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Hiroyoshi Kunimoto
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Journal Articles

Cbl Q367P Cooperates with Loss of Tet2 to Drive a Cnl-like Disease Via the NF-Kb Pathway

Takuma Ohashi, Hiroyoshi Kunimoto, Akiko Adachi, Ayaka Miura, Takayuki Sakuma, Junji Ikeda, Yoko Ino, Jotaro Harada, Yuko Shimosato, Keita Yamamoto, Yayoi Kimura, Susumu Goyama, Satoshi Fujii, Tomohiko Tamura, Hiroaki Honda, Sheng F. Cai, Hideaki Nakajima
Journal: Blood
Blood (2024) 144 (Supplement 1): 4515.
https://doi.org/10.1182/blood-2024-206175
Published: 2024
Journal Articles

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Takayuki Kurosawa, Masanobu Takeuchi, Ayaka Miura, Koichi Murakami, Ikuma Kato, Takako Hishiki, Noriyo Hayakawa, Tomomi Matsuura, Megumi Funakoshi-Tago, Akihiko Yokoyama, Kenichi Yoshida, Daisuke Tomizawa, Satoru Miyano, Akio Tawa, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi, Norio Shiba, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2740.
https://doi.org/10.1182/blood-2023-181740
Published: 2023
Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2803.
https://doi.org/10.1182/blood-2023-178436
Published: 2023
Journal Articles

Aberrant EVI1 splicing contributes to EVI1 -rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Journal: Blood
Blood (2022) 140 (8): 875–888.
https://doi.org/10.1182/blood.2021015325
Published: 2022
Includes: Supplemental data
Journal Articles

Regulation of Mitophagy By O -Linked N -Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance

Koichi Murakami, MD, Daisuke Kurotaki, PhD, Wataru Kawase, Graduate student, Shunsuke Soma, MD, Yumi Fukuchi, PhD, Hiroyoshi Kunimoto, MD PhD, Ryusuke Yoshimi, MD PhD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Takako Hishiki, PhD, Noriyo Hayakawa, PhD, Tomomi Matsuura, PhD, Minoru Ko, MD PhD, Mayumi Oda, PhD, Kiichi Yanagisawa, Student, Hiroshi Kobayashi, MD PhD, Yoshitoshi Atobe, PhD, Kengo Funakoshi, MD PhD, Atsushi Iwama, MD PhD, Keiyo Takubo, MD PhD, Shinichiro Okamoto, MD PhD, Tomohiko Tamura, MD PhD, Hideaki Nakajima, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 171.
https://doi.org/10.1182/blood-2018-171
Published: 2018
Journal Articles

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Franck Rapaport, Benjamin Durham, Francine E. Garrett-Bakelman, Elodie Pronier, Alan H. Shih, Ari Melnick, Jayanta Chaudhuri, Ross L. Levine
Journal: Blood
Blood (2017) 129 (13): 1779–1790.
https://doi.org/10.1182/blood-2016-06-721977
Published: 2017
Includes: Supplemental data
Journal Articles

Cooperative Epigenetic Remodeling By TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Hiroyoshi Kunimoto, MD PhD, Cem Meydan, PhD, Abbas Nazir, BS, Kaitlyn Shank, BS, Rebecca Maher, BA, Franck Rapaport, PhD, Elodie Pronier, PhD, Ari Melnick, MD, Ross L. Levine, MD, Alan H. Shih, MD PhD
Journal: Blood
Blood (2016) 128 (22): 433.
https://doi.org/10.1182/blood.V128.22.433.433
Published: 2016
Journal Articles

Tet2- mutated myeloid progenitors possess aberrant in vitro self-renewal capacity

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Keiyo Takubo, Shinichiro Okamoto, Hideaki Nakajima
Journal: Blood
Blood (2014) 123 (18): 2897–2899.
https://doi.org/10.1182/blood-2014-01-552471
Published: 2014
Journal Articles

Detailed Investigation On Characteristics of Japanese Patients with Chronic Phase CML Who Achieved a Durable CMR After Discontinuation of Imatinib – an Updated Result of the Keio STIM Study.

Eri Matsuki, MD, PhD, Yukako Ono, MD, Koharu Tonegawa, Masatoshi Sakurai, MD, Hiroyoshi Kunimoto, MD, Jo Ishizawa, MD, PhD, Norisato Hashimoto, MD, Takayuki Shimizu, MD, PhD, Akiko Yamane, MD, PhD, Maiko Matsushita, MD, PhD, Kenji Yokoyama, MD, PhD, Shinichiro Okamoto, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2788.
https://doi.org/10.1182/blood.V120.21.2788.2788
Published: 2012
Journal Articles

Tet2 Uniquely Regulates Self-Renewal and Long Term Repopulating Capacity of Fetal Liver and Bone Marrow Hematopoietic Stem Cells

Hiroyoshi Kunimoto, MD, Yumi Fukuchi, PhD, Masatoshi Sakurai, MD, Daichi Abe, MD, Ken Sadahira, MD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4739.
https://doi.org/10.1182/blood.V120.21.4739.4739
Published: 2012
Journal Articles

Impaired Hematopoietic Differentiation of iPSCs Derived From Patients with FPD/AML

Masatoshi Sakurai, MD, Hiroyoshi Kunimoto, MD, Naohide Watanabe, MD, PhD, Yumi Fukuchi, PhD, Ken Sadahira, MD, Shinsuke Yuasa, MD, PhD, Keiichi Fukuda, MD, PhD, Satoshi Yamazaki, PhD, Hiromitsu Nakauchi, MD, PhD, Yasuhiro Ebihara, MD, PhD, Kohichiro Tsuji, MD, PhD, Etsuro Ito, Yuka Harada, MD, PhD, Hironori Harada, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 767.
https://doi.org/10.1182/blood.V120.21.767.767
Published: 2012
Journal Articles

Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells

Hiroyoshi Kunimoto, MD, Yumi Fukuchi, PhD, Masatoshi Sakurai, MD, Ken Sadahira, MD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2331.
https://doi.org/10.1182/blood.V118.21.2331.2331
Published: 2011
Journal Articles

Discontinuation of Imatinib in Patients with CML and Sustained Complete Molecular Response (CMR) for Over 2 Years in the Japanese Population – An Interim Analysis of KEIO STIM Study,

Eri Matsuki, MD, PhD, Yukako Ono, MD, Masatoshi Sakurai, MD, Hiroyoshi Kunimoto, MD, Jo Ishizawa, MD, PhD, Takayuki Shimizu, MD, PhD, Akiko Yamane, MD, PhD, Maiko Matsushita, MD, PhD, Kenji Yokoyama, MD, PhD, Shinichiro Okamoto, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3765.
https://doi.org/10.1182/blood.V118.21.3765.3765
Published: 2011