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Journal Articles

Age-Related Cellular Factors Facilitate TET2 Mutant Clonal Hematopoiesis

Daniel J Vail, Dongxu Jiang, Kunho Chung, Yahan Zhang, Sophia Martinez, Luca Guarnera, Yvonne Parker, J. Joseph Melenhorst, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 1278.

https://doi.org/10.1182/blood-2024-211683

Published: 2024

Journal Articles

Clonal Evolution of TP53 Configurations with Treatment Predict Prognosis in Myeloid Neoplasms

Dakshin Padmanabhan, Jeff Aguilar, Paul Kim, Sandhya Dhiman, Asmita Shukla, Vikram Dhillon, Sushmitha Nanja Reddy, David Carr, Jay Yang, Julie Boerner, Jaroslaw Maciejewski, Suresh Kumar Balasubramanian

Blood (2024) 144 (Supplement 1): 1540.

https://doi.org/10.1182/blood-2024-210037

Published: 2024

Journal Articles

Bi-Allelic DDX41 Mutations Exert Stage Specific Effects on Hematopoiesis to Promote Disease

Benjamin Kroger, Yuanyuan Ji, Toby Thomas, Yazan F Madanat, Robert H. Collins, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski, Stephen Chung

Blood (2024) 144 (Supplement 1): 347.

https://doi.org/10.1182/blood-2024-209425

Published: 2024

Journal Articles

Distinct Phenotypes of Myeloid Neoplasia Associated with Truncating C-CBL Mutations

Luca Guarnera, Carmelo Gurnari, Carlos Bravo-Perez, Arda Durmaz, Nakisha D Williams, Hussein Awada, Matteo D'Addona, Naomi Kawashima, Arooj Ahmed, Serhan Unlu, Olisaemeka Ogbue, Christopher Haddad, Aashray Mandala, Yasuo Kubota, Juraj Bodo, Genevieve M Crane, Heesun J. Rogers, Jaroslaw Maciejewski, Valeria Visconte

Blood (2024) 144 (Supplement 1): 2920.

https://doi.org/10.1182/blood-2024-209834

Published: 2024

Journal Articles

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

Xiaorong Gu, Yahan Zhang, Songa Bae, Dongxu Jiang, Nakisha D Williams, Daniel Vail, Simon Schlanger, Jill Durkin, Yvonne Parker, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2918.

https://doi.org/10.1182/blood-2024-207470

Published: 2024

Journal Articles

Using Machine Learning to Predict the Risk of Evolution to Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia

Erika Ren, Katayoun Elizabeth Khalilian, Mutlu Mete, Carmelo Gurnari, Jaroslaw Maciejewski, Carlos Bravo-Perez, Taha Bat

Blood (2024) 144 (Supplement 1): 1315.

https://doi.org/10.1182/blood-2024-203826

Published: 2024

Journal Articles

A Dedicated System Accounting for Specific Germline/Somatic Genomic Constellations Is Essential to Predict Outcomes in DDX41 -Mutant Myeloid Neoplasia

Blood (2024) 144 (Supplement 1): 1332.

https://doi.org/10.1182/blood-2024-194024

Published: 2024

Journal Articles

Genomic Landscape of Germline RUNX1 variants in Adult Myeloid Neoplasia According to Functional Impact

Christopher Haddad, Luca Guarnera, Yasuo Kubota, Carlos Bravo-Perez, Carmelo Gurnari, Olisaemeka Ogbue, Arda Durmaz, Serhan Unlu, Aashray Mandala, Mark Orland, Zachary Brady, Kartik Lakhotiya, Matteo D'Addona, Ishani Nautiyal, David S. Bosler, Hetty E. Carraway, Yogen Saunthararajah, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 1328.

https://doi.org/10.1182/blood-2024-210419

Published: 2024

Journal Articles

Budd-Chiari Syndrome: Pathogenetic Factors and Completeness of Screening for Paroxysmal Nocturnal Hemoglobinuria

Aashray Mandala, Carlos Bravo-Perez, Zachary Brady, Matteo D'Addona, Arda Durmaz, Mark Orland, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 1254.

https://doi.org/10.1182/blood-2024-211609

Published: 2024

Journal Articles

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Dongxu Jiang, Yahan Zhang, Xiaorong Gu, Daniel J Vail, Jill Durkin, Simon Schlanger, J. Joseph Melenhorst, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 40.

https://doi.org/10.1182/blood-2024-211171

Published: 2024

Journal Articles

Personalized Transplant Decision Making for Myelofibrosis in the Era of Molecular Genetics and JAK Inhibition

Nico Gagelmann, Barbara Mora, Filippo Branzanti, Alessandro Maria Vannucchi, Massimo Breccia, Giuseppe Alberto Maria Palumbo, Massimiliano Bonifacio, Erika Morsia, Elena Maria Elli, Mario Tiribelli, Giulia Benevolo, Mirko Farina, Fabrizio Pane, Roberto Massimo Lemoli, Giovanni Caocci, Alessia Tieghi, Gianni Binotto, Francesco Cavazzini, Bruno Martino, Alessandro Isidori, Margherita Maffioli, Elisa Rumi, Tiziano Barbui, Francisco Cervantes, Matteo Giovanni Della Porta, Andrew T. Kuykendall, Marianna Caramella, Alessandra Iurlo, Valerio De Stefano, Jean-Jacques Kiladjian, David Ross, Jason Gotlib, Timothy Devos, Marco Ruggeri, Richard T. Silver, Rachel B. Salit, Thomas Schroeder, Carmelo Gurnari, Simona Pagliuca, Christina Rautenberg, Marie Robin, Marie-Thérèse Rubio, Jaroslaw Maciejewski, Alessandro Rambaldi, Maria Chiara Finazzi, Andrea Bacigalupo, Patrizia Chiusolo, Hans Christian Reinhardt, Bart L. Scott, Nicolaus Kröger, Francesco Passamonti, Francesca Palandri

Blood (2024) 144 (Supplement 1): 245.

https://doi.org/10.1182/blood-2024-210804

Published: 2024

Journal Articles

Genetic Determinants of Hypercoagulability in Complement and Hemostatic Systems Shape the Thrombotic Risk of Paroxysmal Nocturnal Hemoglobinuria

Carlos Bravo-Perez, Carmelo Gurnari, Arda Durmaz, Stephan Hutter, Zachary Brady, Hussein Awada, Aashray Mandala, Luca Guarnera, Matteo D'Addona, Kartik Lakhotiya, Praveena Thiagarajan, Alan Eli Lichtin, Torsten Haferlach, Valeria Visconte, Jaroslaw Maciejewski

Blood (2024) 144 (Supplement 1): 31.

https://doi.org/10.1182/blood-2024-208885

Published: 2024

Journal Articles

First Results of High Throughput Pipeline for Serotypic and TCR Clonotypic Specificities in Aplastic Anemia and Large Granular Lymphocyte Leukemia Uncovering Antigenic Peptides Relevant to Disease Etiology

Kartik Lakhotiya, Carmelo Gurnari, Carlos Bravo-Perez, Aashray Mandala, Matteo D'Addona, Christopher Haddad, Mark Orland, Zachary Brady, Luca Guarnera, Praveena Thiagarajan, Ishani Nautiyal, Simona Pagliuca, Hari Krishnamurthy, Karthik Krishna, Vasanth Jayaraman, Valeria Visconte, Jaroslaw Maciejewski, Arda Durmaz

Blood (2024) 144 (Supplement 1): 35.

https://doi.org/10.1182/blood-2024-210990

Published: 2024

Journal Articles

A Molecular-Based Ecosystem to Improve Personalized Medicine in Patients with Chronic Myelomonocytic Leukemia (CMML)

Luca Lanino, Anthony M. Hunter, Nico Gagelmann, Marie Robin, Claudia Sala, Daniele Dall'Olio, Carmelo Gurnari, Lorenzo Dall'Olio, Yu-Hung Wang, Lisa Pleyer, Blanca Xicoy, Guillermo Montalban-Bravo, Lee-Yung Shih, Tamanna Haque, Omar Abdel-Wahab, Klaus Geissler, Alex Bataller, Alexandre Bazinet, Manja Meggendorfer, Ilaria Carola Casetti, Elisabetta Sauta, Erica Travaglino, Laura Palomo, Lurdes Zamora, David Quintela, Andres Jerez, Elena Cornejo, Paloma Garcia Martin, Marina Díaz-Beyá, Alejandro Avendaño Pita, Veronica Roldan, Dolly Viviana Fiallo Suarez, Estefania Cerezo Velasco, Marisa Calabuig, Esperanza Such, Guillermo Sanz, Anne Sophie Kubasch, Cristina Castilla-Llorente, Claude-Éric Bulabois, Laetitia Souchet, Hussein Awada, Massimo Bernardi, Patrizia Chiusolo, Antonio Curti, Luisa Giaccone, Francesco Onida, Lorenza Maria Borin, Francesco Passamonti, Elisa Diral, Vladan Vucinic, Gregorio Maria Bergonzi, Maria Teresa Voso, Hsin-An Hou, Wen-Chien Chou, Chi-Yuan Yao, Chien-Chin Lin, Hwei-Fang Tien, Alessia Campagna, Marta Ubezio, Antonio Russo, Gabriele Todisco, Giulia Maggioni, Cristina Astrid Tentori, Alessandro Buizza, Gianluca Asti, Matteo Zampini, Elena Riva, Mattia Delleani, Angela Consagra, Francesca Ficara, Armando Santoro, Luciana Carota, Tiziana Sanavia, Cesare Rollo, Ahmad Kiwan, Jennifer VanOudenhove, Piero Fariselli, Najla H. Al Ali, David Sallman, Wolfgang Kern, Guillermo Garcia-Manero, Swapna Thota, Elizabeth A. Griffiths, Matilde Yung Follo, Carlo Finelli, Uwe Platzbecker, Francesc Sole, Maria Diez-Campelo, Jaroslaw Maciejewski, Rafael Bejar, Felicitas R. Thol, Nicolaus Kröger, Pierre Fenaux, Raphael Itzykson, Timothy Aaron Graubert, Michaela Fontenay, Amer M. Zeidan, Rami S. Komrokji, Valeria Santini, Torsten Haferlach, Ulrich Germing, Saverio D'Amico, Gastone Castellani, Mrinal M. Patnaik, Eric Solary, Eric Padron, Matteo Giovanni Della Porta

Blood (2024) 144 (Supplement 1): 1003.

https://doi.org/10.1182/blood-2024-200104

Published: 2024

Journal Articles

Combined Use of Ziftomenib and Selinexor Is Effective in NPM1 Mutant Acute Myeloid Leukemia

Sandhya Dhiman, Md. Hafiz Uddin, Vikram Dhillon, Jeff Justin Aguilar, Amro Aboukameel, Husain Khan, Sahar Bannoura, Jay Yang, Gregory Dyson, Steven Buck, Asfar Azmi, Lisa Polin, Francis Burrows, Linda Kessler, Jaroslaw Maciejewski, Suresh Kumar Balasubramanian

Blood (2024) 144 (Supplement 1): 2768.

https://doi.org/10.1182/blood-2024-206075

Published: 2024

Journal Articles

Oncogenic Nexus of TET2 with Thpok in Myeloid Neoplasia

Ejike Ujoatu, Sohini Mukhopadhyay, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski, Jayati Basu, Babal K. Jha, H. Leighton Grimes, Stephen Sykes, Dietmar Kappes

Blood (2024) 144 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2024-207759

Published: 2024

Journal Articles

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Xiaorong Gu, Zeinab Albadry M. Zahran, Ramesh Balusu, Jaroslaw Maciejewski, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 2714.

https://doi.org/10.1182/blood-2024-205887

Published: 2024

Journal Articles

Predicting Extravascular Hemolysis in Paroxysmal Nocturnal Hemoglobinuria

Munevver N. Duran, Zehra Tombul, Mutlu Mete, Ahmet Celal Toprak, Olisaemeka Ogbue, Hussein Awada, Carmelo Gurnari, Jaroslaw Maciejewski, Ibrahim F. Ibrahim, Merve Ozturk, Yusuf M. Ozcan, Brielle Johnson, Christine Ejiofor, Alper Olcal, Taha Bat

Blood (2024) 144 (Supplement 1): 2695.

https://doi.org/10.1182/blood-2024-204213

Published: 2024

Journal Articles

Clinical Outcomes and Variability Based on Baseline Cytogenetic Risk of Patients with MDS Treated with Hypomethylating Agents: An Analysis from the International Consortium for MDS (icMDS) Validate Database

Ted M. Getz, Tariq Kewan, Jan Philipp Bewersdorf, Jessica M. Stempel, Luca Lanino, Wei Wei, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Somedeb Ball, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vasiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Maximilian Stahl, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan

Blood (2024) 144 (Supplement 1): 3219.

https://doi.org/10.1182/blood-2024-202075

Published: 2024

Journal Articles

The Presence of SH2B3 mutations Identifies a Distinct Subtype of Myelodysplastic Neoplasms

Blood (2024) 144 (Supplement 1): 3214.

https://doi.org/10.1182/blood-2024-194488

Published: 2024

NARROW

Age-Related Cellular Factors Facilitate TET2 Mutant Clonal Hematopoiesis

Clonal Evolution of TP53 Configurations with Treatment Predict Prognosis in Myeloid Neoplasms

Bi-Allelic DDX41 Mutations Exert Stage Specific Effects on Hematopoiesis to Promote Disease

Distinct Phenotypes of Myeloid Neoplasia Associated with Truncating C-CBL Mutations

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

Using Machine Learning to Predict the Risk of Evolution to Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia

A Dedicated System Accounting for Specific Germline/Somatic Genomic Constellations Is Essential to Predict Outcomes in DDX41 -Mutant Myeloid Neoplasia

Genomic Landscape of Germline RUNX1 variants in Adult Myeloid Neoplasia According to Functional Impact

Budd-Chiari Syndrome: Pathogenetic Factors and Completeness of Screening for Paroxysmal Nocturnal Hemoglobinuria

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Personalized Transplant Decision Making for Myelofibrosis in the Era of Molecular Genetics and JAK Inhibition

Genetic Determinants of Hypercoagulability in Complement and Hemostatic Systems Shape the Thrombotic Risk of Paroxysmal Nocturnal Hemoglobinuria

First Results of High Throughput Pipeline for Serotypic and TCR Clonotypic Specificities in Aplastic Anemia and Large Granular Lymphocyte Leukemia Uncovering Antigenic Peptides Relevant to Disease Etiology

A Molecular-Based Ecosystem to Improve Personalized Medicine in Patients with Chronic Myelomonocytic Leukemia (CMML)

Combined Use of Ziftomenib and Selinexor Is Effective in NPM1 Mutant Acute Myeloid Leukemia

Oncogenic Nexus of TET2 with Thpok in Myeloid Neoplasia

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Predicting Extravascular Hemolysis in Paroxysmal Nocturnal Hemoglobinuria

Clinical Outcomes and Variability Based on Baseline Cytogenetic Risk of Patients with MDS Treated with Hypomethylating Agents: An Analysis from the International Consortium for MDS (icMDS) Validate Database

The Presence of SH2B3 mutations Identifies a Distinct Subtype of Myelodysplastic Neoplasms

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American Society of Hematology

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