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Michael R. Savona
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Journal Articles

Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement

Clinical Trials & Observations
Uma Borate, Kelly Pugh, Allyson Waller, Rina Li Welkie, Ying Huang, Jan Philipp Bewersdorf, Maximilian Stahl, Amy E. DeZern, Uwe Platzbecker, Mikkael A. Sekeres, Andrew H. Wei, Rena J. Buckstein, Gail J. Roboz, Michael R. Savona, Sanam Loghavi, Robert P. Hasserjian, Pierre Fenaux, David A. Sallman, Christopher S. Hourigan, Matteo Giovanni Della Porta, Stephen Nimer, Richard F. Little, Valeria Santini, Fabio Efficace, Justin Taylor, Guillermo Garcia-Manero, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami S. Komrokji, Elizabeth A. Griffiths, Peter L. Greenberg, Mina L. Xu, Zhuoer Xie, Rafael Bejar, Guillermo F. Sanz, Mrinal M. Patnaik, Maria Figueroa, Hetty E. Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval G. Daver, Jane E. Churpek, Ravindra Majeti, John M. Bennett, Alan F. List, Andrew M. Brunner, Amer M. Zeidan
Journal: Blood
Blood (2025) 145 (13): 1369–1381.
https://doi.org/10.1182/blood.2023023717
Published: 2025
Includes: Supplemental data
Journal Articles

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Alyssa C. Parker, Joseph C. Van Amburg, J. Brett Heimlich, Yash Pershad, Nicole A. Mickels, Taralynn M. Mack, P. Brent Ferrell, Michael R. Savona, Angela L. Jones, Alexander G. Bick
Journal: Blood
Blood (2025) 145 (9): 988–992.
https://doi.org/10.1182/blood.2024026555
Published: 2025
Includes: Supplemental data
Journal Articles

Risk prediction for clonal cytopenia: multicenter real-world evidence

Clinical Trials & Observations
Zhuoer Xie, Rami Komrokji, Najla Al Ali, Alexandra Regelson, Susan Geyer, Anand Patel, Caner Saygin, Amer M. Zeidan, Jan Philipp Bewersdorf, Lourdes Mendez, Ashwin Kishtagari, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, Stephen Chung, Talha Badar, James Foran, Pinkal Desai, Charlton Tsai, Elizabeth A. Griffiths, Monzr M. Al Malki, Idoroenyi Amanam, Catherine Lai, H. Joachim Deeg, Lionel Ades, Cecilia Arana Yi, Afaf E. G. Osman, Shira Dinner, Yasmin Abaza, Justin Taylor, Namrata Chandhok, Deborah Soong, Andrew M. Brunner, Hetty E. Carraway, Abhay Singh, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Eric Padron, Mrinal M. Patnaik, Luca Malcovati, Michael R. Savona, Aref Al-Kali
Journal: Blood
Blood (2024) 144 (19): 2033–2044.
https://doi.org/10.1182/blood.2024024756
Published: 2024
Includes: Supplemental data
Journal Articles

Elevated Clonal Hematopoiesis in Environmentally Exposed Responders Has Distinct Age-Related Patterns and Relies on IL1RAP for Clonal Expansion

Divij Verma, Rachel Zeig Owens, David G Goldfarb, Kith Pradhan, Srabani Sahu, Susheian Kelly, Orsi Giricz, Sakshi Jasra, Yiyu Zou, Colette Prophete, Lidiane Torres, Srinivas Aluri, Samarpana Chakraborty, Shanisha Gordon Mitchell, Rajni Kumari, Jingli Wang, Alexander J Silver, Charles Hall, Ryan Bender, Ola Landgren, Lee Greenberger, Advaitha Madireddy, Aditi Shastri, Lindsay Lafave, Anna Nolan, Michael R. Savona, Ulrich Steidl, David Prezant, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 943.
https://doi.org/10.1182/blood-2024-194127
Published: 2024
Journal Articles

Chive-Impact: Establishing the Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE) Registry and Biorepository in Underserved Areas

Ashwin Kishtagari, Zachary Copeland, Tracy Stewart, Julie Ryder, Carol Ragon, KiOsha Carlyle, Kerri Harrison, Clayton Allen, Ryan Yates, Andrew Benefield, Nina Logan, Brion Randolph, Salil Goorha, Lammers Philip, Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2024) 144 (Supplement 1): 2322.
https://doi.org/10.1182/blood-2024-206418
Published: 2024
Journal Articles

Impact of Co-Mutations, Monocytic Differentiation, and Choice of Hypomethylating Agent Combined with Venetoclax on the Predictive Value of Molecular Prognostic Risk Signature in Newly Diagnosed AML Patients

Kateryna Fedorov, Somedeb Ball, James E Denney, Alexis R Froenlich, Ashwin Kishtagari, Sanjay Mohan, Michael R. Savona, Emily F. Mason
Journal: Blood
Blood (2024) 144 (Supplement 1): 1474.
https://doi.org/10.1182/blood-2024-194259
Published: 2024
Journal Articles

Effect of Prior Treatments on the Clinical Activity of Imetelstat in Transfusion-Dependent Patients with Erythropoiesis-Stimulating Agent, Relapsed or Refractory/Ineligible Lower-Risk Myelodysplastic Syndromes

Uwe Platzbecker, Valeria Santini, Amer M. Zeidan, Mikkael A. Sekeres, Pierre Fenaux, Azra Raza, Moshe Mittelman, Sylvain Thépot, Rena Buckstein, Ulrich Germing, Yazan F Madanat, Maria Diez-Campelo, David Valcarcel, Anna Jonasova, Souria Dougherty, Sheetal Shah, Qi Xia, Libo Sun, Shyamala Navada, Michael R. Savona, Rami S. Komrokji
Journal: Blood
Blood (2024) 144 (Supplement 1): 352.
https://doi.org/10.1182/blood-2024-203612
Published: 2024
Journal Articles

Myelodysplastic Syndromes with Concomitant SF3B1 Mutation and Deletion of the Long Arm of Chromosome 5 ( SF3B1 del5q ): Outcomes and Response to Treatment

Rami S. Komrokji, Zaker I. Schwabkey, Najla H. Al Ali, Luis E. Aguirre, Maximilian Stahl, Somedeb Ball, Emily F. Mason, Michael R. Savona, Valeria Santini, Angela Consagra, Uwe Platzbecker, Anne Sophie Kubasch, Yazan F Madanat, Pierre Fenaux, Lin-Pierre Zhao, Mikkael A. Sekeres, Namrata S. Chandhok, Matteo Giovanni Della Porta, Luca Lanino, Amy E. DeZern, David Sallman, Zhuoer Xie, Eric Padron, Koji Sasaki, Kensuke Takaoka, Akhil Jain, Mónica Del Rey, Maria Diez-Campelo, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 1845.
https://doi.org/10.1182/blood-2024-207474
Published: 2024
Journal Articles

Initial Results from the QTc Substudy of the IMerge Phase 3 Trial Demonstrate Clinically Meaningful Efficacy, Manageable Safety, and Absence of Proarrhythmic Risk in Patients with Lower-Risk Myelodysplastic Syndromes Who Received Prior Therapies Beyond Erythropoiesis Stimulating Agents

Rami S. Komrokji, Valeria Santini, Uwe Platzbecker, Koen Van Eygen, Maria Diez-Campelo, Raquel De Paz, Guillermo Sanz, Sylvain Thépot, Maciej Kaźmierczak, Esther Natalie Oliva, Mikkael A. Sekeres, Pierre Fenaux, Yazan F. Madanat, Michael R. Savona, Jennifer Riggs, Souria Dougherty, Ashley Lennox, Qi Xia, Libo Sun, Tymara Berry, Amer M. Zeidan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4590.
https://doi.org/10.1182/blood-2024-200885
Published: 2024
Journal Articles

Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Stacey M. Frumm, Shougat Barua, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan F Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 664.
https://doi.org/10.1182/blood-2024-208034
Published: 2024
Journal Articles

Results from a Phase 1 Open-Label Dose Escalation and Expansion Trial of Oral Azacitidine + Cedazuridine (ASTX030) in Patients with Myelodysplastic Syndromes (MDS) and MDS/Myeloproliferative Neoplasms (MPN)

Guillermo Garcia-Manero, James McCloskey, Bart L. Scott, Elizabeth A. Griffiths, Bonnie Kiner-Strachan, Andrew M. Brunner, Amer M. Zeidan, Elie Traer, Yazan F. Madanat, Janelle Meyer, Harry Erba, Praneeth Baratam, Uma Borate, Yuri Sano, Aram Oganesian, Lixia Zhu, Harold N. Keer, Michael R. Savona
Journal: Blood
Blood (2024) 144 (Supplement 1): 662.
https://doi.org/10.1182/blood-2024-203569
Published: 2024
Journal Articles

Oral Decitabine/Cedazuridine in Patients with MDS and TP53 Mutations: A Propensity Score Matching Analysis from the Phase II and III Trials

Samuel Urrutia, Koji Sasaki, Alex Bataller, Hagop M. Kantarjian, Guillermo Montalban-Bravo, James McCloskey, Elizabeth A. Griffiths, Karen Yee, Amer M. Zeidan, Michael R. Savona, Aram Oganesian, Yuri Sano, Harold N. Keer, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 661.
https://doi.org/10.1182/blood-2024-193274
Published: 2024
Journal Articles

Clinical Outcomes and Variability Based on Baseline Cytogenetic Risk of Patients with MDS Treated with Hypomethylating Agents: An Analysis from the International Consortium for MDS (icMDS) Validate Database

Ted M. Getz, Tariq Kewan, Jan Philipp Bewersdorf, Jessica M. Stempel, Luca Lanino, Wei Wei, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Somedeb Ball, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vasiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Maximilian Stahl, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3219.
https://doi.org/10.1182/blood-2024-202075
Published: 2024
Journal Articles

Correlation of Patient-Reported Outcomes with Red Blood Cell Transfusion Reduction and Rise in Hemoglobin in Patients with Lower-Risk Myelodysplastic Syndromes in the IMerge Trial

Mikkael A. Sekeres, Valeria Santini, Amer M. Zeidan, Uwe Platzbecker, Rami S. Komrokji, Maria Diez-Campelo, Pierre Fenaux, Michael R. Savona, Yazan F. Madanat, David Valcarcel, Antoine Regnault, Kristin Creel, Nishan Sengupta, Souria Dougherty, Sheetal Shah, Libo Sun, Ying Wan, Shyamala Navada, Esther Natalie Oliva
Journal: Blood
Blood (2024) 144 (Supplement 1): 3210.
https://doi.org/10.1182/blood-2024-199636
Published: 2024
Journal Articles

Synchronous Dual Hematologic Neoplasms of Myeloid and Lymphoid Lineage Are of Common Clonal Origin

Somedeb Ball, Surendra Neupane, Hannah Newman, Joshua A Traina, Najla H. Al Ali, Abhishek Dhawan, Praneeth R Sudalagunta, Ariosto Siqueira Silva, Danny DeAvila, Mohammad Omar Hussaini, Jinming Song, Zhuoer Xie, Onyee Chan, Alison R. Walker, Christopher Ryder, Andrew T. Kuykendall, Jeffrey E Lancet, Lubomir Sokol, P. Brent Ferrell, Ling Zhang, Michael R. Savona, David Sallman, Javier Pinilla-Ibarz, Rami S. Komrokji, Kenneth H. Shain, Eric Padron
Journal: Blood
Blood (2024) 144 (Supplement 1): 4578.
https://doi.org/10.1182/blood-2024-210599
Published: 2024
Journal Articles

Application of a Phenotype-Based Predictive Analytic in a Phase Ib Study of Selinexor and Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Somedeb Ball, Michael T. Byrne, Melissa A Fischer, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Lokesh Patil, Christine J. Gu, Chris Leonardi, Katherine J. Walsh, Gregory Dan Ayers, Ashwin Kishtagari, Kateryna Fedorov, Markus D. Lacher, Joseph Wagner, Sanjay R Mohan, Michael R. Savona
Journal: Blood
Blood (2024) 144 (Supplement 1): 6012.
https://doi.org/10.1182/blood-2024-209403
Published: 2024
Journal Articles

Prediction of Volasertib Sensitivity in Acute Myeloid Leukemia Relapsed or Refractory to Venetoclax Plus Azacitidine

Lokesh Patil, Christine J. Gu, Cristina Tognon, Nicola Long, Kara Johnson, Melissa A Fischer, Somedeb Ball, Michael R. Savona, Chris Leonardi, Joseph Wagner, Glenn Michelson, Markus D. Lacher
Journal: Blood
Blood (2024) 144 (Supplement 1): 5818.
https://doi.org/10.1182/blood-2024-206299
Published: 2024
Journal Articles

Molecular taxonomy of myelodysplastic syndromes and its clinical implications

Clinical Trials & Observations
Elsa Bernard, Robert P. Hasserjian, Peter L. Greenberg, Juan E. Arango Ossa, Maria Creignou, Heinz Tuechler, Jesus Gutierrez-Abril, Dylan Domenico, Juan S. Medina-Martinez, Max Levine, Konstantinos Liosis, Noushin Farnoud, Maria Sirenko, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Yasuhito Nannya, Olivier Kosmider, Matilde Y. Follo, Felicitas Thol, Lurdes Zamora, Ronald F. Pinheiro, Andrea Pellagatti, Harold K. Elias, Detlef Haase, Christina Ganster, Lionel Ades, Magnus Tobiasson, Laura Palomo, Matteo Giovanni Della Porta, Pierre Fenaux, Monika Belickova, Michael R. Savona, Virginia M. Klimek, Fabio P. S. Santos, Jacqueline Boultwood, Ioannis Kotsianidis, Valeria Santini, Francesc Solé, Uwe Platzbecker, Michael Heuser, Peter Valent, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H. Jansen, José Cervera, Norbert Gattermann, Benjamin L. Ebert, Rafael Bejar, Luca Malcovati, Seishi Ogawa, Mario Cazzola, Eva Hellström-Lindberg, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (15): 1617–1632.
https://doi.org/10.1182/blood.2023023727
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular and clinical presentation of UBA1 -mutated myelodysplastic syndromes

Brief Report
Maria Sirenko, Elsa Bernard, Maria Creignou, Dylan Domenico, Andrea Farina, Juan E. Arango Ossa, Olivier Kosmider, Robert Hasserjian, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Carmelo Gurnari, Matilde Yung Follo, Felicitas Thol, Lurdes Zamora, Ronald Feitosa Pinheiro, Andrea Pellagatti, Harold K. Elias, Detlef Haase, Birgitta Sander, Elisa Orna, Katharina Zoldan, Lea Naomi Eder, Wolfgang R. Sperr, Renate Thalhammer, Christina Ganster, Lionel Adès, Magnus Tobiasson, Laura Palomo, Matteo Giovanni Della Porta, Kety Huberman, Pierre Fenaux, Monika Belickova, Michael R. Savona, Virginia M. Klimek, Fabio P. S. Santos, Jacqueline Boultwood, Ioannis Kotsianidis, Valeria Santini, Francesc Solé, Uwe Platzbecker, Michael Heuser, Peter Valent, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Seishi Ogawa, Michaela Fontenay, Joop H. Jansen, Jose Cervera, Benjamin L. Ebert, Rafael Bejar, Peter L. Greenberg, Norbert Gattermann, Luca Malcovati, Mario Cazzola, David B. Beck, Eva Hellström-Lindberg, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (11): 1221–1229.
https://doi.org/10.1182/blood.2023023723
Published: 2024
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE), a Prospective, Longitudinal Clonal Hematopoiesis Cohort and Biorepository

Jonathan Heimlich, Morgan Shannon, Sydney Olson, Alexander J Silver, Ariana Debevec, Zachary Copeland, Caitlyn Vlasschaert, Christina Snider, Ashwin Kishtagari, Donovan J Brown, Travis Spaulding, Manasa R Bhatta, Kelly Pugh, Shannon S Stockton, Jessica Ulloa, Yaomin Xu, Muhamed Baljevic, Sanjay Mohan, Javid J. Moslehi, Eiman Jahangir, Brent Ferrell, Jr., David Slosky, Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 5594.
https://doi.org/10.1182/blood-2023-189808
Published: 2023