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Rajasekhar N.V.S. Suragani
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Journal Articles

Impact of Mutational Landscape and Biomarkers on Response of Luspatercept (ACE-536) Treatment of Anemia in Non-Transfusion Dependent IPSS-R Lower Risk MDS Japanese Subjects (ACE-536-MDS-003- a Ph2 single-arm study)

Bijay Shankar Jaiswal, Manuel Ugidos, Hiroshi Kosugi, Kosei Matsue, Hiromi Murakami, Jin Hayakawa, Daniel Lopes de Menezes, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2024) 144 (Supplement 1): 6725.
https://doi.org/10.1182/blood-2024-201883
Published: 2024
Journal Articles

Luspatercept Reduces Clonal Hematopoiesis-Associated Cardiac Stress Via Modulation of mTORC1 and Inflammatory Signaling Pathways

Maroof Hasan, Shahid Tannu, Shikha Saini, Manuel Ugidos, Guillermo Garcia-Manero, Uwe Platzbecker, Ching-Pin Chang, Anita K. Gandhi, Ricardo Garcia, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2024) 144 (Supplement 1): 4046.
https://doi.org/10.1182/blood-2024-194241
Published: 2024
Journal Articles

Rap-536, a Murine Luspatercept Analog Ameliorates Anemia and Vaso-Occlusion in Experimental Model of Sickle Cell Disease

Thiago Trovati Maciel, Haoua M Bazoum, Rachel Rignault-Bricard, Shikha Saini, Isabelle Chevalme, Sara El Hoss, Robert Li, Slimane Allali, Rajasekhar N.V.S. Suragani, Olivier Hermine
Journal: Blood
Blood (2024) 144 (Supplement 1): 621.
https://doi.org/10.1182/blood-2024-201454
Published: 2024
Journal Articles

Role of Clonal Hematopoiesis (CH) in Lymphoma: Prevalence and Clinical Impact in Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL)

Gonzalo Lopez, Nicholas J. Boddicker, Rahat Hasan, Chris Huang, Arnaud Amzallag, Rajasekhar N.V.S. Suragani, Anita K. Gandhi, Anne J. Novak, James R. Cerhan, Maroof Hasan
Journal: Blood
Blood (2024) 144 (Supplement 1): 2967.
https://doi.org/10.1182/blood-2024-204336
Published: 2024
Journal Articles

Clonal Haematopoiesis with TP53 Mutations Exhibits Abnormal Erythropoiesis and Erythroid Metabolic Stress

Xuesen Zheng, Prodromos Chatzikyriakou, Louis-Francois Handfield, Maroof Hasan, Diego A. Pereira-Martins, Sarah J Mackie, Maria del Pilar Casares Alaez, Isabel Weinhäuser, Nogayhan Seymen, Kai Yi Mok, Viktorija Uksaite, Marta Rzepkowska, Laarni Bogaanay, Matthew Sadler, Jovan Mircetic, Martin Bornhäuser, James Carmichael, Daniel Bromage, Pramila Krishnamurthy, Rajasekhar N.V.S. Suragani, Ghulam Mufti, Giorgio Napolitani, Anita K. Gandhi, Lynn Quek
Journal: Blood
Blood (2024) 144 (Supplement 1): 944.
https://doi.org/10.1182/blood-2024-200108
Published: 2024
Journal Articles

DNMT3A-Mutant Clonal Haematopoiesis Is Associated with Worse Recovery after ST-Elevation Myocardial Infarction Via Increased Inflammation

Sarah J Mackie, Matthew Sadler, Maroof Hasan, Lynette Graver, Rupavidhya Mondi Anandhakrishna, Fulye Argunhan, Louis-Francois Handfield, Hosanna Assefa-Kebede, Laarni Bogaanay, Prodromos Chatzikyriakou, Pilar Casares Alaez, Antonio Cannata, Mohammad Al-Agil, Amandine Tan, Maria Ortiz Estevez, Ching-Pin Chang, Rajasekhar N.V.S. Suragani, Anita K. Gandhi, Ajay Shah, Theresa McDonagh, Aleksander Ivetic, Ghulam Mufti, Giorgio Napolitani, Daniel Bromage, Lynn Quek
Journal: Blood
Blood (2024) 144 (Supplement 1): 1284.
https://doi.org/10.1182/blood-2024-203813
Published: 2024
Journal Articles

Fedratinib Treatment Reduces the Inflammatory Cytokine Profile and Decreases Exhausted T Cells Correlating with Clinical Response in Patients with Myelofibrosis: Biomarker Analysis from the Phase 3 FREEDOM2 Trial

Danny Jeyaraju, Sheida Hayati, Jia Wang, Claire N Harrison, Jean-Jacques Kiladjian, Christopher Hernandez, Patrick Brown, Daniel Lopes De Menezes, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2023-180419
Published: 2023
Journal Articles

Clonal Dynamics of Gene Mutations during Oral Azacitidine Maintenance Therapy in Patients with Acute Myeloid Leukemia (AML): Outcomes from the QUAZAR AML-001 Trial

Daniel Lopes De Menezes, Manuel Ugidos Guerrero, Arnaud Amzallag, Wendy L. See, Alberto Risueno, Charalampos Kyriakopoulos, Rajasekhar N.V.S. Suragani, Barry S. Skikne, C.L. Beach, Thomas Prebet, Maria Teresa Voso, Andre C. Schuh, Gail J. Roboz, Hartmut Döhner, Andrew H. Wei, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1582.
https://doi.org/10.1182/blood-2023-187651
Published: 2023
Journal Articles

An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis

Xuesen Zheng, Amandine Tan, Maria del Pilar Casares Alaez, Garry Mallett, Deniz Ece Kaya, Nogayhan Seymen, Marta Rzepkowska, Sarah Mackie, Prodromos Chatzikyriakou, Laarni Bogaanay, Jen Lewis, Maroof Hasan, Rajasekhar N.V.S. Suragani, James Carmichael, Ghulam Mufti, Anita K. Gandhi, Giorgio Napolitani, Lynn Quek
Journal: Blood
Blood (2023) 142 (Supplement 1): 812.
https://doi.org/10.1182/blood-2023-174947
Published: 2023
Journal Articles

Clonal Hematopoiesis-Related Mutations Are Associated with Favorable Clinical Benefit Following Luspatercept Treatment in Patients with Lower-Risk Myelodysplastic Syndromes: A Subgroup Analysis from the Phase 3 COMMANDS Trial

Maroof Hasan, Sadanand Vodala, Sheida Hayati, Guillermo Garcia-Manero, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3214.
https://doi.org/10.1182/blood-2023-178666
Published: 2023
Journal Articles

Predictive Biomarkers of Response to Luspatercept in Patients with Myelofibrosis- (MF) Associated Anemia: Biomarker Analysis from the ACE-536-MF-001 Study

Danny Jeyaraju, Sheida Hayati, Niloufar Marsousi, Aaron T. Gerds, Francesco Passamonti, Fabian Sanabria, Sadanand Vodala, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 6330.
https://doi.org/10.1182/blood-2023-182155
Published: 2023
Journal Articles

Luspatercept Modulates Inflammation in the Bone Marrow, Restores Effective Erythropoiesis/Hematopoiesis, and Provides Sustained Clinical Benefit Versus Epoetin Alfa (EA): Biomarker Analysis from the Phase 3 COMMANDS Study

Sheida Hayati, Amer M. Zeidan, Guillermo Garcia-Manero, Uwe Platzbecker, Aarif Ahsan, Amit K. Verma, Srinivas Aluri, Manuel Ugidos Guerrero, Anita K. Gandhi, Rajasekhar N.V.S. Suragani, Sadanand Vodala
Journal: Blood
Blood (2023) 142 (Supplement 1): 1845.
https://doi.org/10.1182/blood-2023-178674
Published: 2023
Journal Articles

Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia

Aarif Ahsan, Wei Fang, Manuel Ugidos, Danny V Jeyaraju, Pierre Fenaux, Uwe Platzbecker, Olivier Hermine, John B. Porter, Rajasekhar N.V.S. Suragani, Sadanand Vodala, Anita K. Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8188–8189.
https://doi.org/10.1182/blood-2022-166559
Published: 2022
Journal Articles

Luspatercept Redistributes Body Iron to the Liver in Transfusion-Dependent-Thalassemia (TDT) during Erythropoietic Response

Maciej W. Garbowski, Manuel Ugidos, Alberto Risueño, Rajasekhar N.V.S. Suragani, Jeevan K. Shetty, Sadanand Vodala, Anjan Thakurta, Martin Schwickart, John B. Porter
Journal: Blood
Blood (2021) 138 (Supplement 1): 761.
https://doi.org/10.1182/blood-2021-145975
Published: 2021
Journal Articles

Rap-536 Induces Reticulocyte Maturation in Wild-Type Mice, Increases Survival of Beta-Thalassemic Reticulocytes, and Increases Red Blood Cells in a Mouse Model of Alpha-Thalassemia

Melih Acar, Madhulika Jupelli, Roberto A. Abbiati, Harish N. Ramanathan, Cristina C. Santini, Alexander Ratushny, Diana R. Dunshee, Daniel Lopes de Menezes, PhD, Kyle MacBeth, Rajasekhar N.V.S. Suragani, Remco Loos, Martin Schwickart
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-137373
Published: 2020