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Journal Articles

AML-Mrg Mutation Spectrum and Its Prognosis: A Japanese Multicenter Study HM01-02 Analysis with Full Analysis Sets

Naoko Hosono, Tomoki Naito, Sunggi Chi, Hironori Arai, Koichi Onodera, Kentaro Fukushima, Daisuke Ikeda, Satoshi Iyama, Akihiko Gotoh, Takayuki Ikezoe, Naoto Takahashi, Kensuke Kojima, Junya Kanda, Koji Izutsu, Suguru Fukuhara, Hirotaka Matsui, Goichi Yoshimoto, Junya Kuroda, Takahiro Yamauchi, Kensuke Usuki, Yosuke Minami
Journal: Blood
Blood (2024) 144 (Supplement 1): 6123.
https://doi.org/10.1182/blood-2024-202327
Published: 2024
Journal Articles

Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Joshua F Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Harry P. Erba, Kentaro Fukushima, Takahiro Shima, Neil D. Palmisiano, Eunice S. Wang, Uma Borate, Joseph Brandwein, Cristina Papayannidis, Pau Montesinos, Gina Keiffer, Yasushi Miyazaki, Naoko Hosono, Takayuki Ikezoe, Yoshiaki Ogawa, Timothy S Pardee, Stephen Anthony Strickland, Koichi Onodera, Shang-Ju Wu, Melissa G Ooi, Emmanuel Raffoux, Susana Vives, Alireza Eghtedar, Hongliang Cai, Curtis Allred, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 213.
https://doi.org/10.1182/blood-2024-194827
Published: 2024
Journal Articles

Analysis of On-Target and Off-Target Resistance Factors Associated with Gilteritinib Efficacy in Relapsed or Refractory AML Patients with FLT3 Mutations

Satoshi Iwata, Yuichi Ishikawa, Yoko Ushijima, Kotaro Miyao, Yasuhiko Harada, Takahiro Nishiyama, Naoko Hosono, Koichi Watamoto, Emiko Sakaida, Keiko Niimi, Miki Kobayashi, Kazutaka Ozeki, Tetsuya Nishida, Shingo Kurahashi, Yukiyasu Ozawa, Jeong Hui Kim, Seara Naruse, Marie Nakashima, Naomi Kawashima, Yachiyo Kuwatsuka, Hitoshi Kiyoi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6090.
https://doi.org/10.1182/blood-2024-199957
Published: 2024
Journal Articles

Efficacy and Safety of Cyclosporine Monotherapy for Patients with Non-Severe Aplastic Anemia Not Requiring Transfusions: Results from a Prospective Multicenter Phase II Study

Naoko Hosono, Ken Ishiyama, Hiroki Yamaguchi, Masahide Yamazaki, Hiroyuki Maruyama, Kensuke Usuki, Kazuki Tanimoto, Hiroyuki Sugiura, Noboru Asada, Seishi Ogawa, Yuzuru Kanakura, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2024-198830
Published: 2024
Journal Articles

Timing of Response with Gilteritinib Monotherapy in Relapsed or Refractory FLT3 -Mutated Acute Myeloid Leukemia

Alexander E. Perl, Mark J. Levis, Andrew Wei, Hee-je Kim, June-won Cheong, Yu Zhang, Jian Li, Hisayuki Yokoyama, Naoko Hosono, Nahla Hasabou, Dina Elsouda, Jamie Jung-Hee An, Jianxiang Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2889.
https://doi.org/10.1182/blood-2024-204831
Published: 2024
Journal Articles

NGS Profile and the Mathematical Prediction Model for Venetoclax Combination Therapy in HM-Screen-Japan 02 Study

Tomoaki Ueda, Kentaro Fukushima, Naoki Hosen, Sunggi Chi, Hiroshi Haeno, Goichi Yoshimoto, Hironori Arai, Daisuke Ikeda, Kensuke Usuki, Naoto Takahashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Kazuhito Yamamoto, Junya Kuroda, Yosuke Minami
Journal: Blood
Blood (2023) 142 (Supplement 1): 5761.
https://doi.org/10.1182/blood-2023-180339
Published: 2023
Journal Articles

Phase 1/2 First-in-Human Study of the Menin-MLL Inhibitor DSP-5336 in Patients with Relapsed or Refractory Acute Leukemia

Naval Daver, Joshua F. Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Kentaro Fukushima, Takayuki Ikezoe, Yoshiaki Ogawa, Joseph Brandwein, Eunice S. Wang, Yasushi Miyazaki, Timothy Pardee, Naoko Hosono, Takahiro Shima, Hisayuki Yokoyama, Noboru Asada, Joseph Jurcic, Hongliang Cai, Akinobu Watanabe, Matthew Hitron, Emily Brooks, Bo Xu, Jatin Shah, Hagop M. Kantarjian, Harry P. Erba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2911.
https://doi.org/10.1182/blood-2023-179252
Published: 2023
Journal Articles

Practical and Flexible Genome Profiling Study Using the Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System: HM-Screen-JAPAN02

Naoko Hosono, Takahiro Yamauchi, Chi Sung-Gi, Hironori Arai, Kentaro Fukushima, Daisuke Ikeda, Satoshi Iyama, Akihiko Gotoh, Takayuki Ikezoe, Chikashi Yoshida, Goichi Yoshimoto, Junya Kanda, Naoto Takahashi, Emiko Sakaida, Kensuke Usuki, Yosuke Minami
Journal: Blood
Blood (2023) 142 (Supplement 1): 2279.
https://doi.org/10.1182/blood-2023-184546
Published: 2023
Journal Articles

Evaluation of Hematopoiesis and Disease Status in Patients with Hematologic Malignancies Using Whole-Body Bone Marrow Imaging with 18 F-FLT PET/MRI

Hiroaki Araie, Naoko Hosono, Tetsuya Tsujikawa, Hidehiko Okazawa, Takahiro Yamauchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2272.
https://doi.org/10.1182/blood-2023-173237
Published: 2023
Journal Articles

Combining Inotuzumab Ozogamicin (IO) with PARP Inhibitors, Olaparib and Talazoparib, Exerts Synergistic Cytotoxicity By Inhibiting the Repair of IO-Induced DNA Strand Breaks in IO-Resistant ALL Cells

Naoko Ida, Miyuki Okura, Naoko Hosono, Takahiro Yamauchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 5804.
https://doi.org/10.1182/blood-2023-173907
Published: 2023
Journal Articles

Phase 1/2, Open-Label, Dose Escalation, Dose Expansion Study of Menin Inhibitor DSP-5336 in Adult Patients with Acute Leukemia with and without Mixed-Lineage Leukemia (MLL)-Rearrangement (R) or Nucleophosmin 1 (NPM1) Mutation (m)

Naval Daver, Takayuki Ikezoe, Justin Watts, Naoko Hosono, Yoshiaki Ogawa, Yasushi Miyazaki, Harry P. Erba, John Affinito, Emily Brooks, Ken Eguchi, Hongliang Cai, Bo Xu, Jay Stoudemire, Matthew Hitron, Akinobu Watanabe, Philip Komarnitsky, Junichiro Yuda
Journal: Blood
Blood (2022) 140 (Supplement 1): 3371–3372.
https://doi.org/10.1182/blood-2022-167674
Published: 2022
Journal Articles

A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System : HM-Screen-JAPAN02

Hironori Arai, SungGi Chi, Yoshikazu Utsu, Shinichi Masuda, Nobuyuki Aotsuka, Tomoaki Ueda, Kentaro Fukushima, Daisuke Ikeda, Naoko Hosono, Takahiro Yamauchi, Goichi Yoshimoto, Hiroto Horiguchi, Satoshi Iyama, Junya Kanda, Seiichiro Katagiri, Akihiko Gotoh, Daisuke Koyama, Takayuki Ikezoe, Takeshi Kondo, Yukinori Nakamura, Fumiya Ogasawara, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2022) 140 (Supplement 1): 10722–10724.
https://doi.org/10.1182/blood-2022-159351
Published: 2022
Journal Articles

Follow-up of patients with R/R FLT3- mutation–positive AML treated with gilteritinib in the phase 3 ADMIRAL trial

Clinical Trials & Observations
Alexander E. Perl, Richard A. Larson, Nikolai A. Podoltsev, Stephen Strickland, Eunice S. Wang, Ehab Atallah, Gary J. Schiller, Giovanni Martinelli, Andreas Neubauer, Jorge Sierra, Pau Montesinos, Christian Récher, Sung-Soo Yoon, Naoko Hosono, Masahiro Onozawa, Shigeru Chiba, Hee-Je Kim, Nahla Hasabou, Qiaoyang Lu, Ramon Tiu, Mark J. Levis
Journal: Blood
Blood (2022) 139 (23): 3366–3375.
https://doi.org/10.1182/blood.2021011583
Published: 2022
Includes: Supplemental data
Journal Articles

Genomic Analysis of NPM1 Mutation and KMT2A ( MLL )-Rearrangement/Amplification in Japanese Patients with Acute Myeloid Leukemia: Hematologic Malignancies (HM)-Screen-Japan 01

SungGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Yoshimasa Kamoda, Kensuke Usuki, Yoshikazu Utsu, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuyuki Nagata, Takaaki Ono, Naohito Fujishima, Naoto Takahashi, Hiroto Horiguchi, Satoshi Iyama, Makoto Nakamura, Kensuke Kojima, Kaoru Yamamoto, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2021) 138 (Supplement 1): 4460.
https://doi.org/10.1182/blood-2021-149425
Published: 2021
Journal Articles

Properties and Distribution of IDH-1/2 Mutations in Acute Myeloid Leukemia By the Comprehensive Genomic Analysis

Satoshi Uchiyama, Nakamura Hirotaka, SungGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Kensuke Usuki, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Takaaki Ono, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2021) 138 (Supplement 1): 4447.
https://doi.org/10.1182/blood-2021-149801
Published: 2021
Journal Articles

Genomic Analysis Focusing on RUNX1-RUNX1T1 in Japanese Patients with AML: HM-Screen-Japan 01

Seiichiro Katagiri, Daigo Akahane, Akihiko Gotoh, SungGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Kensuke Usuki, Yoshikazu Utsu, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Takaaki Ono, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinori Nakamura, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2021) 138 (Supplement 1): 4464.
https://doi.org/10.1182/blood-2021-148492
Published: 2021
Journal Articles

Hematologic Malignancies (HM)-Screen-Japan 01: A Mutation Profiling Multicenter Study on Patients with Acute Myeloid Leukemia

Naoko Hosono, Takahiro Yamauchi, SungGi Chi, Kentaro Fukushima, Hirohiko Shibayama, Seiichiro Katagiri, Akihiko Gotoh, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Kensuke Usuki, Yoshikazu Utsu, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Takaaki Ono, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2021) 138 (Supplement 1): 4457.
https://doi.org/10.1182/blood-2021-149960
Published: 2021
Journal Articles

Clinical Significance of FLT3 Mutations in a Comprehensive NGS Multicenter Study of AML: HM-Screen-Japan 01

Kentaro Fukushima, Hirohiko Shibayama, SungGi Chi, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Yoshimasa Kamoda, Kensuke Usuki, Yoshikazu Utsu, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Takaaki Ono, Naoto Takahashi, Satoshi Iyama, Makoto Nakamura, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
Journal: Blood
Blood (2021) 138 (Supplement 1): 2313.
https://doi.org/10.1182/blood-2021-146796
Published: 2021
Journal Articles

Phase 1 Study of Alvocidib (DSP-2033) in Combination with Cytarabine/Mitoxantrone (ACM) or Cytarabine/Daunorubicin (A+7+3) in Japanese Patients (Pts) with Acute Myeloid Leukemia (AML)

Yasuyoshi Morita, Takayuki Ikezoe, MD PhD, Kiyoshi Ando, Masahiro Onozawa, Takahisa Yamane, MD PhD, Naoko Hosono, MD PhD, Toru Kiguchi, Hiromi Iwasaki, Toshihiro Miyamoto, MD PhD, Miho Kasai, Saori Sugimoto, Yasushi Miyazaki, MD PhD, Masahiro Kizaki, MD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-134078
Published: 2020
Journal Articles

Interim Analysis of Hematologic Malignancies (HM)-Screen-Japan 01: A Mutation Profiling Multicenter Study of Patients with AML

Kenichi Miyamoto, MD, Kentaro Fukushima, MD PhD, SungGi Chi, MD PhD, Hirohiko Shibayama, MD PhD, Naoko Hosono, MD PhD, Takahiro Yamauchi, MD PhD, Seiichiro Katagiri, MDPhD, Akihiko Gotoh, MD PhD, Takanobu Morishita, MD, PhD, Masamitsu Yanada, MD PhD, Kazuhito Yamamoto, MD PhD, Naohito Fujishima, MD PhD, Naoto Takahashi, MD PhD, Reiki Ogasawara, MDPhD, Takeshi Kondo, MD PhD, Yoshikazu Utsu, MD PhD, Nobuyuki Aotsuka, MD PhD, Kensuke Usuki, MD PhD, Takaaki ONO, MD PhD, Tsutomu Kobayashi, MD PhD, Junya Kuroda, MD PhD, Hiroto Horiguchi, MDPhD, Satoshi Iyama, MD PhD, Suguru Fukuhara, MD PhD, Koji Izutsu, MD PhD, Makoto Nakamura, MD PhD, Kensuke Kojima, MD PhD, Yosuke Minami, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-139147
Published: 2020