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Dimitri Breems
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Journal Articles

Monotherapy update from Phase 1 portion in Phase1/2 trial of the menin-MLL inhibitor enzomenib (DSP-5336) in patients with relapsed or refractory acute leukemia

Free
Naval Daver, Joshua Zeidner, Justin Watts, Junichiro Yuda, Mark Levis, Pau Montesinos, Cristina Papayannidis, Kentaro Fukushima, Takahiro Shima, Emmanuel Raffoux, Uma Borate, Neil Palmisiano, Joseph Brandwein, Mael Heiblig, Yasushi Miyazaki, Takayuki Ikezoe, Melissa Ooi, Shang-Ju Wu, Eunice Wang, Susana Vives, Stephen Strickland, Dimitri Breems, Naoko Hosono, Yoshiaki Ogawa, Koichi Onodera, Andrew Brunner, Gina Keiffer, Timothy Pardee, Paul Shami, Alireza Eghtedar, Hongliang Cai, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop Kantarjian, Harry Erba
Journal: Blood
Blood (2025) 146 (Supplement 1): 763.
https://doi.org/10.1182/blood-2025-763
Published: 2025
Journal Articles

Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)

Free
Marc Raaijmakers, Hartmut Döhner, Dimitri Breems, John Byrd, Konstanze Döhner, Jordi Esteve, Bjørn Gjertsen, Patrycja Gradowska, Gerwin A. Huls, Ain Kaare, Heeje Kim, Hitoshi Kiyoi, Mika Kontro, Janusz Krawczyk, Vladimir Lazarevic, Andrea Lenartova, Alice Mims, Jeannine Refos, Christoph Röllig, Anika Schrade, Karolina Sikorska, Alexandre Theocharides, Peter Valk, Adriano Venditti, Jianxiang Wang, Andrew Wei, Agnieszka Wierzbowska, Andrius Zucenka, Lucille Ferrante, Christina Drenberg Guttke, Angélique Langlois, Christina Loefgren, Kathryn Packman, Prathap Nagaraja Shastri, Natasha Schuier, Meena Thayu, Danielle Trancucci, Bob Lowenberg, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1654.
https://doi.org/10.1182/blood-2025-1654
Published: 2025
Journal Articles

Pacritinib in transplant-eligible myelofibrosis: Final analysis of the phase 2 HOVON-134 trial

Free
Ruben Van Dijck, Bronno van der Holt, Annoek Broers, Ellen Meijer, Timothy Devos, Mette Hazenberg, Marjolein Van Der Poel, Dimitri Breems, Lien Deleu, Christel van Hooije, Jan J. Cornelissen, Nicolaas Schaap, Peter te Boekhorst
Journal: Blood
Blood (2025) 146 (Supplement 1): 6068.
https://doi.org/10.1182/blood-2025-6068
Published: 2025
Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Free
Lok Lam Ngai, Diana Hanekamp, Angèle Kelder, Willemijn Scholten, Jannemieke Carbaat-Ham, Mona M.H.E Fayed, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Tim R. Mocking, Vincent H.J. Van Der Velden, Jennichjen Slomp, Willemijn Hobo, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Arjan A. van de Loosdrecht, Gert Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2023-181709
Published: 2023
Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Free
Lok Lam Ngai, Coen R. Veenstra, Patrycja Gradowska, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Jesse M. Tettero, Costa Bachas, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Canan Alhan, Theresia M. Westers, Peter J. M. Valk, David C. de Leeuw, Bob Lowenberg, Gert Ossenkoppele, Jacqueline Cloos, Arjan A. van de Loosdrecht
Journal: Blood
Blood (2023) 142 (Supplement 1): 323.
https://doi.org/10.1182/blood-2023-184703
Published: 2023
Journal Articles

A Novel Prognostic Model for Patients with Acute Myeloid Leukemia in First Relapse with Improved Prognostic Accuracy

Free
Niek G. Van Der Maas, Dimitri Breems, Clara Klerk, Thomas Pabst, Patrycja Gradowska, Bart J. Biemond, Jurgen Kuball, Janine Van Elssen, Otto Visser, Marie-Christiane Vekemans, Carlos Graux, Johan Maertens, H. Berna Beverloo, Peter J. M. Valk, Gert J. Ossenkoppele, Bob Lowenberg, Geert A. Huls, Jan J. Cornelissen, Jurjen Versluis
Journal: Blood
Blood (2023) 142 (Supplement 1): 724.
https://doi.org/10.1182/blood-2023-180812
Published: 2023
Journal Articles

Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients

Free
Clinical Trials & Observations
Gerwin Huls, Dana A. Chitu, Violaine Havelange, Mojca Jongen-Lavrencic, Arjan A. van de Loosdrecht, Bart J. Biemond, Harm Sinnige, Beata Hodossy, Carlos Graux, Rien van Marwijk Kooy, Okke de Weerdt, Dimitri Breems, Saskia Klein, Jürgen Kuball, Dries Deeren, Wim Terpstra, Marie-Christiane Vekemans, Gert J. Ossenkoppele, Edo Vellenga, Bob Löwenberg, the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Journal: Blood
Blood (2019) 133 (13): 1457–1464.
https://doi.org/10.1182/blood-2018-10-879866
Published: 2019
Includes: Supplemental data
Journal Articles

Clofarabin Added to Standard Treatment in Adult Patients with Newly Diagnosed ALL: First Results of the Randomized Phase III HOVON-100 Study

Free
A. W. Rijneveld, Bronno van der Holt, Okke de Weerdt, MD, Bart J. Biemond, MD PhD, Arjen van de Loosdrecht, Eefke Petersen, MD, Mar Bellido, Harry C. Schouten, MD, Walter J F M van der Velden, Dominik Selleslag, Martin R. Schipperus, Constantijn J.M. Halkes, Saskia Klein, MD, Violaine Havelange, Marinus van Marwijk Kooij, MD PhD, Marie-Cecile Legdeur, Jeannine Refos, Vincent van der Velden, PhD, Jan J Cornelissen, Crista Homburg, Valerie de Haas, MD PhD, Dries Deeren, MD, Alain Gaddiseur, Harm Sinnige, Dimitri Breems, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2606.
https://doi.org/10.1182/blood.V130.Suppl_1.2606.2606
Published: 2017
Journal Articles

Randomized Maintenance Therapy with Azacitidine (Vidaza) in Older Patients (≥ 60 years of age) with Acute Myeloid Leukemia (AML) and Refractory Anemia with Excess of Blasts (RAEB, RAEB-t). Results of the HOVON97 Phase III Randomized Multicentre Study (EudraCT 2008-001290-15)

Free
Geert Huls, MD PhD, Dana Chitu, Violaine Havelange, Mojca Jongen-Lavrencic, MD PhD, Arjen van de Loosdrecht, Bart J. Biemond, MD PhD, Harm Sinnege, MDPhD, Beata Hodossy, Carlos Graux, Marinus van Marwijk Kooij, MD PhD, Okke de Weerdt, MD, Dimitri Breems, MD PhD, Saskia Klein, MD, Jurgen Kuball, MD, Gert J. Ossenkoppele, MD PhD, Bob Lowenberg, MD PhD, Edo Vellenga, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 463.
https://doi.org/10.1182/blood.V130.Suppl_1.463.463
Published: 2017
Journal Articles

Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)

Free
Clinical Trials & Observations
Gert J. Ossenkoppele, Georg Stussi, Johan Maertens, Kees van Montfort, Bart J. Biemond, Dimitri Breems, August Ferrant, Carlos Graux, Georgine E. de Greef, C. J. M. Halkes, Mels Hoogendoorn, Rene M. Hollestein, Mojca Jongen-Lavrencic, Mark D. Levin, Arjan A. van de Loosdrecht, Marinus van Marwijk Kooij, Yvette van Norden, Thomas Pabst, Harry C. Schouten, Edo Vellenga, Gregor E. G. Verhoef, Okke de Weerdt, Pierre Wijermans, Jakob R. Passweg, Bob Löwenberg
Journal: Blood
Blood (2012) 120 (24): 4706–4711.
https://doi.org/10.1182/blood-2012-04-420596
Published: 2012
Includes: Supplemental data
Journal Articles

CHR-2845, a Monocyte/Macrophage Targeted Histone Deacetylase Inhibitor In a First In Man Clinical Trial In Subjects with Advanced Haematological Malignancies

Free
Gert Ossenkoppele, MD, PhD, Bob Lowenberg, MD, PhD, Pierre Zachee, MD, PhD, Norbert Vey, Dimitri Breems, MD, PhD, Arjan A. Van de Loosdrecht, MD, PhD, Phillip Debnam, PhD, Lindsey Needham, PhD, Lindsay Bawden, PhD, Leon Hooftman, MD
Journal: Blood
Blood (2010) 116 (21): 3279.
https://doi.org/10.1182/blood.V116.21.3279.3279
Published: 2010
Journal Articles

Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study

Free
Clinical Trials & Observations
Bob Löwenberg, Joachim Beck, Carlos Graux, Wim van Putten, Harry C. Schouten, Leo F. Verdonck, Augustin Ferrant, Pieter Sonneveld, Mojca Jongen-Lavrencic, Marie von Lilienfeld-Toal, Bart J. Biemond, Edo Vellenga, Dimitri Breems, Hilde de Muijnck, Ron Schaafsma, Gregor Verhoef, Hartmut Döhner, Alois Gratwohl, Thomas Pabst, Gert J. Ossenkoppele, Johan Maertens, for the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), German Austrian AML Study Group (AMLSG), Swiss Group for Clinical Cancer Research Collaborative Group (SAKK)
Journal: Blood
Blood (2010) 115 (13): 2586–2591.
https://doi.org/10.1182/blood-2009-10-246470
Published: 2010
Journal Articles

Treatment of Older Patients, 40 to 70 Years of Age, with Acute Lymphoblastic Leukemia According to a Chemotherapy Regimen That Includes a Novel Pre-Phase for Rapid Tumor Load Reduction. Results of the Dutch-Belgian HOVON-71 Study.

Free
Simon M. G. J. Daenen, Bronno van der Holt, Adriaan W. Dekker, Roelof Willemze, Anita Rijneveld, Bart J. Biemond, Petra Muus, Arjan A van de Loosdrecht, Harry Schouten, M. van Marwijk Kooy, Dimitri Breems, Johan Maertens, Hilde Demuynck, Pierre W Wijermans, Shulamiet Wittebol, Ellen W. de Klerk, Jan J. Cornelissen
Journal: Blood
Blood (2009) 114 (22): 2028.
https://doi.org/10.1182/blood.V114.22.2028.2028
Published: 2009
Journal Articles

A Phase I Study of CHR-2797, an Orally Active Aminopeptidase Inhibitor in Elderly and/or Treatment Refractory Patients with Acute Myeloid Leukemia or Multiple Myeloma.

Free
Faith Davies, MD, Gert Ossenkoppele, MD, Pierre Zachee, MD, Richard Noppeney, MD, Alan Burnett, MD, Michel Delforge, MD, Pieter Sonneveld, MD, Gareth Morgan, MD, Sonja Zweegman, MD, Dimitri Breems, MD, Alison Richardson, PhD, Leon Hooftman, MD, Bob Lowenberg, MD
Journal: Blood
Blood (2007) 110 (11): 443.
https://doi.org/10.1182/blood.V110.11.443.443
Published: 2007