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Journal Articles

A Study on Experimentally Induced Thrombus Formation in JAK2-V617F and Calr-del52 Mouse Models Using Ligation of the Inferior Vena Cava (IVC)

Vikas Bhuria, Martin Böttcher, Vanja Zeremski, Andreas Müller, Dimitrios Mougiakakos, Thomas Fischer
Journal: Blood
Blood (2024) 144 (Supplement 1): 4521.
https://doi.org/10.1182/blood-2024-210931
Published: 2024
Journal Articles

JAK2-V617F Promotes up-Regulation of Pro-Inflammatory Cytokines Including IL-1 upon Adhesion-Induced Activation of β1/β2 Integrins

Conny K. Baldauf, Emmanouil Charakopoulos, Martin Böttcher, Vanja Zeremski, Dimitrios Mougiakakos, Burkhart Schraven, Thomas Fischer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2023-174058
Published: 2023
Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Lok Lam Ngai, Coen R. Veenstra, Patrycja Gradowska, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Jesse M. Tettero, Costa Bachas, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Canan Alhan, Theresia M. Westers, Peter J. M. Valk, David C. de Leeuw, Bob Lowenberg, Gert Ossenkoppele, Jacqueline Cloos, Arjan A. van de Loosdrecht
Journal: Blood
Blood (2023) 142 (Supplement 1): 323.
https://doi.org/10.1182/blood-2023-184703
Published: 2023
Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Lok Lam Ngai, Diana Hanekamp, Angèle Kelder, Willemijn Scholten, Jannemieke Carbaat-Ham, Mona M.H.E Fayed, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Tim R. Mocking, Vincent H.J. Van Der Velden, Jennichjen Slomp, Willemijn Hobo, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Arjan A. van de Loosdrecht, Gert Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2023-181709
Published: 2023
Journal Articles

Proteomic Profiling and Cytokine Analysis Reveals Molecular Signatures and Inflammatory Factors Associated with Thrombosis in JAK2-V617F Positive Myeloproliferative Neoplasm (MPN) Cohorts

Vikas Bhuria, Marco van Ham, Katrin Vogel, Ana Waldleben, Vanja Zeremski, Martin Böttcher, Monika Brunner-Weinzierl, Dimitrios Mougiakakos, Burkhart Schraven, Lothar Jänsch, Thomas Fischer
Journal: Blood
Blood (2023) 142 (Supplement 1): 6340.
https://doi.org/10.1182/blood-2023-174835
Published: 2023
Journal Articles

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Clinical Trials & Observations
Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A. M. A. Hofland, Mona M. H. E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 141 (21): 2657–2661.
https://doi.org/10.1182/blood.2022019160
Published: 2023
Includes: Supplemental data
Journal Articles

Measurable Residual Disease Guided Therapy in Intermediate-Risk AML Patients Compared to an Unguided Cohort Using Propensity Score Matching

Jesse M. Tettero, Lok Lam Ngai, Costa Bachas, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Patrycja Gradowska, Laimonas Griskevicius, Jeroen J.W.M. Janssen, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob Passweg, Kimmo Porkka, Peter JM Valk, Bob Lowenberg, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 2027–2029.
https://doi.org/10.1182/blood-2022-157009
Published: 2022
Journal Articles

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Patrycja Gradowska, Bob Lowenberg, David C. de Leeuw, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 9125–9127.
https://doi.org/10.1182/blood-2022-157753
Published: 2022
Journal Articles

Reveal the Neutrophil: Elucidating the Role of a Neutrophil-Specific JAK2-V617F Mutation

Tobias Ronny Haage, MD, Andreas Johann Müller, Priyadharshini Arunachalam, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2965.
https://doi.org/10.1182/blood-2019-122660
Published: 2019
Journal Articles

TNFR1 Blockade Rather then TNFR2 Blockade Reduces Chronic Inflammation in JAK2 +/V617F Mice

Peter Müller, PhD, Bärbel Edelmann-Stephan, PhD, Fabian Richter, PhD, Klaus Pfizenmaier, PhD, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2966.
https://doi.org/10.1182/blood-2019-127997
Published: 2019
Journal Articles

Incidence, Risk Factors, Treatment and Long Term Outcome of Refractory and First Relapse AML Patients in the OSHO Studies

Dietger Niederwieser, MD, Rainer Krahl, PhD, Christoph Kahl, MD, Hans-Heinrich Wolf, MD, Sebastian Scholl, Michael Cross, PhD, Ute Hegenbart, MD, Norma Peter, MD, Christian Niederwieser, MD, Axel Florschütz, Kolija Reifenrath, Niklas Zojer, Christian Jakob, MD, Christian Junghanss, MD, Herbert G. Sayer, MD PhD, Volker Schmidt, Sebastian Schwind, MD, Georg Maschmeyer, MD, Thomas Fischer, MD, Andreas Hochhaus, MD, Haifa Kathrin Al-Ali, MD, Thomas Heinicke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1358.
https://doi.org/10.1182/blood-2019-125262
Published: 2019
Journal Articles

In Vivo Blockade of Beta-1 and Beta-2 Integrin Activity Inhibits Splenomegaly in JAK2-V617F Positive Myeloproliferative Disease

Linda Poschmann, Bärbel Edelmann-Stephan, PhD, Peter Müller, PhD, Frank Angenstein, MD, Thomas Fischer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1778.
https://doi.org/10.1182/blood-2018-99-114675
Published: 2018
Journal Articles

Therapeutic Potential of Axl Blockade in BCR-ABL Negative Myeloproliferative Neoplasms (MPN)

Antonia Beitzen-Heineke, MD, Isabel Ben Batalla, PhD, Nikolaus Berenbrok, Sarina Paesler, Victoria Gensch, Gunhild von Amsberg, Philippe Schafhausen, MD, Kristoffer Riecken, PhD, Thomas Fischer, MD, Klaus Pantel, MD, PhD, Carsten Bokemeyer, MD, PhD, Sonja Loges, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3063.
https://doi.org/10.1182/blood-2018-99-118175
Published: 2018
Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, Peter Valent, Mariusz A. Wasik, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2018) 132 (1): 67–77.
https://doi.org/10.1182/blood-2018-02-834895
Published: 2018
Includes: Supplemental data
Journal Articles

Comparison of Clinical Features and Outcomes in Patients with Primary Central Nervous System Lymphoma Treated within and Outside a Clinical Trial: A Retrospective Study

Vanja Zeremski, Thomas Fischer, Enrico Schalk
Journal: Blood
Blood (2017) 130 (Supplement 1): 1565.
https://doi.org/10.1182/blood.V130.Suppl_1.1565.1565
Published: 2017
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

Comparison of Treatment Strategies in Patients over 60 Years with AML: Final Analysis of a Prospective Randomized German AML Intergroup Study

Dietger Niederwieser, MD, Verena Sophia Hoffmann, Dr., Markus Pfirrmann, PhD, Haifa Kathrin Al-Ali, MD, Sebastian Schwind, MD, Vladan Vucinic, MD, Rainer Krahl, PhD, Christoph Kahl, Hans-Heinrich Wolf, MD, Ute Kreibich, Prof., Detlef Hähling, Ute Hegenbart, MD, Carsten Hirt, Norma Peter, MD, Axel Florschuetz, Kolja Reifenrath, Antje Schulze, Niklas Zojer, MD, Sebastian Scholl, Christian Junghanss, MD, Wolfram Pönisch, Simone Heyn, MD, Herbert G. Sayer, Andreas Hochhaus, MD, Thomas Heinicke, MD, Thomas Fischer, MD, Alwin Krämer, MD, Peter Dreger, MD, Georg Maschmeyer, MD, Utz Krug, Maria Christina Sauerland, MSc, Achim Heinecke, Rüdiger Hehlmann, MD, Eva Lengfelder, MD, Wolfgang Hiddemann, MD, Hubert Serve, MD, Carsten Müller-Tidow, Wolfgang E Berdel, MD, Thomas Büchner
Journal: Blood
Blood (2016) 128 (22): 1066.
https://doi.org/10.1182/blood.V128.22.1066.1066
Published: 2016
Journal Articles

Internal Tandem Duplication (ITD) in the Tyrosine Kinase Domain of FLT3 Displays Higher Oncogenic Potential in Acute Myeloid Leukemia

Alissa Marhäll, PhD student, Thomas Fischer, MD, Florian H. Heidel, MD, Julhash U. Kazi, PhD, Lars Rönnstrand, PhD
Journal: Blood
Blood (2016) 128 (22): 5118.
https://doi.org/10.1182/blood.V128.22.5118.5118
Published: 2016
Journal Articles

Bortezomib Consolidation Following Autologous Transplant Equalizes the Outcome for Older Patients with Less Intensive Pretreatment Compared to Younger Patients with Newly Diagnosed Multiple Myeloma

Christian Straka, MD, Stefan Knop, MD, Martin Vogel, MD PhD, Jurgen Müller, Dipl. Stat., Martin Kropff, MD, Bernd Metzner, MD, Christian Langer, MD, Herbert Sayer, MD, Wolfram Jung, MD, Heinz Dürk, MD PhD, Hans-Juergen Salwender, MD, Hannes Wandt, MD, PhD, Florian Bassermann, MD, Martin Gramatzki, MD, Wolf Rösler, MD, Hans-Heinrich Wolf, MD, Wolfram Brugger, MD PhD, Monika Engelhardt, MD, Thomas Fischer, MD, Peter Liebisch, MD, Hermann Einsele, MD
Journal: Blood
Blood (2016) 128 (22): 516.
https://doi.org/10.1182/blood.V128.22.516.516
Published: 2016
Journal Articles

The Novel FLT3-N676K Mutant Induces Acute Leukemia Independently of the Inv(16) Chimeric Gene CBFB-MYH11

Kezhi Huang, Min Yang, Zengkai Pan, Florian H. Heidel, MD, Michaela Scherr, PhD, Matthias Eder, MD, Thomas Fischer, MD, Guntram Buesche, MD, Nils von Neuhoff, PhD, Arnold Ganser, MD, Zhixiong Li, MD
Journal: Blood
Blood (2015) 126 (23): 1383.
https://doi.org/10.1182/blood.V126.23.1383.1383
Published: 2015