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Journal Articles

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

Blood (2025) 146 (25): 3019–3035.

https://doi.org/10.1182/blood.2025028954

Published: 2025

Includes: Supplemental data

Journal Articles

Feasibility and utility of unmatched whole-genome sequencing (uWGS) for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples

Blood (2025) 146 (Supplement 1): 2561.

https://doi.org/10.1182/blood-2025-2561

Published: 2025

Journal Articles

CBFA2T3::GLIS2 directly represses differentiation and is required for AMKL disease maintenance

Rachel Mersfelder, Cory Rillahan, Fanny Gonzales, Giulia DiGiovanni, Maxim Pimkin, Thomas Mercher, Delan Khalid, Gabriela Alexe, Fabio Boniolo, Julie Riviere, Alexia Le Bourgeois, Volker Hovestadt, Kimberly Stegmaier

Blood (2025) 146 (Supplement 1): 1473.

https://doi.org/10.1182/blood-2025-1473

Published: 2025

Journal Articles

ADAR1 Is a Vulnerability in TP53 -Mutant Acute Myeloid Leukemia

Yara Rodriguez, Gabriela Alexe, Audrey Taillon, Constanze Schneider, Kimberly Stegmaier

Blood (2024) 144 (Supplement 1): 2717.

https://doi.org/10.1182/blood-2024-208594

Published: 2024

Journal Articles

Transcriptional Regulation of Cytotoxic T-Cell Responses in Acute Myeloid Leukemia

Xufeng Chen, Zhengxi Sun, Jana Elegast, Hua Zhou, Soobeom Lee, Deedra Nicolet, Qiao Lu, Kun Wang, Jun Wang, Wafa Al-Santli, Ann-Kathrin Eisfeld, Kimberly Stegmaier, Iannis Aifantis, Rebecca Austin

Blood (2024) 144 (Supplement 1): 5733.

https://doi.org/10.1182/blood-2024-193591

Published: 2024

Journal Articles

Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia

Constanze Schneider, Gabriela Alexe, Ashleigh Meyer, Lucy A Merickel, Allen T Basanthakumar, Audrey Taillon, Silvi Salhotra, Yara Rodriguez, Björn Häupl, David E. Root, Thomas Oellerich, Kimberly Stegmaier

Blood (2024) 144 (Supplement 1): 205.

https://doi.org/10.1182/blood-2024-206333

Published: 2024

Journal Articles

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Mark J Althoff, Mohd Minhajuddin, Brett M Stevens, Austin E Gillen, Regan Miller, Ana Vujovic, Sweta B Patel, William Showers, Stephanie Gipson, Monika Dzieciatkowska, Jana M Ellegast, Tristen Wright, Kimberly Stegmaier, Joseph T Opferman, Craig T Jordan

Blood (2024) 144 (Supplement 1): 39.

https://doi.org/10.1182/blood-2024-206516

Published: 2024

Journal Articles

Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia

Stefan Bjelosevic, Rahel Fauth, Brian T Do, Gabriela Alexe, Birgitta Ryback, Allen T Basanthakumar, Lucy A Merickel, Silvi Salhotra, Audrey Taillon, Thomas D Jackson, Giulia DiGiovanni, Muhammad Bin Munim, Ryan Elbashir, Shan Lin, Pere Puigserver, David E. Root, Matthew G Vander Heiden, Kimberly Stegmaier

Blood (2024) 144 (Supplement 1): 626.

https://doi.org/10.1182/blood-2024-208370

Published: 2024

Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Blood (2023) 142 (24): 2079–2091.

https://doi.org/10.1182/blood.2023020331

Published: 2023

Includes: Supplemental data

Journal Articles

The UBE2J2/UBE2K-MARCH5 Ubiquitination Machinery Regulates Apoptosis in Response to Venetoclax in Acute Myeloid Leukemia

Constanze Schneider, Shan Lin, Angela H Su, Gabriela Alexe, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 2785.

https://doi.org/10.1182/blood-2023-182312

Published: 2023

Journal Articles

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Fanny Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 4174.

https://doi.org/10.1182/blood-2023-187187

Published: 2023

Journal Articles

Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia

Nastassja Scheidegger, Gabriela Alexe, Delan Khalid, Rhonda E Ries, Jim Wang, Todd A. Alonzo, Jennifer Perry, Scott A Armstrong, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 166.

https://doi.org/10.1182/blood-2023-185561

Published: 2023

Journal Articles

The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 409.

https://doi.org/10.1182/blood-2023-186264

Published: 2023

Journal Articles

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Jana M Ellegast, Gabriela Alexe, Subha Baniya, Amanda Hamze, Audrey Taillon, Biniam Adane, Amy Saur Conway, Tinghu Zhang, Nathanael S Gray, Scott A Armstrong, Kimberly Stegmaier

Blood (2023) 142 (Supplement 1): 1393.

https://doi.org/10.1182/blood-2023-189304

Published: 2023

Journal Articles

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Fanny C Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier

Blood (2022) 140 (Supplement 1): 5864–5865.

https://doi.org/10.1182/blood-2022-166664

Published: 2022

Journal Articles

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Amy N Sexauer, Gabriela Alexe, Varsha Gandhi, Kimberly Stegmaier, David Sykes

Blood (2022) 140 (Supplement 1): 7795–7797.

https://doi.org/10.1182/blood-2022-167569

Published: 2022

Journal Articles

Proteomic Characterization of Acute Myeloid Leukemia

Blood (2022) 140 (Supplement 1): 3456–3457.

https://doi.org/10.1182/blood-2022-169242

Published: 2022

Journal Articles

Breaking the Pump: Targeting the Sodium-Potassium Pump As a Therapeutic Strategy in Acute Myeloid Leukemia

Constanze Schneider, Hermes Spaink, Gabriela Alexe, Neekesh V. Dharia, Ashleigh Meyer, Delan Khalid, Sebastian Scheich, Björn Häupl, Louis M. Staudt, Thomas Oellerich, Kimberly Stegmaier

Blood (2022) 140 (Supplement 1): 4936–4937.

https://doi.org/10.1182/blood-2022-168226

Published: 2022

Journal Articles

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Blood (2022) 139 (4): 538–553.

https://doi.org/10.1182/blood.2021012081

Published: 2022

Includes: Supplemental data

Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier

Blood (2021) 138 (Supplement 1): 3305.

https://doi.org/10.1182/blood-2021-151511

Published: 2021

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CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

Feasibility and utility of unmatched whole-genome sequencing (uWGS) for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples

CBFA2T3::GLIS2 directly represses differentiation and is required for AMKL disease maintenance

ADAR1 Is a Vulnerability in TP53 -Mutant Acute Myeloid Leukemia

Transcriptional Regulation of Cytotoxic T-Cell Responses in Acute Myeloid Leukemia

Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia

MCL1 Promotes Fatty Acid β-Oxidation in Therapy-Resistant AML through Cytoplasmic Sequestration of the Transcriptional Repressor IRF2BP2

Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

The UBE2J2/UBE2K-MARCH5 Ubiquitination Machinery Regulates Apoptosis in Response to Venetoclax in Acute Myeloid Leukemia

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia

The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Proteomic Characterization of Acute Myeloid Leukemia

Breaking the Pump: Targeting the Sodium-Potassium Pump As a Therapeutic Strategy in Acute Myeloid Leukemia

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

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