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Laura Chiecchio
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Journal Articles

Long-read RNA sequencing of first multiple myeloma patient cohort reveals landscape of variant expression in newly diagnosed patients from the UKMRA RADAR trial

Free
Bethan Hudson-Lund, Anandagopal Srinivasan, Eleanor Calcutt, Neelam Mehta, Ines Fethi, Emma Lyon, Jessica Kimber, Alice Lefever, Conor Garrod-Ketchley, Annabel Laidler, Elise Rees, Amatta Mirandari, Daniel Hughes, Louise Ainley, Jongwon Yoon, Lydia Lee, Maximilian Goodman, Megan Hawksley, Angela Brown, Mohammad Kazeroun, Naser Ansari-Pour, Matthew Jenner, Laura Chiecchio, Martin Kaiser, Michael Chapman, Angela Hamblin, Lorna Barnard, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Guy Pratt, Alan Chant, Jonathan Sive, Christopher Parrish, Udo Oppermann, Karthik Ramasamy, Kwee Yong, Eileen Boyle, Sarah Gooding, Adam Cribbs
Journal: Blood
Blood (2025) 146 (Supplement 1): 2141.
https://doi.org/10.1182/blood-2025-2141
Published: 2025
Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Risk Assignment Using the Myeloma Genome Project Panel: A Comparison to Standard of Care Genetic Testing within the UK-MRA RADAR Trial

Free
Sarah Gooding, Kara-Louise Royle, Mohammad Kazeroun, Robert Cicero, Laura Chiecchio, Dipal Mehta, Emma J Lyon, Bethan Hudson-Lund, Jasmin Rahman, Khrystal McBean, Martin F Kaiser, Catherine Olivier, Doina Levinte, Charlotte Kennaway, Dean Smith, Jonathan Sive, Ceri Bygrave, Guy Pratt, Michael A. Chapman, Graham Jackson, Rakesh Popat, Christopher Parrish, Gordon Cook, Angela Hamblin, Naser Ansari-Pour, David A. Cairns, Anjan Thakurta, Karthik Ramasamy, Eileen M Boyle, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3333.
https://doi.org/10.1182/blood-2024-209772
Published: 2024
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

Free
Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

Karyosequencing: Integrating Genome-Wide and Targeted Sequencing for Comprehensive Diagnosis of Lymphoproliferative Disorders

Free
James Peter Stewart, Louise Harewood, Shambhavi Srivastava, Jana Gazdova, Manisha Maurya, Sirintra Nakjang, Elizabeth Hodges, Laura Chiecchio, Nicholas C.P. Cross, Matthew W Jenner, Mark Catherwood, Sarra Ryan, Anthony V. Moorman, Nikos Darzentas, David Gonzalez
Journal: Blood
Blood (2021) 138 (Supplement 1): 272.
https://doi.org/10.1182/blood-2021-152258
Published: 2021
Journal Articles

Subclonal TP53 copy number is associated with prognosis in multiple myeloma

Free
Clinical Trials & Observations Brief Report
Vallari Shah, David C. Johnson, Amy L. Sherborne, Sidra Ellis, Frances M. Aldridge, Julie Howard-Reeves, Farzana Begum, Amy Price, Jack Kendall, Laura Chiecchio, Suvi Savola, Matthew W. Jenner, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, Faith E. Davies, Richard S. Houlston, Gordon Cook, David A. Cairns, Graham Jackson, Martin F. Kaiser
Journal: Blood
Blood (2018) 132 (23): 2465–2469.
https://doi.org/10.1182/blood-2018-06-857250
Published: 2018
Includes: Supplemental data
Journal Articles

Characterisation of Long-Term Responders to First-Line Myeloma Therapy - Results from the UK Myeloma IX and XI Trials

Free
Vallari Shah, MBBS, David C. Johnson, PhD, Amy L Sherborne, PhD, Sidra Ellis, Amy Price, Jack Kendall, Laura Chiecchio, PhD, Alina Striha, Anna Hockaday, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Matthew Jenner, Mark T Drayson, Roger G Owen, MD, Walter M Gregory, Gareth Morgan, MD, Faith E. Davies, MD, Richard S Houlston, MD PhD, Gordon Cook, David Cairns, Graham H Jackson, Martin Kaiser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2000.
https://doi.org/10.1182/blood-2018-99-110149
Published: 2018
Journal Articles

De novo Richter transformation

Free
Laura Chiecchio, Jonathan Oliver Cullis
Journal: Blood
Blood (2017) 129 (17): 2455.
https://doi.org/10.1182/blood-2017-02-766782
Published: 2017
Journal Articles

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL

Free
Clinical Trials & Observations
Annalisa D’Avola, Samantha Drennan, Ian Tracy, Isla Henderson, Laura Chiecchio, Marta Larrayoz, Matthew Rose-Zerilli, Jonathan Strefford, Christoph Plass, Peter W. Johnson, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Christopher C. Oakes, Francesco Forconi
Journal: Blood
Blood (2016) 128 (6): 816–826.
https://doi.org/10.1182/blood-2016-03-707786
Published: 2016
Includes: Supplemental data
Journal Articles

Surface IgM Levels Independently Influence Clinical Behavior and Associate with Altered Phenotype and Genetics in Chronic Lymphocytic Leukemia

Free
Samantha J Drennan, PhD, Annalisa D'Avola, MSc, Ian Tracy, Isla Henderson, Marta Larrayoz, PhD, Carina Mundy, Andrew S. Duncombe, MD, Andrew J. Davies, MD PhD, Davide Rossi, MD PhD, Fiona M Ross, DPhil, Laura Chiecchio, PhD, Kathleen N. Potter, PhD, Jonathan Strefford, PhD, Andrew J Steele, PhD, Peter W Johnson, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2014) 124 (21): 830.
https://doi.org/10.1182/blood.V124.21.830.830
Published: 2014
Journal Articles

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma

Free
Brian A. Walker, Christopher P. Wardell, Laura Chiecchio, Emma M. Smith, Kevin D. Boyd, Antonino Neri, Faith E. Davies, Fiona M. Ross, Gareth J. Morgan
Journal: Blood
Blood (2011) 117 (2): 553–562.
https://doi.org/10.1182/blood-2010-04-279539
Published: 2011
Includes: Supplemental data
Journal Articles

Deletion 13, Detected by Metaphase Analysis, Is Not a Significant Prognostic Indicator In Myeloma

Free
Fiona M. Ross, DPhil, Laura Chiecchio, PhD, GianPaolo Dagrada, BSc, William J Tapper, PhD, Zoe J Konn, BSc, Kan Luk Cheung, BSc, Rebecca KM Protheroe, BSc, David M Stockley, BSc, Susan E Bell, DPhil, Walter M Gregory, PhD, Alexander J Szubert, MSc, Gordon Cook, MD, Roger G. Owen, MD, Mark T. Drayson, MD, Graham Jackson, DM, Faith Davies, MD, PhD, J. Anthony Child, MD, Gareth J Morgan, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2980.
https://doi.org/10.1182/blood.V116.21.2980.2980
Published: 2010
Journal Articles

Defining High Risk Myeloma Using Co-Segregating FISH Variables; Results of MRC Myeloma IX

Free
Kevin D Boyd, MBBS, Fiona M. Ross, PhD, William J Tapper, PhD, Laura Chiecchio, PhD, GianPaolo Dagrada, Rebecca Protheroe, David Stockley, Zoe Konn, Walter M Gregory, PhD, Brian A Walker, PhD, Christopher P Wardell, PhD, Faith E Davies, MD, Gareth J Morgan, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1907.
https://doi.org/10.1182/blood.V116.21.1907.1907
Published: 2010
Journal Articles

A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value

Free
e-blood
Brian A. Walker, Paola E. Leone, Laura Chiecchio, Nicholas J. Dickens, Matthew W. Jenner, Kevin D. Boyd, David C. Johnson, David Gonzalez, Gian Paolo Dagrada, Rebecca K. M. Protheroe, Zoe J. Konn, David M. Stockley, Walter M. Gregory, Faith E. Davies, Fiona M. Ross, Gareth J. Morgan
Journal: Blood
Blood (2010) 116 (15): e56–e65.
https://doi.org/10.1182/blood-2010-04-279596
Published: 2010
Includes: Supplemental data
Journal Articles

Gain of 1q21 Does Not Predict for Immediate Progression in MGUS.

Free
Laura Chiecchio, Gian Paolo Dagrada, Elizabet Dachs Cabanas, Rebecca K.M. Protheroe, David M. Stockley, Zoe J. Konn, Nicholas C.P. Cross, Christine J. Harrison, Fiona M. Ross
Journal: Blood
Blood (2009) 114 (22): 123.
https://doi.org/10.1182/blood.V114.22.123.123
Published: 2009
Journal Articles

High Resolution Genomic Profiling Using Single Nucleotide Polymorphism Microarrays Identifies Multiple Novel Genomic Minimally Deleted Regions in Multiple Myeloma

Free
Brian A WalKer, PhD, Paola E Leone, PhD, Nicholas J Dickens, DPhil, Matthew W Jenner, MD, Laura Chiecchio, GianPaolo Dagrada, Fiona M Ross, DPhil, Faith E Davies, MD, Gareth J Morgan, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 625.
https://doi.org/10.1182/blood.V112.11.625.625
Published: 2008
Journal Articles

Multiple Myeloma with IGH-Involving del(14q): Report of 34 Cases.

Free
Iwona Wlodarska, PhD, Fiona M. Ross, PhD, Lisa J. Russell, PhD, Helena Pospisilova, Laura Chiecchio, Marie-Astrid Van Caillie, MD, GianPaolo Dagrada, Christiane De Wolf-Peeters, MD, PhD, Christine J. Harrison, PhD, Pascale De Paepe, MD, PhD, Peter Vandenberghe, MD, PhD, Lucienne Michaux, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 991.
https://doi.org/10.1182/blood.V110.11.991.991
Published: 2007
Journal Articles

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

Free
Matthew W. Jenner, Paola E. Leone, Brian A. Walker, Fiona M. Ross, David C. Johnson, David Gonzalez, Laura Chiecchio, Elisabet Dachs Cabanas, Gian Paolo Dagrada, Mathew Nightingale, Rebecca K. M. Protheroe, David Stockley, Monica Else, Nicholas J. Dickens, Nicholas C. P. Cross, Faith E. Davies, Gareth J. Morgan
Journal: Blood
Blood (2007) 110 (9): 3291–3300.
https://doi.org/10.1182/blood-2007-02-075069
Published: 2007
Includes: Supplemental data
Journal Articles

Abnormalities of 16q in Multiple Myeloma Are Associated with Poor Prognosis: 500K Gene Mapping and Expression Correlations Identify Two Potential Tumor Suppressor Genes, WWOX and CYLD .

Free
Matthew W. Jenner, MD, Paola E. Leone, PhD, Brian A. Walker, PhD, David C. Johnson, BSc, Laura Chiecchio, MSc, Elisabet Dachs Cabanas, BSc, Gian Paolo Dagrada, MSc, Mathew Nightingale, Rebecca K.M. Protheroe, BSc, David Stockley, BSc, Monica Else, MSc, Fiona M. Ross, PhD, Nicholas C.P. Cross, PhD, Faith E. Davies, MD, Gareth J. Morgan, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 110.
https://doi.org/10.1182/blood.V108.11.110.110
Published: 2006
Journal Articles

Critical Importance of Conventional Cytogenetics in Detecting Prognostically Significant Chromosome 13 Deletions in Myeloma.

Free
Laura Chiecchio, MBS, Rebecca K.M. Protheroe, BSc, Tim Parker, BSc, Christina Rudduck, PhD, Kan Luk Cheung, BSc, Gianpaolo Dagrada, MBS, Ashutosh Wechalekar, MD, Mathew Nightingale, BSc, Christine J. Harrison, PhD, Nicholas C.P. Cross, PhD, Fiona M. Ross, DPhil
Journal: Blood
Blood (2005) 106 (11): 1544.
https://doi.org/10.1182/blood.V106.11.1544.1544
Published: 2005