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Journal Articles

Modelling the Evolution of Clonal Hematopoiesis to Myeloid Malignancies Under the Selective Pressure of Anti-Cancer Therapy

Christian Koch, Jonas Fullin, Ebru Topçu, Nancy Klemm, Karolina Zielinska, Monika Hebeisen, Joelle Tchinda, Markus G. Manz, Steffen Boettcher

Blood (2024) 144 (Supplement 1): 5651.

https://doi.org/10.1182/blood-2024-205797

Published: 2024

Journal Articles

The Pathogenesis of Therapy-Related Myeloid Neoplasms from TP53 -Mutant Clonal Hematopoiesis

Jonas Fullin, Ebru Topçu, Roman R. Schimmer, Nancy Klemm, Karolina Zielinska, Christian Koch, Francisco Caiado, Cyril Doerdelmann, Melissa Lock, Joelle Tchinda, Markus G. Manz, Massimo Lopes, Steffen Boettcher

Blood (2024) 144 (Supplement 1): 41.

https://doi.org/10.1182/blood-2024-205209

Published: 2024

Journal Articles

Somatic TP53 Mutations Rescue the Hematopoietic Stem and Progenitor Cell Defect at the Expense of Increased Risk for Myeloid Malignancies in ERCC6L2 -Associated Inherited Bone Marrow Failure Syndrome

Roman R. Schimmer, Nancy Klemm, Ebru Topçu, Jonas Fullin, Karolina Zielinska, Cyril Doerdelmann, Melissa Lock, Milena Treacy, Francisco Caiado, Nadja Dietliker, Rahel Schwotzer, Markus G. Manz, Massimo Lopes, Steffen Boettcher

Blood (2024) 144 (Supplement 1): 193.

https://doi.org/10.1182/blood-2024-204925

Published: 2024

Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Blood (2024) 144 (Supplement 1): 2673.

https://doi.org/10.1182/blood-2024-208773

Published: 2024

Journal Articles

CD19 CAR T Cells Drive a Remodeling of the Immune Microenvironment Associated with T-Cell Dysfunction in Acute Lymphoblastic Leukemia

Blood (2024) 144 (Supplement 1): 2834.

https://doi.org/10.1182/blood-2024-206806

Published: 2024

Journal Articles

MDS-AML Aggregative Risk Classification System ( MARCS ): A Novel, Enhanced Risk Stratification System Derived from the Combined Unsupervised Analysis of 7,480 MDS and AML Patients

Marco Roncador, Fritz Bayer, Jeremy W. Deuel, Jack Kuipers, Markus G. Manz, Steffen Boettcher, Niko Beerenwinkel, Stefan Balabanov

Blood (2024) 144 (Supplement 1): 4307.

https://doi.org/10.1182/blood-2024-203134

Published: 2024

Journal Articles

IL-1 in aging and pathologies of hematopoietic stem cells

Francisco Caiado, Markus G. Manz

Blood (2024) 144 (4): 368–377.

https://doi.org/10.1182/blood.2023023105

Published: 2024

Includes: Supplemental data

Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Blood (2023) 142 (Supplement 1): 323.

https://doi.org/10.1182/blood-2023-184703

Published: 2023

Journal Articles

Preclinical Evaluation of the Efficacy of Human Sirpα Antibodies for B-Cell Lymphoma Immunotherapy in Humanized Mouse Models

Yasuyuki Saito, Afroj Tania, Satomi Komori, Tomoko Takai, Okechi S Oduori, Takenori Kotani, Yohei Funakoshi, Yoji Murata, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami, Markus G. Manz, Takashi Matozaki

Blood (2023) 142 (Supplement 1): 1646.

https://doi.org/10.1182/blood-2023-181926

Published: 2023

Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 1572.

https://doi.org/10.1182/blood-2023-181709

Published: 2023

Journal Articles

Efficient Combinatorial Adaptor-Mediated Targeting of Acute Myeloid Leukemia with CAR T-Cells

Laura Volta, Renier Myburgh, Christian Pellegrino, Christian Koch, Monique Maurer, Francesco Manfredi, Mara Hofstetter, Anne Kaiser, Florin Schneiter, Jan Müller, Marco M. Bühler, Roberto De Luca, Nicholas Favalli, Chiara F. Magnani, Timm Schroeder, Dario Neri, Markus G. Manz

Blood (2023) 142 (Supplement 1): 3435.

https://doi.org/10.1182/blood-2023-185853

Published: 2023

Journal Articles

TP53 Deficiency in AML Confers Resistance to CAR T-Cells That Can be Overcome By Targeting the Cholesterol or Wnt Pathways

Jan Mueller, Roman Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Renier Myburgh, Laura Volta, Alexandre Theocharides, Kari Kurppa, Benjamin L. Ebert, Timm Schroeder, Markus G. Manz, Steffen Boettcher

Blood (2023) 142 (Supplement 1): 1019.

https://doi.org/10.1182/blood-2023-185567

Published: 2023

Journal Articles

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Blood (2023) 141 (21): 2657–2661.

https://doi.org/10.1182/blood.2022019160

Published: 2023

Includes: Supplemental data

Journal Articles

Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling

Francisco Caiado, Larisa V. Kovtonyuk, Nagihan G. Gonullu, Jonas Fullin, Steffen Boettcher, Markus G. Manz

Blood (2023) 141 (8): 886–903.

https://doi.org/10.1182/blood.2022016835

Published: 2023

Includes: Supplemental data

Journal Articles

Bayesian Inference for Optimization of Interim Analysis in Clinical Trials By Incorporation of Historical Data: Reanalysis of the HOVON AML 132 Clinical Trial

Niek Van Der Maas, Kazem Nasserinejad, Thomas Pabst, Johan A. Maertens, Dimitri A. Breems, Markus G Manz, Jacqueline Cloos, Gert J. Ossenkoppele, Yngvar Floisand, Patrycja Gradowska, Bob Lowenberg, Gerwin A. Huls, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen, Jurjen Versluis

Blood (2022) 140 (Supplement 1): 127–129.

https://doi.org/10.1182/blood-2022-158137

Published: 2022

Journal Articles

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Emily Mitchell, Kevin J Dawson, Larisa V. Kovtonyuk, Jan Müller, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell

Blood (2022) 140 (Supplement 1): 1572–1573.

https://doi.org/10.1182/blood-2022-166701

Published: 2022

Journal Articles

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Blood (2022) 140 (Supplement 1): 9125–9127.

https://doi.org/10.1182/blood-2022-157753

Published: 2022

Journal Articles

Measurable Residual Disease Guided Therapy in Intermediate-Risk AML Patients Compared to an Unguided Cohort Using Propensity Score Matching

Jesse M. Tettero, Lok Lam Ngai, Costa Bachas, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Patrycja Gradowska, Laimonas Griskevicius, Jeroen J.W.M. Janssen, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob Passweg, Kimmo Porkka, Peter JM Valk, Bob Lowenberg, Gert J. Ossenkoppele, Jacqueline Cloos

Blood (2022) 140 (Supplement 1): 2027–2029.

https://doi.org/10.1182/blood-2022-157009

Published: 2022

Journal Articles

CAR T Cells and Their Immune Environment Synergize to Shape Distinct Immune Profiles in Response Versus Toxicity in B Cell Lymphoma Patients

Stefanie Kreutmair, Maximilian M Schaefer, Sebastian Stolz, Carla Merten, Can Ulutekin, Florian Ingelfinger, Susanne Unger, Chiara Alberti, Tobias Wertheimer, Aakriti Sethi, Thorsten Zenz, Markus G Manz, Antonia Maria Susanne Müller, Corinne C Widmer, Burkhard Becher

Blood (2022) 140 (Supplement 1): 7504–7505.

https://doi.org/10.1182/blood-2022-168905

Published: 2022

Journal Articles

TLR1/2-stimulated DCs “prime” HSCs via IL-1β

Francisco Caiado, Markus G. Manz

Blood (2022) 140 (14): 1576–1578.

https://doi.org/10.1182/blood.2022017137

Published: 2022

NARROW

Modelling the Evolution of Clonal Hematopoiesis to Myeloid Malignancies Under the Selective Pressure of Anti-Cancer Therapy

The Pathogenesis of Therapy-Related Myeloid Neoplasms from TP53 -Mutant Clonal Hematopoiesis

Somatic TP53 Mutations Rescue the Hematopoietic Stem and Progenitor Cell Defect at the Expense of Increased Risk for Myeloid Malignancies in ERCC6L2 -Associated Inherited Bone Marrow Failure Syndrome

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

CD19 CAR T Cells Drive a Remodeling of the Immune Microenvironment Associated with T-Cell Dysfunction in Acute Lymphoblastic Leukemia

MDS-AML Aggregative Risk Classification System ( MARCS ): A Novel, Enhanced Risk Stratification System Derived from the Combined Unsupervised Analysis of 7,480 MDS and AML Patients

IL-1 in aging and pathologies of hematopoietic stem cells

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Preclinical Evaluation of the Efficacy of Human Sirpα Antibodies for B-Cell Lymphoma Immunotherapy in Humanized Mouse Models

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Efficient Combinatorial Adaptor-Mediated Targeting of Acute Myeloid Leukemia with CAR T-Cells

TP53 Deficiency in AML Confers Resistance to CAR T-Cells That Can be Overcome By Targeting the Cholesterol or Wnt Pathways

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling

Bayesian Inference for Optimization of Interim Analysis in Clinical Trials By Incorporation of Historical Data: Reanalysis of the HOVON AML 132 Clinical Trial

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Measurable Residual Disease Guided Therapy in Intermediate-Risk AML Patients Compared to an Unguided Cohort Using Propensity Score Matching

CAR T Cells and Their Immune Environment Synergize to Shape Distinct Immune Profiles in Response Versus Toxicity in B Cell Lymphoma Patients

TLR1/2-stimulated DCs “prime” HSCs via IL-1β

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American Society of Hematology

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ASH Publications

American Society of Hematology

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