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Kristian Gurashi
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Journal Articles

SRSF2 mutation-induced CHD8 exon skipping represents a novel pathogenic mediator and therapeutic dependence in chronic myelomonocytic leukemia (CMML)

Free
Yu-Hung Wang, Kristian Gurashi, Laura Guest, Roberto Paredes, Carlos Rivera, Luciano Nicosia, Shalini Sankar, David Walter, Curtis Hart, Sylvie Lachmann, Wei-Hsiang Lin, Antony Adamson, Kiran Batta, Daniel Wiseman
Journal: Blood
Blood (2025) 146 (Supplement 1): 676.
https://doi.org/10.1182/blood-2025-676
Published: 2025
Journal Articles

Investigating the clonal and biological underpinnings of systemic mastocytosis with an associated hematological neoplasm

Free
Nana Adjoa Ben-Crentsil, Somedeb Ball, Hannah Newman, Christopher Ryder, Surendra Neupane, Anthony Hunter, Yu-Hung Wang, Kiran Batta, Kristian Gurashi, Traci Kruer, Maria Balasis, Ariel Quintana, Rami Komrokji, David Sallman, Andrew Kuykendall, Tracy George, Daniel Wiseman, Eric Padron
Journal: Blood
Blood (2025) 146 (Supplement 1): 3763.
https://doi.org/10.1182/blood-2025-3763
Published: 2025
Journal Articles

Redefining the myeloid disease continuum: Machine learning–based development and validation of an integrated multimodal classification of myeloid neoplasms

Free
Yu-Hung Wang, Kristian Gurashi, Chien-Chin Lin, Carmelo Gurnari, Hussein Awada, Adrian Mosquera, Manuel Perez Encinas, Donal McLornan, Andrius Zucenka, Talha Badar, Bor-Sheng Ko, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Jaroslaw Maciejewski, Nick Telford, Kiran Batta, Daniel Wiseman
Journal: Blood
Blood (2025) 146 (Supplement 1): 4347.
https://doi.org/10.1182/blood-2025-4347
Published: 2025
Journal Articles

Single-Cell Multiomic Profiling of TP53 Mutated Myelodysplastic Neoplasms - All Clones Are Not Equal

Free
Onima Chowdhury, Kristian Gurashi, Amy Wood, Ivan Lukic, Adam Sciambi, Lynn Quek, Daniel H Wiseman, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 3615.
https://doi.org/10.1182/blood-2024-210047
Published: 2024
Journal Articles

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Free
Eleni Louka, Kristian Gurashi, Sean Wen, Mariolina Salio, Christina Simoglou Karali, Roman Doll, Sally-Ann Clark, Anastasia Kosmidou, Rosalin Cooper, Daniel Royston, Deena Iskander, Nawshad Hayder, Renuka Teague, Cristina Tormo Garcia, Maria Greco, Paola Vargas Gutierrez, Joshua Bull, Anupama Rao, Irene Roberts, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 822.
https://doi.org/10.1182/blood-2024-208902
Published: 2024
Journal Articles

Granulocyte Derived Resistin Induces Classical Monocyte Repartition and Immune Suppression in CMML

Free
Nathan J Hull, Rachel Cant, Yu-Hung Wang, Kristian Gurashi, Laura A Guest, Daniel H Wiseman, Kiran Batta
Journal: Blood
Blood (2024) 144 (Supplement 1): 880.
https://doi.org/10.1182/blood-2024-205238
Published: 2024
Journal Articles

MSC Reprogramming and Aberrant Inflammatory Signaling in Myelofibrosis: Insights from Single-Cell RNA-Sequencing of Trephine Bone Marrow Cells

Free
Naseer J Basma, Alexia J Strickson, Kristian Gurashi, Maria Kleppe, Hugh Young Rienhoff Jr., Jr., Tim CP Somervaille
Journal: Blood
Blood (2023) 142 (Supplement 1): 743.
https://doi.org/10.1182/blood-2023-181674
Published: 2023
Journal Articles

Prognostic and Therapeutic Implications of TP53 expression in Chronic Myelomonocytic Leukaemia: Results of a Multicentre Study

Free
Yu-Hung Wang, Chien-Chin Lin, Kristian Gurashi, Fabio Amaral, Chi-Yuan Yao, Joanna Storer, Luciano Nicosia, Bettina Wingelhofer, Hsin-An Hou, Andres Jerez, Wen-Chien Chou, Kiran Batta, Hwei-Fang Tien, Daniel H Wiseman
Journal: Blood
Blood (2023) 142 (Supplement 1): 3213.
https://doi.org/10.1182/blood-2023-180034
Published: 2023
Journal Articles

HMR Mutations Drive Poor Prognosis in Myelofibrosis Patients with Lower JAK2 V617F Allele Burden but Not in Those with Higher Allele Burden: Results of a Multicenter Study

Free
Yu-Hung Wang, Carmelo Gurnari, Chao-Hung Wei, Hussein Awada, Chien-Chin Lin, Andrius Zucenka, Chi-Yuan Yao, Kristian Gurashi, Hsin-An Hou, Kiran Batta, Wen-Chien Chou, Jaroslaw P. Maciejewski, Daniel H Wiseman, Hwei-Fang Tien
Journal: Blood
Blood (2023) 142 (Supplement 1): 627.
https://doi.org/10.1182/blood-2023-179907
Published: 2023
Journal Articles

Integrative Analysis of Blast Phase Chronic Myelomonocytic Leukemia Reveals Distinct Transformation Phenotypes Predictive of Drug Response

Free
Kristian Gurashi, Yu-Hung Wang, Tim C.P Somervaille, Kiran Batta, Daniel H Wiseman
Journal: Blood
Blood (2022) 140 (Supplement 1): 213–214.
https://doi.org/10.1182/blood-2022-168831
Published: 2022
Journal Articles

A Three Gene Leukemic Stem Cell Signature Score Is Robustly Prognostic in Chronic Myelomonocytic Leukemia

Free
Yu-Hung Wang, Chi-Yuan Yao, Chien-Chin Lin, Kristian Gurashi, Fabio Amaral, Andres Jerez, Tim C.P Somervaille, Hsin-An Hou, Wen-Chien Chou, Kiran Batta, Hwei-Fang Tien, Daniel H Wiseman
Journal: Blood
Blood (2022) 140 (Supplement 1): 1104–1105.
https://doi.org/10.1182/blood-2022-165449
Published: 2022
Journal Articles

Multiomic Single-Cell Sequencing Reveals Patterns of Disease Evolution and Acute Transformation in Chronic Myelomonocytic Leukaemia

Free
Kristian Gurashi, John Weightman, Syed M Baker, Kevin Rouault-Pierre, Wolfgang Breitweister, Tim C.P Somervaille, Kiran Batta, Daniel H Wiseman
Journal: Blood
Blood (2021) 138 (Supplement 1): 2586.
https://doi.org/10.1182/blood-2021-153540
Published: 2021