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Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito

Blood (2024) 143 (25): 2627–2643.

https://doi.org/10.1182/blood.2023022247

Published: 2024

Includes: Supplemental data

Journal Articles

EVI1 Promotes Immune-Evasive Microenvironment Via Cyclin D1 in Acute Myeloid Leukemia

Yosuke Masamoto, Akira Chiba, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa

Blood (2022) 140 (Supplement 1): 85–86.

https://doi.org/10.1182/blood-2022-158107

Published: 2022

Journal Articles

EVI1-Positive AML Cells Show Distinct Features and High Dependency on ETS Transcription Factor ERG

Yosuke Masamoto, Akira Chiba, Toshiaki Takezaki, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 784.

https://doi.org/10.1182/blood-2021-149015

Published: 2021

Journal Articles

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Ko Kudo, MD, Rika Kanezaki, PhD, Akie Kobayashi, MD, Tomohiko Sato, MD PhD, Takuya Kamio, MD PhD, Shinya Sasaki, MD PhD, Imamura Masaru, MD PhD, Chihaya Imai, MD PhD, Masahiro Irie, MD PhD, Yoji Sasahara, MD PhD, Kumiko Ando, MD, Harumi Kakuda, MD PhD, Takehiko Doi, MD PhD, Hiroshi Kawaguchi, MD PhD, Kazuko Kudo, MD PhD, Hirokazu Kanegane, MD PhD, Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD

Blood (2019) 134 (Supplement_1): 3588.

https://doi.org/10.1182/blood-2019-127536

Published: 2019

Journal Articles

Assessment of Anemia Prevalence Among Non-Pregnant Women in Urban Areas of Shanghai and Tokyo: A Retrospective Observational Study

Kana Yamamoto, MD, Wang Na, PhD, Morihito Takita, MD PhD, Tomohiko Sato, MD PhD, Tomohiro Morita, MD PhD, Tsunehiko Komatsu, MD PhD, Suguru Tokiwa, MD, Masahiro Kami, MD PhD, Shigeaki Kato, PhD, Tetsuya Tanimoto, MD, Zhao Genming, PhD

Blood (2018) 132 (Supplement 1): 5890.

https://doi.org/10.1182/blood-2018-99-117791

Published: 2018

Journal Articles

Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

Masahiro Uni, MD PhD, Yosuke Masamoto, MD PhD, Tomohiko Sato, MD PhD, Shunya Arai, MD PhD, Eiji Hara, PhD, Mineo Kurokawa, MD PhD

Blood (2017) 130 (Supplement 1): 118.

https://doi.org/10.1182/blood.V130.Suppl_1.118.118

Published: 2017

Journal Articles

Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia

Yoshiki Sumitomo, Junji Koya, Kumi Nakazaki, Keisuke Kataoka, Takako Tsuruta-Kishino, Ken Morita, Tomohiko Sato, Mineo Kurokawa

Blood (2016) 128 (12): 1614–1624.

https://doi.org/10.1182/blood-2015-12-684696

Published: 2016

Includes: Supplemental data

Journal Articles

Adipocyte-Derived Adiponectin Positively Regulates Exit from Quiescence of Hematopoietic Stem Cells By Potentiating mTORC1 Activation after Myelotoxic Injury

Yosuke Masamoto, MDPhD, Shunya Arai, MD, PhD, Tomohiko Sato, MD PhD, Iseki Takamoto, MD PhD, Naoto Kubota, MD PhD, Takashi Kadowaki, MD PhD, Mineo Kurokawa, MD PhD

Blood (2015) 126 (23): 777.

https://doi.org/10.1182/blood.V126.23.777.777

Published: 2015

Journal Articles

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Tatsuya Ito, MD, Kiminori Terui, MDPhD, Isamu Hanada, MD PhD, Fumika Ikeda, MD, Tsutomu Toki, PhD, Rika Kanezaki, PhD, Tomohiko Sato, MD PhD, Takuya Kamio, MDPhD, Ko Kudo, MD, Shinya Sasaki, MD PhD, Yoshihiro Takahashi, MD PhD, Yasuhide Hayashi, MD PhD, Takeshi Inukai, MD PhD, Hiroki Hori, MD PhD, Etsuro Ito, MD PhD

Blood (2015) 126 (23): 4986.

https://doi.org/10.1182/blood.V126.23.4986.4986

Published: 2015

Journal Articles

Heterozygous Dnmt3a Mutation Induces Expansion of Hematopoietic Stem Cell Pool in a Murine Model

Takashi Higo, MD, Junji Koya, MD PhD, Yoshiki Sumitomo, Takako Tsuruta-Kishino, PhD, Keisuke Kataoka, MD PhD, Tomohiko Sato, MD PhD, Mineo Kurokawa, MD

Blood (2015) 126 (23): 2355.

https://doi.org/10.1182/blood.V126.23.2355.2355

Published: 2015

Journal Articles

Enhanced Autophagy Promotes Survival of Peripheral Blast Cells from Murine Acute Myeloid Leukemia

Yoshiki Sumitomo, Junji Koya, MD PhD, Keisuke Kataoka, MD PhD, Takako Tsuruta-Kishino, Ken Morita, MD, Tomohiko Sato, MD PhD, Mineo Kurokawa, MD PhD

Blood (2014) 124 (21): 2339.

https://doi.org/10.1182/blood.V124.21.2339.2339

Published: 2014

Journal Articles

BAALC Acts As a Scaffold-Like Protein In The ERK Signaling Pathway and Promotes Leukemogenesis By Facilitating MEK–mediated ERK Activation

Ken Morita, M.D., Keisuke Kataoka, MD, PhD, Junji Koya, M.D., Takako Tsuruta, Tomohiko Sato, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2013) 122 (21): 2509.

https://doi.org/10.1182/blood.V122.21.2509.2509

Published: 2013

Journal Articles

Anti-Obese Hormone Adiponectin Regulates Emergency Hematopoiesis and Antibacterial Response Through Downregulation Of Socs3 In Hematopoietic Progenitor Cells

Yosuke Masamoto, MD, PhD, Shunya Arai, MD, PhD, Tomohiko Sato, MD, PhD, Akihide Yoshimi, MD, PhD, Iseki Takamoto, MD, PhD, Naoto Kubota, MD, PhD, Takashi Kadowaki, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2013) 122 (21): 221.

https://doi.org/10.1182/blood.V122.21.221.221

Published: 2013

Journal Articles

Leukemia-Associated Mutations Of DNMT3A Inhibit Differentiation Of Hematopoietic Stem Cells and Promote Leukemic Transformation Through Abberant Recruitment Of Bmi1

Junji Koya, M.D., Keisuke Kataoka, MD, PhD, Takako Tsuruta-Kishino, M.S., Hiroshi Kobayashi, M.D., Kensuke Narukawa, M.D., Ph.D., Tomohiko Sato, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2013) 122 (21): 469.

https://doi.org/10.1182/blood.V122.21.469.469

Published: 2013

Journal Articles

Loss Of p53 Induces Leukemic Transformation In a Murine Model Of JAK2V617F-Induced Polycythemia Vera

Takako Tsuruta-Kishino, M.Sc, Keisuke Kataoka, MD, PhD, Hiroshi Kobayashi, M.D., Junji Koya, M.D., Kensuke Narukawa, M.D., Ph.D., Tomohiko Sato, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2013) 122 (21): 269.

https://doi.org/10.1182/blood.V122.21.269.269

Published: 2013

Journal Articles

The shortest isoform of C/EBPβ , liver inhibitory protein ( LIP ), collaborates with Evi1 to induce AML in a mouse BMT model

Naoko Watanabe-Okochi, Akihide Yoshimi, Tomohiko Sato, Toshiyuki Ikeda, Keiki Kumano, Kazuki Taoka, Yumiko Satoh, Akihito Shinohara, Takako Tsuruta, Akiko Masuda, Hiromitsu Yokota, Yutaka Yatomi, Koki Takahashi, Jiro Kitaura, Toshio Kitamura, Mineo Kurokawa

Blood (2013) 121 (20): 4142–4155.

https://doi.org/10.1182/blood-2011-07-368654

Published: 2013

Includes: Supplemental data

Journal Articles

Identification of Two New DBA Genes, RPS27 and RPL27 , by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

Blood (2012) 120 (21): 984.

https://doi.org/10.1182/blood.V120.21.984.984

Published: 2012

Journal Articles

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors

Masahiro Nakagawa, Munetake Shimabe, Naoko Watanabe-Okochi, Shunya Arai, Akihide Yoshimi, Akihito Shinohara, Nahoko Nishimoto, Keisuke Kataoka, Tomohiko Sato, Keiki Kumano, Yasuhito Nannya, Motoshi Ichikawa, Yoichi Imai, Mineo Kurokawa

Blood (2011) 118 (25): 6626–6637.

https://doi.org/10.1182/blood-2010-12-326710

Published: 2011

Includes: Supplemental data

Journal Articles

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Isamu Hanada, MD, Kiminori Terui, MD, PhD, Tsutomu Toki, PhD, Ko Kudo, MD, Tomohiko Sato, MD, PhD, Takuya Kamio, MD, PhD, Shinya Sasaki, MD, PhD, Yoshihiro Takahashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Kanji Sugita, MD, PhD, Seiji Kojima, MD, PhD, Kenichi Koike, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Masao Kobayashi, MD, PhD, Etsuro Ito, MD, PhD

Blood (2011) 118 (21): 1451.

https://doi.org/10.1182/blood.V118.21.1451.1451

Published: 2011

Journal Articles

Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1

Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Takako Tsuruta, Masahiro Nakagawa, Keiki Kumano, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa, MD

Blood (2011) 118 (21): 964.

https://doi.org/10.1182/blood.V118.21.964.964

Published: 2011

NARROW

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

EVI1 Promotes Immune-Evasive Microenvironment Via Cyclin D1 in Acute Myeloid Leukemia

EVI1-Positive AML Cells Show Distinct Features and High Dependency on ETS Transcription Factor ERG

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Assessment of Anemia Prevalence Among Non-Pregnant Women in Urban Areas of Shanghai and Tokyo: A Retrospective Observational Study

Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia

Adipocyte-Derived Adiponectin Positively Regulates Exit from Quiescence of Hematopoietic Stem Cells By Potentiating mTORC1 Activation after Myelotoxic Injury

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Heterozygous Dnmt3a Mutation Induces Expansion of Hematopoietic Stem Cell Pool in a Murine Model

Enhanced Autophagy Promotes Survival of Peripheral Blast Cells from Murine Acute Myeloid Leukemia

BAALC Acts As a Scaffold-Like Protein In The ERK Signaling Pathway and Promotes Leukemogenesis By Facilitating MEK–mediated ERK Activation

Anti-Obese Hormone Adiponectin Regulates Emergency Hematopoiesis and Antibacterial Response Through Downregulation Of Socs3 In Hematopoietic Progenitor Cells

Leukemia-Associated Mutations Of DNMT3A Inhibit Differentiation Of Hematopoietic Stem Cells and Promote Leukemic Transformation Through Abberant Recruitment Of Bmi1

Loss Of p53 Induces Leukemic Transformation In a Murine Model Of JAK2V617F-Induced Polycythemia Vera

The shortest isoform of C/EBPβ , liver inhibitory protein ( LIP ), collaborates with Evi1 to induce AML in a mouse BMT model

Identification of Two New DBA Genes, RPS27 and RPL27 , by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1

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