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Journal Articles

Efficacy and Safety of Fedratinib in Patients with Myelofibrosis and Low Baseline Platelet Counts in the Phase 3 Randomized FREEDOM2 Trial

Haifa Kathrin Al-Ali, Claire Harrison, Ruben Mesa, Moshe Talpaz, Blanca Xicoy, Francesco Passamonti, Alessandro Vannucchi, Patrick Brown, Christopher Hernandez, Jia Wang, Jun He, Jean-Jacques Kiladjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 482.
https://doi.org/10.1182/blood-2024-193645
Published: 2024
Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Andrew Hughes, Rawan Shraim, Lahari Uppuluri, Haley Newman, Gongping Shi, Julie Asare, Theresa Ryan, Elizabeth A. Raetz, James A. Whitlock, Maureen M. O'Brien, Deepa Bhojwani, Rachel E. Rau, Kara L. Davis, Stacy Cooper, Patrick Brown, Stephen P. Hunger, Mignon L. Loh, Laura E. Hogan, Stephan A. Grupp, Jun J. Yang, David T. Teachey, Caroline Diorio
Journal: Blood
Blood (2024) 144 (Supplement 1): 634.
https://doi.org/10.1182/blood-2024-203756
Published: 2024
Journal Articles

Biomarkers of Renal Health in Patients (pts) Treated with Fedratinib in the FREEDOM and FREEDOM2 Trials

Vikas Gupta, Yizhe Chen, Patrick Brown, Danny Jeyaraju, Moshe Talpaz, Ruben Mesa, Richard Pilot, Christopher Hernandez, Jia Wang, Jean-Jacques Kiladjian, Alessandro Vannucchi, Claire Harrison
Journal: Blood
Blood (2024) 144 (Supplement 1): 6623.
https://doi.org/10.1182/blood-2024-194223
Published: 2024
Journal Articles

Efficacy and Safety of Fedratinib in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Results from the Phase 3 Randomized FREEDOM2 Study

Claire N Harrison, Ruben Mesa, Moshe Talpaz, Haifa Kathrin Al-Ali, Blanca Xicoy, Francesco Passamonti, Francesca Palandri, Giulia Benevolo, Alessandro M. Vannucchi, Clemence Mediavilla, Alessandra Iurlo, InHo Kim, Patrick Brown, Christopher Hernandez, Shelonitda Rose, Jia Wang, Jean-Jacques Kiladjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 3204.
https://doi.org/10.1182/blood-2023-173391
Published: 2023
Journal Articles

Fedratinib Treatment Reduces the Inflammatory Cytokine Profile and Decreases Exhausted T Cells Correlating with Clinical Response in Patients with Myelofibrosis: Biomarker Analysis from the Phase 3 FREEDOM2 Trial

Danny Jeyaraju, Sheida Hayati, Jia Wang, Claire N Harrison, Jean-Jacques Kiladjian, Christopher Hernandez, Patrick Brown, Daniel Lopes De Menezes, Anita K. Gandhi, Rajasekhar N.V.S. Suragani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2023-180419
Published: 2023
Journal Articles

Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium

Clinical Trials & Observations
Swantje Buchmann, Martin Schrappe, Andre Baruchel, Andrea Biondi, Michael Borowitz, Myriam Campbell, Gunnar Cario, Giovanni Cazzaniga, Gabriele Escherich, Christine J. Harrison, Mats Heyman, Stephen P. Hunger, Csongor Kiss, Hsi-Che Liu, Franco Locatelli, Mignon L. Loh, Atsushi Manabe, Georg Mann, Rob Pieters, Ching-Hon Pui, Susana Rives, Kjeld Schmiegelow, Lewis B. Silverman, Jan Stary, Ajay Vora, Patrick Brown
Journal: Blood
Blood (2022) 139 (12): 1785–1793.
https://doi.org/10.1182/blood.2021012328
Published: 2022
Includes: Supplemental data
Journal Articles

How I treat infant leukemia

Patrick Brown, Rob Pieters, Andrea Biondi
Journal: Blood
Blood (2019) 133 (3): 205–214.
https://doi.org/10.1182/blood-2018-04-785980
Published: 2019
Journal Articles

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-Risk Leukemias: A Report from the LEAP Consortium

Yana Pikman, MD, Sarah K. Tasian, MD, Maria Luisa Sulis, MD, Todd M Cooper, DO, Melinda Pauly, MD, Kelly W. Maloney, MD, Michael J. Burke, MD, Patrick Brown, MD, Nathan Gossai, MD, Peter Cole, MD, Jennifer McNeer, MD MS, Neerav Shukla, MD, Beth Apsel Winger, MD PhD, Asmani A Adhav, Traci M. Blonquist, MS, Amy Conway, Andrew E. Place, MD PhD, Lia Gore, MD, Stephen P. Hunger, MD, Katherine Janeway, MD MMSc, Lewis B. Silverman, MD, Jeffrey W. Tyner, PhD, Marian H. Harris, MD PhD, Mignon L. Loh, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 261.
https://doi.org/10.1182/blood-2018-99-116948
Published: 2018
Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 918.
https://doi.org/10.1182/blood-2018-99-119206
Published: 2018
Journal Articles

Induction Toxicities Are More Frequent in Young Adults Compared to Children Treated on the Children's Oncology Group (COG) First Relapse B-Lymphoblastic Leukemia Clinical Trial AALL1331

Laura Brook Hogan, MD, Teena Bhatla, MD, Sue Rheingold, MD, Lingyun Ji, PhD, Xinxin Xu, Elizabeth A. Raetz, MD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1382.
https://doi.org/10.1182/blood-2018-99-112269
Published: 2018
Journal Articles

Blinatumomab for MRD + B-ALL: the evidence strengthens

Clinical Trials & Observations
Patrick Brown
Journal: Blood
Blood (2018) 131 (14): 1497–1498.
https://doi.org/10.1182/blood-2018-02-830364
Published: 2018
Journal Articles

Genomic Analysis and Pathway Characterization of Genes with Somatic Variants in Infant Acute Lymphoblastic Leukemia

Jillian Fry, Midhat S. Farooqi, MD PhD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Emily Farrow, PhD CGC, Shannon Kelley, MS, Margaret Gibson, Neil Miller, Jeffrey Johnston, Patrick Brown, MD, Erin Guest, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3970.
https://doi.org/10.1182/blood.V130.Suppl_1.3970.3970
Published: 2017
Journal Articles

Differential Expression of Adhesion Molecule Receptors May Influence Bone Marrow Microenvironment-Mediated Protection of Leukemia-Initiating Cells (LICs) in Infant MLL- rearranged ( MLL- R) Acute Lymphoblastic Leukemia (ALL)

Edward Allan R. Sison, MD, Amos S. Gaikwad, PhD, Gaye Jenkins, Terzah M. Horton, MD PhD, Patrick Brown, MD, Michele S. Redell, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1585.
https://doi.org/10.1182/blood.V128.22.1585.1585
Published: 2016
Journal Articles

Landscape of Somatic Mutations and Gene Expression Changes in Relapsed Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Rumen Kostadinov, PhD, Midhat Farooqi, MD PhD, Byunggil Yoo, MS, Emily Farrow, PhD CGC, Shannon Kelley, Margaret Gibson, Neil Miller, Erin M. Guest, MD, Patrick Brown, MD
Journal: Blood
Blood (2016) 128 (22): 1735.
https://doi.org/10.1182/blood.V128.22.1735.1735
Published: 2016
Journal Articles

High Rates of Minimal Residual Disease-Negative (MRD−) Complete Responses (CR) in Adult and Pediatric and Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) Treated With KTE-C19 (Anti-CD19 Chimeric Antigen Receptor [CAR] T Cells): Preliminary Results of the ZUMA-3 and ZUMA-4 Trials

Bijal Shah, MD, Van Huynh, MD, Leonard S. Sender, MD, Daniel W. Lee, III, MD, Januario E. Castro, MD, William G. Wierda, MD PhD, Andrew C. Dietz, MD MSCR, Gary J. Schiller, MD, Marie José Kersten, MD PhD, Rupert Handgretinger, MD PhD, Patrick Brown, MD, Lia Gore, MD, Nicola Gökbuget, MD, Joseph Rosenthal, MD MS, Marianna Sabatino, MD, Adrian Bot, MD PhD, John M. Rossi, MS, Yizhou Jiang, PhD, Lynn Navale, MS, Shanna Stout, BS, Jeff S. Aycock, BA, Jeff Wiezorek, MD MS, Rajul Jain, MD, Alan S. Wayne, MD
Journal: Blood
Blood (2016) 128 (22): 2803.
https://doi.org/10.1182/blood.V128.22.2803.2803
Published: 2016
Journal Articles

Proteomic/Transcriptomic Signatures of Infant MLL-r Rearranged B-ALL at Diagnosis and Relapse Reveal Lineage Plasticity and Diagnostic Heterogeneity

Jevon Cutler, Raiha Tahir, Rumen Kostadinov, PhD, Raja Sekhar, PhD, Tai-Chung Huang, MD PhD, Akhilesh Pandey, MD PhD, Patrick Brown, MD, Mohammad Heydarian, PhD, Karen Reddy, PhD
Journal: Blood
Blood (2016) 128 (22): 2697.
https://doi.org/10.1182/blood.V128.22.2697.2697
Published: 2016
Journal Articles

Final Report of Phase 1 Study of the DOT1L Inhibitor, Pinometostat (EPZ-5676), in Children with Relapsed or Refractory MLL-r Acute Leukemia

Neerav Shukla, MD, Cynthia Wetmore, MD PhD, Maureen M O'Brien, MD, Lewis B. Silverman, MD, Patrick Brown, MD, Todd M Cooper, DO, Blythe Thomson, MD, Stephen J. Blakemore, PhD, Scott Daigle, Ben Suttle, Nigel J. Waters, PhD, Andrei V Krivstov, PhD, Scott A. Armstrong, MD PhD, Peter T Ho, PhD MD, Lia Gore, MD
Journal: Blood
Blood (2016) 128 (22): 2780.
https://doi.org/10.1182/blood.V128.22.2780.2780
Published: 2016
Journal Articles

Pilot Study of Decitabine and Vorinostat with Chemotherapy for Relapsed ALL: A Report from the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium

Michael J. Burke, MD, Patrick Brown, MD, Richard Sposto, PhD, Lia Gore, MD, Alan S. Wayne, MD
Journal: Blood
Blood (2016) 128 (22): 2781.
https://doi.org/10.1182/blood.V128.22.2781.2781
Published: 2016
Journal Articles

Minimal Residual Disease Assessment of Remission after Induction Therapy Is Superior to Morphologic Assessment for Risk Stratification in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group (COG)

Sumit Gupta, MD, Meenakshi Devidas, PhD, Si Chen, MS, Cindy Wang, MSc, Mignon L. Loh, MD, Elizabeth Raetz, MD, Patrick Brown, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Julie M. Gastier-Foster, PhD, Kimberly P. Dunsmore, MD, Eric Larsen, MD, Kelly Maloney, MD, Leonard A. Mattano, Jr., MD, Stuart Winter, MD, Naomi Winick, MD, William L. Carroll, MD, Stephen Hunger, Michael J. Borowitz, MD PhD, Brent L. Wood, MD PhD
Journal: Blood
Blood (2016) 128 (22): 758.
https://doi.org/10.1182/blood.V128.22.758.758
Published: 2016
Journal Articles

A Wilms Tumor 1 (WT1) Mutation Causes Myelodysplastic Syndrome in a Knock-in Mouse Model, and a Mixed Myelodysplastic/Myeloproliferative Neoplam in Double Knock-in Mice with WT1 and FLT3/ITD Mutations

Colleen E. Annesley, MD, Amy S. Duffield, MD PhD, Rachel E. Rau, MD, Gregory McCarty, Daniel Magoon, Li Li, MD PhD, Vicki Huff, PhD, Donald Small, MD PhD, David Loeb, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2015) 126 (23): 312.
https://doi.org/10.1182/blood.V126.23.312.312
Published: 2015