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Journal Articles

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Mark J Althoff, Mohd Minhajuddin, Brett M Stevens, Austin E Gillen, Regan Miller, Ana Vujovic, Sweta B Patel, William Showers, Stephanie Gipson, Monika Dzieciatkowska, Jana M Ellegast, Tristen Wright, Kimberly Stegmaier, Joseph T Opferman, Craig T Jordan

Blood (2024) 144 (Supplement 1): 39.

https://doi.org/10.1182/blood-2024-206516

Published: 2024

Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Blood (2023) 142 (24): 2079–2091.

https://doi.org/10.1182/blood.2023020331

Published: 2023

Includes: Supplemental data

Journal Articles

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Fanny Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 4174.

https://doi.org/10.1182/blood-2023-187187

Published: 2023

Journal Articles

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Jana M Ellegast, Gabriela Alexe, Subha Baniya, Amanda Hamze, Audrey Taillon, Biniam Adane, Amy Saur Conway, Tinghu Zhang, Nathanael S Gray, Scott A Armstrong, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 1393.

https://doi.org/10.1182/blood-2023-189304

Published: 2023

Journal Articles

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Fanny C Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier

Blood (2022) 140 (Supplement 1): 5864–5865.

https://doi.org/10.1182/blood-2022-166664

Published: 2022

Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier

Blood (2021) 138 (Supplement 1): 3305.

https://doi.org/10.1182/blood-2021-151511

Published: 2021

Journal Articles

Resistance Mechanisms to SYK Inhibition in AML

Anjali Cremer, MD, Jana M Ellegast, MD, Yana Pikman, MD, Gabriela Alexe, PhD, Linda Ross, PhD, Amy Goodale, Federica Piccioni, PhD, Elizabeth S Frank, Thomas Oellerich, MD, Kimberly Stegmaier, MD

Blood (2018) 132 (Supplement 1): 2638.

https://doi.org/10.1182/blood-2018-99-114996

Published: 2018

Journal Articles

Vcp-Regulated Homologous Recombination Represents a New Druggable Vulnerability in Acute Myeloid Leukemia

Lina Benajiba, Nina Fenouille, Edyta Malolepsza, Jana M Ellegast, MD, Gabriela Alexe, Yana Pikman, MD, Frédéric Luciano, Ilene Galinsky, Daniel J. DeAngelo, MD, Richard M. Stone, MD, Patrick Auberger, PhD, Josee Guirouilh-Barbat, Bernard Lopez, Mehdi Khaled, Kasper Lage, Olivier Hermine, MD PhD, Michael Hemann, Alexandre Puissant, Kimberly Stegmaier, MD

Blood (2017) 130 (Supplement 1): 880.

https://doi.org/10.1182/blood.V130.Suppl_1.880.880

Published: 2017

Journal Articles

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Saskia Rudat, MSc, Anja Pfaus, MSc, Claudia Bühler, MD, Sophie Rabe, MSc, Lars Bullinger, MD, Stefan Gröschel, MD, Stephen M. Sykes, PhD, Michael D. Milsom, PhD, Jana M. Ellegast, MD, Stefan Fröhling, MD, Claudia Scholl, MD

Blood (2016) 128 (22): 2849.

https://doi.org/10.1182/blood.V128.22.2849.2849

Published: 2016

Journal Articles

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

Philipp J Rauch, MD, Jana M Ellegast, MD, Larisa V Kovtonyuk, PhD, Ulrich Wagner, PhD, Rouven Müller, MD, Yasuyuki Saito, MD PhD, Nicole Wildner-Verhey van Wijk, PhD, Christine Fritz, Anahita Rafiei, PhD, Veronika Lysenko, Ewa Dudkiewicz, Davide Soldini, MD PhD, Jeroen S Goede, MD, Richard Flavell, PhD, Markus G Manz, MD

Blood (2016) 128 (22): 1078.

https://doi.org/10.1182/blood.V128.22.1078.1078

Published: 2016

Journal Articles

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Philipp J. Rauch, Jana M. Ellegast, Corinne C. Widmer, Kristin Fritsch, Jeroen S. Goede, Peter J. M. Valk, Bob Löwenberg, Hitoshi Takizawa, Markus G. Manz

Blood (2016) 128 (18): 2253–2257.

https://doi.org/10.1182/blood-2016-04-711986

Published: 2016

Includes: Supplemental data

Journal Articles

inv(16) and NPM1 mut AMLs engraft human cytokine knock-in mice

Jana M. Ellegast, Philipp J. Rauch, Larisa V. Kovtonyuk, Rouven Müller, Ulrich Wagner, Yasuyuki Saito, Nicole Wildner-Verhey van Wijk, Christine Fritz, Anahita Rafiei, Veronika Lysenko, Ewa Dudkiewicz, Alexandre P. Theocharides, Davide Soldini, Jeroen S. Goede, Richard A. Flavell, Markus G. Manz

Blood (2016) 128 (17): 2130–2134.

https://doi.org/10.1182/blood-2015-12-689356

Published: 2016

Includes: Supplemental data

Journal Articles

Peripheral blood CD34 + cells efficiently engraft human cytokine knock-in mice

Yasuyuki Saito, Jana M. Ellegast, Anahita Rafiei, Yuanbin Song, Daniel Kull, Mathias Heikenwalder, Anthony Rongvaux, Stephanie Halene, Richard A. Flavell, Markus G. Manz

Blood (2016) 128 (14): 1829–1833.

https://doi.org/10.1182/blood-2015-10-676452

Published: 2016

Includes: Supplemental data

Journal Articles

Mpl Expression on AML Blasts Predicts Cytopenia

Philipp J Rauch, MD, Corinne Widmer, MD, Kristin Fritsch, MS, Jana M Ellegast, MD, Jeroen S Goede, MD, Peter J M Valk, PhD, Hitoshi Takizawa, PhD, Markus G Manz, MD

Blood (2015) 126 (23): 1387.

https://doi.org/10.1182/blood.V126.23.1387.1387

Published: 2015

Journal Articles

Adult Donor-Derived Human CD34 + Cell Engraftment and Hemato-Lymphoid System Development in 3rd Generation Humanized Mice

Yasuyuki Saito, MD PhD, Jana M. Ellegast, MD, Rouven Müller, MD, Richard A. Flavell, PhD, Markus G. Manz, MD

Blood (2014) 124 (21): 4378.

https://doi.org/10.1182/blood.V124.21.4378.4378

Published: 2014

Journal Articles

ΜΙSΤRG Mice Support Good-Risk AML Engraftment

Jana M. Ellegast, MD, Yasuyuki Saito, MD PhD, Richard A. Flavell, PhD, Markus G. Manz, MD

Blood (2014) 124 (21): 3808.

https://doi.org/10.1182/blood.V124.21.3808.3808

Published: 2014

NARROW

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Resistance Mechanisms to SYK Inhibition in AML

Vcp-Regulated Homologous Recombination Represents a New Druggable Vulnerability in Acute Myeloid Leukemia

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

inv(16) and NPM1 mut AMLs engraft human cytokine knock-in mice

Peripheral blood CD34 + cells efficiently engraft human cytokine knock-in mice

Mpl Expression on AML Blasts Predicts Cytopenia

Adult Donor-Derived Human CD34 + Cell Engraftment and Hemato-Lymphoid System Development in 3rd Generation Humanized Mice

ΜΙSΤRG Mice Support Good-Risk AML Engraftment

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American Society of Hematology

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ASH Publications

American Society of Hematology

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