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Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Blood (2024) 144 (Supplement 1): 2673.

https://doi.org/10.1182/blood-2024-208773

Published: 2024

Journal Articles

Mapping Genotype to Phenotype in Clonal Hematopoiesis Uncovers Downregulated MHC-II Molecules in DNMT3A R882 - Mutant Hematopoietic Stem Cells

Patrick Stelmach, Dominik Vonficht, Anne Kathrin Merbach, Dawn S Lin, Sergi Beneyto-Calabuig, Marina Scheller, Aino-Maija Leppä, Florian Grünschläger, George S Vassiliou, Simon Haas, Lars Velten, Carsten Müller-Tidow, Andreas Trumpp

Blood (2024) 144 (Supplement 1): 1292.

https://doi.org/10.1182/blood-2024-203041

Published: 2024

Journal Articles

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Ludovica Marando, George Giotopoulos, Pedro Madrigal, Dhoyazan M A Azazi, Ryan Asby, Maria Erendira Calleja-Cervantes, David Lara-Astiaso, Nicola K. Wilson, Rebecca Hannah, Jaana Bagri, Elsa Barnard, Sarah J Horton, Berthold Gottgens, Elli Papaemmanuil, Shuchi Agrawal Singh, Malgorzata Gozdecka, George S Vassiliou, Brian J P Huntly

Blood (2024) 144 (Supplement 1): 190.

https://doi.org/10.1182/blood-2024-201612

Published: 2024

Journal Articles

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Markus Meyerhöfer, Viral Shah, Aarón Gallego-Crespo, Malte Andreas Behrendt, Yawen Zhou, Maria Saura-Pañella, Björn Häupl, Thomas Kindler, Matthias Theobald, Falk Butter, George S Vassiliou, Michael Kühn, Brian J P Huntly, Thomas Oellerich, Daniel Sasca

Blood (2024) 144 (Supplement 1): 152.

https://doi.org/10.1182/blood-2024-194781

Published: 2024

Journal Articles

Causes and Consequences of Clonal Hematopoiesis with Unknown Drivers in 409,553 Whole-Genome Sequenced UK Biobank Participants

Sean Wen, Marcin Karpinski, Dimitrios Vitsios, Sebastian Wasilewski, Slavé Petrovski, Andrew R. Harper, Margarete A. Fabre, George S Vassiliou, Jonathan Mitchell

Blood (2024) 144 (Supplement 1): 945.

https://doi.org/10.1182/blood-2024-205118

Published: 2024

Journal Articles

SF3B1 Mutations Promote Pervasive Metabolic Reprogramming and Enhanced Sensitivity to Glycolysis Inhibition

Matthew McLoughlin, Laura Bond, Guinevere Grice, Kenny Sham, Joshua Lee, Justyna Rak, Jake Tobin, Giampiero Valenzano, Ilias Moutsopoulos, Dimitris Lagos, James Nathan, Joanna Baxter, Irina Mohorianu, George S Vassiliou

Blood (2024) 144 (Supplement 1): 5726.

https://doi.org/10.1182/blood-2024-207364

Published: 2024

Journal Articles

Immune-Scape in Myeloid Sarcoma and Acute Myeloid Leukemia

Juliana Alvarez Argote, Kristin E Zorn, Cary Stelloh, Alison E Meyer, Maria E Hintzke, Ashley Cunningham, Emily Giever, George S Vassiliou, Ehab L. Atallah, Sridhar Rao

Blood (2024) 144 (Supplement 1): 1554.

https://doi.org/10.1182/blood-2024-202505

Published: 2024

Journal Articles

Prevalence and Significance of Clonal Monocytosis of Undetermined Significance (CMUS) Amongst 431,531 United Kingdom Biobank Participants

William G Dunn, Muxin Gu, Pedro Quiros, Irina Mohorianu, Daniel H Wiseman, George S Vassiliou

Blood (2024) 144 (Supplement 1): 4048.

https://doi.org/10.1182/blood-2024-201387

Published: 2024

Journal Articles

The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia

Margarete A. Fabre, George S. Vassiliou

Blood (2024) 143 (7): 573–581.

https://doi.org/10.1182/blood.2023019964

Published: 2024

Journal Articles

Prevalence and significance of DDX41 gene variants in the general population

Sruthi Cheloor Kovilakam, Muxin Gu, William G. Dunn, Ludovica Marando, Clea Barcena, Serena Nik-Zainal, Irina Mohorianu, Siddhartha P. Kar, Margarete A. Fabre, Pedro M. Quiros, George S. Vassiliou

Blood (2023) 142 (14): 1185–1192.

https://doi.org/10.1182/blood.2023020209

Published: 2023

Includes: Supplemental data

Journal Articles

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly

Blood (2023) 141 (14): 1737–1754.

https://doi.org/10.1182/blood.2022016528

Published: 2023

Includes: Supplemental data

Journal Articles

Genome-Wide CRISPR Screen Reveals Dependency of PPM1D- mutant Cells on DNA Repair

Linda Zhang, Joanne I. Hsu, Etienne D. Braekeleer, Hidetaka Uryu, Elsa Callen-Moreu, Andre Nussenzweig, Koichi Takahashi, George S Vassiliou, Margaret A. Goodell

Blood (2022) 140 (Supplement 1): 1994–1995.

https://doi.org/10.1182/blood-2022-166910

Published: 2022

Journal Articles

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Blood (2022) 140 (16): 1774–1789.

https://doi.org/10.1182/blood.2021014875

Published: 2022

Includes: Supplemental data

Journal Articles

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

Blood (2022) 140 (14): 1592–1606.

https://doi.org/10.1182/blood.2021014009

Published: 2022

Includes: Supplemental data

Journal Articles

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Blood (2022) 140 (14): 1650–1655.

https://doi.org/10.1182/blood.2022015721

Published: 2022

Includes: Supplemental data

Journal Articles

The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis

Blood (2021) 138 (Supplement 2): LBA-2.

https://doi.org/10.1182/blood-2021-154938

Published: 2021

Journal Articles

Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Marianna Rossi, Manja Meggendorfer, Matteo Zampini, Mauro Tettamanti, Emma Riva, Erica Travaglino, Matteo Bersanelli, Sara Mandelli, Alessia Antonella Galbussera, Ettore Mosca, Elena Saba, Chiara Chiereghin, Nicla Manes, Chiara Milanesi, Marta Ubezio, Lucio Morabito, Clelia Peano, Giulia Soldà, Rosanna Asselta, Stefano Duga, Carlo Selmi, Maria De Santis, Karolina Malik, Giulia Maggioni, Marilena Bicchieri, Alessia Campagna, Cristina A. Tentori, Antonio Russo, Efrem Civilini, Paola Allavena, Rocco Piazza, Giovanni Corrao, Claudia Sala, Alberto Termanini, Laura Giordano, Paolo Detoma, Aurelio Malabaila, Luca Sala, Stefano Rosso, Roberto Zanetti, Claudia Saitta, Elena Riva, Gianluigi Condorelli, Francesco Passamonti, Armando Santoro, Francesc Sole, Uwe Platzbecker, Pierre Fenaux, Niccolò Bolli, Gastone Castellani, Wolfgang Kern, George S. Vassiliou, Torsten Haferlach, Ugo Lucca, Matteo G. Della Porta

Blood (2021) 138 (21): 2093–2105.

https://doi.org/10.1182/blood.2021011320

Published: 2021

Includes: Supplemental data

Journal Articles

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Konstantinos Tzelepis, Celine Philippe, Kevin Rattigan, Ryan Asby, Vilma Dembitz, Aoife S.M. Magee, Gudmundur Helgason, Kevin Rouault-Pierre, George S. Vassiliou, Brian J.P Huntly, Paolo Gallipoli

Blood (2021) 138 (Supplement 1): 508.

https://doi.org/10.1182/blood-2021-148489

Published: 2021

Journal Articles

Combinatorial Genetic Uncovers DOCK1/RAC2 As Specific Targets for the Treatment of NPM1;Cohesin Mutated AML

Alison E Meyer, Cary Stelloh, Kirthi Pulakanti, Robert Burns, Joseph B Fisher, Katelyn E Heimbruch, Sergey Tarima, Aaron D Viny, George S. Vassiliou, Sridhar Rao

Blood (2021) 138 (Supplement 1): 3288.

https://doi.org/10.1182/blood-2021-148811

Published: 2021

Journal Articles

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

Blood (2021) 138 (Supplement 1): 598.

https://doi.org/10.1182/blood-2021-150152

Published: 2021

NARROW

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Mapping Genotype to Phenotype in Clonal Hematopoiesis Uncovers Downregulated MHC-II Molecules in DNMT3A R882 - Mutant Hematopoietic Stem Cells

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Causes and Consequences of Clonal Hematopoiesis with Unknown Drivers in 409,553 Whole-Genome Sequenced UK Biobank Participants

SF3B1 Mutations Promote Pervasive Metabolic Reprogramming and Enhanced Sensitivity to Glycolysis Inhibition

Immune-Scape in Myeloid Sarcoma and Acute Myeloid Leukemia

Prevalence and Significance of Clonal Monocytosis of Undetermined Significance (CMUS) Amongst 431,531 United Kingdom Biobank Participants

The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia

Prevalence and significance of DDX41 gene variants in the general population

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Genome-Wide CRISPR Screen Reveals Dependency of PPM1D- mutant Cells on DNA Repair

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis

Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Combinatorial Genetic Uncovers DOCK1/RAC2 As Specific Targets for the Treatment of NPM1;Cohesin Mutated AML

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

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American Society of Hematology

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American Society of Hematology

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