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Journal Articles

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Blood (2025) 146 (Supplement 1): 217.

https://doi.org/10.1182/blood-2025-217

Published: 2025

Journal Articles

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

Mark Orland, Arda Durmaz, Zachary Brady, Carlos Bravo-Perez, Aashray Mandala, Kartik Lakhotiya, Atsushi Marumo, Serhan Unlu, Matteo D'Addona, Luca Guarnera, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5616.

https://doi.org/10.1182/blood-2025-5616

Published: 2025

Journal Articles

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

Serhan Unlu, Tariq Kewan, Christopher Haddad, Olisaemeka Ogbue, Asfand Yar Cheema, Zachary Brady, Mark Orland, Praveena Thiagarajan, Aashray Mandala, Matteo D'Addona, Luca Guarnera, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2025-5614

Published: 2025

Journal Articles

Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari, Olisaemeka Ogbue, Matteo D'Addona, Ahmad Kiwan, Hussein Awada, Simona Pagliuca, Hetty Carraway, Amer Zeidan, Suresh Kumar Balasubramanian, Taha Bat, Yazan Madanat, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3485.

https://doi.org/10.1182/blood-2025-3485

Published: 2025

Journal Articles

Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype

Mark Orland, Carlos Bravo-Perez, Olisaemeka Ogbue, Asfand Yar Cheema, Aashray Mandala, Serhan Unlu, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2995.

https://doi.org/10.1182/blood-2025-2995

Published: 2025

Journal Articles

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Ted Getz, Kelly Pugh, Andrew Brunner, Jan Philipp Bewersdorf, Amy DeZern, Tariq Kewan, Uma Borate, Uwe Platzbecker, Mikkael Sekeres, Andrew Wei, Shahram Kordasti, Rena Buckstein, Gail Roboz, Michael Savona, Sanam Loghavi, Robert Hasserjian, Pierre Fenaux, David Sallman, Christopher Hourigan, Matteo Della Porta, Stephen Nimer, Richard Little, Valeria Santini, Fabio Efficace, Justin Taylor, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami Komrokji, Elizabeth Griffiths, Peter Greenberg, Mina Xu, Zhuoer Xie, Rafael Bejar, Guillermo Sanz, Mrinal Patnaik, Maria E. Figueroa, Hetty Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval Daver, Jane Churpek, Ravi Majeti, John Bennett, Alan List, Adrian Mosquera Orgueira, Klaus Metzeler, Francesc Sole, Lisa Pleyer, Arjan Van de Loosdrecht, Thomas Cluzeau, David Steensma, Ghulam Mufti, Lionel Ades, Luca Lanino, Yazan Madanat, Anne Sophie Kubasch, Marie Sebert, R. Coleman Lindsley, Katharina S. Götze, Carmelo Gurnari, Yasushi Miyazaki, Aref Al-Kali, Abdulraheem Yacoub, Bing Li, Ioannis Kotsianidis, Maximilian Stahl, Amer Zeidan

Blood (2025) 146 (Supplement 1): 3852.

https://doi.org/10.1182/blood-2025-3852

Published: 2025

Journal Articles

Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Blood (2025) 146 (Supplement 1): 3838.

https://doi.org/10.1182/blood-2025-3838

Published: 2025

Journal Articles

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

Zachary Brady, Charlotte Zurowski, Felipe de Almeida Sartori, Tariq Kewan, Olivia Hunyadi, Mark Orland, Aashray Mandala, Christopher Haddad, Hetty Carraway, Abhay Singh, Serhan Unlu, Atsushi Marumo, Kartik Lakhotiya, Carmelo Gurnari, Arda Durmaz, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3174.

https://doi.org/10.1182/blood-2025-3174

Published: 2025

Journal Articles

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

Blood (2025) 146 (Supplement 1): 2068.

https://doi.org/10.1182/blood-2025-2068

Published: 2025

Journal Articles

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Luca Guarnera, Carmelo Gurnari, Zachary Brady, Carlos Bravo-Perez, Matteo D'Addona, Atsushi Marumo, Mark Orland, Praveena Thiagarajan, Serhan Unlu, Christopher Haddad, Aashray Mandala, Eleonora Lumia, Nicole Lelli, Arda Durmaz, Emiliano Fabiani, Maria Teresa Voso, Jaroslaw Maciejewski, Valeria Visconte

Blood (2025) 146 (Supplement 1): 2064.

https://doi.org/10.1182/blood-2025-2064

Published: 2025

Journal Articles

Machine learning uncovers invariant evolutionary molecular trajectories in MDS.

Matteo D'Addona, Arda Durmaz, Tariq Kewan, Waled Bahaj, Carlos Bravo-Perez, Luca Guarnera, Simona Pagliuca, Zachary Brady, Kartik Lakhotiya, Praveena Thiagarajan, Moaath Mustafa Ali, Abhay Singh, Hetty Carraway, Mark Orland, Carmelo Gurnari, Jacob Scott, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2025-2060

Published: 2025

Journal Articles

Etiologic heterogeneity in secondary hemophagocytic lymphohistiocytosis: A retrospective real-world study from a quaternary academic center

Asfand Yar Cheema, Akram Abushamma, Aashray Mandala, Mark Orland, Serhan Unlu, Carlos Bravo-Perez, Praveena Thiagarajan, Arda Durmaz, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 6547.

https://doi.org/10.1182/blood-2025-6547

Published: 2025

Journal Articles

Navigating the complement cascade: A multicenter journey from pegcetacoplan to iptacopan in paroxysmal nocturnal hemoglobinuria

Praveena Thiagarajan, Mark Orland, Serhan Unlu, Arooj Ahmed, Carlos Bravo-Perez, Matteo D Addona, Megan Basch, Soyon Lee, Ver Bilano, Jincy Paulose, Lincy Geevarghese, Vamsi Bollu, Srinivasa Reddy Sanikommu, David Dingli, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 1433.

https://doi.org/10.1182/blood-2025-1433

Published: 2025

Journal Articles

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Aashray Mandala, Arda Durmaz, Mark Orland, Carlos Bravo-Perez, Zachary Brady, Matteo D'Addona, Kartik Lakhotiya, Christopher Haddad, Praveena Thiagarajan, Serhan Unlu, Felipe de Almeida Sartori, Selin Ilaslan, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 1432.

https://doi.org/10.1182/blood-2025-1432

Published: 2025

Journal Articles

Management of a real-world cohort of patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: A multi-institutional analysis

Mark Orland, Praveena Thiagarajan, Serhan Unlu, Arooj Ahmed, Carlos Bravo-Perez, Matteo D Addona, Megan Basch, Soyon Lee, Ver Bilano, Jincy Paulose, Lincy Geevarghese, Vamsi Bollu, David Dingli, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 1430.

https://doi.org/10.1182/blood-2025-1430

Published: 2025

Journal Articles

Bone marrow alterations and clonal hematopoiesis in germline ETV6 mutation carriers without hematologic malignancy

Sara Torres-Esquius, Maria Gabarros-Subira, Carmelo Gurnari, Carlos Bravo-Perez, Guillermo Ramil López, Raquel De Paz Arias, Alejandro Sanz, Maria Muñoz Martinez, Francisco Beas, Sandra Novoa Jáuregui, Marta Pratcorona Canela, Silvia Saumell, Maria Teresa Voso, Jaroslaw Maciejewski, Pamela Acha, David Valcarcel, Andres Jerez, Maria Julia Montoro

Blood (2025) 146 (Supplement 1): 4997.

https://doi.org/10.1182/blood-2025-4997

Published: 2025

Journal Articles

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

Kartik Lakhotiya, Xiaorong Gu, Arda Durmaz, Aashray Mandala, Matteo D'Addona, Carlos Bravo-Perez, Mark Orland, Zachary Brady, Serhan Unlu, Atsushi Marumo, Praveena Thiagarajan, Christopher Haddad, Felipe de Almeida Sartori, ERSAN UNLU, Valeria Visconte, Carmelo Gurnari, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3207.

https://doi.org/10.1182/blood-2025-3207

Published: 2025

Journal Articles

Real-world breakthrough hemolysis patterns across 1,723 patient-years of complement inhibition in paroxysmal nocturnal hemoglobinuria

Mark Orland, Aashray Mandala, Zachary Brady, Carlos Bravo-Perez, Praveena Thiagarajan, Serhan Unlu, Atsushi Marumo, Felipe Sartori, Valeria Visconte, Jaroslaw Maciejewski, Carmelo Gurnari

Blood (2025) 146 (Supplement 1): 3205.

https://doi.org/10.1182/blood-2025-3205

Published: 2025

Journal Articles

Sodium-glucose cotransporter-2 inhibitors may modulate complement pathway activation in paroxysmal nocturnal hemoglobinuria

Asfand Yar Cheema, Mishaal Munir, Aashray Mandala, Serhan Unlu, Mark Orland, Praveena Thiagarajan, Luca Guarnera, Akram Abushamma, Arda Durmaz, Zachary Brady, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 3200.

https://doi.org/10.1182/blood-2025-3200

Published: 2025

Journal Articles

A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

Atsushi Marumo, Arda Durmaz, Aashray Mandala, Christopher Haddad, Felipe Sartori, Olivia Hunyadi, Ersan Unlu, Serhan Unlu, Zachary Brady, Matteo D Addona, Kartik Lakhotiya, Luca Guarnera, Mark Orland, Carlos Bravo-Perez, Carmelo Gurnari, Valeria Visconte, Jaroslaw Maciejewski

Blood (2025) 146 (Supplement 1): 4945.

https://doi.org/10.1182/blood-2025-4945

Published: 2025

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Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms

Germline alterations of hematopoietic growth factor receptors and maladaptive somatic genetic rescue leads to myeloid neoplasia

Which molecular patterns of high-risk myeloid malignancies are concordantly identified using two machine learning algorithms?

Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS

Serum erythropoietin level as a selective pressure in clonal hematopoiesis: Insights into the mutational landscape of myeloid neoplasias

Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes

C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML

Machine learning uncovers invariant evolutionary molecular trajectories in MDS.

Etiologic heterogeneity in secondary hemophagocytic lymphohistiocytosis: A retrospective real-world study from a quaternary academic center

Navigating the complement cascade: A multicenter journey from pegcetacoplan to iptacopan in paroxysmal nocturnal hemoglobinuria

Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing

Management of a real-world cohort of patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: A multi-institutional analysis

Bone marrow alterations and clonal hematopoiesis in germline ETV6 mutation carriers without hematologic malignancy

Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure

Real-world breakthrough hemolysis patterns across 1,723 patient-years of complement inhibition in paroxysmal nocturnal hemoglobinuria

Sodium-glucose cotransporter-2 inhibitors may modulate complement pathway activation in paroxysmal nocturnal hemoglobinuria

A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases

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American Society of Hematology

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