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Guy Pratt
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Journal Articles

Secure: A Prospective Long-Term Observational Study in Patients with Monoclonal Gammopathy of Undetermined Significance

Karthik Ramasamy, Elizabeth Knight, Sulgi Byun, Earnest Heartin, Victoria Garvey, Supratik Basu, Jacqueline Stones, Roderick Oakes, Grace Killingsworth, Patricia Nicholls, Samiya Mahmood, Stella Bowcock, Rachel Ryan, Sarah Essex, Arun Alfred, Dawn Collier, Lally De soysa, Rachel Bradley, Rowena Thomas-Dewing, Kathryn Cawley, Richard Kaczmarski, Magda Al-Obaidi, Freter Cubos, Charlotte Bomken, Simon Stern, Tiina Elonen, Parizade Raymode, Dinusha Chathurani, Louise Jenkins, Ceri Bygrave, Roberto Garcia Consuegra, Wendy Harrison, Fenella Willis, Richard Brouwer, Constantinos Koshiaris, Grant Vallance, Vicki Gamble, Kassim Javaid, Ross Sadler, Guy Pratt
Journal: Blood
Blood (2024) 144 (Supplement 1): 6889.
https://doi.org/10.1182/blood-2024-203107
Published: 2024
Journal Articles

Risk Assignment Using the Myeloma Genome Project Panel: A Comparison to Standard of Care Genetic Testing within the UK-MRA RADAR Trial

Sarah Gooding, Kara-Louise Royle, Mohammad Kazeroun, Robert Cicero, Laura Chiecchio, Dipal Mehta, Emma J Lyon, Bethan Hudson-Lund, Jasmin Rahman, Khrystal McBean, Martin F Kaiser, Catherine Olivier, Doina Levinte, Charlotte Kennaway, Dean Smith, Jonathan Sive, Ceri Bygrave, Guy Pratt, Michael A. Chapman, Graham Jackson, Rakesh Popat, Christopher Parrish, Gordon Cook, Angela Hamblin, Naser Ansari-Pour, David A. Cairns, Anjan Thakurta, Karthik Ramasamy, Eileen M Boyle, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3333.
https://doi.org/10.1182/blood-2024-209772
Published: 2024
Journal Articles

Extended Intensified Consolidation and Maintenance Improve Ultra High-Risk Multiple Myeloma Patient Outcome - Long-Term Follow-up of the Ukmra Optimum/Muknine Trial

Martin F Kaiser, Andrew Hall, Rachel Phillip, Amy Holroyd, Elsa Ferris, Sadie Roberts, Laura Clayton, Kristian Bowles, Mamta Garg, Anand Lokare, Ruth M de Tute, Mark Drayson, Christina Messiou, Roger G Owen, Richard S Houlston, Graham Jackson, Gordon Cook, Guy Pratt, Sarah R Brown, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3354.
https://doi.org/10.1182/blood-2024-201086
Published: 2024
Journal Articles

Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis

Clinical Trials & Observations
Joshua Bomsztyk, Sriram Ravichandran, Hannah V. Giles, Nicola Wright, Oscar Berlanga, Jahanzaib Khwaja, Shameem Mahmood, Brendan Wisniowski, Oliver Cohen, Darren Foard, Janet Gilbertson, Muhammad U. Rauf, Neasa Starr, Ana Martinez-Naharro, Lucia Venneri, Carol Whelan, Marianna Fontana, Philip N. Hawkins, Julian D. Gillmore, Helen Lachmann, Stephen Harding, Guy Pratt, Ashutosh D. Wechalekar
Journal: Blood
Blood (2024) 143 (13): 1259–1268.
https://doi.org/10.1182/blood.2023022399
Published: 2024
Includes: Supplemental data
Journal Articles

Ultra High-Risk Multiple Myeloma Patients with Multi-Hit Tumours and SKY92 High Risk Signature Are at Increased Risk of Early Relapse Even When Treated with Extended Intensified Induction and Consolidation - Results from the Optimum/Muknine Trial

Martin F. Kaiser, Rachel Phillip, Andrew Hall, Amy Holroyd, Laura Bevington, Ruth M de Tute, Laura Clayton, Sadie Roberts, Graham Jackson, Gordon Cook, Richard S Houlston, Mark Drayson, Roger Owen, Guy Pratt, Sarah R Brown, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 881.
https://doi.org/10.1182/blood-2023-177896
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Genetic Standard and High-Risk Disease at Trial Entry: A Cross-Sectional Analysis of RADAR (UK-MRA Myeloma XV)

Catherine SY Lecat, Alan Chant, Orla McCourt, David Meads, Robert Cicero, Kara-Louise Royle, Ceri Bygrave, Andrew Chantry, Michael A. Chapman, Gordon Cook, Bryony Dawkins, Mark Drayson, Graham Jackson, Matthew W. Jenner, Martin F. Kaiser, Dipal Mehta, Roger Owen, Rakesh Popat, Christopher Parrish, Guy Pratt, Jonathan Sive, Dean Smith, Ruth M de Tute, Lorna Barnard, Sharon Jackson, Doina Levinte, Catherine Olivier, Karthik Ramasamy, Kwee Yong, David Allan Cairns
Journal: Blood
Blood (2023) 142 (Supplement 1): 4710.
https://doi.org/10.1182/blood-2023-187453
Published: 2023
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

RADAR Trial: MRD Response Adapted Trial for Newly Diagnosed Transplant Eligible Myeloma Patients

Karthik Ramasamy, David Allan Cairns, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Lorna Barnard, Sharon Jackson, Doina Levinte, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael A. Chapman, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Martin F. Kaiser, Jonathan Sive, Christopher Parrish, Dean Smith, Matthew W. Jenner, Mark Drayson, Roger Owen, Ruth M de Tute, Dipal Mehta, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 3390.
https://doi.org/10.1182/blood-2023-188844
Published: 2023
Journal Articles

Risk-Adapted Therapy Directed According to Response (RADAR, UK-MRA Myeloma XV) - Comparing MRD-Guided Treatment Escalation and De-Escalation Strategies in Patients with Newly Diagnosed Myeloma Suitable for Stem Cell Transplantation

Kwee Yong, Kara-Louise Royle, Karthik Ramasamy, Christopher Parrish, Anna Hockaday, Samir Asher, Mark T Drayson, Ruth M. de Tute, Matthew W Jenner, Martin F. Kaiser, Guy Pratt, Jonathan Sive, Ceri Bygrave, Gordon Cook, Rakesh Popat, Dean Smith, Catherine Olivier, Lorna Barnard, Doina Levinte, Bryony Dawkins, Michael A Chapman, Andrew D Chantry, Graham Jackson, Sergio A Quezada, Roger G Owen, David Cairns
Journal: Blood
Blood (2022) 140 (Supplement 1): 1844–1846.
https://doi.org/10.1182/blood-2022-168842
Published: 2022
Journal Articles

Extended Intensified Post-ASCT Consolidation with Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (Dara-VRd) for Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) and Primary Plasma Cell Leukemia (pPCL): The UK Optimum/Muknine Trial

Martin F. Kaiser, Andrew Hall, Isabelle Smith, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Richard S. Houlston, Graham Jackson, Gordon Cook, Guy Pratt, Mark T Drayson, Roger G Owen, Sarah R Brown, Matthew W Jenner
Journal: Blood
Blood (2022) 140 (Supplement 1): 1833–1835.
https://doi.org/10.1182/blood-2022-159540
Published: 2022
Journal Articles

Pembrowm: Results of a Multi-Centre Phase II Trial Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia

Jaimal Kothari, Toby A. Eyre, Ali Rismani, Helen McCarthy, Angela Collins, David John Lewis, Suzanne O Arulogun, William Wilson, Laura Clifton-Hadley, Darren Edwards, Kushani Ediriwickrema, Rebecca Auer, Guy Pratt, Ruth M. de Tute, Roger G Owen, Shirley D'Sa
Journal: Blood
Blood (2022) 140 (Supplement 1): 3624–3626.
https://doi.org/10.1182/blood-2022-167158
Published: 2022
Journal Articles

Use of Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Free Light Chain Assessment for the Diagnosis and Monitoring of Systemic Immunoglobulin Light Chain (AL) Amyloidosis

Joshua Bomsztyk, Sriram Ravichandran, Hannah Victoria Giles, Oscar Berlanga, Stephen Harding, Jahanzaib Khwaja, Shameem Mahmood, Brendan Wisniowski, Oliver C Cohen, Darren Foard, Janet Gilbertson, Ana Martinez De Azcona Naharro, Lucia Venneri, Carol Whelan, Marianna Fontana, Philip N Hawkins, Julian D Gillmore, Helen J Lachmann, Guy Pratt, Ashutosh D. Wechalekar
Journal: Blood
Blood (2022) 140 (Supplement 1): 2351–2353.
https://doi.org/10.1182/blood-2022-160018
Published: 2022
Journal Articles

Redefining nonmeasurable multiple myeloma using mass spectrometry

Clinical Trials & Observations
Hannah V. Giles, Mark A. Cook, Mark Trehane Drayson, Gordon Cook, Nicola Jane Wright, Simon John North, Stephen Harding, David A. Cairns, Anna Hockaday, Martin F. Kaiser, Paul Moss, Faith E. Davies, Gareth J. Morgan, Graham Jackson, Guy Pratt
Journal: Blood
Blood (2022) 139 (6): 946–950.
https://doi.org/10.1182/blood.2021013794
Published: 2022
Includes: Supplemental data
Journal Articles

Daratumumab, Cyclophosphamide, Bortezomib, Lenalidomide, Dexamethasone (Dara-CVRd), V-Augmented Autologous Stem Cell Transplant (V-ASCT) and Dara-Vrd Consolidation in Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) and Primary Plasma Cell Leukemia (pPCL) Compared with Myeloma XI/XI+ Trial Treatment for Uhir MM: The UK Optimum/Muknine Trial

Martin F. Kaiser, Andrew Hall, Katrina Walker, Nicola Newnham, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Graham Jackson, Gordon Cook, Guy Pratt, Roger G Owen, Mark T Drayson, Sarah R Brown, Matthew W Jenner
Journal: Blood
Blood (2021) 138 (Supplement 1): 465.
https://doi.org/10.1182/blood-2021-144990
Published: 2021
Journal Articles

Response to COVID-19 Vaccines in Patients Receiving Intensified Post-ASCT Therapy with Daratumumab, Lenalidomide, Bortezomib (Dara-VR) Due to Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) or Primary Plasma Cell Leukemia (pPCL): Exploratory Analysis of the UK Optimum/Muknine Trial

Matthew W Jenner, Andrew Hall, Sian E Faustini, Alexandra Pitchford, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Graham Jackson, Guy Pratt, Gordon Cook, Roger G Owen, Sarah R Brown, Mark T Drayson, Martin F. Kaiser
Journal: Blood
Blood (2021) 138 (Supplement 1): 2699.
https://doi.org/10.1182/blood-2021-149268
Published: 2021
Journal Articles

Ethnic Disparities in Waldenström's Macroglobulinaemia in the United Kingdom - Analysis from the Wmuk Rory Morrison Registry

Aisha S Patel, Jahanzaib Khwaja, Helen McCarthy, Guy Pratt, Jaimal Kothari, Jindriska Lindsay, Roger G Owen, Josephine Crowe, Dima El-Sharkawi, Nilima Parry-Jones, Kirsty Cuthill, Maria Atta, Kim Linton, Agapi Parcharidou, Charalampia Kyriakou, Deborah Turner, Jeffery Smith, Simona Gatto, Nicola Crosbie, Suzanne O Arulogun, Shirley D'Sa
Journal: Blood
Blood (2021) 138 (Supplement 1): 1977.
https://doi.org/10.1182/blood-2021-153590
Published: 2021
Journal Articles

Daratumumab, Bortezomib and Dexamethasone (DVd) at First Relapse for Patients with Relapsed/ Refractory Multiple Myeloma (RRMM): A UK Myeloma Research Alliance (UK-MRA) Real-World Multicentre Analysis

Annabel McMillan, Supratik Basu, Kamaraj Karunanithi, Elizabeth A. Parkins, Edward Yan Ming Lau, Gordon Cook, Christopher Parrish, Firas Al-Kaisi, Guy Pratt, Salim Shafeek, Stephen William Hart Jenkins, Shivir Moosai, Danish Memon, Ceri A Bygrave, Xenofon Papanikolaou, Tara Maisel, Sandra Hassan, Gurvin Chander, Bhuvan Kishore, Farheen Karim, Georgina Talbot, Farooq A Wandroo, Dunsi Bolarinwa, Kwee Yong, Rakesh Popat
Journal: Blood
Blood (2021) 138 (Supplement 1): 4120.
https://doi.org/10.1182/blood-2021-147043
Published: 2021
Journal Articles

Residual Monoclonal Free Light Chain Positivity By Mass Spectrometry Identifies Patients at Increased Risk of Early Relapse Following First-Line Anti-Myeloma Treatment

Hannah Victoria Giles, Mark T Drayson, Nicola Wright, Gordon Cook, Faith E. Davies, Gareth J Morgan, Ruth M. de Tute, Roger G Owen, David Cairns, Anna Hockaday, Tom Menzies, Martin F. Kaiser, Charlotte Pawlyn, Graham Jackson, Guy Pratt
Journal: Blood
Blood (2021) 138 (Supplement 1): 820.
https://doi.org/10.1182/blood-2021-150479
Published: 2021
Journal Articles

Neuropathy with IgM Gammopathy: Incidence, Characteristics and Management, a Rory Morrison W.M.U.K Registry Analysis

Oliver Tomkins, BMBS,MRCP, Jindriska Lindsay, FRCPath, Stephen Keddie, MRCP, Aisling Carr, PhDFRCP, Helen McCarthy, PhD FRCPath, Dima El-Sharkawi, MBBS, FRCPath, PhD, Charalampia Kyriakou, MD PhD, Kirsty Cuthill, FRCPath,MBBS,MRCP,PhD, Guy Pratt, FRCPath, Ali Rismani, FRCPath, Michael P Lunn, Shirley D'Sa, MD FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-136558
Published: 2020
Journal Articles

Bendamustine Plus Rituximab for the Treatment of Waldenström Macroglobulinaemia: Patient Outcomes and Impact of Bendamustine Dosing

Suzanne O Arulogun, MBBS, Duncan Brian, Harshita Goradia, Aaron Cooney, Tobias Menne, MD PhD, Dipti Talaulikar, PhD FRACP, FRCPA, MBBS, Aideen Therese O'Neill, FRCPath, Josephine M.I Vos, Guy Pratt, FRCPath, Deborah Turner, Kirsty Marshall, Kate Manos, MBBS, Claire Anderson, Maria Gavriatopoulou, Charalampia Kyriakou, MD PhD, Monique C. Minnema, Dima El-Sharkawi, MBBS, FRCPath, PhD, Marie José Kersten, MD PhD, RayMun Koo, Helen McCarthy, PhD FRCPath, Mark Bishton, MBChB, MRCP, FRCPath, PhD, George Follows, Ashutosh D. Wechalekar, Shirley D'Sa, MD FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-140774
Published: 2020