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Christopher Parrish
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Journal Articles

Is IMWG frailty-score-adjusted dosing the right approach to improve toxicity and outcomes in FRAIL patients? Results from the UK-MRA FiTNEss trial in newly diagnosed myeloma patients ineligible for ASCT.

Free
Charlotte Pawlyn, Kara-Louise Royle, Ethan Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew Jenner, John Jones, Martin Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth de Tute, Christopher Parrish, Alan Chant, David Cairns, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2025) 146 (Supplement 1): 369.
https://doi.org/10.1182/blood-2025-369
Published: 2025
Journal Articles

Cancer-selective targeting of the NF-κB pathway via GADD45β/MKK7 inhibition: Results from the phase I trial of the first-in-class inhibitor, DTP3, in patients with relapsed or refractory multiple myeloma

Free
Aristeidis Chaidos, Dimitrios Potolidis, Jessica Cornice, Holger Auner, Gary Acton, Ceri Bygrave, Gordon Cook, Rakesh Popat, Andrew Davies, Christopher Parrish, Maria Atta, Kim Linton, Dean Smith, Christopher Fox, Iain McNeish, Elizabeth Hadley, Elena Ferrer Martinez Del Peral, Mario Pellegatti, Nigel Adams, Albert Chau, Precious Nnebedum, Daria Capece, Daniela Verzella, Daniel D'Andrea, Jan Rekowski, Christina Yap, Laura Tornatore, Guido Franzoso
Journal: Blood
Blood (2025) 146 (Supplement 1): 5825.
https://doi.org/10.1182/blood-2025-5825
Published: 2025
Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Can a patient questionnaire (VRAT) reduce the need for ocular examinations with less frequent belantamab mafodotin combined with bortezomib and dexamethasone? the ukmra prommise d trial

Free
Rakesh Popat, Robert Cicero, Andrew Hall, Alexandra Welsh, Charlotte Pawlyn, Ceri Bygrave, Dean Smith, Simona Degli Esposti, Daniel Larkin, Gordon Cook, Matthew Jenner, Martin Kaiser, Lydia Lee, Rashmi Chandrashekar, Michael Nathan, Heena Patel, Sadie Roberts, Sarah Brown, Christopher Parrish
Journal: Blood
Blood (2025) 146 (Supplement 1): 4065.
https://doi.org/10.1182/blood-2025-4065
Published: 2025
Journal Articles

The impact of frailty on real world outcomes for multiple myeloma patients in England – a cohort study from the uncover study group and ukmra frailty group.

Free
Thea Chandler, Indrani Karpha, Nurunnahar Akter, Temitope Erinfolami, Hanhua Liu, Brogan Johnston, Yeong Lim, Nagesh Kalakonda, Gillian Brearton, Sally Moore, Hira Mian, Frances Seymour, Christopher Parrish, Charlotte Pawlyn, Catrin Tudur Smith, Andrew Pettitt, Gordon Cook
Journal: Blood
Blood (2025) 146 (Supplement 1): 2792.
https://doi.org/10.1182/blood-2025-2792
Published: 2025
Journal Articles

Long-read RNA sequencing of first multiple myeloma patient cohort reveals landscape of variant expression in newly diagnosed patients from the UKMRA RADAR trial

Free
Bethan Hudson-Lund, Anandagopal Srinivasan, Eleanor Calcutt, Neelam Mehta, Ines Fethi, Emma Lyon, Jessica Kimber, Alice Lefever, Conor Garrod-Ketchley, Annabel Laidler, Elise Rees, Amatta Mirandari, Daniel Hughes, Louise Ainley, Jongwon Yoon, Lydia Lee, Maximilian Goodman, Megan Hawksley, Angela Brown, Mohammad Kazeroun, Naser Ansari-Pour, Matthew Jenner, Laura Chiecchio, Martin Kaiser, Michael Chapman, Angela Hamblin, Lorna Barnard, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Guy Pratt, Alan Chant, Jonathan Sive, Christopher Parrish, Udo Oppermann, Karthik Ramasamy, Kwee Yong, Eileen Boyle, Sarah Gooding, Adam Cribbs
Journal: Blood
Blood (2025) 146 (Supplement 1): 2141.
https://doi.org/10.1182/blood-2025-2141
Published: 2025
Journal Articles

CAR-T cells co-targeting BCMA and CD19 in RRMM: Results from the UKMRA Phase 1 MCARTY trial in relapsed refractory multiple myeloma

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Lydia Lee, Amatta Mirandari, Aditya Prabu, Eileen Boyle, Catriona Mactier, Juliana Pinto, Mhairi Vaughan, Giulia Agliardi, John Garcia, Evie Lewin, Louisa Green, Eleanor Wooderson, Owen Bain, Yashma Pathak, Bilyana Popova, Beth Jarman, Zainab Kalokoh, Helen Holmes, Cristina Realingo, Simon Thomas, Victoria Spanswick, William Wilson, Christopher Parrish, Maeve O'Reilly, Rakesh Popat, Claire Roddie, Kwee Yong, Martin Pule
Journal: Blood
Blood (2025) 146 (Supplement 1): 4173.
https://doi.org/10.1182/blood-2025-4173
Published: 2025
Journal Articles

IMWG Frailty Score-Adjusted Therapy Delivery Reduces the Early Mortality Risk in Newly Diagnosed Tne Multiple Myeloma: Results of the UK Myeloma Research Alliance (UK-MRA) Myeloma XIV Fitness Trial

Free
Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John Jones, Martin F Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, Alan Chant, David A. Cairns, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 673.
https://doi.org/10.1182/blood-2024-209653
Published: 2024
Journal Articles

Cost-Effectiveness of Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma - an Economic Evaluation of the Fitness Trial

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Bryony Dawkins, Georgios Gkountouras, David Meads, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John R Jones, Martin F Kaiser, Bhuvan Kishore, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, David A. Cairns, Alan Chant, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2024) 144 (Supplement 1): 385.
https://doi.org/10.1182/blood-2024-209720
Published: 2024
Journal Articles

Belantamab Mafodotin Plus Cyclophosphamide and Dexamethasone for Patients with Relapsed or Refractory Multiple Myeloma: Interim Results from the UK Myeloma Research Alliance Prommise Clinical Trial

Free
Rakesh Popat, Charlotte Pawlyn, Robert Cicero, Andrew Hall, Ceri Bygrave, Dean Smith, Simona Degli Esposti, Daniel Frank Larkin, Gordon Cook, Matthew W. Jenner, Martin F Kaiser, Lydia Sarah Hui Lee, Amrutha Sridhar, Marzia Rahman, Hanna Renshaw, Jennifer Ryan, Victoria Ware, Thea Chandler, Laura Clayton, Sadie Roberts, Sarah R Brown, Christopher Parrish
Journal: Blood
Blood (2024) 144 (Supplement 1): 1984.
https://doi.org/10.1182/blood-2024-204055
Published: 2024
Journal Articles

Risk Assignment Using the Myeloma Genome Project Panel: A Comparison to Standard of Care Genetic Testing within the UK-MRA RADAR Trial

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Sarah Gooding, Kara-Louise Royle, Mohammad Kazeroun, Robert Cicero, Laura Chiecchio, Dipal Mehta, Emma J Lyon, Bethan Hudson-Lund, Jasmin Rahman, Khrystal McBean, Martin F Kaiser, Catherine Olivier, Doina Levinte, Charlotte Kennaway, Dean Smith, Jonathan Sive, Ceri Bygrave, Guy Pratt, Michael A. Chapman, Graham Jackson, Rakesh Popat, Christopher Parrish, Gordon Cook, Angela Hamblin, Naser Ansari-Pour, David A. Cairns, Anjan Thakurta, Karthik Ramasamy, Eileen M Boyle, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3333.
https://doi.org/10.1182/blood-2024-209772
Published: 2024
Journal Articles

Senescent Immune Signature in Frail and Vulnerable Newly Diagnosed Myeloma Patients: A Cohort Analysis from the UK-MRA Myeloma XIV Fitness Study

Free
Frances Seymour, Claire Taylor, Sharon Gilson, Catherine Olivier, Christopher Parrish, David Allan Cairns, Christopher Winder, Matt Clark, Lesley Smith, Andrew Scarsbrook, Charlotte Pawlyn, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2023) 142 (Supplement 1): 6602.
https://doi.org/10.1182/blood-2023-184553
Published: 2023
Journal Articles

Dynamic Frailty Assessment in Transplant Non-Eligible Newly Diagnosed Myeloma Patients: Initial Data from UK Myeloma Research Alliance (UK-MRA) Myeloma XIV (FiTNEss): A Frailty-Adjusted Therapy Study

Free
Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella J. Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Alan Chant, Matthew W. Jenner, John Robert Jones, Martin F. Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth M de Tute, Christopher Parrish, David Allan Cairns, Graham Jackson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4748.
https://doi.org/10.1182/blood-2023-188672
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Genetic Standard and High-Risk Disease at Trial Entry: A Cross-Sectional Analysis of RADAR (UK-MRA Myeloma XV)

Free
Catherine SY Lecat, Alan Chant, Orla McCourt, David Meads, Robert Cicero, Kara-Louise Royle, Ceri Bygrave, Andrew Chantry, Michael A. Chapman, Gordon Cook, Bryony Dawkins, Mark Drayson, Graham Jackson, Matthew W. Jenner, Martin F. Kaiser, Dipal Mehta, Roger Owen, Rakesh Popat, Christopher Parrish, Guy Pratt, Jonathan Sive, Dean Smith, Ruth M de Tute, Lorna Barnard, Sharon Jackson, Doina Levinte, Catherine Olivier, Karthik Ramasamy, Kwee Yong, David Allan Cairns
Journal: Blood
Blood (2023) 142 (Supplement 1): 4710.
https://doi.org/10.1182/blood-2023-187453
Published: 2023
Journal Articles

Development of a Phase 1 Study Evaluating the Activity of Modular CAR T for Multiple Myeloma (MCARTY) Targeting BCMA and CD19 for Improved Persistence

Free
Lydia Sarah Hui Lee, Wen Chean Lim, Catriona Mactier, Juliana Dias Alves Pinto, Vitoria Pereira, Mhairi Vaughan, Louisa Green, Evie Lewin, John Garcia, Giulia Agliardi, Yashma Pathak, Riaz Jannoo, Leigh Wood, Bilyana Popova, Helen Holmes, Simon Thomas, Victoria Spanswick, William Wilson, Christopher Parrish, Rakesh Popat, Claire Roddie, Kwee Yong, Martin A. Pule
Journal: Blood
Blood (2023) 142 (Supplement 1): 350.
https://doi.org/10.1182/blood-2023-185085
Published: 2023
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

Free
Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

Ixazomib-Based Consolidation and Maintenance Prolongs Progression-Free Survival after Salvage Autologous Stem Cell Transplantation (sASCT): Results from Interim Analysis of UK-MRA Myeloma XII (ACCoRD)

Free
Gordon Cook, A J Ashcroft, Ethan R Senior, Catherine Olivier, Anna Hockaday, Jeanine Richards, James D. Cavenagh, John Snowden, Mark Drayson, Ruth M de Tute, Roger Owen, Kwee Yong, Mamta Garg, Kevin Boyd, Hamdi Sati, Sharon Gillson, Mark Cook, David Allan Cairns, Christopher Parrish
Journal: Blood
Blood (2023) 142 (Supplement 1): 783.
https://doi.org/10.1182/blood-2023-188532
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Fit, Unfit and Frail Patients Enrolled in Fitness (UK-MRA Myeloma XIV): A Cross Sectional Study

Free
Orla McCourt, David Allan Cairns, Sally Moore, Christopher Parrish, Charlotte Pawlyn, Frances Seymour, Ethan R Senior, Kara-Louise Royle, Jennifer Bird, Stella J. Bowcock, Alan Chant, Mark Drayson, Hayley Gardner, Matthew W. Jenner, John R Jones, Martin F. Kaiser, Bhuvan Kishore, Roger Owen, Neil Rabin, Ruth M de Tute, Bryony Dawkins, David Meads, Sharon Gillson, Sharon Jackson, Catherine Olivier, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2023) 142 (Supplement 1): 3368.
https://doi.org/10.1182/blood-2023-187202
Published: 2023
Journal Articles

RADAR Trial: MRD Response Adapted Trial for Newly Diagnosed Transplant Eligible Myeloma Patients

Free
Karthik Ramasamy, David Allan Cairns, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Lorna Barnard, Sharon Jackson, Doina Levinte, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael A. Chapman, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Martin F. Kaiser, Jonathan Sive, Christopher Parrish, Dean Smith, Matthew W. Jenner, Mark Drayson, Roger Owen, Ruth M de Tute, Dipal Mehta, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 3390.
https://doi.org/10.1182/blood-2023-188844
Published: 2023
Journal Articles

Developing and Implementing an Advance Care Planning Service for Patients with Haematological Malignancies Preparing to Undergo CAR-T Therapy

Free
Jenna L Tate, Christopher Parrish, Kathryn Riley, Lydia Skertchly, Thea Chandler, Frances Seymour, Gordon Cook
Journal: Blood
Blood (2022) 140 (Supplement 1): 8052–8053.
https://doi.org/10.1182/blood-2022-159737
Published: 2022