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Souichi Adachi
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Journal Articles

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

Kaito Mimura, Norio Shiba, Ai Okada, Kenichi Chiba, Kentaro Watanabe, Takao Deguchi, Kentaro Ohki, Kotoe Katayama, Seiya Imoto, Akiko M Saito, Yasuhiro Okamoto, Souichi Adachi, Daisuke Tomizawa, Takashi Taga, Yuichi Shiraishi, Hiroshi Moritake, Motohiro Kato, Kenichi Yoshida
Journal: Blood
Blood (2024) 144 (Supplement 1): 5720.
https://doi.org/10.1182/blood-2024-200476
Published: 2024
Journal Articles

Growth Retardation and Adult Height in Children with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitors

Haruko Shima, Chikako Tono, Akihiko Tanizawa, Masaki Ito, Akihiro Watanabe, Yuki Yuza, Kazuko Hamamoto, Hideki Muramatsu, Masahiko Okada, Shoji Saito, Hiroaki Goto, Masaru Imamura, Akiko M Saito, Souichi Adachi, Eiichi Ishii, Hiroyuki Shimada
Journal: Blood
Blood (2024) 144 (Supplement 1): 4537.
https://doi.org/10.1182/blood-2024-198938
Published: 2024
Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Clinical Trials & Observations
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Journal: Blood
Blood (2024) 143 (25): 2627–2643.
https://doi.org/10.1182/blood.2023022247
Published: 2024
Includes: Supplemental data
Journal Articles

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Takayuki Kurosawa, Masanobu Takeuchi, Ayaka Miura, Koichi Murakami, Ikuma Kato, Takako Hishiki, Noriyo Hayakawa, Tomomi Matsuura, Megumi Funakoshi-Tago, Akihiko Yokoyama, Kenichi Yoshida, Daisuke Tomizawa, Satoru Miyano, Akio Tawa, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi, Norio Shiba, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2740.
https://doi.org/10.1182/blood-2023-181740
Published: 2023
Journal Articles

Label-Free Cell Detection of Acute Leukemia Using High-Content Morphological Profiling in Flow

Yoko Kawamura, Kayoko Nakanishi, Yuri Murata, Kazuki Teranishi, Ryusuke Miyazaki, Keisuke Toda, Toru Imai, Yasuhiro Kajiwara, Keiji Nakagawa, Hidemasa Matsuo, Souichi Adachi, Sadao Ota, Hidefumi Hiramatsu
Journal: Blood
Blood (2023) 142 (Supplement 1): 906.
https://doi.org/10.1182/blood-2023-188914
Published: 2023
Journal Articles

Integrated Analysis Focusing on Genome-Wide DNA Methylation in Pediatric Acute Promyelocytic Leukemia: The Jccg Study, JPLSG AML-P05

Etsuko Ishikita, Tomoko Kawai, Genki Yamato, Norio Shiba, Kentaro Ohki, Yusuke Hara, Taeko Kaburagi, Takumi Takizawa, Hirohide Kawasaki, Hiroo Ueno, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Yuki Yuza, Hiroyuki Takahashi, Seishi Ogawa, Yasuhide Hayashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2966.
https://doi.org/10.1182/blood-2023-179285
Published: 2023
Journal Articles

A Nationwide Clinical Trial ALL-B12: An Optimized Therapy for Pediatric B-Precursor Acute Lymphoblastic Leukemia with Excellent Overall Survival and Minimal Non-Relapse Mortality: A Report from the Japan Children's Cancer Group

Motohiro Kato, Yasuhiro Okamoto, Toshihiko Imamura, Akiko Kada, Akiko M Saito, Yuka Iijima-Yamashita, Takao Deguchi, Kentaro Oki, Takashi Fukushima, Ken-ichi Anami, Masashi Sanada, Tomohiko Taki, Yoshiko Hashii, Nobutaka Kiyokawa, Yoshiyuki Kosaka, NAO Yoshida, Yuki Yuza, Masakatsu Yanagimachi, Kenichiro Watanabe, Atsushi Sato, Chihaya Imai, Takashi Taga, Souichi Adachi, Keizo Horibe, Atsushi Manabe, Katsuyoshi Koh
Journal: Blood
Blood (2023) 142 (Supplement 1): 519.
https://doi.org/10.1182/blood-2023-182464
Published: 2023
Journal Articles

Integrated Analysis of KIT Exon 17 Mutations and Flow-MRD Refines Risk Stratification in Pediatric Acute Myeloid Leukemia with RUNX1 :: RUNX1T1

Shin-Ichi Tsujimoto, Shota Kato, Shotaro Iwamoto, Hidefumi Hiramatsu, Yusuke Okuno, Tatsuya Kamitori, Kentaro Ohki, Takao Deguchi, Nobutaka Kiyokawa, Motohiro Kato, Junko Takita, Souichi Adachi, Daisuke Tomizawa, Norio Shiba
Journal: Blood
Blood (2023) 142 (Supplement 1): 1599.
https://doi.org/10.1182/blood-2023-181358
Published: 2023
Journal Articles

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

Genki Yamato, Tomoko Kawai, Norio Shiba, Yusuke Hara, Kentaro Ohki, Taeko Kaburagi, Etsuko Ishikita, Hirohide Kawasaki, Kenichi Yoshida, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Akira Shimada, Manabu Sotomatsu, Takumi Takizawa, Souichi Adachi, Takashi Taga, Keizo Horibe, Seishi Ogawa, Kenichiro Hata, Yasuhide Hayashi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9134–9135.
https://doi.org/10.1182/blood-2022-163226
Published: 2022
Journal Articles

Safety and Efficacy of Arsenic Trioxide in the Treatment of Newly Diagnosed Pediatric Acute Promyelocytic Leukemia: Results from the JPLSG AML-P13 Study

Hiroyuki Takahashi, Shiro Tanaka, Yuki Yuza, Yuka Iijima-Yamashita, Daisuke Hasegawa, Hiroshi Moritake, Kiminori Terui, Shotaro Iwamoto, Akira Shimada, Jun Matsubayashi, Takao Deguchi, Yoshiko Hashii, Nobutaka Kiyokawa, Hayato Miyachi, Akiko Moriya Saito, Takashi Taga, Souichi Adachi, Daisuke Tomizawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 6160–6161.
https://doi.org/10.1182/blood-2022-162177
Published: 2022
Journal Articles

Evaluation of High-Dose Cytarabine Induction Therapy and Flow Cytometric Measurable Residual Disease Monitoring for Children with De Novo Acute Myeloid Leukemia: A Report from the JPLSG-AML-12 Trial

Daisuke Tomizawa, Shiro Tanaka, Shotaro Iwamoto, Hidefumi Hiramatsu, Jun Matsubayashi, Daisuke Hasegawa, Hiroshi Moritake, Daiichiro Hasegawa, Kiminori Terui, Asahito Hama, Shin-ichi Tsujimoto, Nobutaka Kiyokawa, Hayato Miyachi, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Tomohiko Taki, Yasushi Noguchi, Kazutoshi Koike, Katsuyoshi Koh, Yuki Yuza, Akiko Moriya Saito, Keizo Horibe, Takashi Taga, Souichi Adachi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1450–1452.
https://doi.org/10.1182/blood-2022-158664
Published: 2022
Journal Articles

Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, Yuri Ito, Shoji Saito, Yuhki Koga, Hiroshi Moritake, Kiminori Terui, Koji Kawaguchi, Yasuhiro Okamoto, Hideki Nakayama, Kanno Miyako, Moeko Hino, Yusuke Akane, Akiko Inoue, Akira Shimada, Hiroaki Goto, Hiroo Ueno, Junko Takita, Genki Yamato, Norio Shiba, Yasuhide Hayashi, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Seishi Ogawa, Souichi Adachi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2358.
https://doi.org/10.1182/blood-2021-146699
Published: 2021
Journal Articles

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, MDPhD, Kana Nakatani, Yutarou Harata, Moe Higashitani, Yuri Ito, Yasuhiko Kamikubo, Yusuke Shiozawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, Hiroko Tanaka, BA, Ai Okada, Yasuhito Nannya, MD PhD, June Takeda, MD, Hiroo Ueno, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Satoru Miyano, PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-134648
Published: 2020
Journal Articles

RUNX-NFAT Axis As a Novel Therapeutic Target for AML and T Cell Immunity

Tatsuya Masuda, Master Degree, Hirohito Kubota, MD, Naoya Sakuramoto, Master Degree, Asuka Hada, Master Degree, Ayaka Horiuchi, Master Degree, Asami Sasaki, Master Degree, Kanako Takeda, Master Degree, Mizuho Takeda, Master Degree, Hidemasa Matsuo, Hiroshi Sugiyama, PhD, Souichi Adachi, MD PhD, Yasuhiko Kamikubo
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-143458
Published: 2020
Journal Articles

Etoposide, Cytarabine and Mitoxantrone- or Fludarabine, Cytarabine and Granulocyte Colony-Stimulating Factor-Based Intensive Reinduction Chemotherapy Is Recommended for Children with Relapsed Acute Myeloid Leukemia: The Results from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R Study

Hiroshi Moritake, MD PhD, Shiro Tanaka, PhD, Takako Miyamura, MD PhD, Hideki Nakayama, MD, Norio Shiba, MD PhD, Akira Shimada, MDPhD, Kiminori Terui, MD PhD, Yuki Yuza, MD PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD, PhD, Harumi Kakuda, MD PhD, Akiko M Saito, MD PhD, Daisuke Hasegawa, MD PhD, Shotaro Iwamoto, MD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-133272
Published: 2020
Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139312
Published: 2020
Journal Articles

Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia Cells

Kana Nakatani, Hidemasa Matsuo, Yutarou Harata, Moe Higashitani, Asami Koyama, Mina Noura, Yoko Nishinaka-Arai, PhD, Yasuhiko Kamikubo, Souichi Adachi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50.
https://doi.org/10.1182/blood-2020-133881
Published: 2020
Journal Articles

Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

Hirohito Kubota, MD, Kana Furuichi, Tatsuya Masuda, Toshiya Tatsuta, Hidefumi Hiramatsu, MD PhD, Junko Takita, MD PhD, Sugiyama Hiroshi, PhD, Souichi Adachi, MD PhD, Yasuhiko Kamikubo, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3359.
https://doi.org/10.1182/blood-2019-126428
Published: 2019
Journal Articles

Clinical Features of Children with Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis in Japan: Retrospective Nationwide Survey

Hisashi Ishida, MD PhD, Takeo Sarashina, MD PhD, Risa Matsumura, Katsutsugu Umeda, MD, PhD, Tetsuo Mitsui, MD PhD, Naoto Fujita, MD PhD, Daisuke Tomizawa, MD PhD, Kevin Y Urayama, PhD MPH, Yasushi Ishida, MD PhD, Takashi Taga, MD PhD, Masatoshi Takagi, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Toshihiko Imamura, MD PhD, Katsuyoshi Koh, MD, Akira Shimada, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2958.
https://doi.org/10.1182/blood-2019-123429
Published: 2019
Journal Articles

Predictive Factors of the Development of Leukemia in Patients with Transient Abnormal Myelopoiesis and Down Syndrome: The Jccg Study JPLSG TAM-10

Genki Yamato, MD PhD, Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, PhD, Takao Deguchi, MD PhD, Shotaro Iwamoto, MD, Daisuke Hasegawa, MD PhD, Kiminori Terui, MD PhD, Takahiro Ueda, MD PhD, Tomoko Yokosuka, Tsutomu Toki, PhD, Shiro Tanaka, PhD, Ryu Yanagisawa, Katsuyoshi Koh, MD, Akiko M Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Kenichiro Watanabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3833.
https://doi.org/10.1182/blood-2019-125465
Published: 2019