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Journal Articles

DGAT1 Inhibition Enhances Metformin-Induced Ferroptosis in AML By Targeting Lipid Metabolism

Dominique Sternadt, Diego A. Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Ayşegül Erdem, Lieve Oudejans, Shanna Hogeling, Emanuele Ammatuna, Gerwin Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 1393.

https://doi.org/10.1182/blood-2024-208239

Published: 2024

Journal Articles

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Diego A. Pereira-Martins, Vincent Van Den Boom, Isabel Weinhaeuser, Nisha van der Meer, Prodromos Chatzikyriakou, Noortje van Dijk, Xuesen Zheng, Lucio H Pinheiro, Douglas RA Silveira, Thiago Mantello Bianco, César Alexander Ortiz Rojas, Eduardo M. Rego, Stuart A Rushworth, Antonio R. Lucena-Araujo, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 4321.

https://doi.org/10.1182/blood-2024-207421

Published: 2024

Journal Articles

DNMT3A-Mutant Clonal Haematopoiesis Is Associated with Worse Recovery after ST-Elevation Myocardial Infarction Via Increased Inflammation

Blood (2024) 144 (Supplement 1): 1284.

https://doi.org/10.1182/blood-2024-203813

Published: 2024

Journal Articles

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

Lucio Henrique Pinheiro, Isabel Weinhäuser, Diego A. Pereira-Martins, Luise Araujo De Albuquerque Simoes, Matthew Markham, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa, Stuart A Rushworth, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2024-208800

Published: 2024

Journal Articles

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Diego A Pereira-Martins, Antonio Bruno Alves-Silva, Manuela Albuquerque De Melo, Natasha Peixoto Fonseca, Isabel Weinhäuser, Fabio Augusto Bueno Perez, Artur Bernardo Ribeiro Bellomi, Lorena Lobo Figueiredo-Pontes, João Agostinho Machado-Neto, Lynn Quek, Prodromos Chatzikyriakou, Gerwin A. Huls, Emanuele Ammatuna, Jan Jacob Schuringa, Fabiola Traina

Blood (2024) 144 (Supplement 1): 4518.

https://doi.org/10.1182/blood-2024-209823

Published: 2024

Journal Articles

Single-Cell Multiomic Profiling of TP53 Mutated Myelodysplastic Neoplasms - All Clones Are Not Equal

Onima Chowdhury, Kristian Gurashi, Amy Wood, Ivan Lukic, Adam Sciambi, Lynn Quek, Daniel H Wiseman, Adam J Mead

Blood (2024) 144 (Supplement 1): 3615.

https://doi.org/10.1182/blood-2024-210047

Published: 2024

Journal Articles

Clonal Haematopoiesis with TP53 Mutations Exhibits Abnormal Erythropoiesis and Erythroid Metabolic Stress

Blood (2024) 144 (Supplement 1): 944.

https://doi.org/10.1182/blood-2024-200108

Published: 2024

Journal Articles

MLL5-Driven Leukemic Transformation Is Linked to Chromatin Remodeling and Can be Targeted with ATRA in Combination with PARP1 Inhibition

Luise Araujo De Albuquerque Simoes, Isabel Weinhäuser, Diego A Pereira-Martins, Luciana Yamamoto Almeida, Vincent Van Den Boom, Fatemeh Mojallali, Dominique Sternadt, Prodromos Chatzikyriakou, Xuesen Zheng, César Alexander Ortiz Rojas, Ghulam Jeelani Mufti, Lucio Henrique Pinheiro, Lynn Quek, Gerwin A. Huls, Eduardo M. Rego, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 1539.

https://doi.org/10.1182/blood-2024-209817

Published: 2024

Journal Articles

Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia

Isabel Weinhaeuser, Diego Pereira-Martins, Dominique Sternadt, Emmanuel F Griessinger, Douglas RA Silveira, Juan L Coelho-Silva, Antonio Bruno Alves-Silva, Ayşegül Erdem, Bruno Koza Lino Duarte, Lynn Quek, Fabiola Traina, Sara Teresinha Olalla Saad, Jacobien R Hilberink, Emanuele Ammatuna, Eduardo Magalhães Rego, Geert A. Huls, Antonio R Lucena-Araujo, Jan Jacob Schuringa

Blood (2023) 142 (Supplement 1): 294.

https://doi.org/10.1182/blood-2023-186061

Published: 2023

Journal Articles

An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis

Xuesen Zheng, Amandine Tan, Maria del Pilar Casares Alaez, Garry Mallett, Deniz Ece Kaya, Nogayhan Seymen, Marta Rzepkowska, Sarah Mackie, Prodromos Chatzikyriakou, Laarni Bogaanay, Jen Lewis, Maroof Hasan, Rajasekhar N.V.S. Suragani, James Carmichael, Ghulam Mufti, Anita K. Gandhi, Giorgio Napolitani, Lynn Quek

Blood (2023) 142 (Supplement 1): 812.

https://doi.org/10.1182/blood-2023-174947

Published: 2023

Journal Articles

Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2 -Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Isabel Weinhaeuser, Ming Yang, Prodromos Chatzikyriakou, Pilar Casares Alaez, Emanuele Ammatuna, Lieve Oudejans, Gerwin A. Huls, Christian Frezza, Lynn Quek, Jan Jacob Schuringa

Blood (2023) 142 (Supplement 1): 1586.

https://doi.org/10.1182/blood-2023-188524

Published: 2023

Journal Articles

CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia

Diego Pereira-Martins, César Alexander Ortiz Rojas, Isabel Weinhaeuser, Bart-Jan Wierenga, Vincent Van Den Boom, Fatemeh Mojallali, Dominique Sternadt, Thiago Mantello Bianco, Nisha van der Meer, Douglas RA Silveira, Lynn Quek, Emanuele Ammatuna, Antonio R Lucena-Araujo, Gerwin A. Huls, Eduardo Magalhães Rego, Jan Jacob Schuringa

Blood (2023) 142 (Supplement 1): 839.

https://doi.org/10.1182/blood-2023-186399

Published: 2023

Journal Articles

Single Cell Characterisation of Transcriptional Programmes of Responsive and Resistant Leukaemic Progenitors in IDH2 -Mutant Acute Myeloid Leukaemia in the AG221-AML-005 Study

Prodromos Chatzikyriakou, Douglas RA Silveira, Maria del Pilar Casares Aláez, Batchimeg Usukhbayar, Marlen Metzner, Paresh Vyas, Anita K. Gandhi, Alberto Risueño, Maroof Hasan, Lynn Quek

Blood (2022) 140 (Supplement 1): 3414–3415.

https://doi.org/10.1182/blood-2022-163717

Published: 2022

Journal Articles

Single-Cell Transcriptome Analysis Reveals Pathways That Drive Dyserythropoiesis in Myelodysplastic Syndromes, Which Are Targeted By Luspatercept

Onima Chowdhury, Douglas RA Silveira, Sophie Reed, Jennifer O'Sullivan, Sally-Ann Clark, Neil Ashley, Bethan Psaila, Supat Thongjuea, Adam J Mead, Lynn Quek

Blood (2022) 140 (Supplement 1): 9753–9754.

https://doi.org/10.1182/blood-2022-165865

Published: 2022

Journal Articles

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Diego Pereira-Martins, Noortje van Dijk, Isabel Weinhaeuser, Douglas RA Silveira, Juan Coelho Da Silva, Thiago M Bianco, César Alexander Ortiz, Fabiola Traina, Lorena L Figueiredo-Pontes, Emanuele Ammatuna, Lynn Quek, Gerwin A. Huls, Antonio R. Lucena-Araujo, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 6265–6266.

https://doi.org/10.1182/blood-2022-165151

Published: 2022

Journal Articles

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Isabel Weinhaeuser, Shanna M Hogeling, Emanuele Ammatuna, Gerwin A. Huls, Lynn Quek, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 8813–8814.

https://doi.org/10.1182/blood-2022-163282

Published: 2022

Journal Articles

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Isabel Weinhaeuser, Diego Pereira-Martins, Luciana Yamamoto de Almeida, Jacobien R Hilberink, Douglas RA Silveira, Lynn Quek, César Alexander Ortiz, Antonio R. Lucena-Araujo, Nienke Visser, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 1259–1260.

https://doi.org/10.1182/blood-2022-165130

Published: 2022

Journal Articles

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Douglas RA RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Sarah Mackie, Roan Hulks, Olena Yavorska, Paulina Siejka-Zielinska, Marlen Metzner, Alastair Smith, Batchimeg Usukhbayar, Virginie Penard-Lacronique, Chunxiao Song, Anita K. Gandhi, Maroof Hasan, Paresh Vyas, Thomas A. Milne, Skirmantas Kriaucionis, Lynn Quek

Blood (2022) 140 (Supplement 1): 8698–8699.

https://doi.org/10.1182/blood-2022-165898

Published: 2022

Journal Articles

Molecular Features Associated with Response to Combination Therapy with Enasidenib (ENA) Plus Azacitidine (AZA) in Newly Diagnosed IDH2 -Mutated Acute Myeloid Leukemia (AML)

Alberto Risueño, Wendy L. See, Courtney D. DiNardo, Hartmut Döhner, Eytan Stein, Amir T. Fathi, Paresh Vyas, Lynn Quek, Thomas Prebet, Anita K. Gandhi, Maroof Hasan

Blood (2022) 140 (Supplement 1): 732–734.

https://doi.org/10.1182/blood-2022-158967

Published: 2022

Journal Articles

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

Isabel Weinhäuser, Diego A Pereira-Martins, Jacobien R Hilberink, Luciana Yamamoto Almeida, Douglas RA Silveira, Lynn Quek, Shanna M Hogeling, Jose Mauricio Mota, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Gerwin A. Huls, Jan Jacob Schuringa, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 3472.

https://doi.org/10.1182/blood-2021-150699

Published: 2021

NARROW

DGAT1 Inhibition Enhances Metformin-Induced Ferroptosis in AML By Targeting Lipid Metabolism

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

DNMT3A-Mutant Clonal Haematopoiesis Is Associated with Worse Recovery after ST-Elevation Myocardial Infarction Via Increased Inflammation

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Single-Cell Multiomic Profiling of TP53 Mutated Myelodysplastic Neoplasms - All Clones Are Not Equal

Clonal Haematopoiesis with TP53 Mutations Exhibits Abnormal Erythropoiesis and Erythroid Metabolic Stress

MLL5-Driven Leukemic Transformation Is Linked to Chromatin Remodeling and Can be Targeted with ATRA in Combination with PARP1 Inhibition

Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia

An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis

Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2 -Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation

CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia

Single Cell Characterisation of Transcriptional Programmes of Responsive and Resistant Leukaemic Progenitors in IDH2 -Mutant Acute Myeloid Leukaemia in the AG221-AML-005 Study

Single-Cell Transcriptome Analysis Reveals Pathways That Drive Dyserythropoiesis in Myelodysplastic Syndromes, Which Are Targeted By Luspatercept

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Molecular Features Associated with Response to Combination Therapy with Enasidenib (ENA) Plus Azacitidine (AZA) in Newly Diagnosed IDH2 -Mutated Acute Myeloid Leukemia (AML)

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

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American Society of Hematology

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American Society of Hematology

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