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Konstantinos Tzelepis
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Journal Articles

NPM1c Mutations Are Associated with Reduced Levels of Multiple Ribosome Biogenesis Factors Leading to Therapeutic Vulnerabilities

Aristi Damaskou, Rachael Wilson, Vijay Shanmugiah, Justyna Rak, Konstantinos Tzelepis, Berthold Gottgens, Malgorzata Gozdecka, George Vassiliou
Journal: Blood
Blood (2023) 142 (Supplement 1): 2743.
https://doi.org/10.1182/blood-2023-186084
Published: 2023
Journal Articles

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Konstantinos Tzelepis, Celine Philippe, Kevin Rattigan, Ryan Asby, Vilma Dembitz, Aoife S.M. Magee, Gudmundur Helgason, Kevin Rouault-Pierre, George S. Vassiliou, Brian J.P Huntly, Paolo Gallipoli
Journal: Blood
Blood (2021) 138 (Supplement 1): 508.
https://doi.org/10.1182/blood-2021-148489
Published: 2021
Journal Articles

Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD -Mutant AMLs

Suruchi Pacharne, Oliver M. Dovey, PhD, Jonathan L Cooper, Muxin Gu, Vijay Baskar, PhD, Mathias J Friedrich, Malgorzata Gozdecka, PhD, Sandeep S Rajan, PhD, Etienne De Braekeleer, PhD MSc, Maxim Barenboim, Grace Collord, Hannes Postingl, PhD, Ruben Bautista, Milena Mazan, PhD, Roland Rad, Prof., MD, Konstantinos Tzelepis, Penny Wright, George S. Vassiliou, MD PhD FRCPath, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-141743
Published: 2020
Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 403.
https://doi.org/10.1182/blood-2019-127962
Published: 2019
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou
Journal: Blood
Blood (2018) 132 (Supplement 1): 2615.
https://doi.org/10.1182/blood-2018-99-118827
Published: 2018
Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly
Journal: Blood
Blood (2018) 131 (15): 1639–1653.
https://doi.org/10.1182/blood-2017-12-820035
Published: 2018
Includes: Supplemental data
Journal Articles

SRPK1 Is a Therapeutic Vulnerability in Acute Myeloid Leukemia through Its Effects on Alternative Isoforms of Epigenetic Regulators Including BRD4

Konstantinos Tzelepis, PhD, Etienne De Braekeleer, PhD, Isaia Barbieri, PhD, Vijay Baskar, PhD, Demetrios Aspris, MSc, Francisco Hermida Prado, PhD, Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Hannes Postingl, PhD, David Bates, PhD, Andrew Bannister, PhD, Brian J.P Huntly, Cristina Pina, MDDPhil, Allan Bradley, PhD, Kosuke Yusa, PhD, Tony Kouzarides, PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 781.
https://doi.org/10.1182/blood.V130.Suppl_1.781.781
Published: 2017
Journal Articles

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1 -mutant acute myeloid leukemia

Oliver M. Dovey, Jonathan L. Cooper, Annalisa Mupo, Carolyn S. Grove, Claire Lynn, Nathalie Conte, Robert M. Andrews, Suruchi Pacharne, Konstantinos Tzelepis, M. S. Vijayabaskar, Paul Green, Roland Rad, Mark Arends, Penny Wright, Kosuke Yusa, Allan Bradley, Ignacio Varela, George S. Vassiliou
Journal: Blood
Blood (2017) 130 (17): 1911–1922.
https://doi.org/10.1182/blood-2017-01-760595
Published: 2017
Includes: Supplemental data
Journal Articles

Loss of BCOR Protein in Development of Acute Myeloid Leukaemia

Milena M. Mazan, PhD, Malgorzata Gozdecka, PhD, Emmanouil Metzakopian, PhD, Konstantinos Tzelepis, MSc, Brian J.P Huntly, MD PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2433.
https://doi.org/10.1182/blood.V126.23.2433.2433
Published: 2015
Journal Articles

A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

Konstantinos Tzelepis, MSc, Hiroko Koike-Yusa, MD, Etienne De Braekeleer, PhD, Yilong Li, Emmanouil Metzakopian, PhD, Oliver M. Dovey, PhD, Annalisa Mupo, PhD, Vera Grinkevich, PhD, Milena M. Mazan, PhD, Malgorzata Gozdecka, PhD, Jonathan L. Cooper, Miten Patel, MD, Thomas David Hardman McKerrell, MD, Bin Chen, Hannes Ponstingl, PhD, Brian J.P Huntly, MD PhD, Ultan McDermott, MD PhD, Julio Saez-Rodriguez, PhD, Francesco Iorio, PhD, Kosuke Yusa, PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2015) 126 (23): 554.
https://doi.org/10.1182/blood.V126.23.554.554
Published: 2015