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Journal Articles

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Ted Getz, Kelly Pugh, Andrew Brunner, Jan Philipp Bewersdorf, Amy DeZern, Tariq Kewan, Uma Borate, Uwe Platzbecker, Mikkael Sekeres, Andrew Wei, Shahram Kordasti, Rena Buckstein, Gail Roboz, Michael Savona, Sanam Loghavi, Robert Hasserjian, Pierre Fenaux, David Sallman, Christopher Hourigan, Matteo Della Porta, Stephen Nimer, Richard Little, Valeria Santini, Fabio Efficace, Justin Taylor, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami Komrokji, Elizabeth Griffiths, Peter Greenberg, Mina Xu, Zhuoer Xie, Rafael Bejar, Guillermo Sanz, Mrinal Patnaik, Maria E. Figueroa, Hetty Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval Daver, Jane Churpek, Ravi Majeti, John Bennett, Alan List, Adrian Mosquera Orgueira, Klaus Metzeler, Francesc Sole, Lisa Pleyer, Arjan Van de Loosdrecht, Thomas Cluzeau, David Steensma, Ghulam Mufti, Lionel Ades, Luca Lanino, Yazan Madanat, Anne Sophie Kubasch, Marie Sebert, R. Coleman Lindsley, Katharina S. Götze, Carmelo Gurnari, Yasushi Miyazaki, Aref Al-Kali, Abdulraheem Yacoub, Bing Li, Ioannis Kotsianidis, Maximilian Stahl, Amer Zeidan

Blood (2025) 146 (Supplement 1): 3852.

https://doi.org/10.1182/blood-2025-3852

Published: 2025

Journal Articles

Examining the role of U2AF1 and TET2 mutations in a myeloid malignancy mouse model

Matthew Cheng, Charles Kenworthy, Sambuddha Paul, Hannah Maul-Newby, Jennifer VanOudenhove, Emma Busarello, Martina Vigorelli, Toma Tebaldi, Stephanie Halene, Giulia Biancon

Blood (2025) 146 (Supplement 1): 3837.

https://doi.org/10.1182/blood-2025-3837

Published: 2025

Journal Articles

5-azacytidine treatment reshapes clonal structure and alters mutation-dependent splicing in MDS patients

Xuan Zhang, Mutian Tang, Guangyuan Li, David Bernardicius, Jennifer VanOudenhove, Amy DeZern, Gabriel Ghiaur, Stephanie Halene, Nathan Salomonis, H. Leighton Grimes

Blood (2025) 146 (Supplement 1): 2054.

https://doi.org/10.1182/blood-2025-2054

Published: 2025

Journal Articles

METTL3 inhibition disrupts R-loop homeostasis and activates the cgas-sting pathway in Acute Myeloid Leukemia

Hee Doo Yang, Jennifer VanOudenhove, Manyi Wei, Christian Ramirez, Hannah Maul-Newby, Evan Fedorov, Caroline Conway, Megan King, Zuzana Tothova, Yaara Ofir-Rosenfeld, Toma Tebaldi, Stephanie Halene

Blood (2025) 146 (Supplement 1): 5061.

https://doi.org/10.1182/blood-2025-5061

Published: 2025

Journal Articles

MGMT-silencing as a novel biomarker in AML: Rational application of a dual alkylator-DNA crosslinker for targeted therapy

Prateek Bhardwaj, Amro Baassiri, Ranjini Sundaram, Sam Friedman, James Elia, Ahmad Kiwan, Martin Matthews, Jennifer VanOudenhove, Lourdes Mendez, Susan Gueble, Ranjit Bindra, Stephanie Halene

Blood (2025) 146 (Supplement 1): 322.

https://doi.org/10.1182/blood-2025-322

Published: 2025

Journal Articles

Identification of stage-specific regulators for neutrophil granule biogenesis

Wimeth Dissanayake, Stamatina Aravani, Emma Roberts, Laura Li, Hannah Maul-Newby, Maxwell Scalf, Stephanie Halene, Jun Lu, Shangqin Guo, Julia von Blume

Blood (2025) 146 (Supplement 1): 4761.

https://doi.org/10.1182/blood-2025-4761

Published: 2025

Journal Articles

Target antigen density may impact clinical response in patients with relapsed/refractory multiple myeloma undergoing treatment with elotuzumab and belantamab mafodotin

Francesca Albano, Sabrina Browning, Fangyong Li, Noffar Bar, Terri Parker, Tara Anderson, Erica Stevens, Jennifer VanOudenhove, Martin Matthews, Elan Gorshein, Jason Haldas, Ashita Talsania, Kert Sabbath, Stuart Seropian, Stephanie Halene, Fabiana Perna, Natalia Neparidze

Blood (2025) 146 (Supplement 1): 7578.

https://doi.org/10.1182/blood-2025-7578

Published: 2025

Journal Articles

Prospective evaluation of an AI-powered clinical trial patient matching (CTPM) system in myelodysplastic syndromes (MDS) and multiple myeloma

Blood (2025) 146 (Supplement 1): 1086.

https://doi.org/10.1182/blood-2025-1086

Published: 2025

Journal Articles

Early discharge program cost savings for patients with newly diagnosed acute myeloid leukemia after intensive induction chemotherapy

Cameron Hunter, Karthik Chetlapalli, Satoko Ito, Jan Philipp Bewersdorf, Prajwal Boddu, Sabrina Browning, Stephanie Halene, Terri Parker, Scott Huntington, Shalin Kothari, Lourdes Mendez, Natalia Neparidze, Tarsheen Sethi, Maximilian Stahl, Nikolai Podoltsev, Amer Zeidan, Rory Shallis, George Goshua

Blood (2025) 146 (Supplement 1): 6208.

https://doi.org/10.1182/blood-2025-6208

Published: 2025

Journal Articles

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation

Madeline Y. Mayday, Giulia Biancon, Manyi Wei, Christian Ramirez, Irene Moratti, Andreas P. Pintado-Urbanc, Jether Amos Espinosa, Mi Chen, Lin Wang, Matthew D. Simon, Yaara Ofir-Rosenfeld, Oliver Rausch, Toma Tebaldi, Stephanie Halene, Diane S. Krause

Blood (2025) 146 (9): 1096–1109.

https://doi.org/10.1182/blood.2024027712

Published: 2025

Includes: Supplemental data

Journal Articles

Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement

Uma Borate, Kelly Pugh, Allyson Waller, Rina Li Welkie, Ying Huang, Jan Philipp Bewersdorf, Maximilian Stahl, Amy E. DeZern, Uwe Platzbecker, Mikkael A. Sekeres, Andrew H. Wei, Rena J. Buckstein, Gail J. Roboz, Michael R. Savona, Sanam Loghavi, Robert P. Hasserjian, Pierre Fenaux, David A. Sallman, Christopher S. Hourigan, Matteo Giovanni Della Porta, Stephen Nimer, Richard F. Little, Valeria Santini, Fabio Efficace, Justin Taylor, Guillermo Garcia-Manero, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami S. Komrokji, Elizabeth A. Griffiths, Peter L. Greenberg, Mina L. Xu, Zhuoer Xie, Rafael Bejar, Guillermo F. Sanz, Mrinal M. Patnaik, Maria Figueroa, Hetty E. Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval G. Daver, Jane E. Churpek, Ravindra Majeti, John M. Bennett, Alan F. List, Andrew M. Brunner, Amer M. Zeidan

Blood (2025) 145 (13): 1369–1381.

https://doi.org/10.1182/blood.2023023717

Published: 2025

Includes: Supplemental data

Journal Articles

O6-Guanine Targeting Novel DNA Cross-Linker and ATR Inhibitor Combination for MGMT-Silenced IDH1/2 Mutant Acute Myeloid Leukemia

Prateek Bhardwaj, Ranjini Sundaram, Sam Friedman, Amro Baassiri, Martin Matthews, Jennifer VanOudenhove, Susan Gueble, Stephanie Halene, Ranjit Bindra

Blood (2024) 144 (Supplement 1): 6130.

https://doi.org/10.1182/blood-2024-210621

Published: 2024

Journal Articles

MISTRG6kit W41 : Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model

Amro Baassiri, Jamie Maziarz, Holly Nicole Blackburn, Hannah Maul-Newby, Jennifer VanOudenhove, Xuan Zhang, Martin Matthews, Sambuddha Paul, Wei Liu, Esen Sefik, Nathan Salomonis, H. Leighton Grimes, Richard Flavell, Stephanie Halene

Blood (2024) 144 (Supplement 1): 1815.

https://doi.org/10.1182/blood-2024-211908

Published: 2024

Journal Articles

Immune Landscape and Outcomes of Patients with RNA Splicing Factor-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes Treated with Azacitidine +/- the Anti-PD-L1 Antibody Durvalumab

Jan Philipp Bewersdorf, Vanessa Hasle, Rory M. Shallis, Ethan G. Thompson, Daniel Lopes De Menezes, Shelonitda Rose, Isaac W. Boss, Lourdes Mendez, Nikolai A. Podoltsev, Maximilian Stahl, Tariq Kewan, Stephanie Halene, Torsten Haferlach, Brian Fox, Amer M. Zeidan

Blood (2024) 144 (Supplement 1): 4585.

https://doi.org/10.1182/blood-2024-194929

Published: 2024

Journal Articles

Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response

Xuan Zhang, Guangyuan Li, Anna Oliverio, Jennifer VanOudenhove, Amy E. DeZern, Gabriel Ghiaur, Stephanie Halene, H. Leighton Grimes, Nathan Salomonis

Blood (2024) 144 (Supplement 1): 1810.

https://doi.org/10.1182/blood-2024-211099

Published: 2024

Journal Articles

Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring Treatment

Ahmad Kiwan, Tariq Kewan, Carlos Bravo-Perez, Valeria Visconte, Carmelo Gurnari, Arda Durmaz, Alexa Siddon, Stephanie Halene, Tarsheen Sethi, Jaroslaw Maciejewski, Francine M. Foss

Blood (2024) 144 (Supplement 1): 4436.

https://doi.org/10.1182/blood-2024-209344

Published: 2024

Journal Articles

Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies

Giulia Biancon, Emma Busarello, Matthew Cheng, Simone Sidoli, Jennifer VanOudenhove, Giorgia Bucciarelli, Toma Tebaldi, Stephanie Halene

Blood (2024) 144 (Supplement 1): 4117.

https://doi.org/10.1182/blood-2024-211265

Published: 2024

Journal Articles

Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal Hematopoiesis

Blood (2024) 144 (Supplement 1): 5634.

https://doi.org/10.1182/blood-2024-209240

Published: 2024

Journal Articles

Feasibility, Safety and Predictors of Outcomes of Patients with Newly Diagnosed Acute Myeloid Leukemia Discharged “Early” after Intensive Induction Therapy

Cameron Hunter, Wei Cheng, Stephanie Halene, Lourdes Mendez, Nikolai A. Podoltsev, Amer M. Zeidan, Lisa Barbarotta, Rory M. Shallis

Blood (2023) 142 (Supplement 1): 589.

https://doi.org/10.1182/blood-2023-182989

Published: 2023

Journal Articles

CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS)

Tariq Kewan, Sayeef Mirza, Alexander B Pine, Yusuf Rasheed, Ramzi Hamouche, Etienne Leveille, George Goshua, Sean X Gu, Yuxin Liu, Jennifer Vanoudenhove, Noffar Bar, Natalia Neparidze, Francine M. Foss, Lohith Gowda, Iris Isufi, Stephanie Halene, Alfred I Lee, Stuart Seropian

Blood (2023) 142 (Supplement 1): 2132.

https://doi.org/10.1182/blood-2023-187295

Published: 2023

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Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Examining the role of U2AF1 and TET2 mutations in a myeloid malignancy mouse model

5-azacytidine treatment reshapes clonal structure and alters mutation-dependent splicing in MDS patients

METTL3 inhibition disrupts R-loop homeostasis and activates the cgas-sting pathway in Acute Myeloid Leukemia

MGMT-silencing as a novel biomarker in AML: Rational application of a dual alkylator-DNA crosslinker for targeted therapy

Identification of stage-specific regulators for neutrophil granule biogenesis

Target antigen density may impact clinical response in patients with relapsed/refractory multiple myeloma undergoing treatment with elotuzumab and belantamab mafodotin

Prospective evaluation of an AI-powered clinical trial patient matching (CTPM) system in myelodysplastic syndromes (MDS) and multiple myeloma

Early discharge program cost savings for patients with newly diagnosed acute myeloid leukemia after intensive induction chemotherapy

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation

Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement

O6-Guanine Targeting Novel DNA Cross-Linker and ATR Inhibitor Combination for MGMT-Silenced IDH1/2 Mutant Acute Myeloid Leukemia

MISTRG6kit W41 : Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model

Immune Landscape and Outcomes of Patients with RNA Splicing Factor-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes Treated with Azacitidine +/- the Anti-PD-L1 Antibody Durvalumab

Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response

Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring Treatment

Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies

Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal Hematopoiesis

Feasibility, Safety and Predictors of Outcomes of Patients with Newly Diagnosed Acute Myeloid Leukemia Discharged “Early” after Intensive Induction Therapy

CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS)

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