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Christian Frezza
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Journal Articles

DGAT1 Inhibition Enhances Metformin-Induced Ferroptosis in AML By Targeting Lipid Metabolism

Dominique Sternadt, Diego A. Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Ayşegül Erdem, Lieve Oudejans, Shanna Hogeling, Emanuele Ammatuna, Gerwin Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1393.
https://doi.org/10.1182/blood-2024-208239
Published: 2024
Journal Articles

Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2 -Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Emanuele Ammatuna, Lieve Oudejans, Gerwin A. Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2023) 142 (Supplement 1): 1586.
https://doi.org/10.1182/blood-2023-188524
Published: 2023
Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly
Journal: Blood
Blood (2018) 131 (15): 1639–1653.
https://doi.org/10.1182/blood-2017-12-820035
Published: 2018
Includes: Supplemental data