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Nikos Darzentas
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Journal Articles

Circulating Tumor DNA Kinetics at Day 14 after CAR T-Cell Therapy Identifies Patients with B-Cell Lymphoma at Risk for Early Treatment Failure

Tim Versteegen, Philipp Nakov, Nikos Darzentas, Guranda Chitadze, Ingram Iaccarino, Wolfram Klapper, Natalie Schub, Monika Brüggemann, Friedrich Stoelzel, Claudia D Baldus, Christiane Pott, Mouhamad Khouja
Journal: Blood
Blood (2024) 144 (Supplement 1): 2959.
https://doi.org/10.1182/blood-2024-207721
Published: 2024
Journal Articles

C/EBP Family Member Gene Fusions and Cooperating Genomic Events Define Two Distinct Molecular Sub-Groups in Adult B Precursor ALL

Björn-Thore Hansen, Thomas Beder, Sören Döhle, Wencke Walter, Malwine J Barz, Cecilia Bozzetti, Johanna Horns, Axel Künstner, Alina M. Hartmann, Sören Franzenburg, Michael Wittig, Barbara Ritter, Stefan Schwartz, Hauke Busch, Nikos Darzentas, Claudia Haferlach, Nicola Goekbuget, Monika Brüggemann, Claudia D Baldus, Lorenz Bastian
Journal: Blood
Blood (2024) 144 (Supplement 1): 1458.
https://doi.org/10.1182/blood-2024-211088
Published: 2024
Journal Articles

IDH2 Mutations from Clonal Hematopoiesis and Acquired IKZF1 Deletions Define a Novel B-ALL Subtype after Lenalidomide Therapy for Multiple Myeloma

Johanna Maria Horns, Thomas Beder, Malwine J Barz, Aeint-Steffen Ströh, Axel Künstner, Sonja Bendig, Guranda Chitadze, Cecilia Bozzetti, Nikos Darzentas, Katharina Iben, Michaela Kotrova, Martin Neumann, Wiebke Weßels, Hauke Busch, Lennart Lenk, Judith S. Hecker, Stefan Knop, Boris Böll, Johannes Duell, Walter Fiedler, Christoph Faul, Christoph Röllig, Bernd Spriewald, Björn Steffen, Maher Hanoun, Nicola Goekbuget, Claudia D Baldus, Lorenz Bastian, Monika Brüggemann
Journal: Blood
Blood (2024) 144 (Supplement 1): 631.
https://doi.org/10.1182/blood-2024-199601
Published: 2024
Journal Articles

Reshaping MRD Detection Strategies: Next-Generation Sequencing and High DNA Input Identify Previously Missed Measurable Residual Disease in Peripheral Blood of B-Cell Precursor Acute Lmyphoblastic Leukemia

Sonja Bendig, Sandra Bufe, Birgit Fricke, Constantin Proske, Nikos Darzentas, Britta Kehden, Guranda Chitadze, Claudia D Baldus, Michaela Kotrova, Nicola Goekbuget, Monika Brüggemann
Journal: Blood
Blood (2023) 142 (Supplement 1): 4354.
https://doi.org/10.1182/blood-2023-174458
Published: 2023
Journal Articles

Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis

P. Martijn Kolijn, Florentin Späth, Mouhamad Khouja, Paul J. Hengeveld, Lina van der Straten, Nikos Darzentas, Magnus Hultdin, James D. McKay, Christiane Pott, Roel C. H. Vermeulen, Anton W. Langerak
Journal: Blood
Blood (2023) 142 (16): 1399–1403.
https://doi.org/10.1182/blood.2023019609
Published: 2023
Includes: Supplemental data
Journal Articles

Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia

Guranda Chitadze, Anna Stengel, Cathrin John-Klaua, Julien Bruckmüller, Heiko Trautmann, Michaela Kotrova, Franziska Darzentas, Miriam Kelm, Karol Pal, Nikos Darzentas, Lorenz Bastian, Britta Kehden, Wiebke Wessels, Aeint-Steffen Ströh, Hans-Heinrich Oberg, Philipp M. Altrock, Constance Baer, Manja Meggendorfer, Nicola Gökbuget, Claudia D. Baldus, Claudia Haferlach, Monika Brüggemann
Journal: Blood
Blood (2023) 141 (13): 1640–1644.
https://doi.org/10.1182/blood.2022017249
Published: 2023
Includes: Supplemental data
Journal Articles

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Clinical Trials & Observations Brief Report
Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H. J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova
Journal: Blood
Blood (2023) 141 (5): 529–533.
https://doi.org/10.1182/blood.2022017003
Published: 2023
Includes: Supplemental data
Journal Articles

Genotyping and Minimal Residual Disease (MRD) Assessment in cfDNA By the Euroclonality-NGS DNA Capture (EC-NDC) Panel in Mantle Cell Lymphoma (MCL)

Mouhamad Khouja, Elisa Genuardi, Simone Ferrero, Beatrice Alessandria, Onno Verhagen, Christa Homburg, Vincent H.J. van der Velden, Paula Gameiro, Ramón García-Sanz, Alejandro Medina, Eva Fronkova, Monika Brüggemann, Martin Dreyling, Eva Hoster, Anton Langerak, Nikos Darzentas, Karol Pal, Peter James Stewart, David Gonzalez, Christiane Pott
Journal: Blood
Blood (2022) 140 (Supplement 1): 3518–3520.
https://doi.org/10.1182/blood-2022-166043
Published: 2022
Journal Articles

NGS-Based MRD Quantitation: An Alternative to qPCR Validated on a Large Consecutive Cohort of Children with ALL

Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H.J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova
Journal: Blood
Blood (2021) 138 (Supplement 1): 1314.
https://doi.org/10.1182/blood-2021-152971
Published: 2021
Journal Articles

Karyosequencing: Integrating Genome-Wide and Targeted Sequencing for Comprehensive Diagnosis of Lymphoproliferative Disorders

James Peter Stewart, Louise Harewood, Shambhavi Srivastava, Jana Gazdova, Manisha Maurya, Sirintra Nakjang, Elizabeth Hodges, Laura Chiecchio, Nicholas C.P. Cross, Matthew W Jenner, Mark Catherwood, Sarra Ryan, Anthony V. Moorman, Nikos Darzentas, David Gonzalez
Journal: Blood
Blood (2021) 138 (Supplement 1): 272.
https://doi.org/10.1182/blood-2021-152258
Published: 2021
Journal Articles

Disease Kinetics Measured By Circulating Tumor DNA Correlates with Treatment Response after Tafasitamab in Combination with R-CHOP with or without Lenalidomide in First Line Treatment of DLBCL

Mouhamad Khouja, Anke Schilhabel, Michaela Kotrova, Monika Brüggemann, Christian Kuffer, Derek Blair, Nikos Darzentas, Christiane Pott
Journal: Blood
Blood (2021) 138 (Supplement 1): 3498.
https://doi.org/10.1182/blood-2021-153176
Published: 2021
Journal Articles

Targeted Next Generation Sequencing Improves Diagnosis in Unclassifiable Leukemic Indolent B-Cell Non-Hodgkin Lymphoma and Identifies a Subset with Recurrent MYD88 Mutations in a Prospective Multicentre Study

Matthew J Cross, MBBS, BSc, Grzegorz Pietka, PhD, Sarah Dunne, Leonora Conneely, Michael Hubank, PhD, Corinne De Lord, MD FRCPath, Michelle Furtado, MD FRCPath, PhD, Pawel Kaczmarek, MD PhD, Dima El-Sharkawi, Claire E. Dearden, MD FRCP, FRCPath, Kabir Mohammed, Alan Stewart Dunlop, MSc, BS, Ricardo Morilla, Karol Pal, PhD, Nikos Darzentas, PhD, David Gonzalez, PhD, Dorte Wren, PhDFRCPath, Sunil Iyengar, MD FRCPath, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-141542
Published: 2020
Journal Articles

Euroclonality-NGS DNA Capture Panel for Integrated Analysis of IG/TR Rearrangements, Translocations, Copy Number and Sequence Variation in Lymphoproliferative Disorders

Peter Stewart, PhD, Jana Gazdova, MSc, Nikos Darzentas, PhD, Dorte Wren, PhDFRCPath, Paula Proszek, Grazia Fazio, Simona Songia, Miguel Alcoceba, Maria Eugenia Sarasquete, PhD, Patrick Villarese, PhD, Michèle Y van der Klift, Kim Heezen, Neil McCafferty, MSc, Karol Pal, MSc, Mark Catherwood, PhD, Chang Sik Kim, PhD, Shambhavi Srivastava, PhD, Elizabeth Hodges, PhD, Kostas Stamatopoulos, Wolfram Klapper, Simone Ferrero, MD, Michiel van den Brand, MD, Giovanni Cazzaniga, PhD, Frederic Davi, MD PhD, Ramon Garcia-Sanz, MD PhD, Patricia Groenen, Elizabeth Macintyre, PhDMD, Monika Brüggemann, Christiane Pott, MD PhD, Elisa Genuardi, Anton W Langerak, PhD, David Gonzalez, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 888.
https://doi.org/10.1182/blood-2019-127822
Published: 2019
Journal Articles

Deep Immunoprofiling By Flow Cytometry and NGS Reveals Distinct T Cell Profile in Pediatric Hepatitis-Associated Aplastic Anemia

Michaela Novakova, Michael Svaton, MD, Martina Sukova, MD, Veronika Kanderova, MSc, PhD, Nikos Darzentas, PhD, Lenka Kramna, MSc, PhD, Ondrej Cinek, Prof., MD PhD, Dagmar Pospisilova, Prof MD PhD, Jan Trka, Prof., MD PhD, Ondrej Hrusak, MD PhD, Jan Stary, Prof., MD PhD, Ester Mejstrikova, MD PhD, Eva Fronkova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2508.
https://doi.org/10.1182/blood-2019-127986
Published: 2019
Journal Articles

The IG/TR Next Generation Marker Screening Developed within Euroclonality-NGS Consortium Is Successful in 94% of Acute Lymphoblastic Leukemia Samples

Michaela Kotrova, MD PhD, Henrik Knecht, PhD, Dietrich Herrmann, Martin Schwarz, Karin Olsen, Heiko Trautmann, PhD, Nicola Goekbuget, MD, Christiane Pott, Nikos Darzentas, PhD, Monika Brüggemann
Journal: Blood
Blood (2018) 132 (Supplement 1): 2830.
https://doi.org/10.1182/blood-2018-99-112828
Published: 2018
Journal Articles

Monitoring of the Clonal Architecture of B-Cell Precursor ALL during Induction Chemoimmunotherapy

Michaela Kotrova, MD PhD, Monika Szczepanowski, PhD, Henrik Knecht, PhD, Christoph Faul, MD, Mustafa Kondakci, MD, Björn Steffen, MD, Andreas Viardot, MD, Michael Kneba, Dieter Hoelzer, MD PhD, Nicola Goekbuget, MD, Nikos Darzentas, PhD, Monika Brüggemann
Journal: Blood
Blood (2018) 132 (Supplement 1): 1555.
https://doi.org/10.1182/blood-2018-99-112844
Published: 2018
Journal Articles

Standardized IGH-Based Next-Generation Sequencing for MRD Detection in Follicular Lymphoma

Christiane Pott, MD, PhD, Henrik Knecht, PhD, Arved Herzog, Elisa Genuardi, Michael Unterhalt, MD PhD, Barbara Mantoan, Irene Dogliotti, Wolfgang Hiddemann, MD PhD, Mario Boccadoro, Dietrich Herrmann, Michael Kneba, MD, Anton W Langerak, Nikos Darzentas, Patricia Groenen, Monika Brüggemann, MD, Eva Hoster, Marco Ladetto, Simone Ferrero
Journal: Blood
Blood (2017) 130 (Supplement 1): 1491.
https://doi.org/10.1182/blood.V130.Suppl_1.1491.1491
Published: 2017
Journal Articles

A Versatile DNA/RNA NGS Targeted Capture Strategy for Detection of Fusion Genes in Pediatric ALL

Grazia Fazio, PhD, Andrea Grioni, Tomas Reigl, Silvia Rigamonti, Vojtech Bystry, Simona Songia, Andrea Biondi, MD, Nikos Darzentas, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2016) 128 (22): 2913.
https://doi.org/10.1182/blood.V128.22.2913.2913
Published: 2016
Journal Articles

Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites

Andreas Agathangelidis, Anastasia Hadzidimitriou, Eva Minga, Lesley-Ann Sutton, Eleftheria Polychronidou, Tait D. Shanafelt, MD, Zadie Davis, Xiao-Jie Yan, MD PhD, Karla Plevova, Myriam Boudjoghra, Alba Navarro, Davide Rossi, Lone Bredo Pedersen, Vasilis Bikos, Panagiotis Baliakas, Lydia Scarfò, MD, Mattias Mattsson, Aliki Xochelli, MD PhD, Paola Francia di Celle, Krzysztof Giannopoulos, Katrina Vanura, Ludo Evers, Silvio Veronese, Monica Facco, Panagiotis Moschonas, Vojtech Bystry, Teodora Karan-Djurasevic, Maria Roumelioti, Sonja Pavlovic, Larry Mansouri, Charles Chu, Evangelia Stalika, Veronique Giudicelli, Panagiotis Panagiotidis, Andrey Sudarikov, Achilles Anagnostopoulos, Livio Trentin, MD, Mark Catherwood, Marco Montillo, MD, Niki Stavroyianni, MD, Gianluca Gaidano, Elias Campo, Carsten Utoft Niemann, Anton W. Langerak, Sarka Pospisilova, Marie-Paule Lefranc, Ulrich Jaeger, Arnon Kater, MD PhD, Christiane Pott, Nicholas Chiorazzi, MD, David Oscier, Diane F. Jelinek, Stephan Stilgenbauer, Michael Hallek, Dimitrios Tzovaras, Nikos Darzentas, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4376.
https://doi.org/10.1182/blood.V128.22.4376.4376
Published: 2016
Journal Articles

High Resolution Igh Repertoire Analysis Reveals the Human Fetal Liver As the Origin of Life-Long, Innate B Lymphopoiesis

Anindita Roy, MDPhD, Vojtech Bystry, Georg Bohn, Katerina Goudevenou, Tomas Reigl, Maria Papaioannou, Adam Krejci, Sorcha O'Byrne, Aristeidis Chaidos, Andrea Grioni, Nikos Darzentas, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2016) 128 (22): 127.
https://doi.org/10.1182/blood.V128.22.127.127
Published: 2016