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Michael Spencer Chapman
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Journal Articles

Clonal Origin of Therapy-Related Myeloid Neoplasms after Autologous Stem Cell Transplant

Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Hui Yang, Courtney D. DiNardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Latasha Little, Curtis Gumbs, Robert Z. Orlowski, Muzaffar H. Qazilbash, Kapil N. Bhalla, Simona Colla, Hagop M. Kantarjian, Rashmi Kanagal-Shamanna, Carlos E. Bueso-Ramos, Daisuke Nakada, Jeffrey J. Molldrem, Gheath Alatrash, Andrew Futreal, Elizabeth J. Shpall, Margaret Goodell, Guillermo Garcia-Manero, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 346.
https://doi.org/10.1182/blood-2024-208106
Published: 2024
Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori Kregar, C. Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Stanley Ng, George S Vassiliou, Kate Gowers, Sam Janes, Matt Hoare, Anthony R Green, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Inigo Martincorena, Michael Stratton, Jyoti Nangalia, Tim H.H. Coorens, Peter Campbell
Journal: Blood
Blood (2024) 144 (Supplement 1): 2673.
https://doi.org/10.1182/blood-2024-208773
Published: 2024
Journal Articles

Pervasive Positive Selection in Blood in 200,618 Individuals and Novel Drivers of Clonal Hematopoiesis

Nicholas Bernstein, Michael Spencer Chapman, Kudzai Nyamondo, Zhenghao Chen, Nicholas Williams, Emily Mitchell, Peter Campbell, Robert L Cohen, Jyoti Nangalia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4062.
https://doi.org/10.1182/blood-2023-185188
Published: 2023
Journal Articles

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Emily Mitchell, Kevin J Dawson, Larisa V. Kovtonyuk, Jan Müller, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell
Journal: Blood
Blood (2022) 140 (Supplement 1): 1572–1573.
https://doi.org/10.1182/blood-2022-166701
Published: 2022
Journal Articles

Cancer Chemotherapy Accelerates the Loss of Clonal Diversity in Hematopoietic Stem Cells and Promotes the Convergent Evolution of Therapy-Related Clonal Hematopoiesis

Hidetaka Uryu, Koichi Saeki, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne I. Hsu, Carlos E. Bueso-Ramos, Shujuan Chen, Hui Yang, Hagop Kantarjian, Courtney D. DiNardo, Naval Daver, Simona Colla, Irene Ganan-Gomez, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Robert Z. Orlowski, Richard E Champlin, Muzaffar H Qazilbash, Elizabeth J Shpall, Guillermo Garcia-Manero, Hiroshi Haeno, Koichi Takahashi, Andrew Futreal
Journal: Blood
Blood (2022) 140 (Supplement 1): 2232–2233.
https://doi.org/10.1182/blood-2022-160294
Published: 2022
Journal Articles

The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis

Margarete A Fabre, Jose Guillherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orru, Michele Marongiu, MS Vijayabaskar, Joanna E Baxter, Claire Hardy, Federico Abascal, Michael Spencer Chapman, Nicholas Williams, Jyoti Nangalia, Inigo Martincorena, Peter J Campbell, Eoin F Mckinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
Journal: Blood
Blood (2021) 138 (Supplement 2): LBA-2.
https://doi.org/10.1182/blood-2021-154938
Published: 2021
Journal Articles

Clonal Tracking By Whole Genome Sequencing Permits Comprehensive Mapping of the Genomic Landscape in Pre- and Post-Gene Therapy Sickle Cell Patients

Alyssa H. Cull, Michael Spencer Chapman, Marioara Ciuculescu, Emily Mitchell, Myriam Armant, Grace Boyd, Erica B. Esrick, David A. Williams, Peter J. Campbell, David G. Kent
Journal: Blood
Blood (2021) 138 (Supplement 1): 559.
https://doi.org/10.1182/blood-2021-152262
Published: 2021
Journal Articles

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily Calderbank, Hyunchul Jung, Thomas J Mitchell, Tim Coorens, David Spencer, Heather E Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete Alice Fabre, Krishnaa Mahbubani, Federico Abascal, George S. Vassiliou, Joanna E Baxter, Inigo Martincorena, Michael Stratton, David G. Kent, Krishna Chatterjee, Kourosh Saeb-Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J. Campbell
Journal: Blood
Blood (2021) 138 (Supplement 1): 598.
https://doi.org/10.1182/blood-2021-150152
Published: 2021
Journal Articles

Long-Term Clonal Dynamics upon Allogeneic Haematopoietic Stem Cell Transplantation Revealed Using Somatic Mutations As Clonal Tracking Marks in HSC Donor and Recipient Pairs

Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Larisa V. Kovtonyuk, Emily Mitchell, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell
Journal: Blood
Blood (2021) 138 (Supplement 1): 3813.
https://doi.org/10.1182/blood-2021-146151
Published: 2021