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Journal Articles

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

Kaito Mimura, Norio Shiba, Ai Okada, Kenichi Chiba, Kentaro Watanabe, Takao Deguchi, Kentaro Ohki, Kotoe Katayama, Seiya Imoto, Akiko M Saito, Yasuhiro Okamoto, Souichi Adachi, Daisuke Tomizawa, Takashi Taga, Yuichi Shiraishi, Hiroshi Moritake, Motohiro Kato, Kenichi Yoshida

Blood (2024) 144 (Supplement 1): 5720.

https://doi.org/10.1182/blood-2024-200476

Published: 2024

Journal Articles

Prognostic Factors for T-Cell Acute Lymphoblastic Leukemia in Children and Young Adults: ALL-T11 Study Conducted By Japan Children's Cancer Group and Japan Adult Leukemia Study Group

Blood (2024) 144 (Supplement 1): 1426.

https://doi.org/10.1182/blood-2024-199500

Published: 2024

Journal Articles

Clinical Utility of Rapid and Comprehensive Genome Profiling Method Using Nanopore Sequencer for Pediatric Leukemia

Shota Kato, Aiko Sato-Otsubo, Wataru Nakamura, Masahiro Sugawa, Ai Okada, Kenichi Chiba, Nao Takasugi, Tomoya Irikura, Moe Hidaka, Masahiro Sekiguchi, Kentaro Watanabe, Yuichi Shiraishi, Motohiro Kato

Blood (2024) 144 (Supplement 1): 2236.

https://doi.org/10.1182/blood-2024-194040

Published: 2024

Journal Articles

Low-Frequency Mosaicism of the BRAF Mutation As the Origin of Langerhans Cell Histiocytosis

Nao Takasugi, Ryota Shirai, Tomoo Osumi, Kenichi Sakamoto, Ko Kudo, Mariko Tanaka, Toru Uchiyama, Daisuke Tomizawa, Tetsuo Ushiku, Takako Yoshioka, Yoko Shioda, Motohiro Kato

Blood (2024) 144 (Supplement 1): 3907.

https://doi.org/10.1182/blood-2024-202354

Published: 2024

Journal Articles

A Nationwide Clinical Trial ALL-B12: An Optimized Therapy for Pediatric B-Precursor Acute Lymphoblastic Leukemia with Excellent Overall Survival and Minimal Non-Relapse Mortality: A Report from the Japan Children's Cancer Group

Blood (2023) 142 (Supplement 1): 519.

https://doi.org/10.1182/blood-2023-182464

Published: 2023

Journal Articles

Integrated Analysis of KIT Exon 17 Mutations and Flow-MRD Refines Risk Stratification in Pediatric Acute Myeloid Leukemia with RUNX1 :: RUNX1T1

Shin-Ichi Tsujimoto, Shota Kato, Shotaro Iwamoto, Hidefumi Hiramatsu, Yusuke Okuno, Tatsuya Kamitori, Kentaro Ohki, Takao Deguchi, Nobutaka Kiyokawa, Motohiro Kato, Junko Takita, Souichi Adachi, Daisuke Tomizawa, Norio Shiba

Blood (2023) 142 (Supplement 1): 1599.

https://doi.org/10.1182/blood-2023-181358

Published: 2023

Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan

Blood (2023) 142 (Supplement 1): 845.

https://doi.org/10.1182/blood-2023-178688

Published: 2023

Journal Articles

Outcomes of Hematopoietic Cell Transplantation for Patients with Refractory Cytopenia with Multilineage Dysplasia: A Comparison Children with Adolescents and Young Adults

Blood (2023) 142 (Supplement 1): 2202.

https://doi.org/10.1182/blood-2023-189000

Published: 2023

Journal Articles

Impact of Nelarabine, Intensive L-Asparaginase, and Protracted Intrathecal Therapy on Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group and the Japan Adult Leukemia Study Group

Blood (2021) 138 (Supplement 1): 3393.

https://doi.org/10.1182/blood-2021-149110

Published: 2021

Journal Articles

Outcomes of Haploidentical Salvage Transplantation Using Post-Transplant Cyclophosphamide for Graft Failure Following Allogeneic Hematopoietic Stem Cell Transplantation

Kaito Harada, Shigeo Fuji, Yuho Najima, Motohiro Kato, Akihito Shinohara, Masako Toyosaki, Hirohisa Nakamae, Daisuke Hasegawa, Hiroatsu Iida, Makoto Onizuka, Yoshiko Hashii, Tatsuo Ichinohe, Yoshiko Atsuta, Hideki Nakasone

Blood (2021) 138 (Supplement 1): 2871.

https://doi.org/10.1182/blood-2021-149549

Published: 2021

Journal Articles

Chemotherapy with the Use of TKIs Based on MRD Has the Potential to Avoid Hematopoietic Stem Cell Transplantation in Treatment for Children with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL). Results of the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study ALL-Ph13

Atsushi Sato, Hirohide Kawasaki, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Sachiko Yonezawa, Chiyo K Imamura, Haruko Shima, Hirotoshi Sakaguchi, Yuichi Kodama, Keisuke Kato, Motohiro Kato, Hidefumi Hiramatsu, Nobutaka Kiyokawa, Akiko Kada, Akiko M Saito, Keizo Horibe, Atsushi Manabe, Hiroyuki Shimada

Blood (2021) 138 (Supplement 1): 3394.

https://doi.org/10.1182/blood-2021-148264

Published: 2021

Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Blood (2019) 134 (Supplement_1): 2751.

https://doi.org/10.1182/blood-2019-125713

Published: 2019

Journal Articles

A Retrospective Study on Inotuzumab Ozogamicin in Infants and Young Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Erica Brivio, MD, Raoull Hoogendijk, MSc, Christophe Chantrain, MD PhD, Fanny Rialland, MD, Audrey Contet, Sarah Elitzur, MD, Luciano Dalla-Pozza, MBBS FRACP, Krisztian Kallay, MD, Chi Kong Li, MBBS,MD, Motohiro Kato, MD PhD, Inna V Markova, Dr., Kjeld Schmiegelow, Professor MD DMSc., Nicole Bodmer, Rob Pieters, MDPhDMSc, Christian Michel Zwaan, MD PhD

Blood (2019) 134 (Supplement_1): 3890.

https://doi.org/10.1182/blood-2019-126472

Published: 2019

Journal Articles

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Yoichi Tanaka, PhD, Motohiro Kato, MD PhD, Takaya Moriyama, MD PhD, Yuki Arakawa, MD, Daisuke Hasegawa, MD PhD, Junya Fujimura, MD PhD, Dai Keino, MD PhD, Atsushi Sato, MD, Takahiro Ueda, MD PhD, Yuichi Taneyama, MD, Masatoshi Takagi, MD PhD, Masaki Yamamoto, MD, Masaki Matsuoka, MD, Moeko Hino, MD, Hiroki Hori, MD PhD, Katsuyoshi Koh, MD, Allen Eng Juh Yeoh, MD, Jun J. Yang, PhD, Atsushi Manabe, MD PhD

Blood (2018) 132 (Supplement 1): 4032.

https://doi.org/10.1182/blood-2018-99-114290

Published: 2018

Journal Articles

Hematopoietic Stem Cell Transplantation in Children with Refractory Acute Lymphoblastic Leukemia

Yasuhiro Okamoto, MD, Yozo Nakazawa, MD, PhD, Masami Inoue, MD, Kenichiro Watanabe, MD PhD, Hiroaki Goto, MD, Nao Yoshida, MD PhD, Maiko Noguchi, MD, Atsushi Kikuta, MD, Koji Kato, MD PhD, Yoshiko Hashii, MD PhD, Yoshiko Atsuta, MD PhD, Motohiro Kato, MD PhD

Blood (2018) 132 (Supplement 1): 2173.

https://doi.org/10.1182/blood-2018-99-111301

Published: 2018

Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Blood (2018) 132 (Supplement 1): 4089.

https://doi.org/10.1182/blood-2018-99-111092

Published: 2018

Journal Articles

Preclinical evaluation of NUDT15 -guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Blood (2018) 131 (22): 2466–2474.

https://doi.org/10.1182/blood-2017-11-815506

Published: 2018

Includes: Supplemental data

Journal Articles

Clinical Significance of Natural Killer Cell-Mediated Alloreactivity in Unrelated Cord Blood Transplantation for Children with Acute Leukemia: A Japanese National Registry Study

Hirotoshi Sakaguchi, MD PhD, Nobuyoshi Arima, MD PhD, Atsushi Narita, MD PhD, Sae Ishimaru, MD, Daisuke Tomizawa, MD PhD, Daiichiro Hasegawa, MD PhD, Motohiro Kato, MD, Hiroyuki Ishida, MD PhD, Junya Kanda, MD, Masami Inoue, MD PhD, Nao Yoshida, MD PhD, Katsuyoshi Koh, MD, Jiro Inagaki, MD PhD, Atsushi Ogawa, MD PhD, Tsukasa Hori, MD PhD, Yoshiko Hashii, MD, PhD, Koji Kato, MD, PhD, Yoshiko Atsuta, MD PhD

Blood (2017) 130 (Supplement 1): 3315.

https://doi.org/10.1182/blood.V130.Suppl_1.3315.3315

Published: 2017

Journal Articles

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Koichi Oshima, MD PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Maria Luisa Sulis, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Maddalena Paganin, PhD, Giuseppe Basso, MD, Julie M. Gastier-Foster, PhD, Mignon L. Loh, MD, Renate Kirschner-Schwabe, PhD, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 2602.

https://doi.org/10.1182/blood.V130.Suppl_1.2602.2602

Published: 2017

Journal Articles

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

Takaya Moriyama, MDPhD, Rina Nishii, Laura Janke, DVM, PhD, Lie Li, Chen Ru, Scott A Brown, PhD, Ting-Nien Lin, Chase Suiter, Kentaro Kihira, MD, Hidemi Toyoda, MD PhD, Motohiro Kato, MD PhD, Atushi Manabe, MD PhD, Katsuyoshi Koh, MD, Masatoshi Takagi, MD PhD, Hiroki Hori, MD PhD, Jun J. Yang, PhD

Blood (2017) 130 (Supplement 1): 3879.

https://doi.org/10.1182/blood.V130.Suppl_1.3879.3879

Published: 2017

NARROW

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

Prognostic Factors for T-Cell Acute Lymphoblastic Leukemia in Children and Young Adults: ALL-T11 Study Conducted By Japan Children's Cancer Group and Japan Adult Leukemia Study Group

Clinical Utility of Rapid and Comprehensive Genome Profiling Method Using Nanopore Sequencer for Pediatric Leukemia

Low-Frequency Mosaicism of the BRAF Mutation As the Origin of Langerhans Cell Histiocytosis

A Nationwide Clinical Trial ALL-B12: An Optimized Therapy for Pediatric B-Precursor Acute Lymphoblastic Leukemia with Excellent Overall Survival and Minimal Non-Relapse Mortality: A Report from the Japan Children's Cancer Group

Integrated Analysis of KIT Exon 17 Mutations and Flow-MRD Refines Risk Stratification in Pediatric Acute Myeloid Leukemia with RUNX1 :: RUNX1T1

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Outcomes of Hematopoietic Cell Transplantation for Patients with Refractory Cytopenia with Multilineage Dysplasia: A Comparison Children with Adolescents and Young Adults

Impact of Nelarabine, Intensive L-Asparaginase, and Protracted Intrathecal Therapy on Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group and the Japan Adult Leukemia Study Group

Outcomes of Haploidentical Salvage Transplantation Using Post-Transplant Cyclophosphamide for Graft Failure Following Allogeneic Hematopoietic Stem Cell Transplantation

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

A Retrospective Study on Inotuzumab Ozogamicin in Infants and Young Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Hematopoietic Stem Cell Transplantation in Children with Refractory Acute Lymphoblastic Leukemia

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Preclinical evaluation of NUDT15 -guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Clinical Significance of Natural Killer Cell-Mediated Alloreactivity in Unrelated Cord Blood Transplantation for Children with Acute Leukemia: A Japanese National Registry Study

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

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