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Journal Articles

A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

Atsushi Marumo, Arda Durmaz, Aashray Mandala, Christopher Haddad, Felipe Sartori, Olivia Hunyadi, Ersan Unlu, Serhan Unlu, Zachary Brady, Matteo D Addona, Kartik Lakhotiya, Luca Guarnera, Mark Orland, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 4945.

https://doi.org/10.1182/blood-2025-4945

Published: 2025

Journal Articles

Exploring the spectrum of non-malignant complications in germline DDX41-associated hematologic disorders

Valeria Visconte, Serhan Unlu, Mark Orland, Praveena Thiagarajan, Aashray Mandala, Matteo D'Addona, Olivia Hunyadi, Zachary Brady, Kartik Lakhotiya, Felipe de Almeida Sartori, Carmelo Gurnari, Arda Durmaz, Carlos Bravo-Perez, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 1445.

https://doi.org/10.1182/blood-2025-1445

Published: 2025

Journal Articles

Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits

Arda Durmaz, Carlos Bravo-Perez, Olivia Hunyadi, Zachary Brady, Luca Guarnera, Mark Orland, Serhan Unlu, Praveena Thiagarajan, Asfand Yar Cheema, Kartik Lakhotiya, Aashray Mandala, Felipe de Almeida Sartori, Matteo D'Addona, Jacob Scott, Carmelo Gurnari, Jaroslaw Maciejewski, Valeria Visconte

Blood (2025) 146 (Supplement 1): 1443.

https://doi.org/10.1182/blood-2025-1443

Published: 2025

Journal Articles

TP53 mutational spectrum and fitness landscape in myeloid neoplasia

ERSAN UNLU, Waled Bahaj, Tariq Kewan, Carlos Bravo-Perez, Serhan Unlu, Zachary Brady, Asfand Yar Cheema, Olivia Hunyadi, Charlotte Zurowski, Atsushi Marumo, Kartik Lakhotiya, Felipe de Almeida Sartori, Aashray Mandala, Mark Orland, Luca Guarnera, Carmelo Gurnari, Jaroslaw Maciejewski, Valeria Visconte, Arda Durmaz

Blood (2025) 146 (Supplement 1): 4360.

https://doi.org/10.1182/blood-2025-4360

Published: 2025

Journal Articles

Redefining the myeloid disease continuum: Machine learning–based development and validation of an integrated multimodal classification of myeloid neoplasms

Yu-Hung Wang, Kristian Gurashi, Chien-Chin Lin, Carmelo Gurnari, Hussein Awada, Adrian Mosquera, Manuel Perez Encinas, Donal McLornan, Andrius Zucenka, Talha Badar, Bor-Sheng Ko, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Jaroslaw Maciejewski, Nick Telford, Kiran Batta, Daniel Wiseman

Blood (2025) 146 (Supplement 1): 4347.

https://doi.org/10.1182/blood-2025-4347

Published: 2025

Journal Articles

Serum ferritin changes in iptacopan-treated patients with paroxysmal nocturnal hemoglobinuria

Antonio Risitano, Carlos de Castro, Camilla Frieri, Bing Han, Richard Kelly, Austin Kulasekararaj, Jaroslaw Maciejewski, Vinod Pullarkat, Alexander Röth, Phillip Scheinberg, Flore Sicre-de-Fontbrune, Yasutaka Ueda, Tim Costigan, Marion Dahlke, Philippe Ferber, Tomasz Lawniczek, Stefanie Senger, Regis Peffault De Latour

Blood (2025) 146 (Supplement 1): 4974.

https://doi.org/10.1182/blood-2025-4974

Published: 2025

Journal Articles

Etiologic heterogeneity in secondary hemophagocytic lymphohistiocytosis: A retrospective real-world study from a quaternary academic center

Asfand Yar Cheema, Akram Abushamma, Aashray Mandala, Mark Orland, Serhan Unlu, Carlos Bravo-Perez, Praveena Thiagarajan, Arda Durmaz, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 6547.

https://doi.org/10.1182/blood-2025-6547

Published: 2025

Journal Articles

Navigating the complement cascade: A multicenter journey from pegcetacoplan to iptacopan in paroxysmal nocturnal hemoglobinuria

Praveena Thiagarajan, Mark Orland, Serhan Unlu, Arooj Ahmed, Carlos Bravo-Perez, Matteo D Addona, Megan Basch, Soyon Lee, Ver Bilano, Jincy Paulose, Lincy Geevarghese, Vamsi Bollu, Srinivasa Reddy Sanikommu, David Dingli, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 1433.

https://doi.org/10.1182/blood-2025-1433

Published: 2025

Journal Articles

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Aashray Mandala, Arda Durmaz, Mark Orland, Carlos Bravo-Perez, Zachary Brady, Matteo D'Addona, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Serhan Unlu, Felipe de Almeida Sartori, Selin Ilaslan, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 1432.

https://doi.org/10.1182/blood-2025-1432

Published: 2025

Journal Articles

Management of a real-world cohort of patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: A multi-institutional analysis

Mark Orland, Praveena Thiagarajan, Serhan Unlu, Arooj Ahmed, Carlos Bravo-Perez, Matteo D Addona, Megan Basch, Soyon Lee, Ver Bilano, Jincy Paulose, Lincy Geevarghese, Vamsi Bollu, David Dingli, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 1430.

https://doi.org/10.1182/blood-2025-1430

Published: 2025

Journal Articles

Bone marrow alterations and clonal hematopoiesis in germline ETV6 mutation carriers without hematologic malignancy

Sara Torres-Esquius, Maria Gabarros-Subira, Carmelo Gurnari, Carlos Bravo-Perez, Guillermo Ramil López, Raquel De Paz Arias, Alejandro Sanz, Maria Muñoz Martinez, Francisco Beas, Sandra Novoa Jáuregui, Marta Pratcorona Canela, Silvia Saumell, Maria Teresa Voso, Jaroslaw Maciejewski, Pamela Acha, David Valcarcel, Andres Jerez, Maria Julia Montoro

Blood (2025) 146 (Supplement 1): 4997.

https://doi.org/10.1182/blood-2025-4997

Published: 2025

Journal Articles

Chromodomain helicase DNA binding protein CHD2 interacts with TET2 and regulates lineage defining transcription in hematopoietic stem and progenitor cells

Songa Bae, Xiaorong Gu, Mamta Sumi, Dongxu Jiang, Daniel Vail, Yahan Zhang, Kacey O'Donnell, Yogen Saunthararajah, Jaroslaw Maciejewski, Babal Jha

Blood (2025) 146 (Supplement 1): 3237.

https://doi.org/10.1182/blood-2025-3237

Published: 2025

Journal Articles

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

Kartik Lakhotiya, Xiaorong Gu, Arda Durmaz, Aashray Mandala, Matteo D'Addona, Carlos Bravo-Perez, Mark Orland, Zachary Brady, Serhan Unlu, Atsushi Marumo, Praveena Thiagarajan, Christopher Haddad, Felipe de Almeida Sartori, ERSAN UNLU, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3207.

https://doi.org/10.1182/blood-2025-3207

Published: 2025

Journal Articles

Real-world breakthrough hemolysis patterns across 1,723 patient-years of complement inhibition in paroxysmal nocturnal hemoglobinuria

Mark Orland, Aashray Mandala, Zachary Brady, Carlos Bravo-Perez, Praveena Thiagarajan, Serhan Unlu, Atsushi Marumo, Felipe Sartori, Valeria Visconte, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 3205.

https://doi.org/10.1182/blood-2025-3205

Published: 2025

Journal Articles

Sodium-glucose cotransporter-2 inhibitors may modulate complement pathway activation in paroxysmal nocturnal hemoglobinuria

Asfand Yar Cheema, Mishaal Munir, Aashray Mandala, Serhan Unlu, Mark Orland, Praveena Thiagarajan, Luca Guarnera, Akram Abushamma, Arda Durmaz, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3200.

https://doi.org/10.1182/blood-2025-3200

Published: 2025

Journal Articles

The basis for the differential impact of BCOR and BCORL1 in aplastic anemia/paroxysmal nocturnal hemoglobinuria and myeloid neoplasia

Atsushi Marumo, Arda Durmaz, Aashray Mandala, Christopher Haddad, Felipe Sartori, Olivia Hunyadi, Ersan Unlu, Serhan Unlu, Zachary Brady, Matteo D Addona, Kartik Lakhotiya, Luca Guarnera, Masanori Yoshida, Mark Orland, Carlos Bravo-Perez, Carmelo Gurnari, Marcin Wlodarski, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3196.

https://doi.org/10.1182/blood-2025-3196

Published: 2025

Journal Articles

A pilot study of nicotinamide riboside supplementation in allogeneic bone marrow transplantation

Ronald Sobecks, Navneet Majhail, Xiaorong Gu, Xuefei Jia, Megan Molnar, John Desamito, Dongxu Jiang, Kacey O'Donnell, Songa Bae, Craig Sauter, Andrew Trunk, Deepa Jagadeesh, Matt Kalaycio, Betty K. Hamilton, Claudio Brunstein, Jaroslaw Maciejewski, Babal Jha

Blood (2025) 146 (Supplement 1): 2437.

https://doi.org/10.1182/blood-2025-2437

Published: 2025

Journal Articles

First-in-human evaluation of IL2RG blockade in patients with severe aplastic anemia that is refractory to or relapsed on immunosuppressive therapy

Blood (2025) 146 (Supplement 1): 27.

https://doi.org/10.1182/blood-2025-27

Published: 2025

Journal Articles

Final results of a phase I/II trial of palbociclib and CPX-351 in patients with Acute Myeloid Leukemia

Chana Peysin, Aziz Nazha, Wei Wei, Aaron Gerds, Xiaoying Chen, Hetty Carraway, Abhay Singh, Anjali Advani, Moaath Mustafa Ali, John Molina, Sophia Balderman, Akriti Jain, Eric Parsons, Jenna Thomas, Bhumika Patel, Jaroslaw Maciejewski, Mikkael Sekeres, Babal Jha, Sudipto Mukherjee

Blood (2025) 146 (Supplement 1): 3420.

https://doi.org/10.1182/blood-2025-3420

Published: 2025

Journal Articles

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

Mark Orland, Arda Durmaz, Zachary Brady, Carlos Bravo-Perez, Aashray Mandala, Kartik Lakhotiya, Atsushi Marumo, Serhan Unlu, Matteo D'Addona, Luca Guarnera, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5616.

https://doi.org/10.1182/blood-2025-5616

Published: 2025

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A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

Exploring the spectrum of non-malignant complications in germline DDX41-associated hematologic disorders

Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits

TP53 mutational spectrum and fitness landscape in myeloid neoplasia

Redefining the myeloid disease continuum: Machine learning–based development and validation of an integrated multimodal classification of myeloid neoplasms

Serum ferritin changes in iptacopan-treated patients with paroxysmal nocturnal hemoglobinuria

Etiologic heterogeneity in secondary hemophagocytic lymphohistiocytosis: A retrospective real-world study from a quaternary academic center

Navigating the complement cascade: A multicenter journey from pegcetacoplan to iptacopan in paroxysmal nocturnal hemoglobinuria

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Management of a real-world cohort of patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: A multi-institutional analysis

Bone marrow alterations and clonal hematopoiesis in germline ETV6 mutation carriers without hematologic malignancy

Chromodomain helicase DNA binding protein CHD2 interacts with TET2 and regulates lineage defining transcription in hematopoietic stem and progenitor cells

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

Real-world breakthrough hemolysis patterns across 1,723 patient-years of complement inhibition in paroxysmal nocturnal hemoglobinuria

Sodium-glucose cotransporter-2 inhibitors may modulate complement pathway activation in paroxysmal nocturnal hemoglobinuria

The basis for the differential impact of BCOR and BCORL1 in aplastic anemia/paroxysmal nocturnal hemoglobinuria and myeloid neoplasia

A pilot study of nicotinamide riboside supplementation in allogeneic bone marrow transplantation

First-in-human evaluation of IL2RG blockade in patients with severe aplastic anemia that is refractory to or relapsed on immunosuppressive therapy

Final results of a phase I/II trial of palbociclib and CPX-351 in patients with Acute Myeloid Leukemia

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

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American Society of Hematology

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