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Ruth de Tute
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Journal Articles

Challenging the concept of functional high-risk myeloma through transcriptional and genetic profiling

Open Access
Clinical Trials & Observations
Sina A. Beer, David A. Cairns, Charlotte Pawlyn, Amy Holroyd, Elsa Ferris, Gordon Cook, Mark Drayson, Kevin Boyd, Paula Proszek, Faith E. Davies, Ruth de Tute, Matthew Jenner, Gareth J. Morgan, Roger Owen, Michael Hubank, Richard Houlston, Graham Jackson, Martin F. Kaiser
Journal: Blood
Blood (2025) 146 (22): 2670–2680.
https://doi.org/10.1182/blood.2025029987
Published: 2025
Includes: Supplemental data
Journal Articles

MRD-guided ibrutinib plus venetoclax improves outcomes in CLL patients with TP53, ATM, or NOTCH1 aberrations compared to ibrutinib and FCR: Results from the Phase III NCRI FLAIR trial

Free
Surita Dalal, Jane Shingles, Sean Girvan, David Cairns, Paul Glover, Helen Warren, Thomas Grand, Nichola Webster, Andy Rawstron, Darren Newton, Charlotte Evans, Ruth de Tute, Anna Hockaday, Sharon Jackson, Sue Bell, Natasha Greatorex, David Stones, David Allsup, Adrian Bloor, Anita Sarma, Abraham Mullasseril Varghese, Peter Hillmen, Talha Munir
Journal: Blood
Blood (2025) 146 (Supplement 1): 679.
https://doi.org/10.1182/blood-2025-679
Published: 2025
Journal Articles

Acquired Bruton's tyrosine kinase mutations in patients treated on the ibrutinib and rituximab, ibrutinib alone, and ibrutinib and venetoclax arms of the national multi-centre Phase III FLAIR study in previously untreated CLL patients

Free
Charlotte Evans, Surita Dalal, Darren Newton, Jennifer Carter, Nichola Webster, Andy Rawstron, Ruth de Tute, Anna Hockaday, Sharon Jackson, Sue Bell, Natasha Greatorex, David Stones, David Allsup, Adrian Bloor, Anita Sarma, Abraham Mullasseril Varghese, Peter Hillmen, Talha Munir
Journal: Blood
Blood (2025) 146 (Supplement 1): 796.
https://doi.org/10.1182/blood-2025-796
Published: 2025
Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Is IMWG frailty-score-adjusted dosing the right approach to improve toxicity and outcomes in FRAIL patients? Results from the UK-MRA FiTNEss trial in newly diagnosed myeloma patients ineligible for ASCT.

Free
Charlotte Pawlyn, Kara-Louise Royle, Ethan Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew Jenner, John Jones, Martin Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth de Tute, Christopher Parrish, Alan Chant, David Cairns, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2025) 146 (Supplement 1): 369.
https://doi.org/10.1182/blood-2025-369
Published: 2025
Journal Articles

Optimising MRD-guided treatment: UMRD4 as a half-way treatment timepoint for ibrutinib-venetoclax substantially delays MRD relapse after end of treatment in both IGHV-mutated and IGHV-unmutated CLL.

Free
Andy Rawstron, David Cairns, Nichola Webster, Surita Dalal, Jane Shingles, Ruth de Tute, Anna Hockaday, Sharon Jackson, Sue Bell, Natasha Greatorex, David Stones, David Allsup, Adrian Bloor, Anita Sarma, Abraham Mullasseril Varghese, Talha Munir, Peter Hillmen
Journal: Blood
Blood (2025) 146 (Supplement 1): 794.
https://doi.org/10.1182/blood-2025-794
Published: 2025
Journal Articles

The Prognosis Of Transformed Follicular Lymphoma Is Determined By Prior Exposure To Chemotherapy

Free
Andrew Jack, PhD, Alexandra Smith, PhD, Ruth de Tute, Daniel Painter, BSc, Eve Roman, PhD, Russell Patmore, MD
Journal: Blood
Blood (2013) 122 (21): 78.
https://doi.org/10.1182/blood.V122.21.78.78
Published: 2013
Journal Articles

Peripheral Blood Disease Monitoring in Marginal Zone Lymphoma Using Flow Cytometry

Free
Ruth de Tute, Andy C Rawstron, BSc, PhD, Roger G Owen, Andrew Jack, MD, FRCPath
Journal: Blood
Blood (2008) 112 (11): 5307.
https://doi.org/10.1182/blood.V112.11.5307.5307
Published: 2008