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Journal Articles

Deep Learning Unveils Characteristics of Immune B Cell Aging in >17,000 Samples and Identifies Changes in the Immunoglobulin Repertoire Distribution and the Development of Monoclonal Gammopathy

Blood (2024) 144 (Supplement 1): 4984.

https://doi.org/10.1182/blood-2024-194368

Published: 2024

Journal Articles

Single-Cell Whole-Genome Sequencing of Circulating Tumor Cells in Relapsed/Refractory Multiple Myeloma Patients Receiving BCMA- or GPRC5D-Targeted Immunotherapies

Rosa Toenges, Jean-Baptiste Alberge, Francesco Corrado, Nayda Bidikian, David M. Cordas Dos Santos, Ankit K. Dutta, Elizabeth D. Lightbody, Romanos Sklavenitis Pistofidis, Adam S. Sperling, Kenneth C. Anderson, Shonali Midha, Yuxin Liu, Jacob P. Laubach, Eric L. Smith, Nikhil C. Munshi, Omar Nadeem, Irene Ghobrial, Gad Getz

Blood (2024) 144 (Supplement 1): 492.

https://doi.org/10.1182/blood-2024-204132

Published: 2024

Journal Articles

Tumor-Intrinsic and Immune Predictors of Response to Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Blood (2024) 144 (Supplement 1): 1928.

https://doi.org/10.1182/blood-2024-203684

Published: 2024

Journal Articles

Single-Cell Profiling of ~1.7 Million Plasma Cells across >250 Individuals Reveals Transcriptional Signatures of Progression and Clonal Expansion in Multiple Myeloma and Its Precursor Stages

Blood (2024) 144 (Supplement 1): 4637.

https://doi.org/10.1182/blood-2024-206540

Published: 2024

Journal Articles

A 1,000-Genome Map for Multiple Myeloma and Its Precursor Stages, and Its Impact on Clinical Outcome

Blood (2024) 144 (Supplement 1): 1019.

https://doi.org/10.1182/blood-2024-203517

Published: 2024

Journal Articles

Improved Risk Stratification of Smoldering Multiple Myeloma (SMM) Using Trajectory Data in the Pangea 2.0 Model: A Multicenter Study in 1,431 Participants

Blood (2024) 144 (Supplement 1): 1017.

https://doi.org/10.1182/blood-2024-205705

Published: 2024

Journal Articles

Longitudinal Single-Cell Immune Profiling Reveals Distinct Dynamics of Response to Teclistamab in Patients with High-Risk Smoldering Myeloma Compared to Relapsed-Refractory Multiple Myeloma

Nayda Bidikian, Francesco Corrado, Romanos Sklavenitis-Pistofidis, Yoshinobu Konishi, Rosa Toenges, Jean-Baptiste Alberge, Michelle P. Aranha, Ting Wu, Michael Timonian, Shonali Midha, Elizabeth K. O'Donnell, Yuxin Liu, Sophie Magidson, Ashlee Strutevant, Kenneth C. Anderson, Nikhil C. Munshi, Omar Nadeem, Gad Getz, Irene Ghobrial

Blood (2024) 144 (Supplement 1): 488.

https://doi.org/10.1182/blood-2024-207299

Published: 2024

Journal Articles

Pharmacological Targeting of IRF4 As a Therapeutic Strategy for Multiple Myeloma

Michael P. Agius, Laura Hevenor, N Connor Payne, Qi Liu, Hyuk-Soo Seo, Romanos Sklavenitis-Pistofidis, Daniel Heilpern-Mallory, Puspalata Bashyal, Michelle P. Aranha, Elizabeth D. Lightbody, Ralph Mazitschek, Sirano Dhe-Paganon, Jun Qi, Irene Ghobrial

Blood (2024) 144 (Supplement 1): 155.

https://doi.org/10.1182/blood-2024-203381

Published: 2024

Journal Articles

Comprehensive Characterization of the Plasma Proteome of Multiple Myeloma and Its Precursor Conditions and Identification of a Proteomic Signature to Improve Risk Prediction of Disease Progression

Blood (2024) 144 (Supplement 1): 1903.

https://doi.org/10.1182/blood-2024-209286

Published: 2024

Journal Articles

Genomic Evolution By Serial Single-Cell Sequencing Identifies High Tumor Expression of LYN As a Promoter of Resistance in Waldenstrom's Macroglobulinemia Undergoing Ibrutinib Monotherapy

Hao Sun, Romanos Sklavenitis-Pistofidis, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Andres Felipe Ramirez Gamero, Catherine A. Flynn, Christopher J Patterson, Mu Hao, Lu-Gui Qiu, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Shirong Liu, Steven P. Treon

Blood (2024) 144 (Supplement 1): 4338.

https://doi.org/10.1182/blood-2024-211597

Published: 2024

Journal Articles

Single-Cell RNA-Sequencing of 6 Million Tumor and Immune Cells in 365 Patients with MGUS and SMM Demonstrates Complex Progressive Changes in Immune Cell Functionality with a Distinct Footprint on Tumor Cell Biology and Disease Control

Romanos Sklavenitis-Pistofidis, Ting Wu, Elizabeth D. Lightbody, Yoshinobu Konishi, Mahshid Rahmat, Michael P. Agius, Junko Tsuji, Jean-Baptiste Alberge, Michael Timonian, Ankit K. Dutta, Michelle P. Aranha, Nayda Bidikian, Hadley Barr, Nicholas J. Haradhvala, Moshe Sade-Feldman, Gad Getz, Irene Ghobrial

Blood (2024) 144 (Supplement 1): 1895.

https://doi.org/10.1182/blood-2024-208837

Published: 2024

Journal Articles

Novel Non-Coding Candidate Drivers of Multiple Myeloma Linked to Plasma Cell Tumor Biology and B Cell Development

Blood (2024) 144 (Supplement 1): 1894.

https://doi.org/10.1182/blood-2024-205523

Published: 2024

Journal Articles

Early Serum Protein Clonal Dynamics Preceding Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma Years before Diagnosis

Blood (2024) 144 (Supplement 1): 3279.

https://doi.org/10.1182/blood-2024-203937

Published: 2024

Journal Articles

Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects

Blood (2023) 142 (Supplement 1): 2548.

https://doi.org/10.1182/blood-2023-178062

Published: 2023

Journal Articles

Single-Cell RNA Sequencing Reveals Hypo-Responsiveness of T and NK Cells to Interferon Stimulation As an Immune Hallmark in Asymptomatic Waldenstrom's Macroglobulinemia

Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Daniel L. Mallory, Ting Wu, Michelle P. Aranha, Junko Tsuji, Nicholas J Haradhvala, Elizabeth D. Lightbody, Katherine Towle, Laura Hevenor, Nickolas Tsakmaklis, Xiyue Wang, Alexa G Canning, Christine-Ivy Liacos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Steven P Treon, Gady Getz, Irene M. Ghobrial

Blood (2023) 142 (Supplement 1): 2026.

https://doi.org/10.1182/blood-2023-186470

Published: 2023

Journal Articles

Genome Sequencing to Discover Drivers of Clonal Expansion in Smoldering Multiple Myeloma

Jean-Baptiste Alberge, Ankit K. Dutta, Elizabeth D. Lightbody, Andrea Poletti, Sofia Wallin, Andrew Dunford, Tim Coorens, Xavi Loinaz, Cody J. Boehner, Nang Kham Su, Laura Hevenor, Katherine Towle, Jacqueline Perry, Kirsten Kübler, Romanos Sklavenitis-Pistofidis, Julian Hess, Chip Stewart, Gad Getz, Irene M. Ghobrial

Blood (2023) 142 (Supplement 1): 4143.

https://doi.org/10.1182/blood-2023-184900

Published: 2023

Journal Articles

Single-Cell RNA Sequencing of Circulating Tumor Cells in Precursor Myeloma Patients Reveals Mechanisms of Disease Dissemination

Blood (2023) 142 (Supplement 1): 872.

https://doi.org/10.1182/blood-2023-189760

Published: 2023

Journal Articles

Genomic Profiling to Interpret the Outcomes of Early Intervention for High-Risk Smoldering Myeloma

Benjamin Diamond, Dickran Kazandjian, Marios Papadimitriou, Bachisio Ziccheddu, Patrick Blaney, Monika Chojnacka, Michael Durante, Elizabeth Hill, Romanos Sklavenitis-Pistofidis, Kylee H Maclachlan, Ryan M. Young, Saad Z Usmani, Faith E. Davies, Gad Getz, Irene M. Ghobrial, Gareth J. Morgan, Francesco Maura, Ola Landgren

Blood (2023) 142 (Supplement 1): 757.

https://doi.org/10.1182/blood-2023-181817

Published: 2023

Journal Articles

Reconstructing the Genomic History of Multiple Myeloma Precursor Disease: Novel Insights and Clinical Applicability

Blood (2022) 140 (Supplement 1): 4257–4258.

https://doi.org/10.1182/blood-2022-167041

Published: 2022

Journal Articles

Single-Cell RNA-Sequencing of 370 Bone Marrow and Peripheral Blood Immune Cell Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveal Significant Immune Dysregulation at the MGUS Stage, and Novel Interactions between Tumor and Immune Cells

Romanos Sklavenitis-Pistofidis, Ting Wu, Mahshid Rahmat, Yoshinobu Konishi, Elizabeth D. Lightbody, Michael Timonian, Junko Tsuji, Danielle T. Firer, Nicholas J. Haradhvala, Cinnie Yentia Soekojo, Xiyue Wang, Daniel Heilpern-Mallory, François Aguet, Gad Getz, Irene Ghobrial

Blood (2022) 140 (Supplement 1): 860–861.

https://doi.org/10.1182/blood-2022-168911

Published: 2022

NARROW

Deep Learning Unveils Characteristics of Immune B Cell Aging in >17,000 Samples and Identifies Changes in the Immunoglobulin Repertoire Distribution and the Development of Monoclonal Gammopathy

Single-Cell Whole-Genome Sequencing of Circulating Tumor Cells in Relapsed/Refractory Multiple Myeloma Patients Receiving BCMA- or GPRC5D-Targeted Immunotherapies

Tumor-Intrinsic and Immune Predictors of Response to Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Single-Cell Profiling of ~1.7 Million Plasma Cells across >250 Individuals Reveals Transcriptional Signatures of Progression and Clonal Expansion in Multiple Myeloma and Its Precursor Stages

A 1,000-Genome Map for Multiple Myeloma and Its Precursor Stages, and Its Impact on Clinical Outcome

Improved Risk Stratification of Smoldering Multiple Myeloma (SMM) Using Trajectory Data in the Pangea 2.0 Model: A Multicenter Study in 1,431 Participants

Longitudinal Single-Cell Immune Profiling Reveals Distinct Dynamics of Response to Teclistamab in Patients with High-Risk Smoldering Myeloma Compared to Relapsed-Refractory Multiple Myeloma

Pharmacological Targeting of IRF4 As a Therapeutic Strategy for Multiple Myeloma

Comprehensive Characterization of the Plasma Proteome of Multiple Myeloma and Its Precursor Conditions and Identification of a Proteomic Signature to Improve Risk Prediction of Disease Progression

Genomic Evolution By Serial Single-Cell Sequencing Identifies High Tumor Expression of LYN As a Promoter of Resistance in Waldenstrom's Macroglobulinemia Undergoing Ibrutinib Monotherapy

Single-Cell RNA-Sequencing of 6 Million Tumor and Immune Cells in 365 Patients with MGUS and SMM Demonstrates Complex Progressive Changes in Immune Cell Functionality with a Distinct Footprint on Tumor Cell Biology and Disease Control

Novel Non-Coding Candidate Drivers of Multiple Myeloma Linked to Plasma Cell Tumor Biology and B Cell Development

Early Serum Protein Clonal Dynamics Preceding Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma Years before Diagnosis

Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects

Single-Cell RNA Sequencing Reveals Hypo-Responsiveness of T and NK Cells to Interferon Stimulation As an Immune Hallmark in Asymptomatic Waldenstrom's Macroglobulinemia

Genome Sequencing to Discover Drivers of Clonal Expansion in Smoldering Multiple Myeloma

Single-Cell RNA Sequencing of Circulating Tumor Cells in Precursor Myeloma Patients Reveals Mechanisms of Disease Dissemination

Genomic Profiling to Interpret the Outcomes of Early Intervention for High-Risk Smoldering Myeloma

Reconstructing the Genomic History of Multiple Myeloma Precursor Disease: Novel Insights and Clinical Applicability

Single-Cell RNA-Sequencing of 370 Bone Marrow and Peripheral Blood Immune Cell Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveal Significant Immune Dysregulation at the MGUS Stage, and Novel Interactions between Tumor and Immune Cells

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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