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Journal Articles

Age-Related Cellular Factors Facilitate TET2 Mutant Clonal Hematopoiesis

Daniel J Vail, Dongxu Jiang, Kunho Chung, Yahan Zhang, Sophia Martinez, Luca Guarnera, Yvonne Parker, J. Joseph Melenhorst, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 1278.

https://doi.org/10.1182/blood-2024-211683

Published: 2024

Journal Articles

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

Xiaorong Gu, Yahan Zhang, Songa Bae, Dongxu Jiang, Nakisha D Williams, Daniel Vail, Simon Schlanger, Jill Durkin, Yvonne Parker, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2918.

https://doi.org/10.1182/blood-2024-207470

Published: 2024

Journal Articles

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Dongxu Jiang, Yahan Zhang, Xiaorong Gu, Daniel J Vail, Jill Durkin, Simon Schlanger, J. Joseph Melenhorst, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 40.

https://doi.org/10.1182/blood-2024-211171

Published: 2024

Journal Articles

Oncogenic Nexus of TET2 with Thpok in Myeloid Neoplasia

Ejike Ujoatu, Sohini Mukhopadhyay, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski, Jayati Basu, Babal K. Jha, H. Leighton Grimes, Stephen Sykes, Dietmar Kappes

Blood (2024) 144 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2024-207759

Published: 2024

Journal Articles

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Xiaorong Gu, Zeinab Albadry M. Zahran, Ramesh Balusu, Jaroslaw Maciejewski, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 2714.

https://doi.org/10.1182/blood-2024-205887

Published: 2024

Journal Articles

PTPN12 Is Targetable and Context-Specific TSG in -7/del7q Myeloid Neoplasia

Daniel J Vail, Jill Durkin, Dongxu Jiang, Thomas Laframboise, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2756.

https://doi.org/10.1182/blood-2024-208538

Published: 2024

Journal Articles

Identification of Tumor Suppressors and Synthetic Lethal Targets in -7/del7q Myeloid Neoplasms By Iterative Computational Analysis Coupled with Experimental Validation

Daniel J Vail, Valeria Visconte, Babal K. Jha, Jill Durkin, Jaroslaw Maciejewski, Thomas Laframboise

Blood (2024) 144 (Supplement 1): 4303.

https://doi.org/10.1182/blood-2024-210881

Published: 2024

Journal Articles

Loss of TET2 Increases MHC Class I Expression in Acute Myeloid Leukemia

Xiaorong Gu, Songa Bae, Yahan Zhang, Nakisha D Williams, Dongxu Jiang, Simon Schlanger, Valeria Visconte, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 4159.

https://doi.org/10.1182/blood-2024-208348

Published: 2024

Journal Articles

Loss of TET2 Creates a Distinct Immunopeptidome in Acute Myeloid Leukemia

Xiaorong Gu, Yahan Zhang, Songa Bae, Dongxu Jiang, Daniel Vail, Simon Schlanger, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 4154.

https://doi.org/10.1182/blood-2024-208025

Published: 2024

Journal Articles

Low Regimen Therapeutic Strategies to Mitigate TET2 Mutant Clonal Hematopoiesis

Dongxu Jiang, Daniel J Vail, Yahan Zhang, Raziullah Khan, Anand Tiwari, Simon Schlanger, Kunho Chung, Cassandra Gilmour, Xiaorong Gu, Yvonne Parker, J. Joseph Melenhorst, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2664.

https://doi.org/10.1182/blood-2024-211363

Published: 2024

Journal Articles

Rap Guanine Nucleotide Exchange Factor RAPGEF5 Is a Novel Tumor Suppressor in 7/del7q Myeloid Neoplasia

Jill Durkin, Daniel Vail, Dongxu Jiang, Yahan Zhang, Simon Schlanger, Jaroslaw Maciejewski, Thomas Laframboise, Babal K. Jha

Blood (2024) 144 (Supplement 1): 5727.

https://doi.org/10.1182/blood-2024-207943

Published: 2024

Journal Articles

Understanding the Molecular Mechanism of Plasma Cell Clonality and Disease Evolution in Light Chain Amyloidosis

Yahan Zhang, Sandra Mazzoni, Simon Schlanger, Jack Khouri, Louis Williams, Babal K. Jha

Blood (2024) 144 (Supplement 1): 6820.

https://doi.org/10.1182/blood-2024-208082

Published: 2024

Journal Articles

Loss of Function MBD4 Mutation Impairs DNA Repair in Association with TET2 in Acute Myeloid Leukemia

Naomi Kawashima, Dongxu Jiang, Daniel Vail, Divya Jyoti Singh, Xiaorong Gu, Simon Schlanger, Carmelo Gurnari, Yasuo Kubota, Brittany L Stewart, Valeria Visconte, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2023) 142 (Supplement 1): 1371.

https://doi.org/10.1182/blood-2023-182142

Published: 2023

Journal Articles

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Zeinab Albadry M. Zahran, Xiaorong Gu, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2023) 142 (Supplement 1): 1375.

https://doi.org/10.1182/blood-2023-187016

Published: 2023

Journal Articles

Methyl-CpG Binding Domain Protein MBD2 Is a Targetable Vulnerability in TET2 Mutant Myeloid Neoplasia

Dongxu Jiang, Yihong Guan, Shinjini Ganguly, Aysegul Balyimez, Andrew Muskara, Divya Jyoti Singh, Simona Pagliuca, Daniel Vail, Yahan Zhang, Jill Durkin, Naomi Kawashima, Xiaorong Gu, Carmelo Gurnari, Jaroslaw P. Maciejewski, Omar Mian, Babal K. Jha

Blood (2023) 142 (Supplement 1): 2766.

https://doi.org/10.1182/blood-2023-186924

Published: 2023

Journal Articles

Clinical and Mechanistic Relationship of T -Cell Large Granular Lymphocytic Leukemia ( TLGL) and monoclonal Gammopathy of Undetermined Significance (MGUS)

Danai Dima, Fauzia Ullah, Najiullah Omar, Carmelo Gurnari, Puneet Dhillon, Valeria Visconte, Babal K. Jha, Jaroslaw P. Maciejewski

Blood (2022) 140 (Supplement 1): 9402–9403.

https://doi.org/10.1182/blood-2022-165601

Published: 2022

Journal Articles

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Dongxu Jiang, Feng Pan, Yihong Guan, Xiaorong Gu, Naomi Kawashima, Divya Jyoti Singh, Danai Dima, Guangbo Qu, Edward F Greenberg, Valeria Visconte, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 1989–1990.

https://doi.org/10.1182/blood-2022-169467

Published: 2022

Journal Articles

Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Danai Dima, Metis Hasipek, Divya Jyoti Singh, Dongxu Jiang, Anand D. Tiwari, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Jianjun Zhao, Kenneth H. Shain, Jack Khouri, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 7100–7101.

https://doi.org/10.1182/blood-2022-169516

Published: 2022

Journal Articles

Role of MBD4 Mutation in Neoplastic Evolution of Acute Myeloid Leukemia

Naomi Kawashima, Dongxu Jiang, Divya Jyoti Singh, Dale Grabowski, Carmelo Gurnari, Yasuo Kubota, Mai Aly, Valeria Visconte, Brittany L Griffin, Torsten Haferlach, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 8783–8784.

https://doi.org/10.1182/blood-2022-163694

Published: 2022

Journal Articles

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

Blood (2021) 138 (26): 2781–2798.

https://doi.org/10.1182/blood.2021012900

Published: 2021

Includes: Supplemental data

NARROW

Age-Related Cellular Factors Facilitate TET2 Mutant Clonal Hematopoiesis

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Oncogenic Nexus of TET2 with Thpok in Myeloid Neoplasia

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

PTPN12 Is Targetable and Context-Specific TSG in -7/del7q Myeloid Neoplasia

Identification of Tumor Suppressors and Synthetic Lethal Targets in -7/del7q Myeloid Neoplasms By Iterative Computational Analysis Coupled with Experimental Validation

Loss of TET2 Increases MHC Class I Expression in Acute Myeloid Leukemia

Loss of TET2 Creates a Distinct Immunopeptidome in Acute Myeloid Leukemia

Low Regimen Therapeutic Strategies to Mitigate TET2 Mutant Clonal Hematopoiesis

Rap Guanine Nucleotide Exchange Factor RAPGEF5 Is a Novel Tumor Suppressor in 7/del7q Myeloid Neoplasia

Understanding the Molecular Mechanism of Plasma Cell Clonality and Disease Evolution in Light Chain Amyloidosis

Loss of Function MBD4 Mutation Impairs DNA Repair in Association with TET2 in Acute Myeloid Leukemia

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Methyl-CpG Binding Domain Protein MBD2 Is a Targetable Vulnerability in TET2 Mutant Myeloid Neoplasia

Clinical and Mechanistic Relationship of T -Cell Large Granular Lymphocytic Leukemia ( TLGL) and monoclonal Gammopathy of Undetermined Significance (MGUS)

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Role of MBD4 Mutation in Neoplastic Evolution of Acute Myeloid Leukemia

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

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