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Satoru Miyano
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Journal Articles

Deciphering the Heterogeneity of Acute Myeloid Leukemia through Chromatin Accessibility Profiling

Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzén, Petar Antunovic, Stefan Deneberg, Martin Jadersten, Vladimir Lazarevic, Bertil Uggla, Lovisa Wennström, Emma Olander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Masanori Motomura, Masahiro M Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Akinori Yoda, Rurika Okuda, Guoxiang Xie, Albin Osterroos, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Hiroshi I Suzuki, Akifumi Takaori-Kondo, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 639.
https://doi.org/10.1182/blood-2024-200415
Published: 2024
Journal Articles

High-Throughput and Highly Sensitive Single Cell Genotyping with Simultaneous Chromatin Accessibility Measurement in Myeloid Precursor Conditions

Masanori Motomura, Yotaro Ochi, Masahiro M Nakagawa, Yasuhito Nannya, Nobuyuki Kakiuchi, Yutaka Kuroda, Nobuo Sezaki, Tomoe Nakagawa, Lanying Zhao, Satoru Miyano, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 5635.
https://doi.org/10.1182/blood-2024-206815
Published: 2024
Journal Articles

Molecular Taxonomy Classification for Transplant Decision Making of Myelodysplastic Syndromes

Rurika Okuda, Yotaro Ochi, Tetsuichi Yoshizato, Yasuhito Nannya, Yoshiko Atsuta, Yuichi Shiraishi, Yusuke Shiozawa, Hiroko Tanaka, Makoto Onizuka, Kenichi Chiba, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Keizo Horibe, Satoru Miyano, Hideki Makishima, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3203.
https://doi.org/10.1182/blood-2024-206498
Published: 2024
Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Clinical Trials & Observations
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Journal: Blood
Blood (2024) 143 (25): 2627–2643.
https://doi.org/10.1182/blood.2023022247
Published: 2024
Includes: Supplemental data
Journal Articles

Epigenetic Classification of Acute Myeloid Leukemia Revealed By Genome-Wide Chromatin Profiling

Yotaro Ochi, Yasuhito Nannya, Markus Liew-Littorin, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Albin Osterroos, Masanori Motomura, Masahiro Marshall Nakagawa, Ryunosuke Saiki, Akinori Yoda, Rurika Okuda, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Akifumi Takaori-Kondo, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 836.
https://doi.org/10.1182/blood-2023-180336
Published: 2023
Journal Articles

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Takayuki Kurosawa, Masanobu Takeuchi, Ayaka Miura, Koichi Murakami, Ikuma Kato, Takako Hishiki, Noriyo Hayakawa, Tomomi Matsuura, Megumi Funakoshi-Tago, Akihiko Yokoyama, Kenichi Yoshida, Daisuke Tomizawa, Satoru Miyano, Akio Tawa, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi, Norio Shiba, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2740.
https://doi.org/10.1182/blood-2023-181740
Published: 2023
Journal Articles

Clonal Hematopoiesis Is Associated with Severe COVID-19 Enhancing Inflammatory Responses in Myeloid Cells

Ryunosuke Saiki, Ryuya Edahiro, Kyuto Sonehara, Qingbo S Wang, Ho Namkoong, Takanori Hasegawa, Hiromu Tanaka, Shuhei Azekawa, Shotaro Chubachi, Shinichi Namba, Kenichi Yamamoto, Nobuyuki Kakiuchi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Makishima, Yasuhito Nannya, Ryuji Koike, Tomomi Takano, Makoto Ishii, Akinori Kimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 1321.
https://doi.org/10.1182/blood-2023-181354
Published: 2023
Journal Articles

Insights from Trajectories of PIGA -Mutated Clones in Paroxysmal Nocturnal Hemoglobinuria

Hiroyuki Takamori, Yasutaka Ueda, Yoshikazu Matsuoka, Tatsuya Fujioka, Hideki Makishima, Yoshiko Murakami, Taroh Kinoshita, Satoru Miyano, Yuzuru Kanakura, Jun-Ichi Nishimura, Naoki Hosen, Seishi Ogawa, Yasuhito Nannya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2724.
https://doi.org/10.1182/blood-2023-188992
Published: 2023
Journal Articles

Clonal Evolution of Der(1;7)(q10;p10) Myeloid Neoplasms

Rurika Okuda, Yotaro Ochi, Ryunosuke Saiki, Nobuhiro Hiramoto, Masashi Sanada, Hiroshi Handa, Senji Kasahara, Shinya Sato, Nobuhiro Kanemura, Toshiyuki Kitano, Mizuki Watanabe, Wolfgang Kern, Maria Creignou, Yuichi Shiraishi, Mitsumasa Watanabe, Kensuke Usuki, Shinsaku Imashuku, Eva Hellstrom Lindberg, Torsten Haferlach, Shigeru Chiba, Nobuo Sezaki, Lee-Yung Shih, Yasushi Miyazaki, Takayuki Ishikawa, Kazuma Ohyashiki, Yoshiko Atsuta, Yusuke Shiozawa, Satoru Miyano, Koichi Matsuda, Hideki Makishima, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 1000.
https://doi.org/10.1182/blood-2023-185857
Published: 2023
Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2023) 141 (5): 534–549.
https://doi.org/10.1182/blood.2022018221
Published: 2023
Includes: Supplemental data
Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 208–210.
https://doi.org/10.1182/blood-2022-158851
Published: 2022
Journal Articles

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

Genki Yamato, Tomoko Kawai, Norio Shiba, Yusuke Hara, Kentaro Ohki, Taeko Kaburagi, Etsuko Ishikita, Hirohide Kawasaki, Kenichi Yoshida, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Akira Shimada, Manabu Sotomatsu, Takumi Takizawa, Souichi Adachi, Takashi Taga, Keizo Horibe, Seishi Ogawa, Kenichiro Hata, Yasuhide Hayashi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9134–9135.
https://doi.org/10.1182/blood-2022-163226
Published: 2022
Journal Articles

Molecular Landscape of Myeloid Neoplasms with Der(1;7)(q10;p10)

Rurika Okuda, Yotaro Ochi, Kazuhisa Chonabayashi, Nobuhiro Hiramoto, Masashi Sanada, Hiroshi Handa, Senji Kasahara, Shinya Sato, Nobuhiro Kanemura, Toshiyuki Kitano, Mizuki Watanabe, Wolfgang Kern, Maria Creignou, Yuichi Shiraishi, Mitsumasa Watanabe, Kensuke Usuki, Shinsaku Imashuku, Eva Hellström-Lindberg, Torsten Haferlach, Shigeru Chiba, Nobuo Sezaki, Lee-Yung Shih, Yasushi Miyazaki, Yoshinori Yoshida, Takayuki Ishikawa, Kazuma Ohyashiki, Yoshiko Atsuta, Yusuke Shiozawa, Satoru Miyano, Hideki Makishima, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 6902–6904.
https://doi.org/10.1182/blood-2022-168213
Published: 2022
Journal Articles

Detailed Analysis of the Impact of Clonal Hematopoiesis on the Risk of Severe COVID-19 Infection

Ryunosuke Saiki, Ho Namkoong, Ryuya Edahiro, Kyuto Sonehara, Qingbo S Wang, Takanori Hasegawa, Yukihide Momozawa, Hideki Makishima, Yasuhito Nannya, Nobuyuki Kakiuchi, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Akinori Kimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Koich Fukunaga, Yukinori Okada, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 5747–5748.
https://doi.org/10.1182/blood-2022-160436
Published: 2022
Journal Articles

Whole-genome landscape of adult T-cell leukemia/lymphoma

Yasunori Kogure, Takuro Kameda, Junji Koya, Makoto Yoshimitsu, Kisato Nosaka, Jun-ichirou Yasunaga, Yoshitaka Imaizumi, Mizuki Watanabe, Yuki Saito, Yuta Ito, Marni B. McClure, Mariko Tabata, Sumito Shingaki, Kota Yoshifuji, Kenichi Chiba, Ai Okada, Nobuyuki Kakiuchi, Yasuhito Nannya, Ayako Kamiunten, Yuki Tahira, Keiichi Akizuki, Masaaki Sekine, Kotaro Shide, Tomonori Hidaka, Yoko Kubuki, Akira Kitanaka, Michihiro Hidaka, Nobuaki Nakano, Atae Utsunomiya, R. Alejandro Sica, Ana Acuna-Villaorduna, Murali Janakiram, Urvi Shah, Juan Carlos Ramos, Tatsuhiro Shibata, Kengo Takeuchi, Akifumi Takaori-Kondo, Yasushi Miyazaki, Masao Matsuoka, Kenji Ishitsuka, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, B. Hilda Ye, Kazuya Shimoda, Keisuke Kataoka
Journal: Blood
Blood (2022) 139 (7): 967–982.
https://doi.org/10.1182/blood.2021013568
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, Yuri Ito, Shoji Saito, Yuhki Koga, Hiroshi Moritake, Kiminori Terui, Koji Kawaguchi, Yasuhiro Okamoto, Hideki Nakayama, Kanno Miyako, Moeko Hino, Yusuke Akane, Akiko Inoue, Akira Shimada, Hiroaki Goto, Hiroo Ueno, Junko Takita, Genki Yamato, Norio Shiba, Yasuhide Hayashi, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Seishi Ogawa, Souichi Adachi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2358.
https://doi.org/10.1182/blood-2021-146699
Published: 2021
Journal Articles

Mass Cytometric Analysis Revealed Dynamic Alteration of the Tumor Immune Environment in Bone Marrow from Children with Recurrent B Cell Precursor Acute Lymphoblastic Leukemia

Takashi Mikami, Itaru Kato, James Badger Wing, Hiroo Ueno, Keiji Tasaka, Kuniaki Tanaka, Hirohito Kubota, Satoshi Saida, Katsutsugu Umeda, Hidefumi Hiramatsu, Tomoya Isobe, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Hiroko Tanaka, Satoru Miyano, Soichi Adachi, Keiko Iwaisako, Seishi Ogawa, Shimon Sakaguchi, Junko Takita
Journal: Blood
Blood (2021) 138 (Supplement 1): 2390.
https://doi.org/10.1182/blood-2021-146420
Published: 2021
Journal Articles

Der(1;7)(q10;p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms

Rurika Okuda, Yasuhito Nannya, Yotaro Ochi, Maria Creignou, Hideki Makishima, Tetsuichi Yoshizato, Yasunobu Nagata, June Takeda, Kenichi Yoshida, Masashi Sanada, Ayana Kon, Yuichi Shiraishi, Satoru Miyano, Wolfgang Kern, Constance Baer, Niroshan Nadarajah, Claudia Haferlach, Yoshiko Atsuta, Senji Kasahara, Hiroshi Handa, Shigeru Chiba, Kazuma Ohyashiki, Torsten Haferlach, Eva Hellstrom Lindberg, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 1513.
https://doi.org/10.1182/blood-2021-149556
Published: 2021
Journal Articles

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

June Takeda, Kenichi Yoshida, Masahiro Marshall Nakagawa, Yasuhito Nannya, Akinori Yoda, Daisuke Morishita, Ryunosuke Saiki, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Ming-Chung Kuo, Cassandra M Kerr, Yasunobu Nagata, Nobuhiro Hiramoto, Akira Hangaishi, Hideyuki Nakazawa, Ken Ishiyama, Satoru Miyano, Shigeru Chiba, Yasushi Miyazaki, Toshiyuki Kitano, Kensuke Usuki, Nobuo Sezaki, Hisashi Tsurumi, Shuichi Miyawaki, Jaroslaw P. Maciejewski, Takayuki Ishikawa, Kazuma Ohyashiki, Arnold Ganser, Michael Heuser, Felicitas Thol, Lee-Yung Shih, Akifumi Takaori-Kondo, Hideki Makishima, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 610.
https://doi.org/10.1182/blood-2021-152800
Published: 2021
Journal Articles

Frequent genetic alterations in immune checkpoint–related genes in intravascular large B-cell lymphoma

Kazuyuki Shimada, Kenichi Yoshida, Yasuhiro Suzuki, Chisako Iriyama, Yoshikage Inoue, Masashi Sanada, Keisuke Kataoka, Masaaki Yuge, Yusuke Takagi, Shigeru Kusumoto, Yasufumi Masaki, Takahiko Ito, Yuichiro Inagaki, Akinao Okamoto, Yachiyo Kuwatsuka, Masahiro Nakatochi, Satoko Shimada, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Shiozawa, Yasuhito Nannya, Asako Okabe, Kei Kohno, Yoshiko Atsuta, Koichi Ohshima, Shigeo Nakamura, Seishi Ogawa, Akihiro Tomita, Hitoshi Kiyoi
Journal: Blood
Blood (2021) 137 (11): 1491–1502.
https://doi.org/10.1182/blood.2020007245
Published: 2021
Includes: Supplemental data