan Zhou, PhD, Mingjiang Xu, MD PhD, Qianfei Wang, PhD, Feng-Chun Yang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 652.
https://doi.org/10.1182/blood-2018-99-110964
Published: 2018
Journal Articles

Hoxblinc Is Aberrantly Expressed in Acute Myeloid Leukemia and Functions As a Potent Oncogenic Long Non-Coding RNA in Leukemogenesis

Ganqian Zhu, PhD, Huacheng Luo, Shi Chen, Qian Lai, Ying Guo, Olga A Guryanova, MDPhD, Yi Qiu, Feng-Chun Yang, MD PhD, Wei Li, Stephen D. Nimer, MD, Suming Huang, Mingjiang Xu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 886.
https://doi.org/10.1182/blood-2018-99-112232
Published: 2018
Journal Articles

Activation of Hottip lncrna Perturbs HSC Function Leading to AML like Disease in Mice

Huacheng Luo, Ganqian Zhu, PhD, Jie Zha, MD, Bowen Yan, Ph. D, Ying Guo, Jianfeng Xu, PhD, Qian Lai, Bing Xu, MD PhD, Feng-Chun Yang, MD PhD, Wei Li, Yi Qiu, Mingjiang Xu, MD PhD, Suming Huang
Journal: Blood
Blood (2018) 132 (Supplement 1): 3877.
https://doi.org/10.1182/blood-2018-99-110218
Published: 2018
Journal Articles

Suv39h1 Represses the Progression of MLL -Rearranged Myeloid Leukemia Via Hoxb13

Yajing Chu, PhD, Yangpeng Chen, Huidong Guo, PhD, Mengke Li, Jun Shi, MD, Tao Cheng, MD, Feng-Chun Yang, MD PhD, Mingjiang Xu, MD PhD, Weiping Yuan, PhDMD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3878.
https://doi.org/10.1182/blood-2018-99-113732
Published: 2018
Journal Articles

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Huacheng Luo, Fei Wang, Jie Zha, Haoli Li, Bowen Yan, Qinghua Du, Fengchun Yang, Amin Sobh, Christopher Vulpe, Leylah Drusbosky, Christopher Cogle, Iouri Chepelev, Bing Xu, Stephen D. Nimer, Jonathan Licht, Yi Qiu, Baoan Chen, Mingjiang Xu, Suming Huang
Journal: Blood
Blood (2018) 132 (8): 837–848.
https://doi.org/10.1182/blood-2017-11-814319
Published: 2018
Includes: Supplemental data
Journal Articles

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Hui Yang, Stefan Kurtenbach, Ying Guo, Ines Lohse, Michael A. Durante, Jianping Li, Zhaomin Li, Hassan Al-Ali, Lingxiao Li, Zizhen Chen, Matthew G. Field, Peng Zhang, Shi Chen, Shohei Yamamoto, Zhuo Li, Yuan Zhou, Stephen D. Nimer, J. William Harbour, Claes Wahlestedt, Mingjiang Xu, Feng-Chun Yang
Journal: Blood
Blood (2018) 131 (3): 328–341.
https://doi.org/10.1182/blood-2017-06-789669
Published: 2018
Includes: Supplemental data
Journal Articles

Gain-of-Function of ASXL1 Truncating Protein in the Pathogenesis of Myeloid Malignancies

Hui Yang, PhD, Stefan Kurtenbach, PhD, Ying Guo, MD PhD, Ines Lohse, PhD, Michael Durante, PhD candidate, Peng Zhang, PhD, Yuan Zhou, PhD, William Harbour, MDPhD, Claes Wahlestedt, Mingjiang Xu, MDPhD, Feng-Chun Yang, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 564.
https://doi.org/10.1182/blood.V130.Suppl_1.564.564
Published: 2017
Journal Articles

TET2 and MSH6: A Novel Role for MMR in the Pathogenesis of Myeloid Malignancies

Edward F Greenberg, MD, Cassandra M. Hirsch, BS, Feng Pan, PhD, Babal K Jha, PhD, Yihong Guan, PhD, Valeria Visconte, PhD, Dewen You, PhD, Guangbo Qu, PhD, Amy Graham, Bartlomiej P. Przychodzen, MSc, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Daniel Gackowski, PhD, Ryszard Ólinski, Professor, Yu-Wei Cheng, PhD, Mikkael A. Sekeres, MD MS, Mingjiang Xu, MDPhD, Jaroslaw P. Maciejewski, PhD MD FACP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1668.
https://doi.org/10.1182/blood.V130.Suppl_1.1668.1668
Published: 2017