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Adam S. Sperling
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Journal Articles

Phase 2 Registrational Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma: Preliminary Results from the IMMagine-1 Trial

Ciara Louise Freeman, Binod Dhakal, Gurbakhash Kaur, Richard T. Maziarz, Natalie Callander, Adam S. Sperling, Carolina Schinke, Andrzej J Jakubowiak, Noa Biran, Douglas W Sborov, Cindy Varga, Abhinav Deol, Abraham S. Kanate, Mehmet Hakan Koçoğlu, Melhem M. Solh, Kamalika Banerjee, Rebecca Chan, Myrna Nahas, Ana Kostic, Enrique Granados, Carolyn Jackson, Christopher R. Heery, Tim Welliver, Krina K. Patel, Matthew Frigault
Journal: Blood
Blood (2024) 144 (Supplement 1): 1031.
https://doi.org/10.1182/blood-2024-198499
Published: 2024
Journal Articles

Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Shuntaro Ikegawa, Adam S. Sperling, Sarah Nikiforow, Andrew Ghazi, Anthony Christidis, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Allison Charles, Marc Credi, Nina Orwitz, Madisyn Strange, Rakuyo Tamada, Kevin M. Panaro, Casey Gervais, Michela Ansuinelli, Yohei Arihara, Rao Prabhala, Carol G. Reynolds, Robert Gentleman, Serena De Vita, Nikhil C. Munshi, Jerome Ritz
Journal: Blood
Blood (2024) 144 (Supplement 1): 149.
https://doi.org/10.1182/blood-2024-199890
Published: 2024
Journal Articles

Single-Cell Whole-Genome Sequencing of Circulating Tumor Cells in Relapsed/Refractory Multiple Myeloma Patients Receiving BCMA- or GPRC5D-Targeted Immunotherapies

Rosa Toenges, Jean-Baptiste Alberge, Francesco Corrado, Nayda Bidikian, David M. Cordas Dos Santos, Ankit K. Dutta, Elizabeth D. Lightbody, Romanos Sklavenitis Pistofidis, Adam S. Sperling, Kenneth C. Anderson, Shonali Midha, Yuxin Liu, Jacob P. Laubach, Eric L. Smith, Nikhil C. Munshi, Omar Nadeem, Irene Ghobrial, Gad Getz
Journal: Blood
Blood (2024) 144 (Supplement 1): 492.
https://doi.org/10.1182/blood-2024-204132
Published: 2024
Journal Articles

Distinct Impact of Platinum Chemotherapies on the Fitness and Genome of Hematopoietic Stem Cells and the Risk of Therapy-Related Myeloid Neoplasms

Jeremy Connors, Linda Zhang, Hidetaka Uryu, Koji Sasaki, Jennifer Padilla, Zongrui Li, Ken Furudate, Tomoyuki Tanaka, Courtney D. DiNardo, Nicholas J. Short, Naval Daver, Gautham Borthakur, Farhad Ravandi, Tapan M. Kadia, Hagop M. Kantarjian, Elias Jabbour, Simona Colla, Branko Cuglievan, Andrew Futreal, Adam S. Sperling, Guillermo Garcia-Manero, Margaret Goodell, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1816.
https://doi.org/10.1182/blood-2024-212052
Published: 2024
Journal Articles

Phase II Trial of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Omar Nadeem, Sophie Magidson, Robert A. Redd, Jacob P. Laubach, Clifton C. Mo, Elizabeth K. O'Donnell, Adam S. Sperling, Monique A. Hartley-Brown, Shonali Midha, Yuxin Liu, Frances Arters, Marjorie Marto, Christine Davie, Caroline Ricciardi, Dechen Choden, Ashlee Strutevant, Jillian Alberti, Amy Goguen, Michael Constantine, Pedro Sanz-Altamira, Lorenzo Trippa, Nikhil C. Munshi, Kenneth C. Anderson, Paul G. Richardson, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 3360.
https://doi.org/10.1182/blood-2024-202653
Published: 2024
Journal Articles

Bone Marrow Spatial Signatures Predict Survival Outcomes and Toxicities after CAR-T Therapy in Patients with Relapsed/Refractory Multiple Myeloma

Yoshinobu Konishi, David M. Cordas Dos Santos, Jacopo U. Verga, Patrick Costello, Sujal I. Shah, Qanber Raze, Liang S. Lim, Arnaldo G. Barican, David Howell, David King, Katherine Towle, Ruben D. Carrasco, Scott J. Rodig, Jon C. Aster, Adam S. Sperling, Eric L. Smith, Jacob Laubach, Nikhil C. Munshi, Kenneth C. Anderson, Omar Nadeem, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 590.
https://doi.org/10.1182/blood-2024-204144
Published: 2024
Journal Articles

Development of the ASH Research Collaborative Multiple Myeloma Program: A Multicenter, Real-World Evidence Generation Network

Shaji Kumar, William A. Wood, Kenneth C. Anderson, Emily A. Semmel, Shandra James, Donna S. Neuberg, Kathleen Hewitt, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Manisha Bhutani, Peter M. Voorhees, Adam S. Sperling, Susan M. Geyer, Michael W. Craige, Sam Walters, Andriy Derkach, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 3792.5.
https://doi.org/10.1182/blood-2024-210957
Published: 2024
Journal Articles

Early Safety and Efficacy of CAR-T Cell Therapy in Precursor Myeloma: Results of the CAR-PRISM Study Using Ciltacabtagene Autoleucel in High-Risk Smoldering Myeloma

Omar Nadeem, Sarah Nikiforow, Kevin DeBraganca, Anna Bosch-Vilaseca, Elizabeth K. O'Donnell, Adam S. Sperling, Yuxin Liu, Frances Arters, Marjorie Marto, Colin O'Donnell, Brendan Kineavy, Sarah Holmes, Hope Wei, Emily Durlacher, Elizabeth Grimm, Amy Goguen, Rocio Montes de Oca, Lorenzo Trippa, Eric L. Smith, Kenneth C. Anderson, Nikhil C. Munshi, Mark Wildgust, Jerome Ritz, Craig Tendler, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1027.
https://doi.org/10.1182/blood-2024-202676
Published: 2024
Journal Articles

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A -r and NPM1c AML

Wallace Bourgeois, Jevon A. Cutler, Brandon J. Aubrey, Daniela V. Wenge, Florian Perner, Cynthia Martucci, Jill A. Henrich, Kelly Klega, Radosław P. Nowak, Katherine A. Donovan, Meaghan Boileau, Yanhe Wen, Charlie Hatton, Athina A. Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A. Pollard, Jennifer A. Perry, Adam S. Sperling, Benjamin L. Ebert, Gerard M. McGeehan, Brian D. Crompton, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2024) 143 (15): 1513–1527.
https://doi.org/10.1182/blood.2023021105
Published: 2024
Includes: Supplemental data
Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Peter G. Miller, Adam S. Sperling, Christina Mayerhofer, Marie E. McConkey, Jana M. Ellegast, Carmen Da Silva, Drew N. Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J. Gibson, David T. Scadden, Kimberly Stegmaier, Shruti Bhatt, R. Coleman Lindsley, Benjamin L. Ebert
Journal: Blood
Blood (2023) 142 (24): 2079–2091.
https://doi.org/10.1182/blood.2023020331
Published: 2023
Includes: Supplemental data
Journal Articles

Expansion, Persistence, and Characteristics of Autologous, Bhv-1100 Armored Memory-like NK Cells Infused Prior to Autologous Stem Cell Transplant in MRD+ Multiple Myeloma Patients: A First-in-Human Trial

Grace Caroline Birch, Juliana Vergara-Cadavid, Mohsin Maqbool, Alba Martini, Khanlinh Dinh, Roman M. Shapiro, Michela Ansuinelli, Tuyet Nguyen, Carol Reynolds, Im Soo Y, Hope Wei, Sarah Hogan, Elizabeth Kendricken, Adam S. Sperling, Omar Nadeem, Jacob Laubach, Alissa Rybicki, Steven Schnittman, Elyse Stock, Diego Hernandez Rodriguez, Heather Daley, Sarah Nikiforow, Jerome Ritz, Robert J. Soiffer, Giada Bianchi, Rizwan Romee
Journal: Blood
Blood (2023) 142 (Supplement 1): 2105.
https://doi.org/10.1182/blood-2023-180224
Published: 2023
Journal Articles

T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity

Shuntaro Ikegawa, Adam S. Sperling, Michela Ansuinelli, Sarah Nikiforow, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Lawrence Rispoli, Marc A Credi, Nina Orwitz, Yohei Arihara, Rao Prabhala, Lakshmi Bhavani Potluri, Carol Reynolds, Serena De Vita, Nikhil C Munshi, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2023-177721
Published: 2023
Journal Articles

Phase II Trial of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in High-Risk Smoldering Multiple Myeloma

Omar Nadeem, Sophie Magidson, Robert A. Redd, Jacob Laubach, Clifton C. Mo, Elizabeth K. O'Donnell, Adam S. Sperling, Monique A Hartley-Brown, Shonali Midha, Marjorie Marto, Christine Davie, Caroline Ricciardi, Dechen Choden, Ashlee Strutevant, Jillian Alberti, Lorenzo Trippa, Nikhil C Munshi, Kenneth C. Anderson, Paul G. Richardson, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 3382.
https://doi.org/10.1182/blood-2023-177947
Published: 2023
Journal Articles

Immuno-PRISM: A Randomized Phase II Platform Study of Bispecific Antibodies in High-Risk Smoldering Myeloma

Omar Nadeem, Sophie Magidson, Shonali Midha, Elizabeth K. O'Donnell, Monique A Hartley-Brown, Adam S. Sperling, Robert A. Redd, Marjorie Marto, Christine Davie, Caroline Ricciardi, Dechen Choden, Ashlee Strutevant, Jillian Alberti, Clifton C. Mo, Jacob Laubach, Paul G. Richardson, Kenneth C. Anderson, Nikhil C Munshi, Lorenzo Trippa, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 206.
https://doi.org/10.1182/blood-2023-177954
Published: 2023
Journal Articles

Heterogeneity in Access and Toxicity Management of Commercially Available BCMA-Directed CAR-T and Bispecific T-Cell Engager Therapy Among the International Myeloma Community

Hamza Hassan, Mehmet K. Samur, Adam D. Cohen, Philippe Moreau, Paula Rodríguez Otero, Shaji Kunnathu Kumar, María Victoria Mateos, David Avigan, Adam S. Sperling, Omar Nadeem, Michael Hudecek, Carlos Fernández de Larrea, Joaquin Martínez-López, Maria Themeli, Kwee Yong, Jesus G. Berdeja, Ajai Chari, Pieter Sonneveld, Francesca Gay, Amrita Krishnan, Saad Z Usmani, Kenneth C. Anderson, Sundar Jagannath, Hermann Einsele, Nikhil C Munshi, Shonali Midha
Journal: Blood
Blood (2023) 142 (Supplement 1): 7248.
https://doi.org/10.1182/blood-2023-184710
Published: 2023
Journal Articles

DNMT3A -Mutated Stem and Progenitor Cells Contribute to Altered T Cell Activation in Clonal Hematopoiesis

Ksenia R. Safina, Shawn David, Kyle A. Romine, Kristina D. Mujica, Daniel Ssozi, Jonathan Good, Nurefsan Sariipek, Yoke Seng Lee, Adrienne Parsons, Sarah Bibeau, Adam S. Sperling, Christopher James Gibson, Gabriel K. Griffin, Alexander G. Bick, Antonia Kreso, Jennifer J. Trowbridge, Peter van Galen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1320.
https://doi.org/10.1182/blood-2023-180180
Published: 2023
Journal Articles

High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma

Mehmet Kemal Samur, Marco Roncador, Anil Aktas Samur, Mariateresa Fulciniti, Abdul Hamid Bazarbachi, Raphael Szalat, Masood A. Shammas, Adam S. Sperling, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, Aurore Perrot, Jill Corre, Philippe Moreau, Anjan Thakurta, Giovanni Parmigiani, Kenneth C. Anderson, Hervé Avet-Loiseau, Nikhil C. Munshi
Journal: Blood
Blood (2023) 141 (14): 1724–1736.
https://doi.org/10.1182/blood.2022017094
Published: 2023
Includes: Supplemental data
Journal Articles

Molecular Characterization of Adult Acute Lymphoblastic Leukemia Identifies a Subgroup with Myeloid Mutations and Pre-Existing Clonal Hematopoiesis

Caner Saygin, Jacob Stauber, Ibrahim Aldoss, Adam S. Sperling, Lachelle D. Weeks, Marlise R. Luskin, Todd C. Knepper, Pankhuri Wanjari, Peng Wang, Angela Lager, Jeremy Segal, Benjamin Kaumeyer, Sandeep Gurbuxani, Girish Venkataraman, Jason Xiaojun Cheng, Bartholomew Eisfelder, Oliver Bohorquez, Anand Ashwin Patel, Olatoyosi Odenike, Richard A. Larson, Lucy A. Godley, Daniel A. Arber, Benjamin L. Ebert, John M. Greally, Ulrich G. Steidl, Bijal D. Shah, Wendy Stock
Journal: Blood
Blood (2022) 140 (Supplement 1): 1050–1052.
https://doi.org/10.1182/blood-2022-167977
Published: 2022
Journal Articles

UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability

Jonathan M Tsai, Jacob D Aguirre, Jared Brown, Vivian Focht, Yen-Der Li, Georg Kempf, Lukas Kater, Pius Galli, Simone Cavadini, Brittany E Sandoval, Charles Zou, Justine Rutter, Katherine Donovan, Quinlan Sievers, Paul Park, Jevon A. Cutler, Charlie Hatton, Elizabeth Ener, Micah T Sperling, Mikolaj Slabicki, Peter G. Miller, Roger Belizaire, Adam S. Sperling, Scott A. Armstrong, Eric S. Fischer, Nicolas Thomä, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (Supplement 1): 2968–2969.
https://doi.org/10.1182/blood-2022-167615
Published: 2022
Journal Articles

Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

Peter G. Miller, Geoffrey G. Fell, Brody H. Foy, Allison K. Scherer, Christopher J. Gibson, Adam S. Sperling, Bala B. Burugula, Tetsushi Nakao, Md M. Uddin, Hailey Warren, Lynn Bry, Olga Pozdnyakova, Matthew J. Frigault, Alex G. Bick, Donna Neuberg, John M. Higgins, Michael K. Mansour, Pradeep Natarajan, Annette S. Kim, Jacob O. Kitzman, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (18): 1993–1997.
https://doi.org/10.1182/blood.2022018052
Published: 2022
Includes: Supplemental data