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Journal Articles

Efficacy and Safety of Cyclosporine Monotherapy for Patients with Non-Severe Aplastic Anemia Not Requiring Transfusions: Results from a Prospective Multicenter Phase II Study

Naoko Hosono, Ken Ishiyama, Hiroki Yamaguchi, Masahide Yamazaki, Hiroyuki Maruyama, Kensuke Usuki, Kazuki Tanimoto, Hiroyuki Sugiura, Noboru Asada, Seishi Ogawa, Yuzuru Kanakura, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2024-198830
Published: 2024
Journal Articles

Myeloma Cell-Derived Monoclonal Immunoglobulins Trigger IL-1β Secretion Via Inflammasome Activation in Tolerogenic Dendritic Cells

Mariko Ishibashi, Mika Sunakawa-Kii, Yoichi Imai, Hiroki Yamaguchi, Rimpei Morita, Hideto Tamura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1900.
https://doi.org/10.1182/blood-2024-202957
Published: 2024
Journal Articles

A Phase 3, Randomized, Double-Blind, Active-Comparator-Controlled Study of Bomedemstat Versus Hydroxyurea in Patients with Essential Thrombocythemia Naïve to Cytoreductive Therapy

Yuka Sugimoto, Eran Zimran, Yoshimitsu Shimomura, Hiroki Yamaguchi, Hans Carl Hasselbach, Jean-Jacques Kiladjian, Steffen Koschmeider, Harinder Gill, Kristen Pettit, David M Ross, Claire Harrison, Alejandro Berkovits, Ahmet Muzaffer Demir, Tsai-Yun Chen, Stefan Scheding, Claudia Barrera Carmona, Alessandro Vannuchi, Shiyu Zhang, Uzor C. Ogbu, Keita Kirito
Journal: Blood
Blood (2024) 144 (Supplement 1): 4569.3.
https://doi.org/10.1182/blood-2024-200881
Published: 2024
Journal Articles

Efficacy and Safety of Avatrombopag in Japanese Adults with Chronic Immune Thrombocytopenia: Open-Label, Phase 3 Study

Hiroki Yamaguchi, Masaki Iino, Yutaka Imamura, Shugo Kowata, Ryusuke Yamamoto, Jun Yamanouchi, Masato Fujii, Jessica Zhang, Yoshiaki Tomiyama, Brian Jamieson
Journal: Blood
Blood (2024) 144 (Supplement 1): 5426.
https://doi.org/10.1182/blood-2024-205479
Published: 2024
Journal Articles

Elucidating the Role of Tolerogenic Dendritic Cells in Immune Tolerance and Disease Progression in Multiple Myeloma

Mariko Ishibashi, Mika Sunakawa-Kii, Hiroki Yamaguchi, Rimpei Morita, Hideto Tamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 6596.
https://doi.org/10.1182/blood-2023-179078
Published: 2023
Journal Articles

DNAM-1/Tigit/CD155/CD112 Axis Is a Novel Target of NK-Cell Therapy in Acute Myeloid Leukemia

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai
Journal: Blood
Blood (2022) 140 (Supplement 1): 4514–4516.
https://doi.org/10.1182/blood-2022-164435
Published: 2022
Journal Articles

Mutational Analysis of DNMT3A Improves the Prognostic Stratification Using NPM1 / FLT3 -ITD Genotypes in Patients with Acute Myeloid Leukemia

Atsushi Marumo, Satoshi Wakita, Kaoru Morita, Shinichi Kako, Takashi Toya, Yuho Najima, Noriko Doki, Junya Kanda, Junya Kuroda, Shin-Ichiro Mori, Atsushi Satake, Kensuke Usuki, Toshimitsu Ueki, Nobuhiko Uoshima, Yutaka Kobayashi, Eri Kawata, Kazutaka Nakayama, Yuhei Nagao, Katsuhiro Shono, Motoharu Shibusawa, Jiro Tadokoro, Masao Hagihara, Hitoji Uchiyama, Naoyuki Uchida, Yasushi Kubota, Shinya Kimura, Hisao Nagoshi, Tatsuo Ichinohe, Saiko Kurosawa, Sayuri Motomura, Hashimoto Akiko, Hideharu Muto, Eriko Sato, Masao Ogata, Kenjiro Mitsuhashi, Jun Ando, Haruko Tashiro, Masahiro Sakaguchi, Shunsuke Yui, Kunihito Arai, Tomoaki Kitano, Miho Miyata, Takahiro Fukuda, Yoshinobu Kanda, Hiroki Yamaguchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8914–8916.
https://doi.org/10.1182/blood-2022-158686
Published: 2022
Journal Articles

Importance of the Duration of TKI Treatment in Treatment-Free Remission of Chronic Phase Chronic Myeloid Leukemia: Results of D-Free Trial

Chikashi Yoshida, Hiroki Yamaguchi, Noriko Doki, Kazunori Murai, Masaki Iino, Yoshihiro Hatta, Makoto Onizuka, Norio Yokose, Katsumichi Fujimaki, Masao Hagihara, Gaku Oshikawa, Kayoko Murayama, Takashi Kumagai, Shinya Kimura, Hideharu Muto, Kensuke Usuki, Kenji Yokoyama, Koh Yamamoto, Nobuyuki Aotsuka, Kenichi Ishizawa, Naoki Takezako, Takuto Miyagishima, Tadao Ishida, Atsushi Shinagawa, Kentaro Wakasa, Tsuyoshi Nakamaki, Naoto Tomita, Katsutoshi Ozaki, Takayoshi Itoh, Shugo Kowata, Kenji Tajika, Takayuki Fujio, Masahiro Onozawa, Masahide Yamamoto, Takeshi Kondo, Yuho Najima, Noriyoshi Iriyama, Ikuyo Tsutsumi, Koji Oba, Hiroshi Kojima, Hisashi Sakamaki, Koiti Inokuchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1477.
https://doi.org/10.1182/blood-2021-145483
Published: 2021
Journal Articles

The Presence of Minimal Residual Disease, As Determined By Highly Sensitive Quantitation of NPM1 -Mutatation, Provided Powerful Prognostic Information in Acute Myeloid Leukemia

Atsushi Marumo, MD, Hiroki Yamaguchi, Yuho Najima, MD PhD, Kensuke Usuki, MD PhD, Shinichi Kako, MD, Hitoji Uchiyama, Yuhei Nagao, Katsuhiro Shono, Saiko Kurosawa, Masao Hagihara, Junya Kanda, Yasushi Kubota, MD PhD, Jun Ando, Kenta Date, Marika Kuboyama, Masahiro Sakaguchi, Shunsuke Yui, Satoshi Wakita, Kunihito Arai, Tomoaki Kitano, Kazuhiko Kakihana, MD PhD, Takahiro Fukuda, Noriko Doki, MD PhD, Kazuteru Ohashi, MD PhD, Koiti Inokuchi, MD PhD Prof.
Journal: Blood
Blood (2019) 134 (Supplement_1): 5097.
https://doi.org/10.1182/blood-2019-127725
Published: 2019
Journal Articles

Classical Empiric Antifungal Therapy Vs. D-Index Guided Early Therapy Using Micafungin for Persistent Febrile Neutropenia (CEDMIC trial): A Randomized Controlled Trial from Japan FN Study Group

Shun-Ichi Kimura, MD PhD, Yoshinobu Kanda, MD PhD, Masaki Iino, MD PhD, Takahiro Fukuda, MD PhD, Emiko Sakaida, MD PhD, Tatsuo Oyake, Hiroki Yamaguchi, MD PhD, Shin-ichiro Fujiwara, MD PhD, Junji Suzumiya, MD PhD, Akinao Okamoto, MD PhD, Hiroyuki Fujita, MD PhD, Yasushi Takamatsu, MD PhD, Yoshio Saburi, MD PhD, Jun Yamanouchi, MD PhD, Itaru Matsumura, MD, Souichi Shiratori, Moritaka Gotoh, MD PhD, Shingen Nakamura, MD PhD, Kazuo Tamura, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 816.
https://doi.org/10.1182/blood-2018-99-111154
Published: 2018
Journal Articles

Clinical Sequencing of 347 Children with Acquired and Inherited Bone Marrow Failure Syndromes

Hideki Muramatsu, MD PhD, Yusuke Okuno, MD PhD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Sayoko Doisaki, Atsushi Narita, MD PhD, Hirotoshi Sakaguchi, MD PhD, Nozomu Kawashima, MD PhD, Xinan Wang, PhDMD, Yinyan Xu, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Asahito Hama, Masashi Sanada, MD PhD, Yoshiyuki Takahashi, MD PhD, Hitoshi Kanno, MDPhD, Hiroki Yamaguchi, MDPhD, Shouichi Ohga, Atsushi Manabe, MD PhD, Hideo Harigae, MD, Shinji Kunishima, PhD, Eiichi Ishii, MD PhD, Masao Kobayashi, MD PhD, Kenichi Koike, MD PhD, Kenichiro Watanabe, MD PhD, Etsuro Ito, MD PhD, Minoru Takata, MD PhD, Miharu Yabe, Seishi Ogawa, MD PhD, Satoru Miyano, PhD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2468.
https://doi.org/10.1182/blood.V130.Suppl_1.2468.2468
Published: 2017
Journal Articles

Amlexanox As a Possible Breakthrough Drug for MLL/AF4 -Positive Acute Lymphoblastic Leukemia

Hayato Tamai, MD PhD, Hiroki Yamaguchi, MD PhD, Koichi Miyake, MD PhD, Miyuki Takatori, Tomoaki Kitano, Syunsuke Yui, MD, Keiko Fukunaga, MD, Kazutaka Nakayama, MD PhD, Koiti Inokuchi, PhD MD
Journal: Blood
Blood (2016) 128 (22): 1590.
https://doi.org/10.1182/blood.V128.22.1590.1590
Published: 2016
Journal Articles

The Clinical Features and Prognostic Impact of PRDM16 gene Expression in Adult Acute Myeloid Leukemia

Genki Yamato, MD, Hiroki Yamaguchi, MD PhD, Hiroshi Handa, MD PhD, Norio Shiba, MD PhD, Satoshi Wakita, Koiti Inokuchi, MD PhD Prof, Yusuke Hara, MD, Kentaro Ohki, MD PhD, Jun Okubo, MD PhD, Manabu Sotomatsu, MD, Hirokazu Arakawa, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5228.
https://doi.org/10.1182/blood.V128.22.5228.5228
Published: 2016
Journal Articles

Analysis of Genetic Mutation of the Elderly Patients with Acute Myeloid Leukemia

Yusuke Fujiwara, MD, Hiroki Yamaguchi, MD PhD, Atsushi Marumo, Ikuko Omori, Satoshi Yamanaka, Kazuki Terada, MD, Shunsuke Yui, MD, Keiko Fukunaga, MD, Takeshi Ryotokuji, MD, Tsuneaki Hirakawa, Masahiro Okabe, Satoshi Wakita, Yoshiki Osaki, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Muneo Okamoto, Kazutaka Nakayama, MD PhD, Koiti Inokuchi, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5172.
https://doi.org/10.1182/blood.V128.22.5172.5172
Published: 2016
Journal Articles

The Prognostic Impact of KIT D816 Mutations in Core Binding Factor Acute Myeloid Leukemia

Shunsuke Yui, MD, Saiko Kurosawa, Hiroki Yamaguchi, MDPhD, Heiwa Kanamori, Toshimitsu Ueki, Nobuhiko Uoshima, Ishikazu Mizuno, Katsuhiro Shono, Kensuke Usuki, Yasushi Okoshi, Yukinori Nakamura, Masamitsu Yanada, MD PhD, Junya Kanda, Kenji Tajika, MD PhD, Seiji Gomi, MD PhD, Keiko Fukunaga, MD, Satoshi Wakita, Takeshi Ryotokuji, MD, Takahiro Fukuda, MD, Koiti Inokuchi, PhD MD
Journal: Blood
Blood (2016) 128 (22): 2785.
https://doi.org/10.1182/blood.V128.22.2785.2785
Published: 2016
Journal Articles

Profiling of somatic mutations in acute myeloid leukemia with FLT3 -ITD at diagnosis and relapse

Clinical Trials & Observations
Manoj Garg, Yasunobu Nagata, Deepika Kanojia, Anand Mayakonda, Kenichi Yoshida, Sreya Haridas Keloth, Zhi Jiang Zang, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ling-Wen Ding, Tamara Alpermann, Qiao-Yang Sun, De-Chen Lin, Wenwen Chien, Vikas Madan, Li-Zhen Liu, Kar-Tong Tan, Abhishek Sampath, Subhashree Venkatesan, Koiti Inokuchi, Satoshi Wakita, Hiroki Yamaguchi, Wee Joo Chng, Shirley-Kow Yin Kham, Allen Eng-Juh Yeoh, Masashi Sanada, Joanna Schiller, Karl-Anton Kreuzer, Steven M. Kornblau, Hagop M. Kantarjian, Torsten Haferlach, Michael Lill, Ming-Chung Kuo, Lee-Yung Shih, Igor-Wolfgang Blau, Olga Blau, Henry Yang, Seishi Ogawa, H. Phillip Koeffler
Journal: Blood
Blood (2015) 126 (22): 2491–2501.
https://doi.org/10.1182/blood-2015-05-646240
Published: 2015
Includes: Supplemental data
Journal Articles

Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy

Clinical Trials & Observations
Yasuyuki Arai, June Takeda, Kazunari Aoki, Tadakazu Kondo, Satoshi Takahashi, Yasushi Onishi, Yukiyasu Ozawa, Nobuyuki Aotsuka, Yasuji Kouzai, Hirohisa Nakamae, Shuichi Ota, Chiaki Nakaseko, Hiroki Yamaguchi, Koji Kato, Yoshiko Atsuta, Akiyoshi Takami
Journal: Blood
Blood (2015) 126 (3): 415–422.
https://doi.org/10.1182/blood-2015-04-642652
Published: 2015
Includes: Supplemental data
Journal Articles

The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Ikuko Omori, MD, Hiroki Yamaguchi, MD PhD, Tomoaki Kitano, Noriko Miyake, PhD, Koichi Miyake, MD PhD, Koiti Inokuchi, PhD MD
Journal: Blood
Blood (2014) 124 (21): 2224.
https://doi.org/10.1182/blood.V124.21.2224.2224
Published: 2014
Journal Articles

The Clinical and Genetic Features of Dyskeratosis Congenita, Cryptic Dyskeratosis Congenita, and Hoyeraal-Hreidarsson Syndrome in Japan

Hiroki Yamaguchi, MD PhD, Hirotoshi Sakaguchi, MD, Kenichi Yoshida, MD PhD, Miharu Yabe, MD PhD, Hiromasa Yabe, MD PhD, Yusuke Okuno, MD PhD, Hideki Muramatsu, MD PhD, Shunsuke Yui, Koiti Inokuchi, PhD MD, Etsuro Ito, MD PhD, Seishi Ogawa, MD PhD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1608.
https://doi.org/10.1182/blood.V124.21.1608.1608
Published: 2014
Journal Articles

Decision Analysis of Allogeneic Hematopoietic Stem Cell Transplantation Versus Chemotherapy in Cytogenetically Standard-Risk Acute Myeloid Leukemia in First Complete Remission: The Impact of FLT3-ITD Profile

Saiko Kurosawa, MD, Hiroki Yamaguchi, Takuhiro Yamaguchi, Keiko Fukunaga, Shunsuke Yui, Heiwa Kanamori, Kensuke Usuki, Nobuhiko Uoshima, Masamitsu Yanada, Katsuhiro Shono, Toshimitsu Ueki, Ishikazu Mizuno, Shingo Yano, Jin Takeuchi, Junya Kanda, Hiroshi Okamura, Kinuko Tajima, Yoshihiro Inamoto, Koiti Inokuchi, MD PhD, Takahiro Fukuda
Journal: Blood
Blood (2014) 124 (21): 1221.
https://doi.org/10.1182/blood.V124.21.1221.1221
Published: 2014