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Holger Auner
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Journal Articles

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

Free
Monica Roman-Trufero, Kevin Blighe, Armin Zebisch, Bianca Perfler, Sereina Annik Herzog, Richard Butt, Holger Auner, Nadine Clemo
Journal: Blood
Blood (2025) 146 (Supplement 1): 1503.
https://doi.org/10.1182/blood-2025-1503
Published: 2025
Journal Articles

Cancer-selective targeting of the NF-κB pathway via GADD45β/MKK7 inhibition: Results from the phase I trial of the first-in-class inhibitor, DTP3, in patients with relapsed or refractory multiple myeloma

Free
Aristeidis Chaidos, Dimitrios Potolidis, Jessica Cornice, Holger Auner, Gary Acton, Ceri Bygrave, Gordon Cook, Rakesh Popat, Andrew Davies, Christopher Parrish, Maria Atta, Kim Linton, Dean Smith, Christopher Fox, Iain McNeish, Elizabeth Hadley, Elena Ferrer Martinez Del Peral, Mario Pellegatti, Nigel Adams, Albert Chau, Precious Nnebedum, Daria Capece, Daniela Verzella, Daniel D'Andrea, Jan Rekowski, Christina Yap, Laura Tornatore, Guido Franzoso
Journal: Blood
Blood (2025) 146 (Supplement 1): 5825.
https://doi.org/10.1182/blood-2025-5825
Published: 2025
Journal Articles

Cancer-Selective Targeting of the NF-κB Survival Pathway in Multiple Myeloma with the GADD45β/MKK7 Inhibitor, DTP3

Free
Laura Tornatore, Gary Acton, Nigel Adams, Elizabeth A Campbell, James Kelly, Richard M Szydlo, BSc, PhD, Mike Tarbit, Salina Bannoo, Daniel D'Andrea, Daria Capece, Annamaria Sandomenico, Julian Dyson, Antonio Leonardi, Christoph Driessen, Menotti Ruvo, Ishara Anees, Metod Oblak, Sheena Quaid, Magda J Al-Obaidi, Holger Auner, Reuben Benbenjamin, Richard S Kaczmarski, Martin F Kaiser, Atul Mehta, Heather E Oakervee, Stephen A Schey, Ashutosh Wechalekar, Jane F. Apperley, MD, Guido Franzoso
Journal: Blood
Blood (2015) 126 (23): 868.
https://doi.org/10.1182/blood.V126.23.868.868
Published: 2015
Journal Articles

Optimizing Patient Selection for Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia.

Free
Jiri Pavlu, Andrea Kew, Beatrice Taylor-Roberts, Holger Auner, John Goldman, Jane Apperley, Richard Szydlo
Journal: Blood
Blood (2009) 114 (22): 3392.
https://doi.org/10.1182/blood.V114.22.3392.3392
Published: 2009