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Journal Articles

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

Cheuk-Him Man, Wing Lam, Chee-Chean Dang, Xiao-yuan Zeng, Li-Chuan Zheng, Natalie Nok-Man Chan, Ka-Lam Ng, Koon-Chuen Chan, Tsz-Ho Kwok, Timothy Chi-Chun Ng, Wing-Yan Leung, Michael Shing-Yan Huen, Carmen Chak-Lui Wong, Chi Wai Eric So, Zhixun Dou, Susumu Goyama, Mark Robert Bray, Tak Wah Mak, Anskar Yu-Hung Leung

Blood (2023) 142 (23): 2002–2015.

https://doi.org/10.1182/blood.2023019782

Published: 2023

Journal Articles

SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML

Yu-Hsuan Chang, Keita Yamamoto, Takeshi Fujino, Teh-Wei Wang, Emi Sugimoto, Wenyu Zhang, Tomohiro Yabushita, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Yutaka Enomoto, Yoichi Imai, Toshio Kitamura, Susumu Goyama

Blood (2023) 142 (Supplement 1): 713.

https://doi.org/10.1182/blood-2023-177531

Published: 2023

Journal Articles

DNAM-1/Tigit/CD155/CD112 Axis Is a Novel Target of NK-Cell Therapy in Acute Myeloid Leukemia

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai

Blood (2022) 140 (Supplement 1): 4514–4516.

https://doi.org/10.1182/blood-2022-164435

Published: 2022

Journal Articles

Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment

Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Hitoshi Sato, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama

Blood (2022) 140 (Supplement 1): 8776–8777.

https://doi.org/10.1182/blood-2022-168499

Published: 2022

Journal Articles

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142284

Published: 2020

Journal Articles

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

Blood (2020) 136 (14): 1670–1684.

https://doi.org/10.1182/blood.2019004613

Published: 2020

Includes: Supplemental data

Journal Articles

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, MSc, Hirotaka Takahasi, PhD, Tatsuya Sawasaki, PhD, Toshio Kitamura, MD PhD, Susumu Goyama, MD PhD

Blood (2019) 134 (Supplement_1): 1252.

https://doi.org/10.1182/blood-2019-126264

Published: 2019

Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 2514.

https://doi.org/10.1182/blood-2019-125472

Published: 2019

Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Blood (2019) 134 (Supplement_1): 2525.

https://doi.org/10.1182/blood-2019-126663

Published: 2019

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 821.

https://doi.org/10.1182/blood-2019-127904

Published: 2019

Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD

Blood (2019) 134 (Supplement_1): 1240.

https://doi.org/10.1182/blood-2019-125207

Published: 2019

Journal Articles

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

Shuhei Asada, MD, Susumu Goyama, MD PhD, Daichi Inoue, MD PhD, Reina Takeda, MD, Masahito Kawazu, Hiroyuki Mano, MDPhD, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 562.

https://doi.org/10.1182/blood.V130.Suppl_1.562.562

Published: 2017

Journal Articles

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

Susumu Goyama, MD PhD, Yasutaka Hayashi, XiaoXiao Liu, Shiori Shikata, Yosuke Tanaka, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 796.

https://doi.org/10.1182/blood.V130.Suppl_1.796.796

Published: 2017

Journal Articles

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Blood (2017) 130 (Supplement 1): 104.

https://doi.org/10.1182/blood.V130.Suppl_1.104.104

Published: 2017

Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD

Blood (2016) 128 (22): 2730.

https://doi.org/10.1182/blood.V128.22.2730.2730

Published: 2016

Journal Articles

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Kazuya Miyashita, Noritaka Kagaya, PhD, Miho Izumikawa, PhD, Kenji Kitajima, PhD, Kyoko Watakabe-Inamoto, MD, Yuho Najima, Noriko Doki, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Kazuteru Ohashi, Kazuo Shin-ya, PhD, Takahiko Hara, PhD

Blood (2016) 128 (22): 2813.

https://doi.org/10.1182/blood.V128.22.2813.2813

Published: 2016

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Kimihito Cojin Kawabata, MD PhD, Daichi Inoue, MD PhD, Jiro Kitaura, MD PhD, Yuka Harada, MD PhD, Susumu Goyama, MD PhD, Hironori Harada, MD PhD, Hiroyuki Aburatani, MD PhD, Toshio Kitamura, MD PhD

Blood (2015) 126 (23): 4116.

https://doi.org/10.1182/blood.V126.23.4116.4116

Published: 2015

Journal Articles

Xenograft models for normal and malignant stem cells

Susumu Goyama, Mark Wunderlich, James C. Mulloy

Blood (2015) 125 (17): 2630–2640.

https://doi.org/10.1182/blood-2014-11-570218

Published: 2015

NARROW

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML

DNAM-1/Tigit/CD155/CD112 Axis Is a Novel Target of NK-Cell Therapy in Acute Myeloid Leukemia

Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Xenograft models for normal and malignant stem cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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