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Journal Articles

Efficacy and Safety of Cyclosporine Monotherapy for Patients with Non-Severe Aplastic Anemia Not Requiring Transfusions: Results from a Prospective Multicenter Phase II Study

Naoko Hosono, Ken Ishiyama, Hiroki Yamaguchi, Masahide Yamazaki, Hiroyuki Maruyama, Kensuke Usuki, Kazuki Tanimoto, Hiroyuki Sugiura, Noboru Asada, Seishi Ogawa, Yuzuru Kanakura, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2024-198830
Published: 2024
Journal Articles

A Dedicated System Accounting for Specific Germline/Somatic Genomic Constellations Is Essential to Predict Outcomes in DDX41 -Mutant Myeloid Neoplasia

Carmelo Gurnari, Hideki Makishima, Arda Durmaz, Enrico Attardi, Ryunosuke Saiki, Alex Bataller, Guilherme Mendes Sapinho, Lukasz P. Gondek, Yasuhito Nannya, Steve Best, Pramila Krishnamurthy, Kar Lok Kong, Yoshiko Atsuta, Senji Kasahara, Kazuma Ohyashiki, Yasushi Miyazaki, Nobuhiro Kanemura, Nobuhiro Hiramoto, Hussein Awada, Valeria Visconte, Courtney D. DiNardo, Maria Teresa Voso, Amy E. DeZern, Guillermo Garcia-Manero, Austin G. Kulasekararaj, Jaroslaw Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1332.
https://doi.org/10.1182/blood-2024-194024
Published: 2024
Journal Articles

Efficacy and Safety of Eltrombopag Added to Rabbit Anti-Human Thymocyte Globulin+Cyclosporine in Aplastic Anemia: Results from a Prospective Multicenter Phase II Study

Ken Ishiyama, Ritsuro Suzuki, Kinuko Mitani, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Fumiaki Kiyomi, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 2689.
https://doi.org/10.1182/blood-2024-193818
Published: 2024
Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Rio Takahashi, Yoshitaka Zaimoku, Kohei Hosokawa, Seishi Ogawa, Yoshiyuki Takahashi, Takako Miyamura, Yasushi Onishi, Takashi Koike, Tetsuya Nishida, Naoyuki Uchida, Noriko Doki, Masatsugu Tanaka, Tetsuya Eto, Mitsuhiro Itagaki, Masashi Sawa, Yuta Hasegawa, Takahiro Fukuda, Makoto Onizuka, Yoshiko Atsuta, Shinji Nakao, Takamasa Katagiri
Journal: Blood
Blood (2024) 144 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2024-197892
Published: 2024
Journal Articles

Whole-Genome Analysis Revealed the Genetic Landscape of Intravascular Large B-Cell Lymphoma

Takuto Mori, Kazuyuki Shimada, Kaito Mimura, Nobuyuki Kakiuchi, Hirona Maeda, Akifumi Takaori-Kondo, Seishi Ogawa, Akihiro Tomita, Kenichi Yoshida
Journal: Blood
Blood (2024) 144 (Supplement 1): 2983.
https://doi.org/10.1182/blood-2024-204466
Published: 2024
Journal Articles

Clinical Outcomes and Variability Based on Baseline Cytogenetic Risk of Patients with MDS Treated with Hypomethylating Agents: An Analysis from the International Consortium for MDS (icMDS) Validate Database

Ted M. Getz, Tariq Kewan, Jan Philipp Bewersdorf, Jessica M. Stempel, Luca Lanino, Wei Wei, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Somedeb Ball, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vasiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Maximilian Stahl, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3219.
https://doi.org/10.1182/blood-2024-202075
Published: 2024
Journal Articles

Molecular Taxonomy Classification for Transplant Decision Making of Myelodysplastic Syndromes

Rurika Okuda, Yotaro Ochi, Tetsuichi Yoshizato, Yasuhito Nannya, Yoshiko Atsuta, Yuichi Shiraishi, Yusuke Shiozawa, Hiroko Tanaka, Makoto Onizuka, Kenichi Chiba, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Keizo Horibe, Satoru Miyano, Hideki Makishima, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3203.
https://doi.org/10.1182/blood-2024-206498
Published: 2024
Journal Articles

Impacts of Monoallelic and Biallelic DDX41 Mutations on Hematopoiesis and the Development of Myeloid Malignancies

Ayana Kon, Masahiro M Nakagawa, Azumi Tomita, Keisuke Kataoka, Nobuyuki Kakiuchi, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2024-209922
Published: 2024
Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single-Cell Multi-Omics Sequencing

Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Ayana Kon, Masanori Motomura, Yotaro Ochi, Lanying Zhao, Koji Okazaki, June Takeda, Xingxing Qi, Akinori Yoda, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 5630.
https://doi.org/10.1182/blood-2024-210050
Published: 2024
Journal Articles

Deciphering the Heterogeneity of Acute Myeloid Leukemia through Chromatin Accessibility Profiling

Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzén, Petar Antunovic, Stefan Deneberg, Martin Jadersten, Vladimir Lazarevic, Bertil Uggla, Lovisa Wennström, Emma Olander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Masanori Motomura, Masahiro M Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Akinori Yoda, Rurika Okuda, Guoxiang Xie, Albin Osterroos, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Hiroshi I Suzuki, Akifumi Takaori-Kondo, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 639.
https://doi.org/10.1182/blood-2024-200415
Published: 2024
Journal Articles

High-Throughput and Highly Sensitive Single Cell Genotyping with Simultaneous Chromatin Accessibility Measurement in Myeloid Precursor Conditions

Masanori Motomura, Yotaro Ochi, Masahiro M Nakagawa, Yasuhito Nannya, Nobuyuki Kakiuchi, Yutaka Kuroda, Nobuo Sezaki, Tomoe Nakagawa, Lanying Zhao, Satoru Miyano, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 5635.
https://doi.org/10.1182/blood-2024-206815
Published: 2024
Journal Articles

Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Stacey M. Frumm, Shougat Barua, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan F Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 664.
https://doi.org/10.1182/blood-2024-208034
Published: 2024
Journal Articles

Molecular taxonomy of myelodysplastic syndromes and its clinical implications

Clinical Trials & Observations
Elsa Bernard, Robert P. Hasserjian, Peter L. Greenberg, Juan E. Arango Ossa, Maria Creignou, Heinz Tuechler, Jesus Gutierrez-Abril, Dylan Domenico, Juan S. Medina-Martinez, Max Levine, Konstantinos Liosis, Noushin Farnoud, Maria Sirenko, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Yasuhito Nannya, Olivier Kosmider, Matilde Y. Follo, Felicitas Thol, Lurdes Zamora, Ronald F. Pinheiro, Andrea Pellagatti, Harold K. Elias, Detlef Haase, Christina Ganster, Lionel Ades, Magnus Tobiasson, Laura Palomo, Matteo Giovanni Della Porta, Pierre Fenaux, Monika Belickova, Michael R. Savona, Virginia M. Klimek, Fabio P. S. Santos, Jacqueline Boultwood, Ioannis Kotsianidis, Valeria Santini, Francesc Solé, Uwe Platzbecker, Michael Heuser, Peter Valent, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H. Jansen, José Cervera, Norbert Gattermann, Benjamin L. Ebert, Rafael Bejar, Luca Malcovati, Seishi Ogawa, Mario Cazzola, Eva Hellström-Lindberg, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (15): 1617–1632.
https://doi.org/10.1182/blood.2023023727
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular and clinical presentation of UBA1 -mutated myelodysplastic syndromes

Brief Report
Maria Sirenko, Elsa Bernard, Maria Creignou, Dylan Domenico, Andrea Farina, Juan E. Arango Ossa, Olivier Kosmider, Robert Hasserjian, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Carmelo Gurnari, Matilde Yung Follo, Felicitas Thol, Lurdes Zamora, Ronald Feitosa Pinheiro, Andrea Pellagatti, Harold K. Elias, Detlef Haase, Birgitta Sander, Elisa Orna, Katharina Zoldan, Lea Naomi Eder, Wolfgang R. Sperr, Renate Thalhammer, Christina Ganster, Lionel Adès, Magnus Tobiasson, Laura Palomo, Matteo Giovanni Della Porta, Kety Huberman, Pierre Fenaux, Monika Belickova, Michael R. Savona, Virginia M. Klimek, Fabio P. S. Santos, Jacqueline Boultwood, Ioannis Kotsianidis, Valeria Santini, Francesc Solé, Uwe Platzbecker, Michael Heuser, Peter Valent, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Seishi Ogawa, Michaela Fontenay, Joop H. Jansen, Jose Cervera, Benjamin L. Ebert, Rafael Bejar, Peter L. Greenberg, Norbert Gattermann, Luca Malcovati, Mario Cazzola, David B. Beck, Eva Hellström-Lindberg, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (11): 1221–1229.
https://doi.org/10.1182/blood.2023023723
Published: 2024
Includes: Supplemental data
Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Clinical Trials & Observations
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Journal: Blood
Blood (2024) 143 (25): 2627–2643.
https://doi.org/10.1182/blood.2023022247
Published: 2024
Includes: Supplemental data
Journal Articles

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia

Kazunari Aoki, Mizuki Hyuga, Yusuke Tarumoto, Gohei Nishibuchi, Atsushi Ueda, Yotaro Ochi, Seiichi Sugino, Takashi Mikami, Hirokazu Kobushi, Itaru Kato, Koshi Akahane, Takeshi Inukai, Akifumi Takaori-Kondo, Junko Takita, Seishi Ogawa, Kosuke Yusa
Journal: Blood
Blood (2024) 143 (7): 604–618.
https://doi.org/10.1182/blood.2023020857
Published: 2024
Includes: Supplemental data
Journal Articles

Epigenetic Classification of Acute Myeloid Leukemia Revealed By Genome-Wide Chromatin Profiling

Yotaro Ochi, Yasuhito Nannya, Markus Liew-Littorin, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Albin Osterroos, Masanori Motomura, Masahiro Marshall Nakagawa, Ryunosuke Saiki, Akinori Yoda, Rurika Okuda, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Akifumi Takaori-Kondo, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 836.
https://doi.org/10.1182/blood-2023-180336
Published: 2023
Journal Articles

The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53 -Mutated AML

Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Takahiro Maeda, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2741.
https://doi.org/10.1182/blood-2023-188986
Published: 2023
Journal Articles

Genetic Profile of Myeloid Neoplasms Developed with Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome

Mayu Morishita, Miharu Yabe, Nobuyuki Kakiuchi, Minoru Takata, Kotoe Katayama, Seiya Imoto, Seishi Ogawa, Hiromasa Yabe, Kenichi Yoshida
Journal: Blood
Blood (2023) 142 (Supplement 1): 2738.
https://doi.org/10.1182/blood-2023-184552
Published: 2023
Journal Articles

Insights from Trajectories of PIGA -Mutated Clones in Paroxysmal Nocturnal Hemoglobinuria

Hiroyuki Takamori, Yasutaka Ueda, Yoshikazu Matsuoka, Tatsuya Fujioka, Hideki Makishima, Yoshiko Murakami, Taroh Kinoshita, Satoru Miyano, Yuzuru Kanakura, Jun-Ichi Nishimura, Naoki Hosen, Seishi Ogawa, Yasuhito Nannya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2724.
https://doi.org/10.1182/blood-2023-188992
Published: 2023