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Emmanuel Raffoux
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Journal Articles

Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Joshua F Zeidner, Junichiro Yuda, Justin M. Watts, Mark J. Levis, Harry P. Erba, Kentaro Fukushima, Takahiro Shima, Neil D. Palmisiano, Eunice S. Wang, Uma Borate, Joseph Brandwein, Cristina Papayannidis, Pau Montesinos, Gina Keiffer, Yasushi Miyazaki, Naoko Hosono, Takayuki Ikezoe, Yoshiaki Ogawa, Timothy S Pardee, Stephen Anthony Strickland, Koichi Onodera, Shang-Ju Wu, Melissa G Ooi, Emmanuel Raffoux, Susana Vives, Alireza Eghtedar, Hongliang Cai, Curtis Allred, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 213.
https://doi.org/10.1182/blood-2024-194827
Published: 2024
Journal Articles

Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study

Hervé Dombret, Alexandra Coelho, Laurène Fenwarth, Jean-Baptiste Micol, Lionel Ades, Thomas Cluzeau, Emmanuel Raffoux, Sylvain Chantepie, Pierre Arnautou, Mathieu Leclerc, Delphine Lebon, Thorsten Braun, Ollivier Legrand, Claire Bories, Céline Berthon, Juliette Lambert, Ahmad Aljijakli, Emilie Lemasle, Pascal Turlure, Benjamin Carpentier, Jamile Frayfer, Stephanie Haiat, Ambroise Marcais, Isabelle Plantier, Kevin-James Wattebled, Madalina Uzunov, Iona Vaida, Mael Heiblig, Lauris Gastaud, Laure Farnault, Dominique Penther, Nicole Raus, Renaud Buffet, Karine Celli-Lebras, Claude Preudhomme, Nicolas Duployez, Raphael Itzykson, Stephane De Botton
Journal: Blood
Blood (2024) 144 (Supplement 1): 2424.
https://doi.org/10.1182/blood-2024-207226
Published: 2024
Journal Articles

Secondary Genetic Alterations and Measurable Residual Disease in Core Binding Factor Acute Myeloid Leukemia - a Study from the Acute Leukemia French Intergroup

Loic Vasseur, Matthieu Duchmann, Nicolas Duployez, Emmanuel Raffoux, Celine Berthon, Mael Heiblig, Alexis Genthon, Thorsten Braun, Mathieu Leclerc, Delphine Lebon, Sylvain Chantepie, Jean-Baptiste Micol, Juliette Lambert, Christian Recher, Marie-Lorraine Chrétien, Thomas Cluzeau, Julien Vaidie, Jean-Valère Malfuson, Madalina Uzunov, Arnaud Pigneux, Pierre Peterlin, Sihem Tarfi, Pierre Hirsch, Dominique Penther, Eric Jourdan, Karine Celli-Lebras, Claude Preudhomme, Hervé Dombret, Jérôme Lambert, Nicolas Boissel, Raphael Itzykson
Journal: Blood
Blood (2024) 144 (Supplement 1): 227.
https://doi.org/10.1182/blood-2024-194060
Published: 2024
Journal Articles

IL-1RAP Is a Targetable Surface Antigen in Relapsed/Refractoy AML

Mohamad Sabbah, Morgane Fontaine, Kim Pacchiardi, Alexis Delabrière, Stephane De Botton, Catherine Lonchamp, Renaud Buffet, Laure Farnault, Jean-Baptiste Micol, Typhaine Dumas-Rivero, Emmanuel Raffoux, Lionel Ades, Nicolas Boissel, Juliette Lambert, Kevin-James Wattebled, Matthieu Duchmann, Karine Celli-Lebras, Alexandra Coelho, Hervé Dombret, Edouard De Dreuzy, Marina Deschamps, Christophe Ferrand, Jens Hasskarl, Richard Sainson, Raphael Itzykson
Journal: Blood
Blood (2024) 144 (Supplement 1): 4311.
https://doi.org/10.1182/blood-2024-199673
Published: 2024
Journal Articles

JAK Inhibition Results in Aggressive Cutaneous Squamous Cell Carcinoma through MAPK Pathway Activation and Shapes the Tumor Immune Microenvironment to Create Novel Therapeutic Opportunities

Helene Pasquer, Valeria Bisio, Antoine Forget, Maxime Battistella, Barouyr Baroudjian, Raphael Marie, Emmanuelle Latour, Cecile Culeux, Lea Pelissier, Blandine Roux, Khansa Saadallah, Matthieu Duchmann, Thierry Tchenio, Abdellah Tebani, Amandine Gouverneur, Fanelie Jouenne, Jerome Lambert, Isabelle Madelaine, Lionel Ades, Emmanuel Raffoux, Pernelle Noize, Bruno Cassinat, Soumeya Bekri, Juliette Soret-Dulphy, Samia Mourah, Camille Lobry, Alexandre Puissant, Jean-Jacques Kiladjian, Nicolas Dulphy, Celeste Lebbe, Lina Benajiba
Journal: Blood
Blood (2024) 144 (Supplement 1): 4513.
https://doi.org/10.1182/blood-2024-205839
Published: 2024
Journal Articles

Cerebrospinal fluid distribution and pharmacokinetics of ponatinib in Ph1 + acute lymphoblastic leukemia

Pierre Walczak, Sofiane Fodil, Nicolas Vignal, Aurélie Cabannes-Hamy, Nicolas Boissel, Emmanuel Raffoux, Jean-Michel Cayuela, Lauriane Goldwirt, Etienne Lengliné
Journal: Blood
Blood (2024) 144 (10): 1127–1130.
https://doi.org/10.1182/blood.2024024838
Published: 2024
Journal Articles

Nilotinib with or without cytarabine for Philadelphia-positive acute lymphoblastic leukemia

Clinical Trials & Observations
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Céline Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Véronique Lhéritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2024) 143 (23): 2363–2372.
https://doi.org/10.1182/blood.2023023502
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic alterations and MRD refine risk assessment for KMT2A -rearranged B-cell precursor ALL in adults: a GRAALL study

Rathana Kim, Hugo Bergugnat, Cédric Pastoret, Florence Pasquier, Emmanuel Raffoux, Lise Larcher, Marie Passet, Nathalie Grardel, Eric Delabesse, Susanne Kubetzko, Aurélie Caye-Eude, Claus Meyer, Rolf Marschalek, Marine Lafage-Pochitaloff, Anne Thiebaut-Bertrand, Marie Balsat, Martine Escoffre-Barbe, Sabine Blum, Michael Baumann, Anne Banos, Nicole Straetmans, Maria-Pilar Gallego-Hernanz, Yves Chalandon, Carlos Graux, Jean Soulier, Thibaut Leguay, Mathilde Hunault, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2023) 142 (21): 1806–1817.
https://doi.org/10.1182/blood.2023021501
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax in Combination with Intermediate Doses of Cytarabine in Consolidation Phase for Acute Myeloid Leukemia Patients in First Complete Remission; Results of the Part 1 of the Phase 1/2 Multicentric Covenidac Study

Lauris Gastaud, Pierre Peterlin, Mathilde Hunault, Emmanuel Raffoux, Sarah Bertoli, Martin Carré, Cecile Pautas, Sylvain Chantepie, Juliette Lambert, Nicolas Duployez, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Vey, Arnaud Pigneux, Eric Delabesse, Claude Preudhomme, Adriana Plesa, Francois Vergez, Jean-François Hamel, Herve Dombret, Christian Recher
Journal: Blood
Blood (2023) 142 (Supplement 1): 4261.
https://doi.org/10.1182/blood-2023-173656
Published: 2023
Journal Articles

Gemtuzumab Ozogamicin for Patients with Newly Diagnosed CD33 Positive Acute Myeloid Leukemia: Results from a French Retrospective Observational Study

Juliette Lambert, Emmanuel Raffoux, Delphine Lebon, Thorsten Braun, Mael Heiblig, Alberto Santagostino, Karin Gogat-Marchant, Cécile Pautas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2893.
https://doi.org/10.1182/blood-2023-179575
Published: 2023
Journal Articles

The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia

Camille Vaganay, Frank Ling, Lois M. Kelly, Duong Ho Nhat, Antoine Forget, Paul-Arthur Meslin, Hélène Pasquer, Rathana Kim, Marie Passet, Sofiane Fodil, Tony Huynh, Angela H Su, Christopher F Bassil, Matthieu Duchmann, Gabriela Alexe, Gael Fortin, Carine Legrand, Khansa Saadallah, Christopher Delaney, Kim Pacchiardi, Anja Kocijancic, Lisa Aziez, Nina Fenouille, Marie Sebert, Lionel Ades, Emmanuel Raffoux, Emmanuelle Clappier, Lina Benajiba, Kimberly Stegmaier, Kris C. Wood, Raphael Itzykson, Camille Lobry, Alexandre Puissant
Journal: Blood
Blood (2023) 142 (Supplement 1): 409.
https://doi.org/10.1182/blood-2023-186264
Published: 2023
Journal Articles

Impact of Arsenic Trioxide in the Treatment of Higher Risk Acute Promyelocytic Leukemia

Audrey Da Rocha, Bruno Cassinat, Mael Heiblig, Christian Recher, Sarah Bertoli, Caroline Bonmati, Gabrielle Roth-Guepin, Anne Zilliox, Marie Laloi, Mathilde Hunault, Céline Berthon, Nicolas Duployez, Christophe Willekens, Maria Pilar Gallego Hernanz, Marlene Ochmann, Thomas Cluzeau, Fatiha Chermat, Alexis Caulier, Emmanuel Raffoux, Pierre Fenaux, Jean Pierre Marolleau, Lionel Ades, Delphine Lebon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1471.
https://doi.org/10.1182/blood-2023-174446
Published: 2023
Journal Articles

Current Results of Intensive Therapy in Younger Adults with Acute Myeloid Leukemia (AML): The Large Randomized French Backbone Intergroup (BIG)-1 Study on Behalf of the Filo, ALFA, and SFGM-TC Study Groups

Hunault-Berger Mathilde, Cécile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Tony Marchand, Marie Anne Hospital, Mael Heiblig, Sylvain Chantepie, Martin Carré, Pierre Peterlin, Emilie Lemasle, Célestine Simand, Maria Pilar Gallego Hernanz, Anne Huynh, Edouard Forcade, Raynier Devillier, Stéphanie Nguyen Quoc, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Gerard Socié, Jean-Yves Cahn, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Arnaud Pigneux, Christian Recher, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 967.
https://doi.org/10.1182/blood-2023-179376
Published: 2023
Journal Articles

Long-Term Real-World Experience of CPX-351 in Combined French-Italian Cohorts Identified High Rate of Negative Measurable Residual Disease (MRD) and Prolonged Overall Survival

Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahmé, Sarah Bertoli, Livio Pagano, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Mohamad Mohty, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina Dargenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christian Recher, Norbert Vey, Francesco Grimaldi, Lionel Ades, Roberto Massimo Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 4255.
https://doi.org/10.1182/blood-2023-177951
Published: 2023
Journal Articles

Characteristics of Germline CHEK2 Mutated Patients in a Large Cohort of 2322 Myeloid Malignancies

Lucie Freiman, Lise Larcher, Giulia Tueur, Nadia Vasquez, Mélanie Da Costa, Emmanuel Raffoux, Lionel Ades, Pierre Fenaux, Jean Soulier, Emmanuelle Clappier, Raphael Itzykson
Journal: Blood
Blood (2022) 140 (Supplement 1): 4082–4083.
https://doi.org/10.1182/blood-2022-158799
Published: 2022
Journal Articles

Fractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL): Results of the EWALL-INO Study

Patrice Chevallier, Thibault Leguay, Rathana KIM, Marc Delord, Michael Doubek, Francoise Huguet, Aurelie Cabannes-Hamy, Ulla Wartiovaara-Kautto, Colombe Saillard, Emmanuel Raffoux, Thomas Cluzeau, Stephane Lepretre, Marie Balsat, Anna Berceanu, Nicolas Boissel, Claude Gardin, Emmanuelle Clappier, Herve Dombret, Philippe Rousselot
Journal: Blood
Blood (2022) 140 (Supplement 1): 6114–6116.
https://doi.org/10.1182/blood-2022-166035
Published: 2022
Journal Articles

Gilteritinib Activity in Refractory or Relapsed FLT3 -Mutated Acute Myeloid Leukemia Patients Previously Treated By Intensive Chemotherapy and Midostaurin: A Study from the French AML Intergroup ALFA/Filo

Pierre-Yves Dumas, Emmanuel Raffoux, Emilie Berard, Sarah Bertoli, Marie Anne Hospital, Mael Heiblig, Yohan Desbrosses, Caroline Bonmati, Cecile Pautas, Juliette Lambert, Corentin Orvain, Anne Banos, Florence Pasquier, Pierre Peterlin, Tony Marchand, Madalina Uzunov, Jamilé Frayfer, Pascal Turlure, Thomas Cluzeau, Eric Jourdan, Chantal Himberlin, Emmanuelle Tavernier, Alban Villate, Stéphanie Haiat, Marie-Lorraine Chretien, Martin Carre, Sylvain Chantepie, Iona Vaida, Mathieu Wemeau, Safia Chebrek, Gaëlle Guillerm, Romain Guieze, Houria Debarri, Eve Gehlkopf, Kamel Laribi, Ambroise Marçais, Alberto Santagostino, Marie C Bene, Ariane C Mineur, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2022) 140 (Supplement 1): 8996–8998.
https://doi.org/10.1182/blood-2022-159125
Published: 2022
Journal Articles

Distinct Clinico-Molecular Arterial and Venous Thrombotic Scoring Systems for MPN Patients Risk Stratification

Hélène Pasquer, Rafael Daltro De Oliveira, Juliette Soret, Nabih Maslah, Lin-Pierre Zhao, Clemence Marcault, Marine Cazaux, Nicolas Gauthier, Emmanuelle Verger, Nathalie Parquet, William Vainchenker, Emmanuel Raffoux, Stephane Giraudier, Bruno Cassinat, Jean-Jacques Kiladjian, Lina Benajiba
Journal: Blood
Blood (2022) 140 (Supplement 1): 830–831.
https://doi.org/10.1182/blood-2022-160329
Published: 2022
Journal Articles

JAK Inhibition Mediates Clonal Selection of RAS Pathway Mutations in Myeloproliferative Neoplasms

Nabih Maslah, Blandine Roux, Nina Kaci, Emmanuelle Verger, Rafael Daltro De Oliveira, Hélène Pasquer, Nicolas Gauthier, Juliette Soret, Saravanan Ganesan, Panhong Gou, Frank Ling, Nathalie Parquet, William Vainchenker, Emmanuel Raffoux, Rose Ann Padua, Stephane Giraudier, Alexandre Puissant, Camille Lobry, Jean-Jacques Kiladjian, Bruno Cassinat, Lina Benajiba
Journal: Blood
Blood (2022) 140 (Supplement 1): 795–796.
https://doi.org/10.1182/blood-2022-167719
Published: 2022
Journal Articles

In silico and Functional Studies for Classification of EPAS1/HIF2A Genetic Variants Identified in Patients with Erythrocytosis

Valéna Karaghiannis, Darko Maric, Céline Garrec, Nada Maaziz, Alexandre Buffet, Vincent Antunes, Amandine le Roy, Fabrice Airaud, Bernard Aral, Loic Schmitt, Sébastien Corbineau, Lamisse Mansour-Hendili, Valentine Lesieur, Antoine Rimbert, Fabien Laporte, Marine Delamare, Stephane Bezieau, Bruno Cassinat, Frédéric Galactéros, Anne-Paule Gimenez-Roqueplo, Nelly Burnichon, Holger Cario, Richard van Wijk, Celeste Bento, Anaise Blouet, Juliette Bouteloup, Françoise Boyer perrard, Aisha Aiko Bruce, Emilie Cayssials, Nicole Casadevall, Brieuc Cherel, Marielaure Couec, Louis Drevon, Cecile Dumesnil, Thierry Lamy De La Chapelle, Marion Gambart, Loic Garcon, Brigitte Granel, Pierre Hirsch, Agnès Lahary, Amira Mejri, Sandrine Meunier, Franck E. Nicolini, Emmanuel Raffoux, Dana Ranta, Nicolas Schleinitz, Jean Baptiste Valentin, Mathieu Wemeau, Francois Girodon, David Hoogewijs, Betty Gardie, Olivier Hermine
Journal: Blood
Blood (2022) 140 (Supplement 1): 8157–8158.
https://doi.org/10.1182/blood-2022-163123
Published: 2022