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Journal Articles

Vitamin A Directly Enhances TET2 Activity and Suppresses Clonal Hematopoiesis

John P Brabson, Tiffany Leesang, Yoon Sing Yap, Daniela A Barbieri, Joey Pinzone, Minh Quang Lam, Peter D Lyon, Maria E Figueroa, Namrata S. Chandhok, Felipe Beckedorff, Aristeidis Telonis, Luisa Cimmino

Blood (2024) 144 (Supplement 1): 4051.

https://doi.org/10.1182/blood-2024-210278

Published: 2024

Journal Articles

Vitamin C Enhances PARPi Efficacy for the Treatment of AML

John P Brabson, Tiffany Leesang, Byron Fang, Jingjing Wang, Victoria Strippoli, Yoon-Sing Yap, Sofia Mohammad, Carolina Bañuelos, Peter Lyon, Sana Chaudhry, Minh Lam, Benjamin G Neel, Stephen Nimer, Ramiro E Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino

Blood (2021) 138 (Supplement 1): 1168.

https://doi.org/10.1182/blood-2021-153884

Published: 2021

Journal Articles

A FLI1-KLF6 Axis Regulates Aging in Human Hematopoietic Stem and Progenitor Cells and Normalization of KLF6 Levels in Aged Cells Leads to Their Rejuvenation

Alejandro Roisman, Emmalee R. Adelman, Natalia Weich, Aristeidis G. Telonis, Dean Wade, Daniel Bilbao, Ramiro E Verdun, Maria E. Figueroa

Blood (2021) 138 (Supplement 1): 19.

https://doi.org/10.1182/blood-2021-151060

Published: 2021

Journal Articles

The Autocrine Secreted PDZD2 Functions As a Novel Tumor Suppressor in AML, Inducing Growth Inhibition and Cell Cycle Arrest

Marlise L Guerrero Schimpf, Maria E. Figueroa

Blood (2021) 138 (Supplement 1): 3320.

https://doi.org/10.1182/blood-2021-151441

Published: 2021

Journal Articles

Age-Acquired Downregulation of Lmna Leads to Epigenetic Deregulation and Altered HSPC Function

Hsuan-Ting Huang, Dean Wade, Daniel Bilbao, Gabriel S Gaidosh, Ramin Shiekhattar, Maria E. Figueroa

Blood (2021) 138 (Supplement 1): 3280.

https://doi.org/10.1182/blood-2021-153020

Published: 2021

Journal Articles

Intronic Architecture Links DNA Methylation to Gene Expression and Helps Drive Subtype-Specific Transcriptional Landscapes in DNMT3A - and IDH1/2 -Mutant Acute Myeloid Leukemias (AML)

Aristeidis G. Telonis, Qin Yang, Hsuan-Ting Huang, Maria E. Figueroa

Blood (2021) 138 (Supplement 1): 3290.

https://doi.org/10.1182/blood-2021-146622

Published: 2021

Journal Articles

Development of a Fast and Reproducible Assay for the Clinical Implementation of Epigenetic Biomarkers to Predict Decitabine Response in Patients with Chronic Myelomonocytic Leukemia

Masataka Taguchi, Maikel Anthonissen, Aristeidis G. Telonis, Qin Yang, Eric Solary, Valeria Santini, Maria E. Figueroa

Blood (2021) 138 (Supplement 1): 1515.

https://doi.org/10.1182/blood-2021-147855

Published: 2021

Journal Articles

Epigenetic deregulation in myeloid malignancies

Hsuan-Ting Huang, Maria E. Figueroa

Blood (2021) 138 (8): 613–624.

https://doi.org/10.1182/blood.2019004262

Published: 2021

Journal Articles

Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

Blood (2021) 137 (24): 3390–3402.

https://doi.org/10.1182/blood.2020008729

Published: 2021

Includes: Supplemental data

Journal Articles

Analysis of the Global Methylation Profile of Accelerated and Blast Phase Myeloproliferative Neoplasms and Its Association with Response to Decitabine-Based Therapy

Raajit K. Rampal, MD PhD, Qin Yang, Richard P. Koche, PhD, Erin McGovern, BA, Christopher Famulare, MS, Rona Singer Weinberg, PhD, John Mascarenhas, MD, Ross L. Levine, MD, Ronald Hoffman, MD, Maria E. Figueroa, MD

Blood (2020) 136 (Supplement 1): 18–20.

https://doi.org/10.1182/blood-2020-139505

Published: 2020

Journal Articles

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Na Man, Gloria Mas Martin, PhD, Daniel Karl, PhD, Jun Sun, PhD, Fan Liu, PhD, Miguel Torres-Martin, PhD, Hidehiro Itonaga, MD PhD, Concepcion Martinez, B.S., Shi Chen, Stephanie Duffort, Pierre-Jacques Hamard, PhD, Ye Xu, PhD, Luisa Cimmino, PhDBSc, Feng-Chun Yang, MD PhD, Philip A. Cole, MD PhD, Mingjiang Xu, MD PhD, Maria E. Figueroa, MD, Stephen Nimer, MD

Blood (2019) 134 (Supplement_1): 561.

https://doi.org/10.1182/blood-2019-130507

Published: 2019

Journal Articles

Loss of KLF6 Recapitulates Molecular and Functional Changes Associated with Aging in Human Hematopoietic Stem and Progenitor Cells

Alejandro Roisman, PhD, Emmalee R. Adelman, BA, Hsuan-Ting Huang, PhD, Dean Wade, Daniel Bilbao, Maria E. Figueroa, MD

Blood (2019) 134 (Supplement_1): 447.

https://doi.org/10.1182/blood-2019-130800

Published: 2019

Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD

Blood (2018) 132 (Supplement 1): 2721.

https://doi.org/10.1182/blood-2018-99-115411

Published: 2018

Journal Articles

Dysregulation of RUNX3 in Aged Human HSPCs May Contribute to Perturbations in Erythropoiesis and Balanced Lineage Output

Peter Balogh, Brian Capaldo, PhD, Sandeep Singh, PhD, Kamaleldin Elagib, MBBS, PhD, Hui Li, PhD, Eli Zunder, PhD, Maria E. Figueroa, MD, Wendy Pang, MD, Adam Goldfarb, MD

Blood (2018) 132 (Supplement 1): 2553.

https://doi.org/10.1182/blood-2018-99-115245

Published: 2018

Journal Articles

Differentiation Response to Quizartinib, a Potent 2 nd Generation FLT3 Inhibitor, in Relapsed FLT3 -Mutant AML Patients Correlates with Specific DNA Methylation Signature Prior to Therapy

Miguel Torres Martin, PhD, Grace Jeschke, PhD, Alexander E. Perl, MD, Martin Carroll, MD, Maria E. Figueroa, MD

Blood (2017) 130 (Supplement 1): 3922.

https://doi.org/10.1182/blood.V130.Suppl_1.3922.3922

Published: 2017

Journal Articles

Integrative Epigenetic and Single-Cell RNA-Seq Profiling of Human Hematopoietic Stem Cells Reveals Epigenetic Reprogramming of Enhancer and Regulatory Elements during Normal Aging

Emmalee Adelman, BA, André Olsson, MSc, PhD, Tingting Qin, PhD, R. Coleman Lindsley, MD PhD, Rafael Bejar, MD PhD, Nathan Salomonis, PhD, Lee Grimes, Maria E. Figueroa, MD

Blood (2017) 130 (Supplement 1): 770.

https://doi.org/10.1182/blood.V130.Suppl_1.770.770

Published: 2017

Journal Articles

DNA Methylation in Cancer and Development: An Evolving Paradigm

Maria E. Figueroa, MD

Blood (2017) 130 (Supplement 1): SCI-50.

https://doi.org/10.1182/blood.V130.Suppl_1.SCI-50.SCI-50

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

Hyperactive Nras and Dose Reduction of Tet2 Collaborate to Dys-Regulate Hematopoietic Stem Cells and Promote Leukemogenesis

Xi Jin, PhD, Tingting Qin, PhD, Nathanael G Bailey, MD, Meiling Zhao, MS, Kevin B Yang, Victor Ng, MS, Lu Liu, PhD, Rosemary Coolon, MS, Gina Ney, MD PhD, Maria E Figueroa, MD, Qing Li, MD PhD

Blood (2016) 128 (22): 1204.

https://doi.org/10.1182/blood.V128.22.1204.1204

Published: 2016

Journal Articles

Aldehyde Dehydrogenase Activity in the Leukemic Stem Cell Compartment Uncovers Opposing Methylation Patterns of Leukemia Stem Cells in AML

Lauren Suarez, Tingting Qin, PhD, Kristen Meldi, PhD, Manjusha Thakar, Sarah Sakoian, Gabriel Ghiaur, MD PhD, Jonathan M. Gerber, MD, Hetty E. Carraway, MD MBA, Maria E Figueroa, MD, Steven D. Gore, MD

Blood (2016) 128 (22): 3925.

https://doi.org/10.1182/blood.V128.22.3925.3925

Published: 2016

NARROW

Vitamin A Directly Enhances TET2 Activity and Suppresses Clonal Hematopoiesis

Vitamin C Enhances PARPi Efficacy for the Treatment of AML

A FLI1-KLF6 Axis Regulates Aging in Human Hematopoietic Stem and Progenitor Cells and Normalization of KLF6 Levels in Aged Cells Leads to Their Rejuvenation

The Autocrine Secreted PDZD2 Functions As a Novel Tumor Suppressor in AML, Inducing Growth Inhibition and Cell Cycle Arrest

Age-Acquired Downregulation of Lmna Leads to Epigenetic Deregulation and Altered HSPC Function

Intronic Architecture Links DNA Methylation to Gene Expression and Helps Drive Subtype-Specific Transcriptional Landscapes in DNMT3A - and IDH1/2 -Mutant Acute Myeloid Leukemias (AML)

Development of a Fast and Reproducible Assay for the Clinical Implementation of Epigenetic Biomarkers to Predict Decitabine Response in Patients with Chronic Myelomonocytic Leukemia

Epigenetic deregulation in myeloid malignancies

Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

Analysis of the Global Methylation Profile of Accelerated and Blast Phase Myeloproliferative Neoplasms and Its Association with Response to Decitabine-Based Therapy

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Loss of KLF6 Recapitulates Molecular and Functional Changes Associated with Aging in Human Hematopoietic Stem and Progenitor Cells

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Dysregulation of RUNX3 in Aged Human HSPCs May Contribute to Perturbations in Erythropoiesis and Balanced Lineage Output

Differentiation Response to Quizartinib, a Potent 2 nd Generation FLT3 Inhibitor, in Relapsed FLT3 -Mutant AML Patients Correlates with Specific DNA Methylation Signature Prior to Therapy

Integrative Epigenetic and Single-Cell RNA-Seq Profiling of Human Hematopoietic Stem Cells Reveals Epigenetic Reprogramming of Enhancer and Regulatory Elements during Normal Aging

DNA Methylation in Cancer and Development: An Evolving Paradigm

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Hyperactive Nras and Dose Reduction of Tet2 Collaborate to Dys-Regulate Hematopoietic Stem Cells and Promote Leukemogenesis

Aldehyde Dehydrogenase Activity in the Leukemic Stem Cell Compartment Uncovers Opposing Methylation Patterns of Leukemia Stem Cells in AML

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American Society of Hematology

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ASH Publications

American Society of Hematology

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