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Julia Alten
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Journal Articles

Drug Sensitivity and Treatment Response Are Modulated By the Cell of Origin, the Underlying Gene Fusion, and Patient Age in KMT2A -Rearranged BCP-ALL

Alina M. Hartmann, Lorenz Bastian, Malwine J Barz, Eric Amelunxen, Johannes Haas, Lennart Lenk, Michaela Kotrova, Thomas Beder, Fabio D. Steffen, Kerstin K. Rauwolf, Nadine Wolgast, Patrick Ehm, Sonja Bendig, Julia Alten, Mayukh Mondal, Aeint-Steffen Ströh, Thomas Burmeister, Nicola Goekbuget, Beat Bornhauser, Jean-Pierre Bourquin, Monika Brüggemann, Martin Schrappe, Gunnar Cario, Claudia D Baldus
Journal: Blood
Blood (2024) 144 (Supplement 1): 318.
https://doi.org/10.1182/blood-2024-199017
Published: 2024
Journal Articles

The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis

Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Anna Dietterle, Dorothee Winterberg, Caroline Mary, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Stéphanie Neyton, Mylène Déramé, Sabrina Pengam, Fotini Vogiatzi, Beat Bornhauser, Jean-Pierre Bourquin, Simon Raffel, Vladyslava Dovhan, Thomas Schüler, Gabriele Escherich, Monique L. den Boer, Judith M. Boer, Wiebke Wessels, Matthias Peipp, Julia Alten, Željko Antić, Anke K. Bergmann, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis M. Schewe
Journal: Blood
Blood (2024) 143 (26): 2735–2748.
https://doi.org/10.1182/blood.2023021088
Published: 2024
Includes: Supplemental data
Journal Articles

CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Clinical Trials & Observations
Barbara Buldini, Elena Varotto, Margarita Maurer-Granofszky, Giuseppe Gaipa, Angela Schumich, Monika Brüggemann, Ester Mejstrikova, Giovanni Cazzaniga, Ondrej Hrusak, Monika Szczepanowski, Pamela Scarparo, Martin Zimmermann, Sabine Strehl, Dagmar Schinnerl, Marketa Zaliova, Leonid Karawajew, Jean-Pierre Bourquin, Tamar Feuerstein, Gunnar Cario, Julia Alten, Anja Möricke, Alessandra Biffi, Rosanna Parasole, Franca Fagioli, Maria Grazia Valsecchi, Andrea Biondi, Franco Locatelli, Andishe Attarbaschi, Martin Schrappe, Valentino Conter, Giuseppe Basso, Michael N. Dworzak
Journal: Blood
Blood (2024) 143 (17): 1738–1751.
https://doi.org/10.1182/blood.2023021952
Published: 2024
Includes: Supplemental data
Journal Articles

Drug Response Profiling Informs Personalized Bridging to Cell Therapy for Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Fabio D. Steffen, Andrej Lissat, Julia Alten, Cornelia Eckert, Nicole Bodmer, Bodil E. Thorhauge Als-Nielsen, Adriana Balduzzi, Barbara Buldini, Sarah Elitzur, Andras Kriston, Gergely Nyiri, Imre Västrik, Ferenc Kovacs, Francesco Ceppi, Lucie Sramkova, Larissa Schori, Arianna Arpagaus, Silvia Gutnik, Andishe Attarbaschi, Birgitte Klug Albertsen, Jeanette Greiner, Marc Ansari, Judith M. Boer, Elad Jacoby, Martin Stanulla, Uri Ilan, Peter M. Hoogerbrugge, Tim Lammens, Barbara De Moerloose, Petter Svenberg, Nicolas von der Weid, David O'Connor, Hélène Cavé, Franco Locatelli, Martin Schrappe, André Baruchel, Andreas Kulozik, Kjeld Schmiegelow, Gunnar Cario, Arend von Stackelberg, Peter Horvath, Beat Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2023-179306
Published: 2023
Journal Articles

In-Depth Immune Profiling in Children with BCP-ALL within the AIEOP-BFM ALL 2017 Study

Anna Laqua, Hartmann Raifer, Miriam Kelm, Johanna Horns, Arunabh Sharma, Anja Möricke, Michaela Vossen-Gajcy, Julia Alten, Lena Fischer-Riepe, Bianca Altvater, Mahdi Rasa, Britta Kehden, Constantin Proske, Jan Kässens, Thomas Beder, Sonja Bendig, Nadine Wolgast, Lorenz Bastian, Matthias Ritgen, Magdalena Huber, Astrid Dempfle, Claudia D Baldus, Gunnar Cario, Martin Schrappe, Claudia Rossig, Monika Brüggemann, Guranda Chitadze
Journal: Blood
Blood (2023) 142 (Supplement 1): 595.
https://doi.org/10.1182/blood-2023-186998
Published: 2023
Journal Articles

Hypersensitivity Reactions to Native E. coli L-Asparaginase in Children with Acute Lymphoblastic Leukemia May Vary By Treatment Schedule and Type of Glucocorticoid in Induction: Results of Trial ALL-BFM 2000

Anja Möricke, Martin Schrappe, Carmelo Rizzari, Julia Alten, Andishe Attarbaschi, Rita Beier, Andrea Biondi, Birgit Burkhardt, Nicole Bodmer, Joachim Boos, Gunnar Cario, Valentino Conter, Christian Flotho, Andreas E. Kulozik, Claudia Lanvers-Kaminsky, Georg Mann, Felix Niggli, Daniela Silvestri, Arend von Stackelberg, Martin Stanulla, Maria Grazia Valsecchi, Martin Zimmermann
Journal: Blood
Blood (2022) 140 (Supplement 1): 11676–11678.
https://doi.org/10.1182/blood-2022-163142
Published: 2022
Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

Recurrent DNMT3B Alterations Are Associated with Unfavorable Outcome in Dicentric (9;20)-Positive Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Željko Antić, Alena van Bömmel, Konstantin Riege, Jana Lentes, Charlotte Schröder, Julia Alten, Lara Fuhrmann, Martin Zimmermann, Cornelia Eckert, Gunnar Cario, Martin Schrappe, Brigitte Schlegelberger, Steve Hoffmann, Anke K. Bergmann
Journal: Blood
Blood (2022) 140 (Supplement 1): 9185–9186.
https://doi.org/10.1182/blood-2022-163404
Published: 2022
Journal Articles

Implication of ICOSLG on Relapse in Infant T(4;11) Acute Lymphoblastic Leukemia

Marius Külp, Anna Lena Siemund, Claus Meyer, Patrizia Larghero, Alissa Dietz, Julia Alten, Gunnar Cario, Aurélie Caye-Eude, Hélène Cavé, Michela Bardini, Paola De Lorenzo, Giovanni Cazzaniga, Laura Diehl, Halvard Bonig, Rolf Marschalek
Journal: Blood
Blood (2021) 138 (Supplement 1): 3481.
https://doi.org/10.1182/blood-2021-146181
Published: 2021
Journal Articles

Minimal Residual Disease and Outcome Characteristics in Infant KMT2A-Germline Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, Paola De Lorenzo, Inge M. Van Der Sluis, Julia Alten, Philip Ancliffe, Andishe Attarbaschi, Luis Alberto Aversa, Judith M. Boer, Andrea Biondi, Benoit Brethon, Paulina Diaz, Giovanni Gazzaniga, Gabriele Escherich, Alina Ferster, Rishi S Kotecha, Birgitte Lausen, Alex WK Leung, Franco Locatelli, Lewis B. Silverman, Jan Stary, Tomasz Szczepanski, Vincent H.J. Van Der Velden, Ajay Vora, Jan Zuna, Martin Schrappe, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 2383.
https://doi.org/10.1182/blood-2021-145058
Published: 2021
Journal Articles

Clinical Implications of Minimal Residual Disease Detection in Infants with KMT2A -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, MDPhD, Inge M. van der Sluis, MD PhD, Paola De Lorenzo, Julia Alten, MD, Philip Ancliff, MD, Andishe Attarbaschi, MD, Benoit Brethon, MD, Andrea Biondi, MD, Myriam Campbell, MD, Giovanni Cazzaniga, PhD, Gabriele Escherich, MD, Alina Ferster, MD, Rishi Sury Kotecha, MBBChir, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Luca Lo Nigro, PhDMD, Franco Locatelli, MD PhD, Rolf Marschalek, PhD, Martin Schrappe, MDPhD, Jan Stary, MD PhD, Ajay Vora, MD, Jan Zuna, PhD, Vincent H.J. Van Der Velden, PhD, Tomasz Szczepanski, MD PhD, Maria Grazia Valsecchi, PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-134303
Published: 2020
Journal Articles

In Vitro Drug Response Profiling in BCP- and T-ALL Primary Samples Adds a Robust Functional Layer Enabling Optimized Guidance of Individualized Therapy in Relapsed and Refractory Pediatric Acute Leukemia Patients

Andrej Lissat, Despina Maniotis, Michael Nosswitz, Julia Alten, MD, Silvia Jenni, PhD, Yi-Chien Tsai, Gunnar Cario, MD PhD, Roberta La Starza, MDPhD, Ondrej Hrusak, MD PhD, Andreas E. Kulozik, MD PhD, Olaf Witt, Martin Stanulla, MD, Martin Schrappe, MDPhD, Christian M. Zwaan, MD PhD, Cornelia Eckert, PhD, Arend von Stackelberg, MD, Andre Baruchel, Elad Jacoby, MD, Axel Karow, Francesco Ceppi, MD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-142314
Published: 2020
Journal Articles

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL -rearranged acute lymphoblastic leukemia xenografts

Denis M. Schewe, Ameera Alsadeq, Cornelia Sattler, Lennart Lenk, Fotini Vogiatzi, Gunnar Cario, Simon Vieth, Thomas Valerius, Sophia Rosskopf, Fabian Meyersieck, Julia Alten, Martin Schrappe, Martin Gramatzki, Matthias Peipp, Christian Kellner
Journal: Blood
Blood (2017) 130 (13): 1543–1552.
https://doi.org/10.1182/blood-2017-01-764316
Published: 2017
Includes: Supplemental data
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

Jessica I Hoell, MD, Sebastian Ginzel, MSc, Cornelia Eckert, PhD, Michael Gombert, PhD, Ute Fischer, PhD, Martin Stanulla, MD, Martin Schrappe, MD PhD, Udo zur Stadt, PhD, Peter Bader, MD, Brigitte Strahm, MD, Julia Alten, Anja Moericke, MD, Gabriele Escherich, MD, Arend Stackelberg, MD, Christina Peters, MD, Arndt Borkhardt, MD, Roland Meisel, MD
Journal: Blood
Blood (2016) 128 (22): 601.
https://doi.org/10.1182/blood.V128.22.601.601
Published: 2016
Journal Articles

Invasive Fungal Infections in Pediatric Acute Lymphoblastic Leukemia: Incidence, Characterization, Outcome and Risk Analysis of Study ALL-BFM 2000

Georg Mann, MD, Andishe Attarbaschi, MD PhD, Martin Schrappe, MD, Anja Möricke, Kirsten Bleckmann, MD, Julia Alten, MD, Thomas Lehrnbecher, MD, Martin Zimmermann, PhD, Felix Niggli, MD
Journal: Blood
Blood (2014) 124 (21): 3658.
https://doi.org/10.1182/blood.V124.21.3658.3658
Published: 2014
Journal Articles

Clinical Implication of BCR/ABL Fusion Transcript Monitoring in Addition to Ig/TCR Gene Rearrangement-Based Minimal Residual Disease in Philadelphia Chromosome-Positive Childhood Acute Lymphoblastic Leukemia

Kirsten Bleckmann, MD, Julia Alten, MD, Anja Moericke, MD, Andishe Attarbashi, MD, Andrea Teigler-Schlegel, PhD, Christine Damm-Welk, PhD, Rolf Koehler, PhD, Martin Schrappe, MD
Journal: Blood
Blood (2014) 124 (21): 2258.
https://doi.org/10.1182/blood.V124.21.2258.2258
Published: 2014
Journal Articles

The Strong Prognostic Effect of Concurrent Deletions of IKZF1 and PAX5 , CDKN2A , CDKN2B or PAR1 in the Absence of ERG Deletions (IKZF1 plus ) in Pediatric Acute Lymphoblastic Leukemia Strongly Depends on Minimal Residual Disease Burden after Induction Treatment

Elif Dagdan, PhD, Marketa Zaliova, MD PhD, Petra Dörge, Anja Möricke, Martin Zimmermann, PhD, Andrea Teigler-Schlegel, PhD, Claus R Bartram, MD, Rolf Koehler, PhD, Richard Ratei, MD, Wolf-Dieter Ludwig, MD, Julia Alten, MD, Denis Martin Schewe, MD, Christian Kratz, Prof. Dr., Richard S Houlston, Jean-Pierre Bourquin, MD PhD, Andrea Biondi, Giovanni Cazzaniga, Giuseppe Basso, MD, Geertruy te Kronnie, Marie-Laure Yaspo, Dr., Martin Schrappe, MD, Gunnar Cario, MD, Martin Stanulla, MD
Journal: Blood
Blood (2014) 124 (21): 131.
https://doi.org/10.1182/blood.V124.21.131.131
Published: 2014
Journal Articles

Comparison of MRD Monitoring By IG/TR Rearrangement and BCR/ABL1 Transcript in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with Imatinib in the Esphall Study

Giovanni Cazzaniga, Paola de Lorenzo, Anders Castor, Hans O Madsen, Virginie Gandemer, Hélène Cavé, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, MD, Udo zur Stadt, Silja Rottgers, Julia Alten, Jeremy Hancock, Giulia Ferrari, Maurizio Arico', Vaskar Saha, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi
Journal: Blood
Blood (2014) 124 (21): 3782.
https://doi.org/10.1182/blood.V124.21.3782.3782
Published: 2014
Journal Articles

Analyses of a Pair of Concordant Twins with Infant ALL and Discordant Clinical Outcome Reveals Immunoescape As a Mechanism of Disease Persistence in MLL-Rearranged Leukemia

Henning Fedders, PhD, Ameera Alsadeq, PhD, Britt-Sabina Petersen, PhD, Christian Kellner, PhD, Matthias Peipp, PhD, Thomas Valerius, MD, Robert Haesler, PhD, Julia Alten, MD, Anja Möricke, Susanne Strube, PhD, Thomas Wiesel, MD, Gunnar Cario, MD, Martin Schrappe, Andre Franke, PhD, Martin Stanulla, MD, Denis Martin Schewe, MD
Journal: Blood
Blood (2014) 124 (21): 3791.
https://doi.org/10.1182/blood.V124.21.3791.3791
Published: 2014