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Journal Articles

Belantamab Mafodotin in Combination with Lenalidomide Plus Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Safety and Efficacy Analysis of DREAMM-6 Trial Arm-a

Rakesh Popat, Bradley Augustson, Mercedes Gironella, Cindy Lee, Paul Cannell, Nashita Patel, Ravi Kasinathan, Rachel Rogers, Amy Curry, Fernando Carreno, Sumita Roy-Ghanta, Joanna Opalinska, Hang Quach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2010.
https://doi.org/10.1182/blood-2023-178044
Published: 2023
Journal Articles

The GLAMM1 Study - Global Access to Myeloma Medications: Potential Barriers to Chimeric Antigen Receptors (CART) and T-Cell-Engaging Bispecific Antibodies (TCE) Globally

Rawan Atallah, Yara Shatnawi, Aytaj Mammadzadeh, Shahrukh K Hashmi, Shabeeha K Rana, Muhammad Umair Mushtaq, Benlazar Mohamed, Nihar Desai, Thiago Xavier Carneiro, Rakesh Popat, Joseph P McGuirk, Shebli Atrash, Zahra Mahmoudjafari, Al-Ola Abdallah, Nausheen Ahmed
Journal: Blood
Blood (2023) 142 (Supplement 1): 3327.
https://doi.org/10.1182/blood-2023-179050
Published: 2023
Journal Articles

High Neoantigen Load Confers a Major Benefit from Autologous Stem Cell Transplantation Compared to Consolidation in Newly Diagnosed Multiple Myeloma

Ieuan Walker, Venetia D'Arcy, Kane Foster, Garima Khandelwal, Georgina S.F. Anderson, William Wilson, Evie Fitzsimons, Daria Galas-Filipowicz, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Sumaiya Kamora, James D. Cavenagh, Elizabeth Phillips, Laura Clifton-Hadley, Charlotte Tyson, Fuad Fananapazir, Krupali Parikh, Roger Owen, Javier Herrero, Kwee Yong, Michael A. Chapman
Journal: Blood
Blood (2023) 142 (Supplement 1): 3306.
https://doi.org/10.1182/blood-2023-186318
Published: 2023
Journal Articles

Polb 001, an Oral Broad-Spectrum Anti-Inflammatory with the Potential to Prevent Cytokine Release Syndrome (CRS)

Emma Searle, Liam Tremble, Rakesh Popat, Digna de Bruin, Matthijs Moerland, Brendan Buckley
Journal: Blood
Blood (2023) 142 (Supplement 1): 2093.
https://doi.org/10.1182/blood-2023-189062
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Genetic Standard and High-Risk Disease at Trial Entry: A Cross-Sectional Analysis of RADAR (UK-MRA Myeloma XV)

Catherine SY Lecat, Alan Chant, Orla McCourt, David Meads, Robert Cicero, Kara-Louise Royle, Ceri Bygrave, Andrew Chantry, Michael A. Chapman, Gordon Cook, Bryony Dawkins, Mark Drayson, Graham Jackson, Matthew W. Jenner, Martin F. Kaiser, Dipal Mehta, Roger Owen, Rakesh Popat, Christopher Parrish, Guy Pratt, Jonathan Sive, Dean Smith, Ruth M de Tute, Lorna Barnard, Sharon Jackson, Doina Levinte, Catherine Olivier, Karthik Ramasamy, Kwee Yong, David Allan Cairns
Journal: Blood
Blood (2023) 142 (Supplement 1): 4710.
https://doi.org/10.1182/blood-2023-187453
Published: 2023
Journal Articles

Global Access to Multiple Myeloma Medications (GLAMM-2 Study): Access and Barriers to Chemoimmunotherapies and Transplant

Aytaj Mammadzadeh, Yara Shatnawi, Rawan Atallah, Benlazar Mohamed, Nihar Desai, Shahrukh K Hashmi, Thiago Xavier Carneiro, Hira Shaikh, Christopher Strouse, Rakesh Popat, Zahra Mahmoudjafari, Muhammad Umair Mushtaq, Al-Ola Abdallah, Nausheen Ahmed
Journal: Blood
Blood (2023) 142 (Supplement 1): 4727.
https://doi.org/10.1182/blood-2023-185151
Published: 2023
Journal Articles

Infection Risk and Use of Prophylaxis with Anti-BCMA Bispecific T Cell Engagers and Belantamab Mafodotin for Patients with Relapsed and Refractory Multiple Myeloma

Rakesh Popat, Kathleen Cheok, Amrutha Sridhar, Conor Feely, Catriona Mactier, Annabel Mcmillan, Ashutosh D. Wechalekar, Neil Rabin, Jonathan Sive, Charalampia Kyriakou, Ke Xu, Xenofon Papanikolaou, Shameem Mahmood, Kwee Yong, Lydia Sarah Hui Lee
Journal: Blood
Blood (2023) 142 (Supplement 1): 4702.
https://doi.org/10.1182/blood-2023-182725
Published: 2023
Journal Articles

Co-Expression of GPRC5D, FcRH5 and BCMA Suggests That Targeting More Than One Cell Surface Marker May be a Viable Strategy in Relapsed/Refractory Multiple Myeloma (RRMM): Biomarker Results from the Phase I Study of Forimtamig, a GPRC5DxCD3 Bispecific Antibody

Iryna Dekhtiarenko, Iva Lelios, Wolfgang Jacob, Meike Schneider, Martin Weisser, Carmelo Carlo-Stella, Salomon Manier, Simon J. Harrison, Rakesh Popat, Anna Caroline Hasselbalch Riley, Ann-Marie E. Bröske
Journal: Blood
Blood (2023) 142 (Supplement 1): 1948.
https://doi.org/10.1182/blood-2023-177669
Published: 2023
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

Real-World Evaluation of Teclistamab for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM)

Sireesha Asoori, Rakesh Popat, Joaquín Martínez-Lopez, Efstathios Kastritis, Larissa Brunaldi, Radhika Bansal, Andre De Menezes Silva Corraes, Kwee Yong, Catriona Mactier, Magdalena Corona, Adolfo Jesús Sáez Marín, Despina Fotiou, Meletios Athanasios Dimopoulos, Saurabh Chhabra, Sikander Ailawadhi, Ricardo Parrondo, Thomas Martin, Brian GM Durie, Yi Lin
Journal: Blood
Blood (2023) 142 (Supplement 1): 3347.
https://doi.org/10.1182/blood-2023-190793
Published: 2023
Journal Articles

RADAR Trial: MRD Response Adapted Trial for Newly Diagnosed Transplant Eligible Myeloma Patients

Karthik Ramasamy, David Allan Cairns, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Lorna Barnard, Sharon Jackson, Doina Levinte, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael A. Chapman, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Martin F. Kaiser, Jonathan Sive, Christopher Parrish, Dean Smith, Matthew W. Jenner, Mark Drayson, Roger Owen, Ruth M de Tute, Dipal Mehta, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 3390.
https://doi.org/10.1182/blood-2023-188844
Published: 2023
Journal Articles

The Impact of Continuous Lenalidomide Maintenance Treatment on People Living with Multiple Myeloma - a Single-Centre Qualitative Service Evaluation

Caroline Buck, Francisco Castillo, Elena Bettio, Kwee Yong, Annabel Mcmillan, Lydia Sarah Hui Lee, Xenofon Papanikolaou, Ke Xu, Charalampia Kyriakou, Neil Rabin, Ashutosh D. Wechalekar, Rakesh Popat, Joanne Land, Orla McCourt, Helen Poole, Rachel Tarling, Abigail Fisher, Jonathan Sive
Journal: Blood
Blood (2023) 142 (Supplement 1): 6640.
https://doi.org/10.1182/blood-2023-184914
Published: 2023
Journal Articles

Development of a Phase 1 Study Evaluating the Activity of Modular CAR T for Multiple Myeloma (MCARTY) Targeting BCMA and CD19 for Improved Persistence

Lydia Sarah Hui Lee, Wen Chean Lim, Catriona Mactier, Juliana Dias Alves Pinto, Vitoria Pereira, Mhairi Vaughan, Louisa Green, Evie Lewin, John Garcia, Giulia Agliardi, Yashma Pathak, Riaz Jannoo, Leigh Wood, Bilyana Popova, Helen Holmes, Simon Thomas, Victoria Spanswick, William Wilson, Christopher Parrish, Rakesh Popat, Claire Roddie, Kwee Yong, Martin A. Pule
Journal: Blood
Blood (2023) 142 (Supplement 1): 350.
https://doi.org/10.1182/blood-2023-185085
Published: 2023
Journal Articles

Risk-Adapted Therapy Directed According to Response (RADAR, UK-MRA Myeloma XV) - Comparing MRD-Guided Treatment Escalation and De-Escalation Strategies in Patients with Newly Diagnosed Myeloma Suitable for Stem Cell Transplantation

Kwee Yong, Kara-Louise Royle, Karthik Ramasamy, Christopher Parrish, Anna Hockaday, Samir Asher, Mark T Drayson, Ruth M. de Tute, Matthew W Jenner, Martin F. Kaiser, Guy Pratt, Jonathan Sive, Ceri Bygrave, Gordon Cook, Rakesh Popat, Dean Smith, Catherine Olivier, Lorna Barnard, Doina Levinte, Bryony Dawkins, Michael A Chapman, Andrew D Chantry, Graham Jackson, Sergio A Quezada, Roger G Owen, David Cairns
Journal: Blood
Blood (2022) 140 (Supplement 1): 1844–1846.
https://doi.org/10.1182/blood-2022-168842
Published: 2022
Journal Articles

Intravenous and Subcutaneous Administration of RG6234, a Novel GPRC5DxCD3 T-Cell Engaging Bispecific Antibody, Is Highly Active in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Biomarker Results from a Phase I Study

Iryna Dekhtiarenko, Iva Lelios, Jan Attig, Nassim Sleiman, Domenico Lazzaro, Emilie Schindler, Jan Eckmann, Pablo Umana, Wolfgang Jacob, Meike Schneider, Carmelo Carlo-Stella, Rita Mazza, Salomon Manier, Thierry Facon, Sung-Soo Yoon, Youngil Koh, Simon J Harrison, Jeremy Er, Antonio Pinto, Francesco Volzone, Giulia Perrone, Paolo Corradini, Titouan Cazaubiel, Cyrille Hulin, Cyrille Touzeau, Philippe Moreau, Enrique M. Ocio, Carmen Maria Montes Gaisan, Rakesh Popat, Sarah Leong, Fritz Offner, Paula Rodriguez Otero, Ana Alfonso-Pierola, Martin Hutchings, Caroline Hasselbalch Riley, Ann-Marie E Bröske
Journal: Blood
Blood (2022) 140 (Supplement 1): 10137–10139.
https://doi.org/10.1182/blood-2022-158146
Published: 2022
Journal Articles

Developing a Flow Cytometric Signature of Carfilzomib Responsiveness in Myeloma

Ieuan Walker, Venetia D'arcy, Antonio Rodriguez Romera, Georgina Anderson, Anna Aubareda, James Roy, Garima Khandelwal, William Wilson, Evelyn Fitzsimons, Daria Galas-Filipowicz, Kane Foster, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M. de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Elizabeth H. Phillips, Laura Clifton-Hadley, Roger G Owen, Javier Herrero, Kwee Yong, Michael A Chapman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10106–10107.
https://doi.org/10.1182/blood-2022-169882
Published: 2022
Journal Articles

Survey of the Relevance of Quality of Life (QoL) Questionnaires (QoLQs) Currently Used to Evaluate Multiple Myeloma (MM) Patients' Qol in Real-World MM Patients and Healthcare Professionals (HCPs)

Sotirios Bristogiannis, Yadanar Lwin, Catherine SY Lecat, Joanne Sowter, Orla McCourt, Emma Dowling, Nuno Correia, Neil K Rabin, Ke Xu, Jonathan Sive, Xenofon Papanikolaou, Rakesh Popat, Lydia Lee, Annabel McMillan, Sosana Delimpasi, Ashutosh D. Wechalekar, Kwee Yong, Charalampia Kyriakou
Journal: Blood
Blood (2022) 140 (Supplement 1): 12506–12507.
https://doi.org/10.1182/blood-2022-167272
Published: 2022
Journal Articles

Impact of Autologous Stem Cell Transplant (ASCT) Versus Consolidation on Health-Related Quality of Life (HRQoL) for Patients with Multiple Myeloma Receiving Carfilzomib Maintenance: Results from the Cardamon Trial

Rakesh Popat, William Wilson, Marquita Camilleri, Karthik Ramasamy, Matthew Streetly, Jonathan Sive, Ceri Bygrave, Reuben Benjamin, Michael A Chapman, Selina J Chavda, Beth Phillips, Maria del Mar Cuadrado, Gavin Pang, Richard Jenner, Tushhar Dadaga, Sumaiya Kamora, Ruth M. de Tute, James Cavenagh, Laura Clifton-Hadley, Roger G Owen, Kwee Yong
Journal: Blood
Blood (2022) 140 (Supplement 1): 10191–10192.
https://doi.org/10.1182/blood-2022-166344
Published: 2022
Journal Articles

RG6234, a GPRC5DxCD3 T-Cell Engaging Bispecific Antibody, Is Highly Active in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Intravenous (IV) and First Subcutaneous (SC) Results from a Phase I Dose-Escalation Study

Carmelo Carlo-Stella, Rita Mazza, Salomon Manier, Thierry Facon, Sung-Soo Yoon, Youngil Koh, Simon J Harrison, Jeremy Er, Antonio Pinto, Francesco Volzone, Giulia Perrone, Paolo Corradini, Titouan Cazaubiel, Cyrille Hulin, Cyrille Touzeau, Philippe Moreau, Enrique M. Ocio, Carmen Maria Montes Gaisan, Rakesh Popat, Sarah Leong, Fritz Offner, Paula Rodriguez Otero, Ana Alfonso-Pierola, Ann-Marie E Bröske, Iryna Dekhtiarenko, Hans-Joachim Helms, Sara Belli, Eva Rossmann, Tanja Fauti, Jan Eckmann, Tom Moore, Meike Schneider, Wolfgang Jacob, Martin Weisser, Martin Hutchings, Caroline Hasselbalch Riley
Journal: Blood
Blood (2022) 140 (Supplement 1): 397–399.
https://doi.org/10.1182/blood-2022-157988
Published: 2022
Journal Articles

Single-Agent Belantamab Mafodotin in Patients with Relapsed or Refractory Multiple Myeloma: Final Analysis of the DREAMM-2 Trial

Ajay K. Nooka, Adam Cohen, Hans C. Lee, Ashraf Z. Badros, Attaya Suvannasankha, Natalie Callander, Al-Ola Abdallah, Suzanne Trudel, Ajai Chari, Edward Libby, Maria Chaudhry, Malin Hultcrantz, Martin Kortuem, Paul G. Richardson, Rakesh Popat, Douglas W. Sborov, Shawn Hakim, Eric Lewis, Bharat Bhushan, Boris Gorsh, Ira Gupta, Joanna Opalinska, Sagar Lonial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7301–7303.
https://doi.org/10.1182/blood-2022-164877
Published: 2022