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Kimberly Stegmaier
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Journal Articles

Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia

Stefan Bjelosevic, Rahel Fauth, Brian T Do, Gabriela Alexe, Birgitta Ryback, Allen T Basanthakumar, Lucy A Merickel, Silvi Salhotra, Audrey Taillon, Thomas D Jackson, Giulia DiGiovanni, Muhammad Bin Munim, Ryan Elbashir, Shan Lin, Pere Puigserver, David E. Root, Matthew G Vander Heiden, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 626.
https://doi.org/10.1182/blood-2024-208370
Published: 2024
Journal Articles

ADAR1 Is a Vulnerability in TP53 -Mutant Acute Myeloid Leukemia

Yara Rodriguez, Gabriela Alexe, Audrey Taillon, Constanze Schneider, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 2717.
https://doi.org/10.1182/blood-2024-208594
Published: 2024
Journal Articles

Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia

Constanze Schneider, Gabriela Alexe, Ashleigh Meyer, Lucy A Merickel, Allen T Basanthakumar, Audrey Taillon, Silvi Salhotra, Yara Rodriguez, Björn Häupl, David E. Root, Thomas Oellerich, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 205.
https://doi.org/10.1182/blood-2024-206333
Published: 2024
Journal Articles

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Mark J Althoff, Mohd Minhajuddin, Brett M Stevens, Austin E Gillen, Regan Miller, Ana Vujovic, Sweta B Patel, William Showers, Stephanie Gipson, Monika Dzieciatkowska, Jana M Ellegast, Tristen Wright, Kimberly Stegmaier, Joseph T Opferman, Craig T Jordan
Journal: Blood
Blood (2024) 144 (Supplement 1): 39.
https://doi.org/10.1182/blood-2024-206516
Published: 2024
Journal Articles

Transcriptional Regulation of Cytotoxic T-Cell Responses in Acute Myeloid Leukemia

Xufeng Chen, Zhengxi Sun, Jana Elegast, Hua Zhou, Soobeom Lee, Deedra Nicolet, Qiao Lu, Kun Wang, Jun Wang, Wafa Al-Santli, Ann-Kathrin Eisfeld, Kimberly Stegmaier, Iannis Aifantis, Rebecca Austin
Journal: Blood
Blood (2024) 144 (Supplement 1): 5733.
https://doi.org/10.1182/blood-2024-193591
Published: 2024
Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Peter G. Miller, Adam S. Sperling, Christina Mayerhofer, Marie E. McConkey, Jana M. Ellegast, Carmen Da Silva, Drew N. Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J. Gibson, David T. Scadden, Kimberly Stegmaier, Shruti Bhatt, R. Coleman Lindsley, Benjamin L. Ebert
Journal: Blood
Blood (2023) 142 (24): 2079–2091.
https://doi.org/10.1182/blood.2023020331
Published: 2023
Includes: Supplemental data
Journal Articles

The UBE2J2/UBE2K-MARCH5 Ubiquitination Machinery Regulates Apoptosis in Response to Venetoclax in Acute Myeloid Leukemia

Constanze Schneider, Shan Lin, Angela H Su, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 2785.
https://doi.org/10.1182/blood-2023-182312
Published: 2023
Journal Articles

Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia

Nastassja Scheidegger, Gabriela Alexe, Delan Khalid, Rhonda E Ries, Jim Wang, Todd A. Alonzo, Jennifer Perry, Scott A Armstrong, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 166.
https://doi.org/10.1182/blood-2023-185561
Published: 2023
Journal Articles

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Fanny Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 4174.
https://doi.org/10.1182/blood-2023-187187
Published: 2023
Journal Articles

The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia

Camille Vaganay, Frank Ling, Lois M. Kelly, Duong Ho Nhat, Antoine Forget, Paul-Arthur Meslin, Hélène Pasquer, Rathana Kim, Marie Passet, Sofiane Fodil, Tony Huynh, Angela H Su, Christopher F Bassil, Matthieu Duchmann, Gabriela Alexe, Gael Fortin, Carine Legrand, Khansa Saadallah, Christopher Delaney, Kim Pacchiardi, Anja Kocijancic, Lisa Aziez, Nina Fenouille, Marie Sebert, Lionel Ades, Emmanuel Raffoux, Emmanuelle Clappier, Lina Benajiba, Kimberly Stegmaier, Kris C. Wood, Raphael Itzykson, Camille Lobry, Alexandre Puissant
Journal: Blood
Blood (2023) 142 (Supplement 1): 409.
https://doi.org/10.1182/blood-2023-186264
Published: 2023
Journal Articles

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Jana M Ellegast, Gabriela Alexe, Subha Baniya, Amanda Hamze, Audrey Taillon, Biniam Adane, Amy Saur Conway, Tinghu Zhang, Nathanael S Gray, Scott A Armstrong, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 1393.
https://doi.org/10.1182/blood-2023-189304
Published: 2023
Journal Articles

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Fanny C Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2022) 140 (Supplement 1): 5864–5865.
https://doi.org/10.1182/blood-2022-166664
Published: 2022
Journal Articles

Breaking the Pump: Targeting the Sodium-Potassium Pump As a Therapeutic Strategy in Acute Myeloid Leukemia

Constanze Schneider, Hermes Spaink, Gabriela Alexe, Neekesh V. Dharia, Ashleigh Meyer, Delan Khalid, Sebastian Scheich, Björn Häupl, Louis M. Staudt, Thomas Oellerich, Kimberly Stegmaier
Journal: Blood
Blood (2022) 140 (Supplement 1): 4936–4937.
https://doi.org/10.1182/blood-2022-168226
Published: 2022
Journal Articles

Proteomic Characterization of Acute Myeloid Leukemia

Sebastian Wolf, Ashok Kumar Jayavelu, Florian Buettner, Gabriela Alexe, Björn Häupl, Constanze Schneider, Anne C Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Julius Christoph Enssle, Anjali Cremer, Christoph Röllig, Christian Thiede, Björn Steffen, Martin Bornhäuser, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Journal: Blood
Blood (2022) 140 (Supplement 1): 3456–3457.
https://doi.org/10.1182/blood-2022-169242
Published: 2022
Journal Articles

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Amy N Sexauer, Gabriela Alexe, Varsha Gandhi, Kimberly Stegmaier, David Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 7795–7797.
https://doi.org/10.1182/blood-2022-167569
Published: 2022
Journal Articles

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Anne C. Wilke, Carmen Doebele, Alena Zindel, Kwang Seok Lee, Sara A. Rieke, Michele Ceribelli, Federico Comoglio, James D. Phelan, James Q. Wang, Yana Pikman, Dominique Jahn, Björn Häupl, Constanze Schneider, Sebastian Scheich, Frances A. Tosto, Hanibal Bohnenberger, Philipp Stauder, Frank Schnütgen, Mikolaj Slabicki, Zana A. Coulibaly, Sebastian Wolf, Kamil Bojarczuk, Björn Chapuy, Christian H. Brandts, Philipp Stroebel, Caroline A. Lewis, Michael Engelke, Xincheng Xu, Hahn Kim, Thanh Hung Dang, Roland Schmitz, Daniel J. Hodson, Kimberly Stegmaier, Henning Urlaub, Hubert Serve, Clemens A. Schmitt, Fernando Kreuz, Gero Knittel, Joshua D. Rabinowitz, Hans Christian Reinhardt, Matthew G. Vander Heiden, Craig Thomas, Louis M. Staudt, Thorsten Zenz, Thomas Oellerich
Journal: Blood
Blood (2022) 139 (4): 538–553.
https://doi.org/10.1182/blood.2021012081
Published: 2022
Includes: Supplemental data
Journal Articles

Alisertib Synergistically Strengthens the Anti-Leukemia Activity of Venetoclax in TCF3-Hlf B-ALL

Asen Bagashev, Joseph Patrick Loftus, Colin Wakefield, Gerald Wertheim, Christian Hurtz, Martin P. Carroll, Kimberly Stegmaier, Yana Pikman, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 705.
https://doi.org/10.1182/blood-2021-148671
Published: 2021
Journal Articles

An In Vivo CRISPR Screening Platform to Identify New Therapeutic Targets in AML

Shan Lin, Clement Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Jerome Tamburini, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 266.
https://doi.org/10.1182/blood-2021-153039
Published: 2021
Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
https://doi.org/10.1182/blood-2021-151511
Published: 2021
Journal Articles

SLC5A3 Transports Myo-Inositol to Support the Growth of Acute Myeloid Leukemia

Shan Lin, Nastassja K. Scheidegger, Gabriela Alexe, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2021-152023
Published: 2021