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Giovanni Cazzaniga
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Journal Articles

NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLLr B-ALL by regulating NR3C1 expression

Belén Lopez-Millan, Alba Rubio-Gayarre, Meritxell Vinyoles, Juan L. Trincado, Mario F. Fraga, Narcís Fernandez-Fuentes, Mercedes Guerrero-Murillo, Alba Martinez, Talia Velasco-Hernandez, Aïda Falgàs, Carla Panisello, Gemma Valcarcel, José Luis Sardina, Paula López-Martí, Biola M. Javierre, Beatriz Del Valle-Pérez, Antonio García de Herreros, Franco Locatelli, Rob Pieters, Michela Bardini, Giovanni Cazzaniga, Juan Carlos Rodríguez-Manzaneque, Thomas Hanewald, Rolf Marschalek, Thomas A. Milne, Ronald W. Stam, Juan Ramón Tejedor, Pablo Menendez, Clara Bueno
Journal: Blood
Blood (2024) 144 (19): 2002–2017.
https://doi.org/10.1182/blood.2023022050
Published: 2024
Includes: Supplemental data
Journal Articles

Frequency and Early Prognostic Significance of Gene-Class Fusions Identified By RNA-Seq in Children and Adolescent with T-Cell Acute Lymphoblastic Leukemia Enrolled on AIEOP-BFM ALL 2017 Study

Giacomo Gotti, Claudia Saitta, Daniela Silvestri, Arianna Colombo, Federica Colnaghi, Stefano Rebellato, Matilde Marzorati, Nicolò Peccatori, Nicoletta Bertorello, Luca Lo Nigro, Franco Locatelli, Rosanna Parasole, Maria Caterina Putti, Valentino Conter, Antonella Colombini, Barbara Buldini, Andrea Biondi, Maria Grazia Valsecchi, Giovanni Cazzaniga, Grazia Fazio, Carmelo Rizzari
Journal: Blood
Blood (2024) 144 (Supplement 1): 4217.
https://doi.org/10.1182/blood-2024-207345
Published: 2024
Journal Articles

CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Clinical Trials & Observations
Barbara Buldini, Elena Varotto, Margarita Maurer-Granofszky, Giuseppe Gaipa, Angela Schumich, Monika Brüggemann, Ester Mejstrikova, Giovanni Cazzaniga, Ondrej Hrusak, Monika Szczepanowski, Pamela Scarparo, Martin Zimmermann, Sabine Strehl, Dagmar Schinnerl, Marketa Zaliova, Leonid Karawajew, Jean-Pierre Bourquin, Tamar Feuerstein, Gunnar Cario, Julia Alten, Anja Möricke, Alessandra Biffi, Rosanna Parasole, Franca Fagioli, Maria Grazia Valsecchi, Andrea Biondi, Franco Locatelli, Andishe Attarbaschi, Martin Schrappe, Valentino Conter, Giuseppe Basso, Michael N. Dworzak
Journal: Blood
Blood (2024) 143 (17): 1738–1751.
https://doi.org/10.1182/blood.2023021952
Published: 2024
Includes: Supplemental data
Journal Articles

First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis

Ilaria Crespiatico, Mattia Zaghi, Cristina Mastini, Deborah D’Aliberti, Mario Mauri, Carl Mirko Mercado, Diletta Fontana, Silvia Spinelli, Valentina Crippa, Elena Inzoli, Beatrice Manghisi, Ivan Civettini, Daniele Ramazzotti, Valentina Sangiorgio, Michele Gengotti, Virginia Brambilla, Andrea Aroldi, Federica Banfi, Cristiana Barone, Roberto Orsenigo, Ludovica Riera, Mara Riminucci, Alessandro Corsi, Massimo Breccia, Alessandro Morotti, Daniela Cilloni, Aldo Roccaro, Antonio Sacco, Fabio Stagno, Marta Serafini, Federica Mottadelli, Giovanni Cazzaniga, Fabio Pagni, Roberto Chiarle, Emanuele Azzoni, Alessandro Sessa, Carlo Gambacorti-Passerini, Elena Maria Elli, Luca Mologni, Rocco Piazza
Journal: Blood
Blood (2024) 143 (14): 1399–1413.
https://doi.org/10.1182/blood.2023021349
Published: 2024
Includes: Supplemental data
Journal Articles

Biallelic PI4KA mutations Disrupt B Cell Mitochondrial Metabolism and Cause Hypogammaglobulinemia

Francesco Saettini, Fabiola Guerra, Mario Mauri, Grazia Fazio, Cristina Bugarin, Manuel Quadri, Stefano Rebellato, Clizia Chinello, Lisa Pagani, Federica Malighetti, Luis González Gutiérrez-Solana, Vanna Denti, Fatemeh Emam Mousavi, Miquell Raspall-Chaure, Martin-Nalda Andrea, Estibaliz Barredo, David Adams, O'Leary Melanie, Precilla D'Souza, Ellen Macnamara, Sergio Rosenzweig, Hye Sun Kuehn, Jennifer Stoddard, Heather C Mefford, Giorgia Mandrile, Lisa Pavinato, Alfredo Brusco, Patricia Valentina Velez Santamaria, Aurora Pujol, Vincent Michaud, Agathe Roubertie, Zoe Nelson, Margaret P Adam, Bernice Lo, Holm Uhlig, Claire G Salter, Emma Baple, Andrew H Crosby, Sanil Bhatia, Fulvio Magni, Giuseppe Paglia, Giovanni Cazzaniga, Rocco Piazza, Andrea Biondi, Matteo Barberis
Journal: Blood
Blood (2023) 142 (Supplement 1): 153.
https://doi.org/10.1182/blood-2023-185551
Published: 2023
Journal Articles

Somatic and Germline Cohesin Genes Alterations in Pediatric Acute Lymphoblastic Leukemia

Stefano Rebellato, Claudia Saitta, Laura Rachele Bettini, Daniela Silvestri, Orietta Spinelli, Agata Pastorczak, Danielle Brandes, Ute Fischer, Arndt Borkhardt, Sabine Strehl, Luca Lo Nigro, Barbara Buldini, Julia Hauer, Franziska Auer, Lennart Kester, Roland P. Kuiper, Luciana Vinti, Franco Locatelli, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga
Journal: Blood
Blood (2023) 142 (Supplement 1): 1600.
https://doi.org/10.1182/blood-2023-189244
Published: 2023
Journal Articles

First-Hit SETBP1 Mutations Cause a Myeloproliferative Disorder with Bone Marrow Fibrosis

Ilaria Crespiatico, Mattia Zaghi, Cristina Mastini, Deborah D'Aliberti, Mario Mauri, Carl Mirko Mercado, Diletta Fontana, Silvia Spinelli, Valentina Crippa, Elena Inzoli, Beatrice Manghisi, Ivan Civettini, Daniele Ramazzotti, Valentina Fabiola Ilenia Lavoro, Michele Gengotti, Virginia Brambilla, Andrea Aroldi, Federica Banfi, Cristiana Barone, Roberto Orsenigo, Ludovica Riera, Mara Riminucci, Alessandro Corsi, Massimo Breccia, Alessandro Morotti, Daniela Cilloni, Aldo Roccaro, Antonio Sacco, Fabio Stagno, Marta Serafini, Federica Mottadelli, Giovanni Cazzaniga, Fabio Pagni, Roberto Chiarle, Emanuele Azzoni, Alessandro Sessa, Carlo Gambacorti-Passerini, Elena Maria Elli, Luca Mologni, Rocco Piazza
Journal: Blood
Blood (2023) 142 (Supplement 1): 4135.
https://doi.org/10.1182/blood-2023-189094
Published: 2023
Journal Articles

Crebbp Mutations Are Associated with Slow Minimal Residual Response to Upfront Induction Chemotherapy in Pediatric High-Hyperdiploid B-Cell Precursor Acute Lymphoblastic Leukemia Treated in the AIEOP-BFM ALL 2009 Protocol

Giacomo Gotti, Daniela Silvestri, Grazia Fazio, Chiara Palmi, Valentino Conter, Maria Grazia Valsecchi, Carmelo Rizzari, Barbara Buldini, Franco Locatelli, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2023) 142 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2023-187833
Published: 2023
Journal Articles

Distinct Pattern of ABL1 Genomic Breakpoints in Chronic Myeloid Leukemia and BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Analysis of 884 Patients with Minor and Major BCR::ABL1 Fusion

Lenka Hovorkova, Lucie Winkowska, Justina Krotka, Manuela Krumbholz, Claus Meyer, Rosemary Sutton, Michelle Henderson, Emmanuelle Clappier, Sabina Chiaretti, Lucie Sramkova, Jan Stary, Adela Benesova, Katerina Machova Polakova, Rolf Marschalek, Markus Metzler, Giovanni Cazzaniga, Gunnar Cario, Jan Trka, Marketa Zaliova, Jan Zuna
Journal: Blood
Blood (2023) 142 (Supplement 1): 1605.
https://doi.org/10.1182/blood-2023-180355
Published: 2023
Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

Impact of Additional Intensive L-Asparaginase Therapy during Consolidation Phase for High-Risk Acute Lymphoblastic Leukemia: Results of a Randomized Controlled Trial in the AIEOP-BFM ALL 2009 Protocol

Valentino Conter, Maria Grazia Valsecchi, Gunnar Cario, Martin Zimmermann, Andishe Attarbaschi, Jan Stary, Felix Niggli, Luciano Dalla Pozza, Sarah Elitzur, Daniela Silvestri, Franco Locatelli, Anja Moericke, Gernot Engstler, Petr Smisek, Nicole Bodmer, Draga Barbaric, Shai Izraeli, Carmelo Rizzari, Joachim Boos, Barbara Buldini, Claudia Lanvers-Kaminsky, Giovanni Cazzaniga, Bernd Gruhn, Andrea Biondi, Martin Schrappe
Journal: Blood
Blood (2022) 140 (Supplement 1): 109–111.
https://doi.org/10.1182/blood-2022-166583
Published: 2022
Journal Articles

First Description of a Frameshift PAX5 Germline Variant in Two Siblings with B-Cell Precursor Acute Lymphoblastic Leukemia

Laura Rachele Bettini, Grazia Fazio, Claudia Saitta, Sonia Palamini, Chiara Buracchi, Stefano Rebellato, Nicola Santoro, Cristiano Simone, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 3489–3490.
https://doi.org/10.1182/blood-2022-169311
Published: 2022
Journal Articles

The RNA Binding Protein Musashi-2 (MSI2) Sustains the Growth and the Leukemogenic Potential of MLL-Rearranged Acute Lymphoblastic Leukemia, and It Is Involved in Glucocorticoid Resistance

Luigia Valsecchi, Simone Naso, Simona Procopio, Mario Mauri, Rocco Piazza, Titus Watrin, Sanil Bhatia, Valentina Pasquale, Elena Sacco, Chiara Palmi, Grazia Fazio, Luca Trentin, Silvia Bresolin, Andrea Biondi, Giovanni Cazzaniga, Michela Bardini
Journal: Blood
Blood (2022) 140 (Supplement 1): 8827–8828.
https://doi.org/10.1182/blood-2022-166313
Published: 2022
Journal Articles

ALL-REZ BFM 2002 Is Associated with Improved Outcome as Compared to ALL-R3 Strategy in Children with Standard Risk Isolated CNS Relapse of Acute Lymphoblastic Leukemia, while Maintaining Comparable Efficacy in Patients with Bone Marrow Relapse. Results of the Multi-National, Multi-Center Trial IntReALL SR 2010

Arend von Stackelberg, Jean-Pierre Bourquin, Martin Zimmermann, Tamas Revesz, Andishe Attarbaschi, Alina Ferster, Lucie Sramkova, Thomas Leth Frandsen, Päivi Maria Lähteenmäki, Ronit Elhasid, Hidemi Toyoda, Peter M. Hoogerbrugge, Inga M. Johannsdottir, Ximo Duarte, Denise Bonney, Vaskar Saha, Ingo G. Steffen, Andrej Lissat, Christiane Chen-Santel, Cornelia Eckert, Andre Baruchel, Arnaud Petit, Hélène Cavé, Carmelo Rizzari, Giovanni Cazzaniga, Luciana Vinti, Pierre Rohrlich, Franco Locatelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 3247–3249.
https://doi.org/10.1182/blood-2022-166234
Published: 2022
Journal Articles

Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia

Grazia Fazio, Manuel Quadri, Silvia Bresolin, Chiara Palmi, Michela Bardini, Athanasios Oikonomou, Jia-Wey Tu, Katerina Scharov, Alberto Peloso, Titus Watrin, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 3107–3108.
https://doi.org/10.1182/blood-2022-169023
Published: 2022
Journal Articles

Novel Drugs to Target JAK2 Rearrangements in Pediatric Acute Lymphoblastic Leukemia

Manuel Quadri, Claudia Saitta, Sonia Palamini, Chiara Palmi, Jia-Wey Tu, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga, Grazia Fazio
Journal: Blood
Blood (2022) 140 (Supplement 1): 364–365.
https://doi.org/10.1182/blood-2022-169437
Published: 2022
Journal Articles

Ph-like and IKZF1plus Features in Children with Down Syndrome and B Cell Precursor Acute Lymphoblastic Leukemia

Chiara Palmi, Silvia Bresolin, Stefanie V. Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Claudia Saitta, Marta Galbiati, Michela Bardini, Sanil Bhatia, Arndt Borkhardt, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruij Te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 6367–6368.
https://doi.org/10.1182/blood-2022-169131
Published: 2022
Journal Articles

Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium

Clinical Trials & Observations
Swantje Buchmann, Martin Schrappe, Andre Baruchel, Andrea Biondi, Michael Borowitz, Myriam Campbell, Gunnar Cario, Giovanni Cazzaniga, Gabriele Escherich, Christine J. Harrison, Mats Heyman, Stephen P. Hunger, Csongor Kiss, Hsi-Che Liu, Franco Locatelli, Mignon L. Loh, Atsushi Manabe, Georg Mann, Rob Pieters, Ching-Hon Pui, Susana Rives, Kjeld Schmiegelow, Lewis B. Silverman, Jan Stary, Ajay Vora, Patrick Brown
Journal: Blood
Blood (2022) 139 (12): 1785–1793.
https://doi.org/10.1182/blood.2021012328
Published: 2022
Includes: Supplemental data
Journal Articles

Potential Role of STAG1 Mutations in Genetic Predisposition to Childhood Hemato-Oncological Diseases

Claudia Saitta, Stefano Rebellato, Laura Rachele Bettini, Giovanni Giudici, Nicolò Panini, Eugenio Erba, Simona Songia, Valentina Massa, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga
Journal: Blood
Blood (2021) 138 (Supplement 1): 1155.
https://doi.org/10.1182/blood-2021-152586
Published: 2021
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Chiara F Magnani, Giuseppe Gaipa, Federico Lussana, Giuseppe Gritti, Daniela Belotti, Sara Napolitano, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Silvia Zaninelli, Giuliana Rizzuto, Gianluca Cavallaro, Sarah Tettamanti, Giovanni Cazzaniga, Stefania Galimberti, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal: Blood
Blood (2021) 138 (Supplement 1): 472.
https://doi.org/10.1182/blood-2021-148703
Published: 2021