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Mark J Althoff
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Journal Articles

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Mark J Althoff, Mohd Minhajuddin, Brett M Stevens, Austin E Gillen, Regan Miller, Ana Vujovic, Sweta B Patel, William Showers, Stephanie Gipson, Monika Dzieciatkowska, Jana M Ellegast, Tristen Wright, Kimberly Stegmaier, Joseph T Opferman, Craig T Jordan
Journal: Blood
Blood (2024) 144 (Supplement 1): 39.
https://doi.org/10.1182/blood-2024-206516
Published: 2024
Journal Articles

Intracellular Calcium Localization Mediates the Activity of Venetoclax in Targeting Acute Myeloid Leukemia Stem Cells

Anagha Inguva, Krysta L. Engel, Hunter Tolison, Mark J Althoff, Shanshan Pei, Maria L. Amaya, Anna Krug, Mohammad Minhajuddin, Courtney L Jones, Austin E. Gillen, Monica Ransom, Sarah Staggs, Daniel A. Pollyea, Clayton Smith, Brett M. Stevens, Craig T. Jordan
Journal: Blood
Blood (2022) 140 (Supplement 1): 5922–5923.
https://doi.org/10.1182/blood-2022-167787
Published: 2022
Journal Articles

Scribble Is a Negative Regulator of Interferon-I Dependent Notch1 Activation in Adult Hematopoietic Stem Cells and Progenitors

Abhishek K Singh, Mark J Althoff, Saimul Islam, Ashley M Wellendorf, Jose A. Cancelas
Journal: Blood
Blood (2021) 138 (Supplement 1): 299.
https://doi.org/10.1182/blood-2021-151046
Published: 2021
Journal Articles

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Karin Golan, Abhishek K. Singh, Orit Kollet, Mayla Bertagna, Mark J. Althoff, Eman Khatib-Massalha, Ekaterina Petrovich-Kopitman, Ashley M. Wellendorf, Hassan Massalha, Smadar Levin-Zaidman, Tali Dadosh, Breanna Bohan, Mruniya V. Gawali, Biplab Dasgupta, Tsvee Lapidot, Jose A. Cancelas
Journal: Blood
Blood (2020) 136 (23): 2607–2619.
https://doi.org/10.1182/blood.2020005399
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate

Mark J. Althoff, Ramesh C. Nayak, Shailaja Hegde, Ashley M. Wellendorf, Breanna Bohan, Marie-Dominique Filippi, Mei Xin, Q. Richard Lu, Hartmut Geiger, Yi Zheng, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas
Journal: Blood
Blood (2020) 136 (16): 1824–1836.
https://doi.org/10.1182/blood.2019004113
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Abhishek K Singh, PhD, Karin Golan, PhD, Mark J Althoff, BS, Ekaterina Petrovich-Kopitman, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Mayla Bertagna, MSc, Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Tsvee Lapidot, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 872.
https://doi.org/10.1182/blood-2018-99-118292
Published: 2018
Journal Articles

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Abhishek K Singh, PhD, Karin Golan, PhD, Mark J Althoff, BS, Ekaterina Petrovich-Kopitman, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Mayla Bertagna, MSc, Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Tsvee Lapidot, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 639.
https://doi.org/10.1182/blood-2018-99-118663
Published: 2018
Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 551.
https://doi.org/10.1182/blood-2018-99-118919
Published: 2018
Journal Articles

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

Mark J Althoff, BS, Ramesh C. Nayak, PhD, Shailaja Hegde, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 710.
https://doi.org/10.1182/blood.V130.Suppl_1.710.710
Published: 2017
Journal Articles

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Karin Golan, PhD, Ashley Wellendorf, Yuji Takihara, MD PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Orit Kollet, PhD, Hui Cheng, PhD, Tao Cheng, MD, Mark J. Althoff, Shiri Gur-Cohen, PhD, Tomer Itkin, PhD, Marie-Dominique Fillipi, PhD, Jose A Cancelas, MD PhD, Toshio Suda, MD PhD, Tsvee Lapidot, PhD
Journal: Blood
Blood (2016) 128 (22): 5.
https://doi.org/10.1182/blood.V128.22.5.5
Published: 2016
Journal Articles

High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1 -Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia

Michelle Churchman, Ph.D., Jonathan Low, Ph.D., Debbie Payne-Turner, Shann-Ching Chen, PhD, Jing Ma, PhD, Mark J. Althoff, Faiyaz Notta, PhD, John E. Dick, PhD, Laura Janke, DVM, PhD, Rodney Kiplin Guy, Ph.D, Taosheng Chen, Ph.D., Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 172.
https://doi.org/10.1182/blood.V122.21.172.172
Published: 2013