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Journal Articles

Approaching Hypercalcemia in Monoclonal Gammopathy of Undetermined Significance: Insights from the iStopMM study

Ástrún Helga Jónsdóttir, Helga Ágústa Sigurjónsdóttir, Prof., Sigrun Thorsteinsdottir, Thorir Einarsson Long, Ingigerður Sólveig Sverrisdóttir, Elias Eythorsson, Jon Thorir Oskarsson, Runólfur Pálsson, Olafur Skuli Indridason, Bryjnar Vidarsson, Pall T Onundarson, Isleifur Olafsson, Ingunn Þorsteinsdóttir, Bjarni A Agnarsson, Margret Sigurdardottir, Asbjorn Jonsson, Malin L. Hultcrantz, Brian G.M. Durie, Stephen Harding, Carl Ola Landgren, Thorvardur Jon Love, Sigurdur Yngvi Kristinsson, Sæmundur Rögnvaldsson
Journal: Blood
Blood blood.2024025624.
https://doi.org/10.1182/blood.2024025624
Published: 2024
Includes: Supplemental data
Journal Articles

Serum free light chains in a racially diverse population including African Americans and populations from South Africa

Luca Bertamini, Jean-Baptiste Alberge, David Jungpa Lee, Habib El-Khoury, Sungjae Kim, Grace Fleming, Ciara Suen Marie Murphy, Julia Colchie, Maya I Davis, Jacqueline Perry, Elizabeth D Lightbody, Sabine Allam, Lindokuhle N Goqwana, Vinitha Philip, Natalie Anne Smyth, NA, Dhananjay Sakrikar, Mark C Perkins, Stephen Harding, Derek Troske, Gad Getz, Elizabeth W Karlson, Nikhil C. Munshi, Kenneth C. Anderson, Lorenzo Trippa, Catherine R Marinac, Wenlong Carl Chen, Maureen Joffe, Irene M Ghobrial
Journal: Blood
Blood blood.2024026078.
https://doi.org/10.1182/blood.2024026078
Published: 2024
Includes: Supplemental data
Journal Articles

Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis

Clinical Trials & Observations
Joshua Bomsztyk, Sriram Ravichandran, Hannah V. Giles, Nicola Wright, Oscar Berlanga, Jahanzaib Khwaja, Shameem Mahmood, Brendan Wisniowski, Oliver Cohen, Darren Foard, Janet Gilbertson, Muhammad U. Rauf, Neasa Starr, Ana Martinez-Naharro, Lucia Venneri, Carol Whelan, Marianna Fontana, Philip N. Hawkins, Julian D. Gillmore, Helen Lachmann, Stephen Harding, Guy Pratt, Ashutosh D. Wechalekar
Journal: Blood
Blood (2024) 143 (13): 1259–1268.
https://doi.org/10.1182/blood.2023022399
Published: 2024
Includes: Supplemental data
Journal Articles

Predicting the Need for Upfront Bone Marrow Sampling in Individuals with MGUS: Derivation of a Multivariable Prediction Model Using the Prospective Population-Based Istopmm Cohort

Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Elin Ruth Reed, Gudrún Ásta Sigurdardóttir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ísleifur Ólafsson, Ingunn Þorsteinsdóttir, Signy Vala Sveinsdottir, Fridbjorn Sigurdsson, Ásdis Rósa Thórdardottir, Runolfur Palsson, Olafur Indridason, Thorir Einarsson Long, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Hlif Steingrimsdottir, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thor Aspelund, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 266–267.
https://doi.org/10.1182/blood-2022-170166
Published: 2022
Journal Articles

Prevalence of Monoclonal Gammopathies Detected By Mass Spectrometry and Their Risk Factors Among Black Africans in South Africa

David J. Lee, Habib El-Khoury, Luca Bertamini, Jean-Baptiste Alberge, Maya I. Davis, Jacqueline Perry, Dhananjay Sakrikar, David Barnidge, Mark C. Perkins, Stephen Harding, Derek Troske, Audrey Pentz, Thulisile Hlubi, Natalie Smyth, Anna Cowan, Angela C. Tramontano, Gad Getz, Timothy R. Rebbeck, Maureen Joffe, Wenlong Carl Chen, Catherine R. Marinac, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7228–7229.
https://doi.org/10.1182/blood-2022-167268
Published: 2022
Journal Articles

Use of Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Free Light Chain Assessment for the Diagnosis and Monitoring of Systemic Immunoglobulin Light Chain (AL) Amyloidosis

Joshua Bomsztyk, Sriram Ravichandran, Hannah Victoria Giles, Oscar Berlanga, Stephen Harding, Jahanzaib Khwaja, Shameem Mahmood, Brendan Wisniowski, Oliver C Cohen, Darren Foard, Janet Gilbertson, Ana Martinez De Azcona Naharro, Lucia Venneri, Carol Whelan, Marianna Fontana, Philip N Hawkins, Julian D Gillmore, Helen J Lachmann, Guy Pratt, Ashutosh D. Wechalekar
Journal: Blood
Blood (2022) 140 (Supplement 1): 2351–2353.
https://doi.org/10.1182/blood-2022-160018
Published: 2022
Journal Articles

Persistence of Monoclonal Gammopathies in Serial Samples from a US Population-Based Screening Study

Habib El-Khoury, Luca Bertamini, Jean-Baptiste Alberge, David J. Lee, Ciara Murphy, Grace Fleming, Christian J. Cea-Curry, Maya I. Davis, Jacqueline Perry, Elizabeth D. Lightbody, Dhananjay Sakrikar, Derek Troske, David Barnidge, Mark C. Perkins, Stephen Harding, Gad Getz, Catherine R. Marinac, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 10101–10103.
https://doi.org/10.1182/blood-2022-169380
Published: 2022
Journal Articles

Abnormal Free Light Chains in Individuals with African Ancestry Screened for Monoclonal Gammopathy: Definition of New Reference Range Accounting for Renal Function and Race

Luca Bertamini, Jean-Baptiste Alberge, Habib El-Khoury, David J. Lee, Ciara Murphy, Grace Fleming, Maya I. Davis, Jacqueline Perry, Christian J. Cea-Curry, Audrey Pentz, Thulisile Hlubi, Natalie Smyth, D.J. Sakrikar, Mark C. Perkins, Stephen Harding, Derek Troske, Gad Getz, Timothy R. Rebbeck, Maureen Joffe, Catherine R. Marinac, Nelson Leung, Carl Wenlong Chen, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 10005–10006.
https://doi.org/10.1182/blood-2022-164436
Published: 2022
Journal Articles

Sars-Cov-2 Vaccinations Do Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study

Robert Palmason, Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Sara Ekberg, Michael Crowther, Elin Ruth Reed, Jon Þórir Oskarsson, Gudrun Asta Sigurdardottir, Thor Aspelund, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Asbjorn Jonsson, Olafur Skuli Indridason, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Hlif Steingrimsdottir, Thorir Einarsson Long, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Runolfur Palsson, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 261–263.
https://doi.org/10.1182/blood-2022-157138
Published: 2022
Journal Articles

Circulating Tumor Plasma Cells in the Screened Istopmm Smoldering Multiple Myeloma Cohort

Sigrún Thorsteinsdóttir, Jon Þórir Oskarsson, Sæmundur Rögnvaldsson, Gauti Gíslason, Thor Aspelund, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnar Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdóttir, Ísleifur Ólafsson, Elias Eythorsson, Ásbjorn Jónsson, Malin Hultcrantz, Ola Landgren, Stephen Harding, Brian G.M. Durie, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 9923–9924.
https://doi.org/10.1182/blood-2022-168690
Published: 2022
Journal Articles

Prevalence of MGUS Is High in the Istopmm Study but the Prevalence of IgA MGUS Does Not Increase with Age in the Way Other Immunoglobulin Subtypes Do

Thorvardur Jon Love, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Thor Aspelund, Elin Ruth Reed, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Isleifur Olafsson, Fridbjorn Sigurdsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Ingigerdur Solveig Sverrisdottir, Hlif Steingrimsdottir, Thorir Einarsson Long, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 256–258.
https://doi.org/10.1182/blood-2022-163169
Published: 2022
Journal Articles

Monoclonal Gammopathy of Undetermined Significance and Risk of Chronic Kidney Disease: Results of the Population-Based Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Thorir Einarsson Long, Elias Eythorsson, Sæmundur Rögnvaldsson, Olafur Indridason, Runolfur Palsson, Sigrún Thorsteinsdóttir, Ingigerdur S Sverrisdottir, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdottir, Ísleifur Ólafsson, Asdis Rosa Thordardottir, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Hlif Steingrimsdottir, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10108–10109.
https://doi.org/10.1182/blood-2022-170623
Published: 2022
Journal Articles

Autoimmune Diseases Are Not Associated with Monoclonal Gammopathy of Undetermined Significance: Results of the Prospective Population-Based Istopmm Study

Ingigerdur S Sverrisdottir, Sigrún Thorsteinsdóttir, Sæmundur Rögnvaldsson, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Önundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Robert Palmason, Ísleifur Ólafsson, Fridbjorn Sigurdsson, Ásdis Rósa Thórdardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Hlif Steingrimsdottir, Thorir Einarsson Long, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Sigurdur Y Kristinsson, Thorvardur Jon Love
Journal: Blood
Blood (2022) 140 (Supplement 1): 10031–10032.
https://doi.org/10.1182/blood-2022-169393
Published: 2022
Journal Articles

Monoclonal Gammopathy of Undetermined Significance (MGUS) with Multiple Paraproteins: Results from the Population-Based Istopmm Screening Study

Sæmundur Rögnvaldsson, Jon Þórir Oskarsson, Sigrun Thorsteinsdottir, Elin Ruth Reed, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Margret Sigurdardottir, Bjarni Agnar Agnarsson, Isleifur Olafsson, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Robert Palmason, Fridbjorn Sigurdsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Thor Aspelund, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Ingigerdur S Sverrisdottir, Gudlaug Katrin Hakonardottir, Thorir Einarsson Long, Ragnar Danielsen, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10024–10026.
https://doi.org/10.1182/blood-2022-168070
Published: 2022
Journal Articles

Hypercalcemia in Individuals with Monoclonal Gammopathy of Undetermined Significance: Results from the Istopmm Study

Ástrún Helga Jónsdóttir, Sæmundur Rögnvaldsson, Helga Ágústa Sigurjónsdóttir, Sigrún Thorsteinsdóttir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdóttir, Ísleifur Ólafsson, Signy Vala Sveinsdottir, Robert Palmason, Ásdis Rósa Thórdardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Ingigerdur S Sverrisdottir, Thorir Einarsson Long, Thor Aspelund, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10099–10100.
https://doi.org/10.1182/blood-2022-168822
Published: 2022
Journal Articles

Transient M-Proteins: Epidemiology, Causes, and the Impact of Mass Spectrometry: The Istopmm Study

Robert Palmason, Oscar Berlanga, Jon Kristinn Sigurdsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Sara Ekberg, Michael Crowther, Marina Levy, Elin Ruth Reed, Jon Þórir Oskarsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Fridbjorn Sigurdsson, Isleifur Olafsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Thor Aspelund, Gauti Gislason, Andri Olafsson, Ingigerdur Solveig Sverrisdottir, Hlif Steingrimsdottir, Thorir Einarsson Long, Malin Hultcrantz, Ola Landgren, Stephen Harding, Brian G.M. Durie, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2022) 140 (Supplement 1): 2338–2340.
https://doi.org/10.1182/blood-2022-164758
Published: 2022
Journal Articles

Redefining nonmeasurable multiple myeloma using mass spectrometry

Clinical Trials & Observations
Hannah V. Giles, Mark A. Cook, Mark Trehane Drayson, Gordon Cook, Nicola Jane Wright, Simon John North, Stephen Harding, David A. Cairns, Anna Hockaday, Martin F. Kaiser, Paul Moss, Faith E. Davies, Gareth J. Morgan, Graham Jackson, Guy Pratt
Journal: Blood
Blood (2022) 139 (6): 946–950.
https://doi.org/10.1182/blood.2021013794
Published: 2022
Includes: Supplemental data
Journal Articles

Defining New Reference Intervals for Serum Free Light Chains in Individuals with Reduced Kidney Function: Results of the Population- Based on Iceland Screens Treats or Prevents Multiple Myeloma (iStopMM) Study

Thorir Einarsson Long, Olafur Skuli Indridason, Runolfur Palsson, Sæmundur Rögnvaldsson, Thorvardur Jon Love, Sigrun Thorsteinsdottir, Ingigerdur Solveig Sverrisdottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Gauti Gislason, Andri Olafsson, Hlif Steingrimsdottir, Petros Kampanis, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Sigurdur Yngvi Kristinsson
Journal: Blood
Blood (2021) 138 (Supplement 1): 542.
https://doi.org/10.1182/blood-2021-153827
Published: 2021
Journal Articles

Estimating Selection Bias in Previous Monoclonal Gammopathy of Undetermined Significance Research - the Importance of Screening: Results from the Population-Based Screening Study Iceland Screens, Treats or Prevents Multiple Myeloma (iStopMM)

Aðalbjörg Ýr Sigurbergsdóttir, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Ingigerdur Solveig Sverrisdottir, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Gauti Kjartan Gislason, Andri Olafsson, Petros Kampanis, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood
Blood (2021) 138 (Supplement 1): 1618.
https://doi.org/10.1182/blood-2021-153188
Published: 2021
Journal Articles

Screening for Monoclonal Gammopathy of Undetermined Significance: A Population-Based Randomized Clinical Trial. First Results from the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Sigurdur Y Kristinsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Elin Ruth Reed, Jon Thorir Thorir Oskarsson, Iris Petursdottir, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Robert Palmason, Isleifur Olafsson, Fridbjorn Sigurdsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Ingigerdur Solveig Sverrisdottir, Maria Soffia Juliusdottir, Gudlaug Katrin Hakonardottir, Hlif Steingrimsdottir, Ragnar Danielsen, Petros Kampanis, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thorvardur Jon Love
Journal: Blood
Blood (2021) 138 (Supplement 1): 156.
https://doi.org/10.1182/blood-2021-152333
Published: 2021